A single nucleotide polymorphism in the corticotropin receptor gene is associated with a blunted cortisol response during pediatric critical illness.
Identifieur interne : 003F77 ( PubMed/Checkpoint ); précédent : 003F76; suivant : 003F78A single nucleotide polymorphism in the corticotropin receptor gene is associated with a blunted cortisol response during pediatric critical illness.
Auteurs : David Jardine [États-Unis] ; Mary Emond ; Kathleen L. Meert ; Rick Harrison ; Joseph A. Carcillo ; Kanwaljeet J S. Anand ; John Berger ; Christopher J L. Newth ; Douglas F. Willson ; Carol Nicholson ; J Michael Dean ; Jerry J. ZimmermanSource :
- Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [ 1529-7535 ] ; 2014.
Descripteurs français
- KwdFr :
- ADN (analyse), Adolescent, Allèles, Enfant, Enfant d'âge préscolaire, Facteur de nécrose tumorale alpha (génétique), Femelle, Génotype, Hormones corticosurrénaliennes (usage thérapeutique), Humains, Hydrocortisone (biosynthèse), Hydrocortisone (sang), Indice de gravité médicale, Maladie grave (), Mâle, Nourrisson, Nouveau-né, Polymorphisme de nucléotide simple, Récepteur de la mélanocortine de type 2 (génétique), Récepteurs des minéralocorticoïdes (génétique), Études prospectives.
- MESH :
- analyse : ADN.
- biosynthèse : Hydrocortisone.
- génétique : Facteur de nécrose tumorale alpha, Récepteur de la mélanocortine de type 2, Récepteurs des minéralocorticoïdes.
- sang : Hydrocortisone.
- usage thérapeutique : Hormones corticosurrénaliennes.
- Adolescent, Allèles, Enfant, Enfant d'âge préscolaire, Femelle, Génotype, Humains, Indice de gravité médicale, Maladie grave, Mâle, Nourrisson, Nouveau-né, Polymorphisme de nucléotide simple, Études prospectives.
English descriptors
- KwdEn :
- Adolescent, Adrenal Cortex Hormones (therapeutic use), Alleles, Child, Child, Preschool, Critical Illness (therapy), DNA (analysis), Female, Genotype, Humans, Hydrocortisone (biosynthesis), Hydrocortisone (blood), Infant, Infant, Newborn, Male, Polymorphism, Single Nucleotide, Prospective Studies, Receptor, Melanocortin, Type 2 (genetics), Receptors, Mineralocorticoid (genetics), Severity of Illness Index, Tumor Necrosis Factor-alpha (genetics).
- MESH :
- chemical , analysis : DNA.
- chemical , biosynthesis : Hydrocortisone.
- chemical , blood : Hydrocortisone.
- chemical , genetics : Receptor, Melanocortin, Type 2, Receptors, Mineralocorticoid, Tumor Necrosis Factor-alpha.
- chemical , therapeutic use : Adrenal Cortex Hormones.
- therapy : Critical Illness.
- Adolescent, Alleles, Child, Child, Preschool, Female, Genotype, Humans, Infant, Infant, Newborn, Male, Polymorphism, Single Nucleotide, Prospective Studies, Severity of Illness Index.
Abstract
The cortisol response during critical illness varies widely among patients. Our objective was to examine single nucleotide polymorphisms in candidate genes regulating cortisol synthesis, metabolism, and activity to determine if genetic differences were associated with variability in the cortisol response among critically ill children.
