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A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.

Identifieur interne : 000A22 ( PubMed/Checkpoint ); précédent : 000A21; suivant : 000A23

A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.

Auteurs : Darin D. Dougherty [États-Unis] ; Ali R. Rezai [États-Unis] ; Linda L. Carpenter [États-Unis] ; Robert H. Howland [États-Unis] ; Mahendra T. Bhati [États-Unis] ; John P. O'Reardon [États-Unis] ; Emad N. Eskandar [États-Unis] ; Gordon H. Baltuch [États-Unis] ; Andre D. Machado [États-Unis] ; Douglas Kondziolka [États-Unis] ; Cristina Cusin [États-Unis] ; Karleyton C. Evans [États-Unis] ; Lawrence H. Price [États-Unis] ; Karen Jacobs [États-Unis] ; Mayur Pandya [États-Unis] ; Timothey Denko [États-Unis] ; Audrey R. Tyrka [États-Unis] ; Tim Brelje [États-Unis] ; Thilo Deckersbach [États-Unis] ; Cynthia Kubu [États-Unis] ; Donald A. Malone [États-Unis]

Source :

Biological psychiatry [ 1873-2402 ] ; 2015.

RBID : pubmed:25726497

Descripteurs français

English descriptors

KwdEn :
- Adult, Aged, Chronic Disease, Deep Brain Stimulation, Depressive Disorder, Major (therapy), Depressive Disorder, Treatment-Resistant (therapy), Female, Humans, Internal Capsule (physiopathology), Male, Middle Aged, Psychiatric Status Rating Scales, Treatment Outcome, Ventral Striatum (physiopathology), Young Adult.
MESH :
- physiopathology : Internal Capsule, Ventral Striatum.
- therapy : Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant.
- Adult, Aged, Chronic Disease, Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Treatment Outcome, Young Adult.

Abstract

Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral capsule/ventral striatum target, have shown encouraging response rates. However, no randomized controlled trials of DBS for TRD have been published.

DOI: 10.1016/j.biopsych.2014.11.023
PubMed: 25726497

Affiliations:

