Network pharmacology analyses of the antithrombotic pharmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats.
Identifieur interne : 002742 ( PubMed/Corpus ); précédent : 002741; suivant : 002743Network pharmacology analyses of the antithrombotic pharmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats.
Auteurs : Shujing Sheng ; Jinxu Wang ; Lirong Wang ; Hong Liu ; Peibo Li ; Menghua Liu ; Chaofeng Long ; Chengshi Xie ; Xiangqun Xie ; Weiwei SuSource :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Disseminated Intravascular Coagulation (drug therapy), Drugs, Chinese Herbal (chemistry), Drugs, Chinese Herbal (isolation & purification), Drugs, Chinese Herbal (pharmacology), Fibrinolytic Agents (chemistry), Fibrinolytic Agents (isolation & purification), Fibrinolytic Agents (pharmacology), Lipopolysaccharides (antagonists & inhibitors), Lipopolysaccharides (pharmacology), Male, Molecular Targeted Therapy, Rats, Rats, Sprague-Dawley.
- MESH :
- chemical , antagonists & inhibitors : Lipopolysaccharides.
- chemical , chemistry : Drugs, Chinese Herbal, Fibrinolytic Agents.
- drug therapy : Disseminated Intravascular Coagulation.
- chemical , isolation & purification : Drugs, Chinese Herbal, Fibrinolytic Agents.
- chemical , pharmacology : Drugs, Chinese Herbal, Fibrinolytic Agents, Lipopolysaccharides.
- Animals, Disease Models, Animal, Male, Molecular Targeted Therapy, Rats, Rats, Sprague-Dawley.
Abstract
Fufang Xueshuantong (FXST) Capsule is developed on a traditional Chinese medicine remedy, with a four-herb formula of Panax notoginseng, Radix astragali, Salvia miltiorrhizae and Radix scrophulariaceae. It has been used for treatment of the clinic cardiovascular disease for many years.
DOI: 10.1016/j.jep.2014.04.048
PubMed: 24832112
Links to Exploration step
pubmed:24832112Le document en format XML
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Electronic address: xix15@pitt.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Weiwei" sort="Su, Weiwei" uniqKey="Su W" first="Weiwei" last="Su">Weiwei Su</name><affiliation><nlm:affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China. Electronic address: lssswwhk@gmail.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24832112</idno><idno type="pmid">24832112</idno><idno type="doi">10.1016/j.jep.2014.04.048</idno><idno type="wicri:Area/PubMed/Corpus">002742</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002742</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Network pharmacology analyses of the antithrombotic pharmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats.</title><author><name sortKey="Sheng, Shujing" sort="Sheng, Shujing" uniqKey="Sheng S" first="Shujing" last="Sheng">Shujing Sheng</name><affiliation><nlm:affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China; Guangdong Zhongsheng Pharmaceutical Co., Ltd., Dongguan 523325, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jinxu" sort="Wang, Jinxu" uniqKey="Wang J" first="Jinxu" last="Wang">Jinxu Wang</name><affiliation><nlm:affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China; Visiting Scholar in Xie's laboratory at University of Pittsburgh, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Lirong" sort="Wang, Lirong" uniqKey="Wang L" first="Lirong" last="Wang">Lirong Wang</name><affiliation><nlm:affiliation>Computational Chemical Genomics Screening Center, Department of Pharmaceutical Sciences, School of Pharmacy, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Hong" sort="Liu, Hong" uniqKey="Liu H" first="Hong" last="Liu">Hong Liu</name><affiliation><nlm:affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Peibo" sort="Li, Peibo" uniqKey="Li P" first="Peibo" last="Li">Peibo Li</name><affiliation><nlm:affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Menghua" sort="Liu, Menghua" uniqKey="Liu M" first="Menghua" last="Liu">Menghua Liu</name><affiliation><nlm:affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Long, Chaofeng" sort="Long, Chaofeng" uniqKey="Long C" first="Chaofeng" last="Long">Chaofeng Long</name><affiliation><nlm:affiliation>Guangdong Zhongsheng Pharmaceutical Co., Ltd., Dongguan 523325, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Chengshi" sort="Xie, Chengshi" uniqKey="Xie C" first="Chengshi" last="Xie">Chengshi Xie</name><affiliation><nlm:affiliation>Guangdong Zhongsheng Pharmaceutical Co., Ltd., Dongguan 523325, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Xiangqun" sort="Xie, Xiangqun" uniqKey="Xie X" first="Xiangqun" last="Xie">Xiangqun Xie</name><affiliation><nlm:affiliation>Computational Chemical Genomics Screening Center, Department of Pharmaceutical Sciences, School of Pharmacy, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: xix15@pitt.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Weiwei" sort="Su, Weiwei" uniqKey="Su W" first="Weiwei" last="Su">Weiwei Su</name><affiliation><nlm:affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China. Electronic address: lssswwhk@gmail.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Disseminated Intravascular Coagulation (drug therapy)</term><term>Drugs, Chinese Herbal (chemistry)</term><term>Drugs, Chinese Herbal (isolation & purification)</term><term>Drugs, Chinese Herbal (pharmacology)</term><term>Fibrinolytic Agents (chemistry)</term><term>Fibrinolytic Agents (isolation & purification)</term><term>Fibrinolytic Agents (pharmacology)</term><term>Lipopolysaccharides (antagonists & inhibitors)</term><term>Lipopolysaccharides (pharmacology)</term><term>Male</term><term>Molecular Targeted Therapy</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Lipopolysaccharides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drugs, Chinese Herbal</term><term>Fibrinolytic Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Disseminated Intravascular Coagulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Drugs, Chinese Herbal</term><term>Fibrinolytic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Drugs, Chinese Herbal</term><term>Fibrinolytic Agents</term><term>Lipopolysaccharides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Male</term><term>Molecular Targeted Therapy</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fufang Xueshuantong (FXST) Capsule is developed on a traditional Chinese medicine remedy, with a four-herb formula of Panax notoginseng, Radix astragali, Salvia miltiorrhizae and Radix scrophulariaceae. It has been used for treatment of the clinic cardiovascular disease for many years.