Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth.
Identifieur interne : 001828 ( PubMed/Checkpoint ); précédent : 001827; suivant : 001829Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth.
Auteurs : Steve N. Caritis [États-Unis] ; Raman Venkataramanan [États-Unis] ; Elizabeth Thom [États-Unis] ; Margaret Harper [États-Unis] ; Mark A. Klebanoff [États-Unis] ; Yoram Sorokin [États-Unis] ; John M. Thorp [États-Unis] ; Michael W. Varner [États-Unis] ; Ronald J. Wapner [États-Unis] ; Jay D. Iams [États-Unis] ; Marshall W. Carpenter [États-Unis] ; William A. Grobman [États-Unis] ; Brian M. Mercer [États-Unis] ; Anthony Sciscione [États-Unis] ; Dwight J. Rouse [États-Unis] ; Susan Ramin [États-Unis]Source :
- American journal of obstetrics and gynecology [ 1097-6868 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Hydroxyprogestérones.
- sang : Deuxième trimestre de grossesse, Hydroxyprogestérones, Naissance prématurée.
- usage thérapeutique : Acides gras omega-3.
- Femelle, Grossesse, Humains, Naissance prématurée, Récidive.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Hydroxyprogesterones.
- chemical , blood : Hydroxyprogesterones.
- chemical , therapeutic use : Fatty Acids, Omega-3.
- blood : Pregnancy Trimester, Second, Premature Birth.
- prevention & control : Premature Birth.
- Female, Humans, Pregnancy, Recurrence.
Abstract
17-alpha hydroxyprogesterone caproate 250 mg weekly reduces recurrent spontaneous preterm birth in women with a prior spontaneous preterm birth by 33%. The dose is not based on pharmacologic considerations. A therapeutic concentration has not been determined hampering any attempt to optimize treatment. This study evaluated the relationship between 17-alpha hydroxyprogesterone caproate plasma concentrations and the rate of spontaneous preterm birth in women with singleton gestation.
DOI: 10.1016/j.ajog.2013.10.008
PubMed: 24113254
Affiliations:
- États-Unis
- Alabama, Caroline du Nord, District de Columbia, Illinois, Maryland, Michigan, Ohio, Pennsylvanie, Rhode Island, Texas, Utah, État de New York
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Links to Exploration step
pubmed:24113254Le document en format XML
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Caritis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Venkataramanan, Raman" sort="Venkataramanan, Raman" uniqKey="Venkataramanan R" first="Raman" last="Venkataramanan">Raman Venkataramanan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Thom, Elizabeth" sort="Thom, Elizabeth" uniqKey="Thom E" first="Elizabeth" last="Thom">Elizabeth Thom</name><affiliation wicri:level="2"><nlm:affiliation>The George Washington University Biostatistics Center, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>The George Washington University Biostatistics Center, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Harper, Margaret" sort="Harper, Margaret" uniqKey="Harper M" first="Margaret" last="Harper">Margaret Harper</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, and University of North Carolina at Chapel Hill, Chapel Hill, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, and University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Klebanoff, Mark A" sort="Klebanoff, Mark A" uniqKey="Klebanoff M" first="Mark A" last="Klebanoff">Mark A. 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Varner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Wapner, Ronald J" sort="Wapner, Ronald J" uniqKey="Wapner R" first="Ronald J" last="Wapner">Ronald J. 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Iams</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, The Ohio State University, Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Carpenter, Marshall W" sort="Carpenter, Marshall W" uniqKey="Carpenter M" first="Marshall W" last="Carpenter">Marshall W. Carpenter</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School, Brown University, Providence, RI.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School, Brown University, Providence</wicri:cityArea></affiliation></author><author><name sortKey="Grobman, William A" sort="Grobman, William A" uniqKey="Grobman W" first="William A" last="Grobman">William A. 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Caritis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Venkataramanan, Raman" sort="Venkataramanan, Raman" uniqKey="Venkataramanan R" first="Raman" last="Venkataramanan">Raman Venkataramanan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Thom, Elizabeth" sort="Thom, Elizabeth" uniqKey="Thom E" first="Elizabeth" last="Thom">Elizabeth Thom</name><affiliation wicri:level="2"><nlm:affiliation>The George Washington University Biostatistics Center, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>The George Washington University Biostatistics Center, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Harper, Margaret" sort="Harper, Margaret" uniqKey="Harper M" first="Margaret" last="Harper">Margaret Harper</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, and University of North Carolina at Chapel Hill, Chapel Hill, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, and University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Klebanoff, Mark A" sort="Klebanoff, Mark A" uniqKey="Klebanoff M" first="Mark A" last="Klebanoff">Mark A. Klebanoff</name><affiliation wicri:level="2"><nlm:affiliation>Maternal-Fetal