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.</title>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation>
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<placeName><region type="state">Ohio</region>
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<author><name sortKey="Malone, Donald A" sort="Malone, Donald A" uniqKey="Malone D" first="Donald A" last="Malone">Donald A. Malone</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation>
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<wicri:cityArea>Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland</wicri:cityArea>
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<series><title level="j">Biological psychiatry</title>
<idno type="eISSN">1873-2402</idno>
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<term>Aged</term>
<term>Chronic Disease</term>
<term>Deep Brain Stimulation</term>
<term>Depressive Disorder, Major (therapy)</term>
<term>Depressive Disorder, Treatment-Resistant (therapy)</term>
<term>Female</term>
<term>Humans</term>
<term>Internal Capsule (physiopathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Psychiatric Status Rating Scales</term>
<term>Treatment Outcome</term>
<term>Ventral Striatum (physiopathology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Capsule interne (physiopathologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Maladie chronique</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Stimulation cérébrale profonde</term>
<term>Striatum ventral (physiopathologie)</term>
<term>Sujet âgé</term>
<term>Trouble dépressif majeur ()</term>
<term>Trouble dépressif résistant aux traitements ()</term>
<term>Échelles d'évaluation en psychiatrie</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Capsule interne</term>
<term>Striatum ventral</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Internal Capsule</term>
<term>Ventral Striatum</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Depressive Disorder, Major</term>
<term>Depressive Disorder, Treatment-Resistant</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Chronic Disease</term>
<term>Deep Brain Stimulation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Psychiatric Status Rating Scales</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
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<term>Adulte d'âge moyen</term>
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<term>Humains</term>
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<term>Résultat thérapeutique</term>
<term>Stimulation cérébrale profonde</term>
<term>Sujet âgé</term>
<term>Trouble dépressif majeur</term>
<term>Trouble dépressif résistant aux traitements</term>
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<front><div type="abstract" xml:lang="en">Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral capsule/ventral striatum target, have shown encouraging response rates. However, no randomized controlled trials of DBS for TRD have been published.</div>
</front>
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<DateCreated><Year>2015</Year>
<Month>07</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>04</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>12</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2402</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>78</Volume>
<Issue>4</Issue>
<PubDate><Year>2015</Year>
<Month>Aug</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Biological psychiatry</Title>
<ISOAbbreviation>Biol. Psychiatry</ISOAbbreviation>
</Journal>
<ArticleTitle>A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.</ArticleTitle>
<Pagination><MedlinePgn>240-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biopsych.2014.11.023</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0006-3223(14)00968-8</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral capsule/ventral striatum target, have shown encouraging response rates. However, no randomized controlled trials of DBS for TRD have been published.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Thirty patients with TRD participated in a sham-controlled trial of DBS at the ventral capsule/ventral striatum target for TRD. Patients were randomized to active versus sham DBS treatment in a blinded fashion for 16 weeks, followed by an open-label continuation phase. The primary outcome measure was response, defined as a 50% or greater improvement on the Montgomery-Åsberg Depression Rating Scale from baseline.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">There was no significant difference in response rates between the active (3 of 15 subjects; 20%) and control (2 of 14 subjects; 14.3%) treatment arms and no significant difference between change in Montgomery-Åsberg Depression Rating Scale scores as a continuous measure upon completion of the 16-week controlled phase of the trial. The response rates at 12, 18, and 24 months during the open-label continuation phase were 20%, 26.7%, and 23.3%, respectively.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results of this first randomized controlled study of DBS for the treatment of TRD did not demonstrate a significant difference in response rates between the active and control groups at the end of the 16-week controlled phase. However, a range of 20% to 26.7% of patients did achieve response at any time during the open-label continuation phase. Future studies, perhaps utilizing alternative study designs and stimulation parameters, are needed.</AbstractText>
<CopyrightInformation>Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dougherty</LastName>
<ForeName>Darin D</ForeName>
<Initials>DD</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: ddougherty@partners.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rezai</LastName>
<ForeName>Ali R</ForeName>
<Initials>AR</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carpenter</LastName>
<ForeName>Linda L</ForeName>
<Initials>LL</Initials>
<AffiliationInfo><Affiliation>Butler Hospital, Alpert Medical School of Brown University, Providence, Rhode Island.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Howland</LastName>
<ForeName>Robert H</ForeName>
<Initials>RH</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bhati</LastName>
<ForeName>Mahendra T</ForeName>
<Initials>MT</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>O'Reardon</LastName>
<ForeName>John P</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Emad N</ForeName>
<Initials>EN</Initials>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baltuch</LastName>
<ForeName>Gordon H</ForeName>
<Initials>GH</Initials>
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</AffiliationInfo>
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</Author>
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<ForeName>Douglas</ForeName>
<Initials>D</Initials>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cusin</LastName>
<ForeName>Cristina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Evans</LastName>
<ForeName>Karleyton C</ForeName>
<Initials>KC</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Price</LastName>
<ForeName>Lawrence H</ForeName>
<Initials>LH</Initials>
<AffiliationInfo><Affiliation>Butler Hospital, Alpert Medical School of Brown University, Providence, Rhode Island.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jacobs</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio.</Affiliation>
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<Author ValidYN="Y"><LastName>Pandya</LastName>
<ForeName>Mayur</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Denko</LastName>
<ForeName>Timothey</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tyrka</LastName>
<ForeName>Audrey R</ForeName>
<Initials>AR</Initials>
<AffiliationInfo><Affiliation>Butler Hospital, Alpert Medical School of Brown University, Providence, Rhode Island.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brelje</LastName>
<ForeName>Tim</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Medtronic, Inc, Minneapolis, Minnesota.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deckersbach</LastName>
<ForeName>Thilo</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kubu</LastName>
<ForeName>Cynthia</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Malone</LastName>
<ForeName>Donald A</ForeName>
<Initials>DA</Initials>
<Suffix>Jr</Suffix>
<AffiliationInfo><Affiliation>Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>12</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Biol Psychiatry</MedlineTA>
<NlmUniqueID>0213264</NlmUniqueID>
<ISSNLinking>0006-3223</ISSNLinking>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Stereotact Funct Neurosurg. 2015;93(5):366-9</RefSource>
<PMID Version="1">26444852</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Biol Psychiatry. 2015 Aug 15;78(4):218-9</RefSource>
<PMID Version="1">26195174</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Evid Based Ment Health. 2016 May;19(2):59</RefSource>
<PMID Version="1">26767391</PMID>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D061218" MajorTopicYN="N">Depressive Disorder, Treatment-Resistant</DescriptorName>
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<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
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<MeshHeading><DescriptorName UI="D066328" MajorTopicYN="N">Ventral Striatum</DescriptorName>
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<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DBS</Keyword>
<Keyword MajorTopicYN="N">Deep brain stimulation</Keyword>
<Keyword MajorTopicYN="N">Major depression</Keyword>
<Keyword MajorTopicYN="N">TRD</Keyword>
<Keyword MajorTopicYN="N">Treatment resistant depression</Keyword>
<Keyword MajorTopicYN="N">Ventral capsule/ventral striatum</Keyword>
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<Day>18</Day>
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<Month>10</Month>
<Day>23</Day>
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<Month>11</Month>
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A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.

A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.

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