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24832112</PMID><DateCreated><Year>2014</Year><Month>06</Month><Day>16</Day></DateCreated><DateCompleted><Year>2016</Year><Month>05</Month><Day>09</Day></DateCompleted><DateRevised><Year>2014</Year><Month>06</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN><JournalIssue CitedMedium="Internet"><Volume>154</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>Jul</Month><Day>03</Day></PubDate></JournalIssue><Title>Journal of ethnopharmacology</Title><ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation></Journal><ArticleTitle>Network pharmacology analyses of the antithrombotic pharmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats.</ArticleTitle><Pagination><MedlinePgn>735-44</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2014.04.048</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0378-8741(14)00347-X</ELocationID><Abstract><AbstractText Label="ETHNOPHARMACOLOGICAL RELEVANCE" NlmCategory="BACKGROUND">Fufang Xueshuantong (FXST) Capsule is developed on a traditional Chinese medicine remedy, with a four-herb formula of Panax notoginseng, Radix astragali, Salvia miltiorrhizae and Radix scrophulariaceae. It has been used for treatment of the clinic cardiovascular disease for many years.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Due to its complexity of compositions and polypharmacological effects, it often complicates understanding of the mechanisms of action. In the present work, we have constructed an integrated model of system pharmacology to investigate the polypharmacological mechanisms of FXST formulation for treatment of thrombosis disease.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The predicted results showed that 22 ingredients in FXST were closely associated with 41 protein targets related to blood coagulation, fibrinolysis and platelet aggregation. Through analysis of the compound-protein target association, significant cross-targets between each herb indicated the multiple active chemical ingredients might interact with the same target simultaneously and thus explained the synergistic mechanisms of the principle of Traditional Chinese medicines (TCMs) as ''Jun (emperor) - Chen (minister) - Zuo (adjuvant) - Shi (courier)''. To validate the polypharmacological effects predicted by our network pharmacology (NetPharm) analysis, we have carried out experimental investigation the effects of FXST on the disorders of the blood coagulation system in a lipopolysaccharide-induced disseminated intravascular coagulation (DIC) rat model. The results showed that FXST could significantly ameliorate the activation of coagulation system, which is congruent with the cross-target prediction by NetPharm approach.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The combined investigations provide more insight into better understanding of the pharmacological mechanisms of FXST, and may also offer an alternative avenue to further explore the chemical and pharmacological basis of TCMs.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sheng</LastName><ForeName>Shujing</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China; Guangdong Zhongsheng Pharmaceutical Co., Ltd., Dongguan 523325, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jinxu</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China; Visiting Scholar in Xie's laboratory at University of Pittsburgh, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Lirong</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Computational Chemical Genomics Screening Center, Department of Pharmaceutical Sciences, School of Pharmacy, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Peibo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Menghua</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Long</LastName><ForeName>Chaofeng</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Guangdong Zhongsheng Pharmaceutical Co., Ltd., Dongguan 523325, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Chengshi</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Guangdong Zhongsheng Pharmaceutical Co., Ltd., Dongguan 523325, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Xiangqun</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Computational Chemical Genomics Screening Center, Department of Pharmaceutical Sciences, School of Pharmacy, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: xix15@pitt.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Weiwei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China. Electronic address: lssswwhk@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>J Ethnopharmacol</MedlineTA><NlmUniqueID>7903310</NlmUniqueID><ISSNLinking>0378-8741</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005343">Fibrinolytic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C530083">fufang xiaojingtong</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004211" MajorTopicYN="N">Disseminated Intravascular Coagulation</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004365" MajorTopicYN="N">Drugs, Chinese Herbal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005343" MajorTopicYN="N">Fibrinolytic Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058990" MajorTopicYN="Y">Molecular Targeted Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Angoroside C (PubChem CID: 6444153)</Keyword><Keyword MajorTopicYN="N">Astragaloside IV (PubChem CID: 158694)</Keyword><Keyword MajorTopicYN="N">Calycosin-7-O-β-d-glucopyranoside (PubChem CID: 5318267)</Keyword><Keyword MajorTopicYN="N">Disseminated intravascular coagulation</Keyword><Keyword MajorTopicYN="N">Fufang Xueshuantong Capsule</Keyword><Keyword MajorTopicYN="N">Ginsenoside Rb1 (PubChem CID: 9898279)</Keyword><Keyword MajorTopicYN="N">Harpagoside (PubChem CID: 5281542)</Keyword><Keyword MajorTopicYN="N">Network pharmacology</Keyword><Keyword MajorTopicYN="N">Panaxytriol (PubChem CID: 93484)</Keyword><Keyword MajorTopicYN="N">Salvianolic acid A (PubChem CID: 5281793)</Keyword><Keyword MajorTopicYN="N">Salvianolic acid B (PubChem CID: 11629084)</Keyword><Keyword MajorTopicYN="N">Tanshinone I (PubChem CID: 114917)</Keyword><Keyword MajorTopicYN="N">Tanshinone IIA (PubChem CID: 164676)</Keyword><Keyword MajorTopicYN="N">Thrombosis disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>04</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>04</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24832112</ArticleId><ArticleId IdType="pii">S0378-8741(14)00347-X</ArticleId><ArticleId IdType="doi">10.1016/j.jep.2014.04.048</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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