Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis.
Identifieur interne : 000155 ( PubMed/Curation ); précédent : 000154; suivant : 000156Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis.
Auteurs : Peter C. Grayson [États-Unis] ; Paul A. Monach [États-Unis] ; Christian Pagnoux [Canada] ; David Cuthbertson [États-Unis] ; Simon Carette [Canada] ; Gary S. Hoffman [États-Unis] ; Nader A. Khalidi [Canada] ; Curry L. Koening [États-Unis] ; Carol A. Langford [États-Unis] ; Kathleen Maksimowicz-Mckinnon [États-Unis] ; Philip Seo [États-Unis] ; Ulrich Specks ; Steven R. Ytterberg ; Peter A. Merkel [États-Unis]Source :
- Rheumatology (Oxford, England) [ 1462-0332 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de régression, Femelle, Granulocytes éosinophiles (anatomopathologie), Granulomatose avec polyangéite (diagnostic), Granulomatose avec polyangéite (sang), Humains, Immunoglobuline E (sang), Indice de gravité médicale, Marqueurs biologiques (sang), Mâle, Numération cellulaire, Protéine C-réactive (métabolisme), Récidive, Sujet âgé, Sujet âgé de 80 ans ou plus, Sédimentation du sang, Tests diagnostiques courants (), Valeur prédictive des tests, Éosinophilie (diagnostic), Éosinophilie (sang), Études de cohortes, Études longitudinales.
- MESH :
- anatomopathologie : Granulocytes éosinophiles.
- diagnostic : Granulomatose avec polyangéite, Éosinophilie.
- métabolisme : Protéine C-réactive.
- sang : Granulomatose avec polyangéite, Immunoglobuline E, Marqueurs biologiques, Éosinophilie.
- Adulte, Adulte d'âge moyen, Analyse de régression, Femelle, Humains, Indice de gravité médicale, Mâle, Numération cellulaire, Récidive, Sujet âgé, Sujet âgé de 80 ans ou plus, Sédimentation du sang, Tests diagnostiques courants, Valeur prédictive des tests, Études de cohortes, Études longitudinales.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Biomarkers (blood), Blood Sedimentation, C-Reactive Protein (metabolism), Cell Count, Cohort Studies, Diagnostic Tests, Routine (methods), Eosinophilia (blood), Eosinophilia (diagnosis), Eosinophils (pathology), Female, Granulomatosis with Polyangiitis (blood), Granulomatosis with Polyangiitis (diagnosis), Humans, Immunoglobulin E (blood), Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Recurrence, Regression Analysis, Severity of Illness Index.
- MESH :
- chemical , blood : Biomarkers, Immunoglobulin E.
- chemical , metabolism : C-Reactive Protein.
- blood : Eosinophilia, Granulomatosis with Polyangiitis.
- diagnosis : Eosinophilia, Granulomatosis with Polyangiitis.
- methods : Diagnostic Tests, Routine.
- pathology : Eosinophils.
- Adult, Aged, Aged, 80 and over, Blood Sedimentation, Cell Count, Cohort Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Recurrence, Regression Analysis, Severity of Illness Index.
Abstract
The aim of this study was to assess the clinical value of absolute eosinophil count, serum IgE, ESR and CRP as longitudinal biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA).
