Intravesical Liposome and Antisense Treatment for Detrusor Overactivity and Interstitial Cystitis/Painful Bladder Syndrome
Identifieur interne : 001B35 ( Pmc/Curation ); précédent : 001B34; suivant : 001B36Intravesical Liposome and Antisense Treatment for Detrusor Overactivity and Interstitial Cystitis/Painful Bladder Syndrome
Auteurs : Pradeep Tyagi [États-Unis] ; Mahendra P. Kashyap [États-Unis] ; Naoki Kawamorita [États-Unis] ; Tsuyoshi Yoshizawa [États-Unis] ; Michael Chancellor [États-Unis] ; Naoki Yoshimura [États-Unis]Source :
- ISRN Pharmacology [ 2090-5165 ] ; 2014.
Abstract
Url:
DOI: 10.1155/2014/601653
PubMed: 24527221
PubMed Central: 3914518
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PMC:3914518Le document en format XML
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<author><name sortKey="Kashyap, Mahendra P" sort="Kashyap, Mahendra P" uniqKey="Kashyap M" first="Mahendra P." last="Kashyap">Mahendra P. Kashyap</name>
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<author><name sortKey="Yoshizawa, Tsuyoshi" sort="Yoshizawa, Tsuyoshi" uniqKey="Yoshizawa T" first="Tsuyoshi" last="Yoshizawa">Tsuyoshi Yoshizawa</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intravesical Liposome and Antisense Treatment for Detrusor Overactivity and Interstitial Cystitis/Painful Bladder Syndrome</title>
<author><name sortKey="Tyagi, Pradeep" sort="Tyagi, Pradeep" uniqKey="Tyagi P" first="Pradeep" last="Tyagi">Pradeep Tyagi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Urology, University of Pittsburgh, PA 15213, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of Pittsburgh, PA 15213</wicri:regionArea>
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<author><name sortKey="Kashyap, Mahendra P" sort="Kashyap, Mahendra P" uniqKey="Kashyap M" first="Mahendra P." last="Kashyap">Mahendra P. Kashyap</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Urology, University of Pittsburgh, PA 15213, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of Pittsburgh, PA 15213</wicri:regionArea>
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<author><name sortKey="Kawamorita, Naoki" sort="Kawamorita, Naoki" uniqKey="Kawamorita N" first="Naoki" last="Kawamorita">Naoki Kawamorita</name>
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<author><name sortKey="Yoshizawa, Tsuyoshi" sort="Yoshizawa, Tsuyoshi" uniqKey="Yoshizawa T" first="Tsuyoshi" last="Yoshizawa">Tsuyoshi Yoshizawa</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Urology, University of Pittsburgh, PA 15213, USA</nlm:aff>
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<wicri:regionArea>Department of Urology, University of Pittsburgh, PA 15213</wicri:regionArea>
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<author><name sortKey="Chancellor, Michael" sort="Chancellor, Michael" uniqKey="Chancellor M" first="Michael" last="Chancellor">Michael Chancellor</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Urology, William Beaumont School of Medicine, Royal oak, MI 48073, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, William Beaumont School of Medicine, Royal oak, MI 48073</wicri:regionArea>
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<author><name sortKey="Yoshimura, Naoki" sort="Yoshimura, Naoki" uniqKey="Yoshimura N" first="Naoki" last="Yoshimura">Naoki Yoshimura</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Urology, University of Pittsburgh, PA 15213, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of Pittsburgh, PA 15213</wicri:regionArea>
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<series><title level="j">ISRN Pharmacology</title>
<idno type="ISSN">2090-5165</idno>
<idno type="eISSN">2090-5173</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p><italic>Purpose</italic>
. The following review focuses on the recent advancements in intravesical drug delivery, which brings added benefit to the therapy of detrusor overactivity and interstitial cystitis/painful bladder syndrome (IC/PBS). <italic>Results</italic>