DOI: 10.1097/PCC.0000000000000193
PubMed: 25055195
Affiliations:
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pubmed:25055195Le document en format XML
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Willson</name></author><author><name sortKey="Nicholson, Carol" sort="Nicholson, Carol" uniqKey="Nicholson C" first="Carol" last="Nicholson">Carol Nicholson</name></author><author><name sortKey="Dean, J Michael" sort="Dean, J Michael" uniqKey="Dean J" first="J Michael" last="Dean">J Michael Dean</name></author><author><name sortKey="Zimmerman, Jerry J" sort="Zimmerman, Jerry J" uniqKey="Zimmerman J" first="Jerry J" last="Zimmerman">Jerry J. Zimmerman</name></author></analytic><series><title level="j">Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies</title><idno type="ISSN">1529-7535</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Alleles</term><term>Child</term><term>Child, Preschool</term><term>Critical Illness (therapy)</term><term>DNA (analysis)</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Hydrocortisone (biosynthesis)</term><term>Hydrocortisone (blood)</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Polymorphism, Single Nucleotide</term><term>Prospective Studies</term><term>Receptor, Melanocortin, Type 2 (genetics)</term><term>Receptors, Mineralocorticoid (genetics)</term><term>Severity of Illness Index</term><term>Tumor Necrosis Factor-alpha (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN (analyse)</term><term>Adolescent</term><term>Allèles</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteur de nécrose tumorale alpha (génétique)</term><term>Femelle</term><term>Génotype</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains</term><term>Hydrocortisone (biosynthèse)</term><term>Hydrocortisone (sang)</term><term>Indice de gravité médicale</term><term>Maladie grave ()</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Polymorphisme de nucléotide simple</term><term>Récepteur de la mélanocortine de type 2 (génétique)</term><term>Récepteurs des minéralocorticoïdes (génétique)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor, Melanocortin, Type 2</term><term>Receptors, Mineralocorticoid</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term><term>Récepteur de la mélanocortine de type 2</term><term>Récepteurs des minéralocorticoïdes</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Critical Illness</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Alleles</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Polymorphism, Single Nucleotide</term><term>Prospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Allèles</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Indice de gravité médicale</term><term>Maladie grave</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Polymorphisme de nucléotide simple</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cortisol response during critical illness varies widely among patients. Our objective was to examine single nucleotide polymorphisms in candidate genes regulating cortisol synthesis, metabolism, and activity to determine if genetic differences were associated with variability in the cortisol response among critically ill children.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25055195</PMID><DateCreated><Year>2014</Year><Month>10</Month><Day>04</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>02</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1529-7535</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies</Title><ISOAbbreviation>Pediatr Crit Care Med</ISOAbbreviation></Journal><ArticleTitle>A single nucleotide polymorphism in the corticotropin receptor gene is associated with a blunted cortisol response during pediatric critical illness.</ArticleTitle><Pagination><MedlinePgn>698-705</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/PCC.0000000000000193</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The cortisol response during critical illness varies widely among patients. Our objective was to examine single nucleotide polymorphisms in candidate genes regulating cortisol synthesis, metabolism, and activity to determine if genetic differences were associated with variability in the cortisol response among critically ill children.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">This was a prospective observational study employing tag single nucleotide polymorphism methodology to examine genetic contributions to the variability of the cortisol response in critical illness. Thirty-one candidate genes and 31 ancestry markers were examined.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Patients were enrolled from seven pediatric critical care units that constitute the Eunice Kennedy Shriver Collaborative Pediatric Critical Care Research Network.</AbstractText><AbstractText Label="SUBJECTS" NlmCategory="METHODS">Critically ill children (n = 92), age 40 weeks gestation to 18 years old, were enrolled.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Blood samples were obtained from all patients for serum cortisol measurements and DNA isolation. Demographic and illness severity data were collected.</AbstractText><AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">Single nucleotide polymorphisms were tested for association with serum free cortisol concentrations in context of higher illness severity as quantified by Pediatric Risk of Mortality III score greater than 7. A single nucleotide polymorphism (rs1941088) in the MC2R gene was strongly associated (p = 0.0005) with a low free cortisol response to critical illness. Patients with the AA genotype were over seven times more likely to have a low free cortisol response to critical illness than those with a GG genotype. Patients with the GA genotype exhibited an intermediate free cortisol response to critical illness.