COPD phenotypes in a lung cancer screening population.
Identifieur interne : 000047 ( PubMed/Checkpoint ); précédent : 000046; suivant : 000048COPD phenotypes in a lung cancer screening population.
Auteurs : Arzu Balkan [Turquie] ; Yonca Bulut [États-Unis] ; Carl R. Fuhrman [États-Unis] ; Stephen N. Fisher [États-Unis] ; David O. Wilson [États-Unis] ; Joel L. Weissfeld [États-Unis] ; Frank C. Sciurba [États-Unis]Source :
- The clinical respiratory journal [ 1752-699X ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Broncho-pneumopathie chronique obstructive (diagnostic), Broncho-pneumopathie chronique obstructive (imagerie diagnostique), Broncho-pneumopathie chronique obstructive (épidémiologie), Détection précoce de cancer (), Emphysème pulmonaire (diagnostic), Emphysème pulmonaire (imagerie diagnostique), Enquêtes et questionnaires, Femelle, Humains, Mâle, Pennsylvanie (épidémiologie), Phénotype, Sujet âgé, Tabagisme (épidémiologie), Tests de la fonction respiratoire (), Tomodensitométrie (), Tumeurs du poumon (diagnostic), Tumeurs du poumon (imagerie diagnostique), Tumeurs du poumon (épidémiologie).
- MESH :
- diagnostic : Broncho-pneumopathie chronique obstructive, Emphysème pulmonaire, Tumeurs du poumon.
- imagerie diagnostique : Broncho-pneumopathie chronique obstructive, Emphysème pulmonaire, Tumeurs du poumon.
- épidémiologie : Broncho-pneumopathie chronique obstructive, Pennsylvanie, Tabagisme, Tumeurs du poumon.
- Adulte d'âge moyen, Détection précoce de cancer, Enquêtes et questionnaires, Femelle, Humains, Mâle, Phénotype, Sujet âgé, Tests de la fonction respiratoire, Tomodensitométrie.
English descriptors
- KwdEn :
- Aged, Early Detection of Cancer (methods), Female, Humans, Lung Neoplasms (diagnosis), Lung Neoplasms (diagnostic imaging), Lung Neoplasms (epidemiology), Male, Middle Aged, Pennsylvania (epidemiology), Phenotype, Pulmonary Disease, Chronic Obstructive (diagnosis), Pulmonary Disease, Chronic Obstructive (diagnostic imaging), Pulmonary Disease, Chronic Obstructive (epidemiology), Pulmonary Emphysema (diagnosis), Pulmonary Emphysema (diagnostic imaging), Respiratory Function Tests (methods), Smoking (epidemiology), Surveys and Questionnaires, Tomography, X-Ray Computed (methods).
- MESH :
- diagnosis : Lung Neoplasms, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema.
- diagnostic imaging : Lung Neoplasms, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema.
- epidemiology : Lung Neoplasms, Pennsylvania, Pulmonary Disease, Chronic Obstructive, Smoking.
- methods : Early Detection of Cancer, Respiratory Function Tests, Tomography, X-Ray Computed.
- Aged, Female, Humans, Male, Middle Aged, Phenotype, Surveys and Questionnaires.
Abstract
COPD (chronic obstructive pulmonary disease) is a very heterogeneous disease, and phenotypic categorization of a high-risk population has many potential benefits. The present study uses a symptom questionnaire, low-dose computed tomography (LDCT) and pulmonary function tests (PFT) to phenotypically subgroup a high-risk population.
