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COPD phenotypes in a lung cancer screening population.

Identifieur interne : 000047 ( PubMed/Checkpoint ); précédent : 000046; suivant : 000048

COPD phenotypes in a lung cancer screening population.

Auteurs : Arzu Balkan [Turquie] ; Yonca Bulut [États-Unis] ; Carl R. Fuhrman [États-Unis] ; Stephen N. Fisher [États-Unis] ; David O. Wilson [États-Unis] ; Joel L. Weissfeld [États-Unis] ; Frank C. Sciurba [États-Unis]

Source :

RBID : pubmed:24989058

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English descriptors

Abstract

COPD (chronic obstructive pulmonary disease) is a very heterogeneous disease, and phenotypic categorization of a high-risk population has many potential benefits. The present study uses a symptom questionnaire, low-dose computed tomography (LDCT) and pulmonary function tests (PFT) to phenotypically subgroup a high-risk population.

DOI: 10.1111/crj.12180
PubMed: 24989058


Affiliations:


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pubmed:24989058

Le document en format XML

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<div type="abstract" xml:lang="en">COPD (chronic obstructive pulmonary disease) is a very heterogeneous disease, and phenotypic categorization of a high-risk population has many potential benefits. The present study uses a symptom questionnaire, low-dose computed tomography (LDCT) and pulmonary function tests (PFT) to phenotypically subgroup a high-risk population.</div>
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<AbstractText Label="BACKGROUND AND AIMS" NlmCategory="OBJECTIVE">COPD (chronic obstructive pulmonary disease) is a very heterogeneous disease, and phenotypic categorization of a high-risk population has many potential benefits. The present study uses a symptom questionnaire, low-dose computed tomography (LDCT) and pulmonary function tests (PFT) to phenotypically subgroup a high-risk population.</AbstractText>
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<AbstractText Label="RESULTS" NlmCategory="RESULTS">The study group consisted of 3183 subjects (age 50-79) subdivided into eight groups according to presence of symptoms, obstruction on PFT and presence of emphysema on LDCT. A total of 501 (15.7%) subjects were asymptomatic, with no airflow obstruction or evidence of emphysema. There were 866 (27.2%) subjects with both obstruction on PFT and emphysema on LDCT, but only 660 (20.7%) had symptoms. Five hundred thirty (16.6%) of the subjects had no emphysema on LDCT but had obstruction on PFT, although only 370 (11.6%) had symptoms. Four hundred seventy-four (14.9%) of subjects had emphysema on LDCT, but no airflow obstruction, with 312 (9.8%) symptomatic. Finally, 812 (25.5%) of subjects had no evidence of airflow obstruction on PFT or emphysema on LDCT, but had symptoms.</AbstractText>
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<li>Turquie</li>
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<name sortKey="Balkan, Arzu" sort="Balkan, Arzu" uniqKey="Balkan A" first="Arzu" last="Balkan">Arzu Balkan</name>
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<country name="États-Unis">
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<name sortKey="Bulut, Yonca" sort="Bulut, Yonca" uniqKey="Bulut Y" first="Yonca" last="Bulut">Yonca Bulut</name>
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<name sortKey="Fisher, Stephen N" sort="Fisher, Stephen N" uniqKey="Fisher S" first="Stephen N" last="Fisher">Stephen N. Fisher</name>
<name sortKey="Fuhrman, Carl R" sort="Fuhrman, Carl R" uniqKey="Fuhrman C" first="Carl R" last="Fuhrman">Carl R. Fuhrman</name>
<name sortKey="Sciurba, Frank C" sort="Sciurba, Frank C" uniqKey="Sciurba F" first="Frank C" last="Sciurba">Frank C. Sciurba</name>
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<name sortKey="Wilson, David O" sort="Wilson, David O" uniqKey="Wilson D" first="David O" last="Wilson">David O. Wilson</name>
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