Medicine Units, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Maternal-Fetal Medicine Units, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Sorokin, Yoram" sort="Sorokin, Yoram" uniqKey="Sorokin Y" first="Yoram" last="Sorokin">Yoram Sorokin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Wayne State University, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Thorp, John M" sort="Thorp, John M" uniqKey="Thorp J" first="John M" last="Thorp">John M. Thorp</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, and University of North Carolina at Chapel Hill, Chapel Hill, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, and University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Varner, Michael W" sort="Varner, Michael W" uniqKey="Varner M" first="Michael W" last="Varner">Michael W. Varner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Wapner, Ronald J" sort="Wapner, Ronald J" uniqKey="Wapner R" first="Ronald J" last="Wapner">Ronald J. Wapner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Iams, Jay D" sort="Iams, Jay D" uniqKey="Iams J" first="Jay D" last="Iams">Jay D. Iams</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, The Ohio State University, Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Carpenter, Marshall W" sort="Carpenter, Marshall W" uniqKey="Carpenter M" first="Marshall W" last="Carpenter">Marshall W. Carpenter</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School, Brown University, Providence, RI.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School, Brown University, Providence</wicri:cityArea></affiliation></author><author><name sortKey="Grobman, William A" sort="Grobman, William A" uniqKey="Grobman W" first="William A" last="Grobman">William A. Grobman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Mercer, Brian M" sort="Mercer, Brian M" uniqKey="Mercer B" first="Brian M" last="Mercer">Brian M. Mercer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Sciscione, Anthony" sort="Sciscione, Anthony" uniqKey="Sciscione A" first="Anthony" last="Sciscione">Anthony Sciscione</name><affiliation wicri:level="2"><nlm:affiliation>Drexel University College of Medicine, Philadelphia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Drexel University College of Medicine, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Rouse, Dwight J" sort="Rouse, Dwight J" uniqKey="Rouse D" first="Dwight J" last="Rouse">Dwight J. Rouse</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, Birmingham, AL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Ramin, Susan" sort="Ramin, Susan" uniqKey="Ramin S" first="Susan" last="Ramin">Susan Ramin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, TX.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston</wicri:cityArea></affiliation></author></analytic><series><title level="j">American journal of obstetrics and gynecology</title><idno type="eISSN">1097-6868</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fatty Acids, Omega-3 (therapeutic use)</term><term>Female</term><term>Humans</term><term>Hydroxyprogesterones (administration & dosage)</term><term>Hydroxyprogesterones (blood)</term><term>Pregnancy</term><term>Pregnancy Trimester, Second (blood)</term><term>Premature Birth (blood)</term><term>Premature Birth (prevention & control)</term><term>Recurrence</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides gras omega-3 (usage thérapeutique)</term><term>Deuxième trimestre de grossesse (sang)</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Hydroxyprogestérones (administration et posologie)</term><term>Hydroxyprogestérones (sang)</term><term>Naissance prématurée ()</term><term>Naissance prématurée (sang)</term><term>Récidive</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxyprogesterones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hydroxyprogesterones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Fatty Acids, Omega-3</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Hydroxyprogestérones</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Pregnancy Trimester, Second</term><term>Premature Birth</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Premature Birth</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Deuxième trimestre de grossesse</term><term>Hydroxyprogestérones</term><term>Naissance prématurée</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acides gras omega-3</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Pregnancy</term><term>Recurrence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Naissance prématurée</term><term>Récidive</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">17-alpha hydroxyprogesterone caproate 250 mg weekly reduces recurrent spontaneous preterm birth in women with a prior spontaneous preterm birth by 33%. The dose is not based on pharmacologic considerations. A therapeutic concentration has not been determined hampering any attempt to optimize treatment. This study evaluated the relationship between 17-alpha hydroxyprogesterone caproate plasma concentrations and the rate of spontaneous preterm birth in women with singleton gestation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24113254</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>27</Day></DateCreated><DateCompleted><Year>2014</Year><Month>03</Month><Day>17</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6868</ISSN><JournalIssue CitedMedium="Internet"><Volume>210</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>American journal of obstetrics and gynecology</Title><ISOAbbreviation>Am. J. Obstet. Gynecol.