DOI: 10.1093/rheumatology/keu427
PubMed: 25406357
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Ulrich Specks<affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Mayo Clinic of Medicine, Rochester.</nlm:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN and.</nlm:affiliation><wicri:noCountry code="subField">MN and</wicri:noCountry></affiliation>Le document en format XML
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Merkel</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA pmerkel@upenn.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Division of Rheumatology, University of Pennsylvania, Philadelphia, PA</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25406357</idno><idno type="pmid">25406357</idno><idno type="doi">10.1093/rheumatology/keu427</idno><idno type="wicri:Area/PubMed/Corpus">000155</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000155</idno><idno type="wicri:Area/PubMed/Curation">000155</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000155</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis.</title><author><name sortKey="Grayson, Peter C" sort="Grayson, Peter C" uniqKey="Grayson P" first="Peter C" last="Grayson">Peter C. Grayson</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Monach, Paul A" sort="Monach, Paul A" uniqKey="Monach P" first="Paul A" last="Monach">Paul A. Monach</name><affiliation wicri:level="1"><nlm:affiliation>Section of Rheumatology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Rheumatology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Pagnoux, Christian" sort="Pagnoux, Christian" uniqKey="Pagnoux C" first="Christian" last="Pagnoux">Christian Pagnoux</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, Mount Sinai Hospital, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Cuthbertson, David" sort="Cuthbertson, David" uniqKey="Cuthbertson D" first="David" last="Cuthbertson">David Cuthbertson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, University of South Florida, Tampa, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Biostatistics, University of South Florida, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Carette, Simon" sort="Carette, Simon" uniqKey="Carette S" first="Simon" last="Carette">Simon Carette</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, Mount Sinai Hospital, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Hoffman, Gary S" sort="Hoffman, Gary S" uniqKey="Hoffman G" first="Gary S" last="Hoffman">Gary S. Hoffman</name><affiliation wicri:level="1"><nlm:affiliation>Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Khalidi, Nader A" sort="Khalidi, Nader A" uniqKey="Khalidi N" first="Nader A" last="Khalidi">Nader A. Khalidi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Koening, Curry L" sort="Koening, Curry L" uniqKey="Koening C" first="Curry L" last="Koening">Curry L. Koening</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, University of Utah, Salt Lake City, UT.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Division of Rheumatology, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Langford, Carol A" sort="Langford, Carol A" uniqKey="Langford C" first="Carol A" last="Langford">Carol A. Langford</name><affiliation wicri:level="1"><nlm:affiliation>Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Maksimowicz Mckinnon, Kathleen" sort="Maksimowicz Mckinnon, Kathleen" uniqKey="Maksimowicz Mckinnon K" first="Kathleen" last="Maksimowicz-Mckinnon">Kathleen Maksimowicz-Mckinnon</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Rheumatology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Seo, Philip" sort="Seo, Philip" uniqKey="Seo P" first="Philip" last="Seo">Philip Seo</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Johns Hopkins University, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Rheumatology, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Specks, Ulrich" sort="Specks, Ulrich" uniqKey="Specks U" first="Ulrich" last="Specks">Ulrich Specks</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Mayo Clinic of Medicine, Rochester.</nlm:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Ytterberg, Steven R" sort="Ytterberg, Steven R" uniqKey="Ytterberg S" first="Steven R" last="Ytterberg">Steven R. Ytterberg</name><affiliation><nlm:affiliation>Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN and.</nlm:affiliation><wicri:noCountry code="subField">MN and</wicri:noCountry></affiliation></author><author><name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A" last="Merkel">Peter A. Merkel</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA pmerkel@upenn.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Division of Rheumatology, University of Pennsylvania, Philadelphia, PA</wicri:regionArea></affiliation></author></analytic><series><title level="j">Rheumatology (Oxford, England)</title><idno type="eISSN">1462-0332</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Biomarkers (blood)</term><term>Blood Sedimentation</term><term>C-Reactive Protein (metabolism)</term><term>Cell Count</term><term>Cohort Studies</term><term>Diagnostic Tests, Routine (methods)</term><term>Eosinophilia (blood)</term><term>Eosinophilia (diagnosis)</term><term>Eosinophils (pathology)</term><term>Female</term><term>Granulomatosis with Polyangiitis (blood)</term><term>Granulomatosis with Polyangiitis (diagnosis)</term><term>Humans</term><term>Immunoglobulin E (blood)</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Recurrence</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de régression</term><term>Femelle</term><term>Granulocytes éosinophiles (anatomopathologie)</term><term>Granulomatose avec polyangéite (diagnostic)</term><term>Granulomatose avec polyangéite (sang)</term><term>Humains</term><term>Immunoglobuline E (sang)</term><term>Indice de gravité médicale</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Numération cellulaire</term><term>Protéine C-réactive (métabolisme)</term><term>Récidive</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Sédimentation du sang</term><term>Tests diagnostiques courants ()</term><term>Valeur prédictive des tests</term><term>Éosinophilie (diagnostic)</term><term>Éosinophilie (sang)</term><term>Études de cohortes</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Immunoglobulin E</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Granulocytes éosinophiles</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Eosinophilia</term><term>Granulomatosis with Polyangiitis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Eosinophilia</term><term>Granulomatosis with Polyangiitis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Granulomatose avec polyangéite</term><term>Éosinophilie</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Tests, Routine</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Eosinophils</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Granulomatose avec polyangéite</term><term>Immunoglobuline