PittsburghV1, PubMed, Checkpoint, bibRecord, 002582

Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.

Identifieur interne : 002582 ( PubMed/Checkpoint ); précédent : 002581; suivant : 002583

Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.

Auteurs : Mikhil N. Bamne [États-Unis] ; F Yesim Demirci [États-Unis] ; Sarah Berman [États-Unis] ; Beth E. Snitz [États-Unis] ; Samantha L. Rosenthal [États-Unis] ; Xingbin Wang [États-Unis] ; Oscar L. Lopez [États-Unis] ; M Ilyas Kamboh [États-Unis]

Source :

Neurobiology of aging [ 1558-1497 ] ; 2014.

RBID : pubmed:24529499

Descripteurs français

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (genetics), Amyloid beta-Protein Precursor (genetics), Case-Control Studies, Cognition Disorders (genetics), Cohort Studies, European Continental Ancestry Group (genetics), Female, Genetic Association Studies, Genotype, Humans, Male, Middle Aged, Mutation (genetics), North America, Risk.
MESH :
- chemical , genetics : Amyloid beta-Protein Precursor.
- geographic : North America.
- genetics : Alzheimer Disease, Cognition Disorders, European Continental Ancestry Group, Mutation.
- Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Female, Genetic Association Studies, Genotype, Humans, Male, Middle Aged, Risk.

Abstract

A rare amyloid precursor protein gene variant, A673T (rs63750847) was recently reported to protect against Alzheimer's disease and age-related cognitive decline among Icelanders and the same rare variant was observed also in Finnish, Norwegian, and Swedish populations. We investigated this variant in 1674 late-onset Alzheimer's disease cases and 2644 elderly control subjects, all North American Whites (US Whites). We did not observe any example of the A673T variant in our large sample. Our findings suggest that this rare variant could be specific to the individuals of the origin from the Nordic countries.

DOI: 10.1016/j.neurobiolaging.2014.01.020
PubMed: 24529499

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">A rare amyloid precursor protein gene variant, A673T (rs63750847) was recently reported to protect against Alzheimer's disease and age-related cognitive decline among Icelanders and the same rare variant was observed also in Finnish, Norwegian, and Swedish populations. We investigated this variant in 1674 late-onset Alzheimer's disease cases and 2644 elderly control subjects, all North American Whites (US Whites). We did not observe any example of the A673T variant in our large sample. Our findings suggest that this rare variant could be specific to the individuals of the origin from the Nordic countries.</div>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2000 Dec 26;55(12):1854-62</RefSource>
<PMID Version="1">11134385</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>JAMA. 2008 Nov 19;300(19):2253-62</RefSource>
<PMID Version="1">19017911</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Transl Psychiatry. 2012;2:e117</RefSource>
<PMID Version="1">22832961</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2014 Apr;35(4):935.e11-2</RefSource>
<PMID Version="1">24126161</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2013 May;34(5):1518.e1-3</RefSource>
<PMID Version="1">23102935</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2013 Oct;34(10):2441.e7-8</RefSource>
<PMID Version="1">23652020</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 Aug 2;488(7409):96-9</RefSource>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<Keyword MajorTopicYN="N">Alzheimer's disease</Keyword>
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<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Bamne, Mikhil N" sort="Bamne, Mikhil N" uniqKey="Bamne M" first="Mikhil N" last="Bamne">Mikhil N. Bamne</name>
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Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.

Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.

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