</ISOAbbreviation></Journal><ArticleTitle>Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth.</ArticleTitle><Pagination><MedlinePgn>128.e1-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ajog.2013.10.008</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0002-9378(13)01046-6</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">17-alpha hydroxyprogesterone caproate 250 mg weekly reduces recurrent spontaneous preterm birth in women with a prior spontaneous preterm birth by 33%. The dose is not based on pharmacologic considerations. A therapeutic concentration has not been determined hampering any attempt to optimize treatment. This study evaluated the relationship between 17-alpha hydroxyprogesterone caproate plasma concentrations and the rate of spontaneous preterm birth in women with singleton gestation.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">A single blood sample was obtained between 25 and 28 weeks' gestation from 315 women with a spontaneous preterm birth who participated in a placebo-controlled, prospective, randomized clinical trial evaluating the benefit of omega-3 supplementation in reducing preterm birth. All women in the parent study received 17-alpha hydroxyprogesterone caproate and 434 received omega-3 supplementation and 418 received a placebo. Plasma from 315 consenting women was analyzed for 17-alpha hydroxyprogesterone caproate concentration.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There were no differences between placebo and omega-3 supplemented groups in demographic variables, outcomes or in mean 17-alpha hydroxyprogesterone caproate concentration. Plasma concentrations of 17-alpha hydroxyprogesterone caproate ranged from 3.7-56 ng/mL. Women with plasma concentrations of 17-alpha hydroxyprogesterone caproate in the lowest quartile had a significantly higher risk of spontaneous preterm birth (P = .03) and delivered at significantly earlier gestational ages (P = .002) than did women in the second to fourth quartiles. The lowest preterm birth rates were seen when median 17-alpha hydroxyprogesterone caproate concentrations exceeded 6.4 ng/mL.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Low plasma 17-alpha hydroxyprogesterone caproate concentration is associated with an increased risk of spontaneous preterm birth. This finding validates efficacy of this treatment but suggests that additional studies are needed to determine the optimal dosage.</AbstractText><CopyrightInformation>Copyright © 2014 Mosby, Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Caritis</LastName><ForeName>Steve N</ForeName><Initials>SN</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venkataramanan</LastName><ForeName>Raman</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology and Reproductive Sciences and Pharmaceutical Sciences, University of Pittsburgh Schools of Medicine and Pharmacy, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thom</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>The George Washington University Biostatistics Center, Washington, DC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harper</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, and University of North Carolina at Chapel Hill, Chapel Hill, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klebanoff</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Maternal-Fetal Medicine Units, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sorokin</LastName><ForeName>Yoram</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thorp</LastName><ForeName>John M</ForeName><Initials>JM</Initials><Suffix>Jr</Suffix><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, and University of North Carolina at Chapel Hill, Chapel Hill, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Varner</LastName><ForeName>Michael W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wapner</LastName><ForeName>Ronald J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iams</LastName><ForeName>Jay D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carpenter</LastName><ForeName>Marshall W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School, Brown University, Providence, RI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grobman</LastName><ForeName>William A</ForeName><Initials>WA</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mercer</LastName><ForeName>Brian M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sciscione</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Drexel University College of Medicine, Philadelphia, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouse</LastName><ForeName>Dwight J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, Birmingham, AL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramin</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, TX.