Fearfulness moderates the link between childhood social withdrawal and adolescent reward response.
Identifieur interne : 000258 ( PubMed/Corpus ); précédent : 000257; suivant : 000259Fearfulness moderates the link between childhood social withdrawal and adolescent reward response.
Auteurs : Judith K. Morgan ; Daniel S. Shaw ; Erika E. ForbesSource :
- Social cognitive and affective neuroscience [ 1749-5024 ] ; 2015.
English descriptors
- KwdEn :
- Child, Child, Preschool, Corpus Striatum (physiology), Depression (physiopathology), Depression (psychology), Depressive Disorder (physiopathology), Depressive Disorder (psychology), Fear (psychology), Female, Humans, Magnetic Resonance Imaging, Male, Peer Group, Prefrontal Cortex (physiology), Reward, Social Behavior, Young Adult.
- MESH :
- physiology : Corpus Striatum, Prefrontal Cortex.
- physiopathology : Depression, Depressive Disorder.
- psychology : Depression, Depressive Disorder, Fear.
- Child, Child, Preschool, Female, Humans, Magnetic Resonance Imaging, Male, Peer Group, Reward, Social Behavior, Young Adult.
Abstract
Withdrawal from peers during childhood may reflect disruptions in reward functioning that heighten vulnerability to affective disorders during adolescence. The association between socially withdrawn behavior and reward functioning may depend on traits that influence this withdrawal, such as fearfulness or unsociability. In a study of 129 boys, we evaluated how boys' fearfulness and sociability at age 5 and social withdrawal at school at ages 6 to 10 and during a summer camp at age 9/10 were associated with their neural response to reward at age 20. Greater social withdrawal during childhood was associated with heightened striatal and mPFC activation when anticipating rewards at age 20. Fearfulness moderated this effect to indicate that social withdrawal was associated with heightened reward-related response in the striatum for boys high on fearfulness. Altered striatal response associated with social withdrawal and fearfulness predicted greater likelihood to have a lifetime history of depression and social phobia at age 20. These findings add greater specificity to previous findings that children high in traits related to fear of novelty show altered reward responses, by identifying fearfulness (but not low levels of sociability) as a potential underlying mechanism that contributes to reward alterations in withdrawn children.
DOI: 10.1093/scan/nsu113
PubMed: 25193948
Links to Exploration step
pubmed:25193948Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fearfulness moderates the link between childhood social withdrawal and adolescent reward response.</title><author><name sortKey="Morgan, Judith K" sort="Morgan, Judith K" uniqKey="Morgan J" first="Judith K" last="Morgan">Judith K. Morgan</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA morganjk@upmc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Shaw, Daniel S" sort="Shaw, Daniel S" uniqKey="Shaw D" first="Daniel S" last="Shaw">Daniel S. Shaw</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Forbes, Erika E" sort="Forbes, Erika E" uniqKey="Forbes E" first="Erika E" last="Forbes">Erika E. Forbes</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25193948</idno><idno type="pmid">25193948</idno><idno type="doi">10.1093/scan/nsu113</idno><idno type="wicri:Area/PubMed/Corpus">000258</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000258</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Fearfulness moderates the link between childhood social withdrawal and adolescent reward response.</title><author><name sortKey="Morgan, Judith K" sort="Morgan, Judith K" uniqKey="Morgan J" first="Judith K" last="Morgan">Judith K. Morgan</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA morganjk@upmc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Shaw, Daniel S" sort="Shaw, Daniel S" uniqKey="Shaw D" first="Daniel S" last="Shaw">Daniel S. Shaw</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Forbes, Erika E" sort="Forbes, Erika E" uniqKey="Forbes E" first="Erika E" last="Forbes">Erika E. Forbes</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Social cognitive and affective neuroscience</title><idno type="eISSN">1749-5024</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Corpus Striatum (physiology)</term><term>Depression (physiopathology)</term><term>Depression (psychology)</term><term>Depressive Disorder (physiopathology)</term><term>Depressive Disorder (psychology)</term><term>Fear (psychology)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Peer Group</term><term>Prefrontal Cortex (physiology)</term><term>Reward</term><term>Social Behavior</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Corpus Striatum</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term><term>Fear</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Peer Group</term><term>Reward</term><term>Social Behavior</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Withdrawal from peers during childhood may reflect disruptions in reward functioning that heighten vulnerability to affective disorders during adolescence. The association between socially withdrawn behavior and reward functioning may depend on traits that influence this withdrawal, such as fearfulness or unsociability. In a study of 129 boys, we evaluated how boys' fearfulness and sociability at age 5 and social withdrawal at school at ages 6 to 10 and during a summer camp at age 9/10 were associated with their neural response to reward at age 20. Greater social withdrawal during childhood was associated with heightened striatal and mPFC activation when anticipating rewards at age 20. Fearfulness moderated this effect to indicate that social withdrawal was associated with heightened reward-related response in the striatum for boys high on fearfulness. Altered striatal response associated with social withdrawal and fearfulness predicted greater likelihood to have a lifetime history of depression and social phobia at age 20. These findings add greater specificity to previous findings that children high in traits related to fear of novelty show altered reward responses, by identifying fearfulness (but not low levels of sociability) as a potential underlying mechanism that contributes to reward alterations in withdrawn children.