E</term><term>Marqueurs biologiques</term><term>Éosinophilie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Blood Sedimentation</term><term>Cell Count</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Recurrence</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de régression</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Numération cellulaire</term><term>Récidive</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Sédimentation du sang</term><term>Tests diagnostiques courants</term><term>Valeur prédictive des tests</term><term>Études de cohortes</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to assess the clinical value of absolute eosinophil count, serum IgE, ESR and CRP as longitudinal biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25406357</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>16</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1462-0332</ISSN><JournalIssue CitedMedium="Internet"><Volume>54</Volume><Issue>8</Issue><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Rheumatology (Oxford, England)</Title><ISOAbbreviation>Rheumatology (Oxford)</ISOAbbreviation></Journal><ArticleTitle>Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis.</ArticleTitle><Pagination><MedlinePgn>1351-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/rheumatology/keu427</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The aim of this study was to assess the clinical value of absolute eosinophil count, serum IgE, ESR and CRP as longitudinal biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients were selected from an observational EGPA cohort. Absolute eosinophil count, IgE, ESR and CRP were measured quarterly. Disease activity was defined by validated assessment tools. The association of tests with disease activity was assessed via regression models, adjusting for repeated measures and treatment status. Survival analysis was used to determine if laboratory tests were predictive of the 3 month future flare risk.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Seventy-four per cent of 892 study visits in 141 patients occurred while patients were on treatment, mostly during remission or mild disease activity, defined as a BVAS for Wegener's granulomatosis (BVAS/WG) of 1 or 2. Correlations between absolute eosinophil count, IgE, ESR and CRP were mostly low or non-significant (r = -0.08 to 0.44). There were few weak associations with disease activity [absolute eosinophil count: OR) 1.01/100 U (95% CI 1.01, 1.02); ESR: OR 1.15/10 mg/l increase (95% CI 1.04, 1.27)]. When BVAS/WG ≥1 defined active disease, the absolute eosinophil count [hazard ratio (HR) 1.01/100 U (95% CI 1.01, 1.02)] was weakly predictive of flare. When BVAS/WG ≥3 defined active disease, ESR was weakly predictive of flare [HR 1.52/10 mm/h increase (95% CI 1.17, 1.67)].</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The absolute eosinophil count, IgE, ESR and CRP have limitations as longitudinal biomarkers of disease activity or predictors of flare in EGPA. These findings suggest that novel biomarkers of disease activity for EGPA are needed.</AbstractText><CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grayson</LastName><ForeName>Peter C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monach</LastName><ForeName>Paul A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Section of Rheumatology, Boston University School of Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pagnoux</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuthbertson</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of South Florida, Tampa, FL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carette</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffman</LastName><ForeName>Gary S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khalidi</LastName><ForeName>Nader A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koening</LastName><ForeName>Curry L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, University of Utah, Salt Lake City, UT.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langford</LastName><ForeName>Carol A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maksimowicz-McKinnon</LastName><ForeName>Kathleen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seo</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Johns Hopkins University, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Specks</LastName><ForeName>Ulrich</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, Mayo Clinic of Medicine, Rochester.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ytterberg</LastName><ForeName>Steven R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merkel</LastName><ForeName>Peter A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA pmerkel@upenn.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Vasculitis Clinical Research Consortium</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U54 RR019497</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000135</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000439</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 AR057319</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR001067</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AR5187404</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Rheumatology (Oxford)</MedlineTA><NlmUniqueID>100883501</NlmUniqueID><ISSNLinking>1462-0324</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>37341-29-0</RegistryNumber><NameOfSubstance UI="D007073">Immunoglobulin E</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive 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MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001799" MajorTopicYN="N">Blood Sedimentation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003955" MajorTopicYN="N">Diagnostic Tests, Routine</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004802" MajorTopicYN="N">Eosinophilia</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004804" MajorTopicYN="N">Eosinophils</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014890" MajorTopicYN="N">Granulomatosis with Polyangiitis</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007073" MajorTopicYN="N">Immunoglobulin E</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012044" MajorTopicYN="N">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="Y">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4502335</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Churg–Strauss syndrome</Keyword><Keyword MajorTopicYN="N">biomarker</Keyword><Keyword MajorTopicYN="N">eosinophil</Keyword><Keyword MajorTopicYN="N">eosinophilic granulomatosis with polyangiitis</Keyword><Keyword MajorTopicYN="N">vasculitis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>06</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25406357</ArticleId><ArticleId IdType="pii">keu427</ArticleId><ArticleId 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