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network and Obstetric-Fetal Pharmacology Research Units Network</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HD36801</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD040500</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UG1 HD027869</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD040544</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD047905</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD27869</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD34136</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United 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States</Country></Grant><Grant><GrantID>U10 HD040560</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD034208</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD34208</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 HD047905</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD27915</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UG1 HD040500</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R24 HD050924</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD040512</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD27917</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD021410</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD036801</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>M01 RR000080</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HD040545</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD40544</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HD036801</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>10</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Obstet Gynecol</MedlineTA><NlmUniqueID>0370476</NlmUniqueID><ISSNLinking>0002-9378</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015525">Fatty Acids, Omega-3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006908">Hydroxyprogesterones</NameOfSubstance></Chemical><Chemical><RegistryNumber>276F2O42F5</RegistryNumber><NameOfSubstance UI="C020365">17-alpha-hydroxy-progesterone 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Version="1">1099445</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D015525" MajorTopicYN="N">Fatty Acids, Omega-3</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006908" MajorTopicYN="N">Hydroxyprogesterones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011262" MajorTopicYN="N">Pregnancy Trimester, Second</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047928" MajorTopicYN="N">Premature Birth</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS543212</OtherID><OtherID Source="NLM">PMC3926421</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">17-hydroxyprogesterone caproate concentration-response</Keyword><Keyword MajorTopicYN="N">dose response</Keyword><Keyword MajorTopicYN="N">pharmacodynamics</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>09</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>10</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24113254</ArticleId><ArticleId IdType="pii">S0002-9378(13)01046-6</ArticleId><ArticleId IdType="doi">10.1016/j.ajog.2013.10.008</ArticleId><ArticleId IdType="pmc">PMC3926421</ArticleId><ArticleId IdType="mid">NIHMS543212</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li><li>Caroline du Nord</li><li>District de Columbia</li><li>Illinois</li><li>Maryland</li><li>Michigan</li><li>Ohio</li><li>Pennsylvanie</li><li>Rhode Island</li><li>Texas</li><li>Utah</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Caritis, Steve N" sort="Caritis, Steve N" uniqKey="Caritis S" first="Steve N" last="Caritis">Steve N. Caritis</name></region><name sortKey="Carpenter, Marshall W" sort="Carpenter, Marshall W" uniqKey="Carpenter M" first="Marshall W" last="Carpenter">Marshall W. Carpenter</name><name sortKey="Grobman, William A" sort="Grobman, William A" uniqKey="Grobman W" first="William A" last="Grobman">William A. Grobman</name><name sortKey="Harper, Margaret" sort="Harper, Margaret" uniqKey="Harper M" first="Margaret" last="Harper">Margaret Harper</name><name sortKey="Iams, Jay D" sort="Iams, Jay D" uniqKey="Iams J" first="Jay D" last="Iams">Jay D. Iams</name><name sortKey="Klebanoff, Mark A" sort="Klebanoff, Mark A" uniqKey="Klebanoff M" first="Mark A" last="Klebanoff">Mark A. Klebanoff</name><name sortKey="Mercer, Brian M" sort="Mercer, Brian M" uniqKey="Mercer B" first="Brian M" last="Mercer">Brian M. Mercer</name><name sortKey="Ramin, Susan" sort="Ramin, Susan" uniqKey="Ramin S" first="Susan" last="Ramin">Susan Ramin</name><name sortKey="Rouse, Dwight J" sort="Rouse, Dwight J" uniqKey="Rouse D" first="Dwight J" last="Rouse">Dwight J. Rouse</name><name sortKey="Sciscione, Anthony" sort="Sciscione, Anthony" uniqKey="Sciscione A" first="Anthony" last="Sciscione">Anthony Sciscione</name><name sortKey="Sorokin, Yoram" sort="Sorokin, Yoram" uniqKey="Sorokin Y" first="Yoram" last="Sorokin">Yoram Sorokin</name><name sortKey="Thom, Elizabeth" sort="Thom, Elizabeth" uniqKey="Thom E" first="Elizabeth" last="Thom">Elizabeth Thom</name><name sortKey="Thorp, John M" sort="Thorp, John M" uniqKey="Thorp J" first="John M" last="Thorp">John M. Thorp</name><name sortKey="Varner, Michael W" sort="Varner, Michael W" uniqKey="Varner M" first="Michael W" last="Varner">Michael W. Varner</name><name sortKey="Venkataramanan, Raman" sort="Venkataramanan, Raman" uniqKey="Venkataramanan R" first="Raman" last="Venkataramanan">Raman Venkataramanan</name><name sortKey="Wapner, Ronald J" sort="Wapner, Ronald J" uniqKey="Wapner R" first="Ronald J" last="Wapner">Ronald J. Wapner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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