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25193948</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>30</Day></DateCreated><DateCompleted><Year>2016</Year><Month>05</Month><Day>24</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1749-5024</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Social cognitive and affective neuroscience</Title><ISOAbbreviation>Soc Cogn Affect Neurosci</ISOAbbreviation></Journal><ArticleTitle>Fearfulness moderates the link between childhood social withdrawal and adolescent reward response.</ArticleTitle><Pagination><MedlinePgn>761-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/scan/nsu113</ELocationID><Abstract><AbstractText>Withdrawal from peers during childhood may reflect disruptions in reward functioning that heighten vulnerability to affective disorders during adolescence. The association between socially withdrawn behavior and reward functioning may depend on traits that influence this withdrawal, such as fearfulness or unsociability. In a study of 129 boys, we evaluated how boys' fearfulness and sociability at age 5 and social withdrawal at school at ages 6 to 10 and during a summer camp at age 9/10 were associated with their neural response to reward at age 20. Greater social withdrawal during childhood was associated with heightened striatal and mPFC activation when anticipating rewards at age 20. Fearfulness moderated this effect to indicate that social withdrawal was associated with heightened reward-related response in the striatum for boys high on fearfulness. Altered striatal response associated with social withdrawal and fearfulness predicted greater likelihood to have a lifetime history of depression and social phobia at age 20. These findings add greater specificity to previous findings that children high in traits related to fear of novelty show altered reward responses, by identifying fearfulness (but not low levels of sociability) as a potential underlying mechanism that contributes to reward alterations in withdrawn children.</AbstractText><CopyrightInformation>© The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Morgan</LastName><ForeName>Judith K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA morganjk@upmc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaw</LastName><ForeName>Daniel S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forbes</LastName><ForeName>Erika E</ForeName><Initials>EE</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA and Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K01 MH099220</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DA026222</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH050907</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DA02622</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>09</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Soc Cogn Affect Neurosci</MedlineTA><NlmUniqueID>101288795</NlmUniqueID><ISSNLinking>1749-5016</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Child Dev. 1987 Dec;58(6):1459-73</RefSource><PMID Version="1">3691195</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2002 Sep 15;52(6):529-42</RefSource><PMID Version="1">12361667</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2010 Jan;35(1):4-26</RefSource><PMID Version="1">19812543</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychol Sci. 2009 Aug;20(8):1009-18</RefSource><PMID 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MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003866" MajorTopicYN="N">Depressive Disorder</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005239" MajorTopicYN="N">Fear</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010379" MajorTopicYN="N">Peer Group</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017397" MajorTopicYN="N">Prefrontal Cortex</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012201" MajorTopicYN="Y">Reward</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012919" MajorTopicYN="Y">Social Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4448017</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">fearfulness</Keyword><Keyword MajorTopicYN="N">reward</Keyword><Keyword MajorTopicYN="N">social withdrawal</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>09</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>09</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>9</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>9</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>5</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25193948</ArticleId><ArticleId IdType="pii">nsu113</ArticleId><ArticleId IdType="doi">10.1093/scan/nsu113</ArticleId><ArticleId IdType="pmc">PMC4448017</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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