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The A allele at rs1941088 in the MC2R gene, which encodes the adrenocorticotropic hormone (corticotropin, ACTH) receptor, is associated with a low cortisol response in critically ill children. These data provide evidence for a genetic basis for a portion of the variability in cortisol production during critical illness. Independent replication of these findings will be important and could facilitate development of personalized treatment for patients with a low cortisol response to severe illness.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jardine</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>1Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA. 2Department of Biostatistics, University of Washington School of Medicine, Seattle, WA. 3Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI. 4Department of Pediatrics, University of California at Los Angeles, Los Angeles, CA. 5Department of Critical Care Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA. 6Department of Pediatrics, Le Bonheur Children's Hospital and University of Tennessee Health Science Center, Memphis, TN. 7Department of Pediatrics, Children's National Medical Center, Washington, DC. 8Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA. 9Department of Pediatrics, University of Virginia Children's Hospital, Charlottesville, VA. 10Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Washington, D.C. 11Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT. 12Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emond</LastName><ForeName>Mary</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Meert</LastName><ForeName>Kathleen L</ForeName><Initials>KL</Initials></Author><Author ValidYN="Y"><LastName>Harrison</LastName><ForeName>Rick</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Carcillo</LastName><ForeName>Joseph A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Anand</LastName><ForeName>Kanwaljeet J S</ForeName><Initials>KJ</Initials></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Newth</LastName><ForeName>Christopher J L</ForeName><Initials>CJ</Initials></Author><Author ValidYN="Y"><LastName>Willson</LastName><ForeName>Douglas F</ForeName><Initials>DF</Initials></Author><Author ValidYN="Y"><LastName>Nicholson</LastName><ForeName>Carol</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Dean</LastName><ForeName>J Michael</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Zimmerman</LastName><ForeName>Jerry J</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><CollectiveName>Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U10HD049945</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01HD049934</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD050012</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD049945</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10HD049981</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UG1 HD050096</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD049981</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD050096</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>3U10HD049945-05S1</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD049983</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10HD050096</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10HD049983</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HD049934</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10HD500009</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10HD050012</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D057666">Research Support, American Recovery and Reinvestment Act</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Crit Care Med</MedlineTA><NlmUniqueID>100954653</NlmUniqueID><ISSNLinking>1529-7535</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C561839">NR3C2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044103">Receptor, Melanocortin, Type 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018161">Receptors, Mineralocorticoid</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Thorax. 2005 May;60(5):357-9</RefSource><PMID Version="1">15860705</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2001 May;142(5):1982-9</RefSource><PMID Version="1">11316764</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Endocrinol. 2005 Nov;153(5):711-5</RefSource><PMID Version="1">16260430</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2005 Aug;1(2):e16</RefSource><PMID Version="1">16110340</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pediatr Crit Care Med. 2006 Jul;7(4):301-7</RefSource><PMID Version="1">16738501</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2006 Oct;91(10):3725-45</RefSource><PMID Version="1">16882746</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biochem. 2006 Dec;293(1-2):147-60</RefSource><PMID Version="1">16845490</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2006 Dec 15;174(12):1319-26</RefSource><PMID Version="1">16973979</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Best Pract Res Clin Endocrinol Metab. 2006 Dec;20(4):547-60</RefSource><PMID Version="1">17161331</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18205-10</RefSource><PMID Version="1">17989225</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2008 Jan 10;358(2):111-24</RefSource><PMID Version="1">18184957</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2008 Jan;4(1):e5</RefSource><PMID Version="1">18208330</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pediatr Res. 2008 Apr;63(4):410-4</RefSource><PMID Version="1">18356748</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2008 Apr 25;435(3):234-9</RefSource><PMID Version="1">18359160</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chin Med J (Engl). 