Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam.
Identifieur interne : 004329 ( PubMed/Corpus ); précédent : 004328; suivant : 004330Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam.
Auteurs : Ronny Kalash ; Hebist Berhane ; Yong Yang ; Michael W. Epperly ; Hong Wang ; Tracy Dixon ; Byung Rhieu ; Joel S. Greenberger ; Mohammed Saiful HuqSource :
- In vivo (Athens, Greece) [ 1791-7549 ]
English descriptors
- KwdEn :
- MESH :
- adverse effects : Radiosurgery.
- radiation effects : Cell Survival.
- Animals, Humans, Mice, Radiotherapy Dosage, Whole-Body Irradiation.
Abstract
We evaluated the radiobiological effects of stereotactic radiosurgery (SRS) photon beams on survival of C57BL/6NTac mice following total body irradiation.
PubMed: 24425830
Links to Exploration step
pubmed:24425830Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam.</title>
<author><name sortKey="Kalash, Ronny" sort="Kalash, Ronny" uniqKey="Kalash R" first="Ronny" last="Kalash">Ronny Kalash</name>
<affiliation><nlm:affiliation>Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Rm. 533, Pittsburgh, PA 15232, U.S.A. greenbergerjs@upmc.edu.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Berhane, Hebist" sort="Berhane, Hebist" uniqKey="Berhane H" first="Hebist" last="Berhane">Hebist Berhane</name>
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<author><name sortKey="Yang, Yong" sort="Yang, Yong" uniqKey="Yang Y" first="Yong" last="Yang">Yong Yang</name>
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<author><name sortKey="Epperly, Michael W" sort="Epperly, Michael W" uniqKey="Epperly M" first="Michael W" last="Epperly">Michael W. Epperly</name>
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<author><name sortKey="Wang, Hong" sort="Wang, Hong" uniqKey="Wang H" first="Hong" last="Wang">Hong Wang</name>
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<author><name sortKey="Dixon, Tracy" sort="Dixon, Tracy" uniqKey="Dixon T" first="Tracy" last="Dixon">Tracy Dixon</name>
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<author><name sortKey="Rhieu, Byung" sort="Rhieu, Byung" uniqKey="Rhieu B" first="Byung" last="Rhieu">Byung Rhieu</name>
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<author><name sortKey="Greenberger, Joel S" sort="Greenberger, Joel S" uniqKey="Greenberger J" first="Joel S" last="Greenberger">Joel S. Greenberger</name>
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<author><name sortKey="Huq, Mohammed Saiful" sort="Huq, Mohammed Saiful" uniqKey="Huq M" first="Mohammed Saiful" last="Huq">Mohammed Saiful Huq</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam.</title>
<author><name sortKey="Kalash, Ronny" sort="Kalash, Ronny" uniqKey="Kalash R" first="Ronny" last="Kalash">Ronny Kalash</name>
<affiliation><nlm:affiliation>Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Rm. 533, Pittsburgh, PA 15232, U.S.A. greenbergerjs@upmc.edu.</nlm:affiliation>
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<author><name sortKey="Berhane, Hebist" sort="Berhane, Hebist" uniqKey="Berhane H" first="Hebist" last="Berhane">Hebist Berhane</name>
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<author><name sortKey="Yang, Yong" sort="Yang, Yong" uniqKey="Yang Y" first="Yong" last="Yang">Yong Yang</name>
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<author><name sortKey="Epperly, Michael W" sort="Epperly, Michael W" uniqKey="Epperly M" first="Michael W" last="Epperly">Michael W. Epperly</name>
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<author><name sortKey="Wang, Hong" sort="Wang, Hong" uniqKey="Wang H" first="Hong" last="Wang">Hong Wang</name>
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<author><name sortKey="Dixon, Tracy" sort="Dixon, Tracy" uniqKey="Dixon T" first="Tracy" last="Dixon">Tracy Dixon</name>
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<author><name sortKey="Rhieu, Byung" sort="Rhieu, Byung" uniqKey="Rhieu B" first="Byung" last="Rhieu">Byung Rhieu</name>
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<author><name sortKey="Greenberger, Joel S" sort="Greenberger, Joel S" uniqKey="Greenberger J" first="Joel S" last="Greenberger">Joel S. Greenberger</name>
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<author><name sortKey="Huq, Mohammed Saiful" sort="Huq, Mohammed Saiful" uniqKey="Huq M" first="Mohammed Saiful" last="Huq">Mohammed Saiful Huq</name>
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<series><title level="j">In vivo (Athens, Greece)</title>