DOI: 10.1111/crj.12180
PubMed: 24989058
Affiliations:
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pubmed:24989058Le document en format XML
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<term>Early Detection of Cancer (methods)</term>
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<term>Lung Neoplasms (diagnosis)</term>
<term>Lung Neoplasms (diagnostic imaging)</term>
<term>Lung Neoplasms (epidemiology)</term>
<term>Male</term>
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<term>Broncho-pneumopathie chronique obstructive (diagnostic)</term>
<term>Broncho-pneumopathie chronique obstructive (imagerie diagnostique)</term>
<term>Broncho-pneumopathie chronique obstructive (épidémiologie)</term>
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<term>Mâle</term>
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<term>Tumeurs du poumon (imagerie diagnostique)</term>
<term>Tumeurs du poumon (épidémiologie)</term>
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<term>Pulmonary Disease, Chronic Obstructive</term>
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<term>Tumeurs du poumon</term>
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<front><div type="abstract" xml:lang="en">COPD (chronic obstructive pulmonary disease) is a very heterogeneous disease, and phenotypic categorization of a high-risk population has many potential benefits. The present study uses a symptom questionnaire, low-dose computed tomography (LDCT) and pulmonary function tests (PFT) to phenotypically subgroup a high-risk population.</div>
</front>
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<DateCreated><Year>2016</Year>
<Month>01</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>11</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>01</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1752-699X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>1</Issue>
<PubDate><Year>2016</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>The clinical respiratory journal</Title>
<ISOAbbreviation>Clin Respir J</ISOAbbreviation>
</Journal>
<ArticleTitle>COPD phenotypes in a lung cancer screening population.</ArticleTitle>
<Pagination><MedlinePgn>48-53</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/crj.12180</ELocationID>
<Abstract><AbstractText Label="BACKGROUND AND AIMS" NlmCategory="OBJECTIVE">COPD (chronic obstructive pulmonary disease) is a very heterogeneous disease, and phenotypic categorization of a high-risk population has many potential benefits. The present study uses a symptom questionnaire, low-dose computed tomography (LDCT) and pulmonary function tests (PFT) to phenotypically subgroup a high-risk population.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Study group consisted of current or former smokers who underwent lung cancer screening with LDCT as a subgroup of Pittsburgh Lung Screening Study. In addition to LDCT, PFT and a symptom query questionnaire were obtained from each patient.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The study group consisted of 3183 subjects (age 50-79) subdivided into eight groups according to presence of symptoms, obstruction on PFT and presence of emphysema on LDCT. A total of 501 (15.7%) subjects were asymptomatic, with no airflow obstruction or evidence of emphysema. There were 866 (27.2%) subjects with both obstruction on PFT and emphysema on LDCT, but only 660 (20.7%) had symptoms. Five hundred thirty (16.6%) of the subjects had no emphysema on LDCT but had obstruction on PFT, although only 370 (11.6%) had symptoms. Four hundred seventy-four (14.9%) of subjects had emphysema on LDCT, but no airflow obstruction, with 312 (9.8%) symptomatic. Finally, 812 (25.5%) of subjects had no evidence of airflow obstruction on PFT or emphysema on LDCT, but had symptoms.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Combining LDCT with PFT and a comprehensive questionnaire allows subgroup classification of COPD phenotypes in a high-risk population and may lead to earlier intervention and an improved framework for future studies.</AbstractText>
<CopyrightInformation>© 2014 John Wiley & Sons Ltd.</CopyrightInformation>
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</AffiliationInfo>
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</AffiliationInfo>
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<affiliations><list><country><li>Turquie</li>
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<region><li>Californie</li>
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<tree><country name="Turquie"><noRegion><name sortKey="Balkan, Arzu" sort="Balkan, Arzu" uniqKey="Balkan A" first="Arzu" last="Balkan">Arzu Balkan</name>
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<name sortKey="Fisher, Stephen N" sort="Fisher, Stephen N" uniqKey="Fisher S" first="Stephen N" last="Fisher">Stephen N. Fisher</name>
<name sortKey="Fuhrman, Carl R" sort="Fuhrman, Carl R" uniqKey="Fuhrman C" first="Carl R" last="Fuhrman">Carl R. Fuhrman</name>
<name sortKey="Sciurba, Frank C" sort="Sciurba, Frank C" uniqKey="Sciurba F" first="Frank C" last="Sciurba">Frank C. Sciurba</name>
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