2008 Sep 5;121(17):1627-32</RefSource><PMID Version="1">19024088</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2008 Dec;93(12):4948-54</RefSource><PMID Version="1">18840636</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Forensic Sci Int Genet. 2007 Dec;1(3-4):273-80</RefSource><PMID Version="1">19083773</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chest. 2009 Jan;135(1):181-93</RefSource><PMID Version="1">19136406</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Genet. 2009;10:39</RefSource><PMID Version="1">19630973</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pharmacogenet Genomics. 2010 Feb;20(2):71-6</RefSource><PMID Version="1">20042918</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2001 Jan 1;29(1):308-11</RefSource><PMID Version="1">11125122</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Shock. 2005 Jul;24(1):3-10</RefSource><PMID Version="1">15988314</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Steroid Biochem Mol Biol. 2001 May;77(2-3):117-22</RefSource><PMID Version="1">11377976</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2004 Apr 15;350(16):1629-38</RefSource><PMID Version="1">15084695</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2004 Jul;89(7):3131-7</RefSource><PMID Version="1">15240582</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Surg. 1976 Sep;184(3):333-41</RefSource><PMID Version="1">786190</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Endocrinol. 1990 Jan 22;68(2-3):R31-6</RefSource><PMID Version="1">2155834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 1991 Jan;128(1):623-9</RefSource><PMID Version="1">1702707</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1995 May 18;332(20):1351-62</RefSource><PMID Version="1">7715646</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Med. 1995 Jul;23(7):1294-303</RefSource><PMID Version="1">7600840</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Med. 1995 Aug;23(8):1430-9</RefSource><PMID Version="1">7634816</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Med. 1996 May;24(5):743-52</RefSource><PMID Version="1">8706448</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Endocrinol (Oxf). 2010 May;72(5):589-94</RefSource><PMID Version="1">19558534</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pediatr Crit Care Med. 2011 Sep;12(5):525-31</RefSource><PMID Version="1">21057361</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2012 Jan 15;185(2):133-9</RefSource><PMID Version="1">21680949</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Med. 2012 Dec;40(12):3283-9</RefSource><PMID Version="1">22975887</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Forensic Sci Int Genet. 2013 Jan;7(1):63-74</RefSource><PMID Version="1">22749789</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Resusc. 2013 Jun;15(2):83-8</RefSource><PMID Version="1">23931038</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Med. 2013 Oct;41(10):2310-7</RefSource><PMID Version="1">23787398</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Pediatr Crit Care Med. 2014 Oct;15(8):769-71</RefSource><PMID Version="1">25280145</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName 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Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044103" MajorTopicYN="N">Receptor, Melanocortin, Type 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018161" MajorTopicYN="N">Receptors, Mineralocorticoid</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS748309</OtherID><OtherID Source="NLM">PMC4712687</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25055195</ArticleId><ArticleId IdType="doi">10.1097/PCC.0000000000000193</ArticleId><ArticleId IdType="pmc">PMC4712687</ArticleId><ArticleId IdType="mid">NIHMS748309</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li></region></list><tree><noCountry><name sortKey="Anand, Kanwaljeet J S" sort="Anand, Kanwaljeet J S" uniqKey="Anand K" first="Kanwaljeet J S" last="Anand">Kanwaljeet J S. Anand</name><name sortKey="Berger, John" sort="Berger, John" uniqKey="Berger J" first="John" last="Berger">John Berger</name><name sortKey="Carcillo, Joseph A" sort="Carcillo, Joseph A" uniqKey="Carcillo J" first="Joseph A" last="Carcillo">Joseph A. Carcillo</name><name sortKey="Dean, J Michael" sort="Dean, J Michael" uniqKey="Dean J" first="J Michael" last="Dean">J Michael Dean</name><name sortKey="Emond, Mary" sort="Emond, Mary" uniqKey="Emond M" first="Mary" last="Emond">Mary Emond</name><name sortKey="Harrison, Rick" sort="Harrison, Rick" uniqKey="Harrison R" first="Rick" last="Harrison">Rick Harrison</name><name sortKey="Meert, Kathleen L" sort="Meert, Kathleen L" uniqKey="Meert K" first="Kathleen L" last="Meert">Kathleen L. Meert</name><name sortKey="Newth, Christopher J L" sort="Newth, Christopher J L" uniqKey="Newth C" first="Christopher J L" last="Newth">Christopher J L. Newth</name><name sortKey="Nicholson, Carol" sort="Nicholson, Carol" uniqKey="Nicholson C" first="Carol" last="Nicholson">Carol Nicholson</name><name sortKey="Willson, Douglas F" sort="Willson, Douglas F" uniqKey="Willson D" first="Douglas F" last="Willson">Douglas F. Willson</name><name sortKey="Zimmerman, Jerry J" sort="Zimmerman, Jerry J" uniqKey="Zimmerman J" first="Jerry J" last="Zimmerman">Jerry J. Zimmerman</name></noCountry><country name="États-Unis"><region name="Washington (État)"><name sortKey="Jardine, David" sort="Jardine, David" uniqKey="Jardine D" first="David" last="Jardine">David Jardine</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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