<idno type="eISSN">1791-7549</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Survival (radiation effects)</term>
<term>Humans</term>
<term>Mice</term>
<term>Radiosurgery (adverse effects)</term>
<term>Radiotherapy Dosage</term>
<term>Whole-Body Irradiation</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiosurgery</term>
</keywords>
<keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cell Survival</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Mice</term>
<term>Radiotherapy Dosage</term>
<term>Whole-Body Irradiation</term>
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<front><div type="abstract" xml:lang="en">We evaluated the radiobiological effects of stereotactic radiosurgery (SRS) photon beams on survival of C57BL/6NTac mice following total body irradiation.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>01</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>09</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1791-7549</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>28</Volume>
<Issue>1</Issue>
<PubDate><MedlineDate>2014 Jan-Feb</MedlineDate>
</PubDate>
</JournalIssue>
<Title>In vivo (Athens, Greece)</Title>
<ISOAbbreviation>In Vivo</ISOAbbreviation>
</Journal>
<ArticleTitle>Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam.</ArticleTitle>
<Pagination><MedlinePgn>1-12</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND/AIM" NlmCategory="OBJECTIVE">We evaluated the radiobiological effects of stereotactic radiosurgery (SRS) photon beams on survival of C57BL/6NTac mice following total body irradiation.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Survival of Lewis lung carcinoma (3LL) cells was tested after irradiation using 6 MV: 300 MU/min or 1400 MU/min; or 10 MV: 300 MU/min or 2400 MU/min. Survival of C57BL/6NTac mice after a dose which is lethal to 50% of the mice in 30 days (LD50/30) (9.25 Gy) total body irradiation (TBI) and 21 Gy to orthotopic 3LL tumors was tested. We quantitated levels of organ-specific gene transcripts by Real Time Polymerase Chain Reaction (RT-PCR).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">While 3LL cell survival and inhibition of orthotopic tumor growth was uniform, 10 MV photons at 2400 MU/min TBI led to significantly greater survival (p=0.0218), with higher levels of intestinal (Sod2), (Gpx1), (Nrf2), and (NFκB) RNA transcripts.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Clinical 10 MV-2400 cGy/min SRS beams led to unexpected protection of mice on TBI and increased radioprotective gene transcripts.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kalash</LastName>
<ForeName>Ronny</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Rm. 533, Pittsburgh, PA 15232, U.S.A. greenbergerjs@upmc.edu.</Affiliation>
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<Author ValidYN="Y"><LastName>Yang</LastName>
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<Author ValidYN="Y"><LastName>Epperly</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Hong</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Dixon</LastName>
<ForeName>Tracy</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rhieu</LastName>
<ForeName>Byung</ForeName>
<Initials>B</Initials>
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<Author ValidYN="Y"><LastName>Greenberger</LastName>
<ForeName>Joel S</ForeName>
<Initials>JS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Huq</LastName>
<ForeName>Mohammed Saiful</ForeName>
<Initials>MS</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 CA047904</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U19 AI068021</GrantID>
<Acronym>AI</Acronym>
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<Country>United States</Country>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
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<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
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<MeshHeading><DescriptorName UI="D016634" MajorTopicYN="N">Radiosurgery</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011879" MajorTopicYN="Y">Radiotherapy Dosage</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014916" MajorTopicYN="Y">Whole-Body Irradiation</DescriptorName>
</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Stereotactic radiosurgery</Keyword>
<Keyword MajorTopicYN="N">dose rate</Keyword>
<Keyword MajorTopicYN="N">photon energy</Keyword>
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