. Intravesical route is a preferred route of administration for restricting the action of extremely potent drugs like DMSO for patients of interstitial cystitis/painful bladder syndrome (IC/PBS) and botulinum toxin for detrusor overactivity. Patients who are either refractory to oral treatment or need to mitigate the adverse effects encountered with conventional routes of administration also chose this route. Its usefulness in some cases can be limited by vehicle (carrier) toxicity or short duration of action. Efforts have been underway to overcome these limitations by developing liposome platform for intravesical delivery of biotechnological products including antisense oligonucleotides. <italic>Conclusions</italic>
. Adoption of forward-thinking approaches can achieve advancements in drug delivery systems targeted to future improvement in pharmacotherapy of bladder diseases. Latest developments in the field of nanotechnology can bring this mode of therapy from second line of treatment for refractory cases to the forefront of disease management.</p>
</div>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Parkin, J" uniqKey="Parkin J">J Parkin</name>
</author>
<author><name sortKey="Shea, C" uniqKey="Shea C">C Shea</name>
</author>
<author><name sortKey="Sant, Gr" uniqKey="Sant G">GR Sant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dowson, C" uniqKey="Dowson C">C Dowson</name>
</author>
<author><name sortKey="Watkins, J" uniqKey="Watkins J">J Watkins</name>
</author>
<author><name sortKey="Khan, Ms" uniqKey="Khan M">MS Khan</name>
</author>
<author><name sortKey="Dasgupta, P" uniqKey="Dasgupta P">P Dasgupta</name>
</author>
<author><name sortKey="Sahai, A" uniqKey="Sahai A">A Sahai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaufman, J" uniqKey="Kaufman J">J Kaufman</name>
</author>
<author><name sortKey="Tyagi, V" uniqKey="Tyagi V">V Tyagi</name>
</author>
<author><name sortKey="Anthony, M" uniqKey="Anthony M">M Anthony</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Killinger, Ka" uniqKey="Killinger K">KA Killinger</name>
</author>
<author><name sortKey="Boura, Ja" uniqKey="Boura J">JA Boura</name>
</author>
<author><name sortKey="Peters, Km" uniqKey="Peters K">KM Peters</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nickel, Jc" uniqKey="Nickel J">JC Nickel</name>
</author>
<author><name sortKey="Hanno, P" uniqKey="Hanno P">P Hanno</name>
</author>
<author><name sortKey="Kumar, K" uniqKey="Kumar K">K Kumar</name>
</author>
<author><name sortKey="Thomas, H" uniqKey="Thomas H">H Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanno, Pm" uniqKey="Hanno P">PM Hanno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giannantoni, A" uniqKey="Giannantoni A">A Giannantoni</name>
</author>
<author><name sortKey="Bini, V" uniqKey="Bini V">V Bini</name>
</author>
<author><name sortKey="Dmochowski, R" uniqKey="Dmochowski R">R Dmochowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lai, Mc" uniqKey="Lai M">MC Lai</name>
</author>
<author><name sortKey="Kuo, Yc" uniqKey="Kuo Y">YC Kuo</name>
</author>
<author><name sortKey="Kuo, Hc" uniqKey="Kuo H">HC Kuo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eldrup, J" uniqKey="Eldrup J">J Eldrup</name>
</author>
<author><name sortKey="Thorup, J" uniqKey="Thorup J">J Thorup</name>
</author>
<author><name sortKey="Nielsen, Sl" uniqKey="Nielsen S">SL Nielsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parsons, Cl" uniqKey="Parsons C">CL Parsons</name>
</author>
<author><name sortKey="Boychuk, D" uniqKey="Boychuk D">D Boychuk</name>
</author>
<author><name sortKey="Jones, S" uniqKey="Jones S">S Jones</name>
</author>
<author><name sortKey="Hurst, R" uniqKey="Hurst R">R Hurst</name>
</author>
<author><name sortKey="Callahan, H" uniqKey="Callahan H">H Callahan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Masuda, H" uniqKey="Masuda H">H Masuda</name>
</author>
<author><name sortKey="De Miguel, F" uniqKey="De Miguel F">F De Miguel</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, V" uniqKey="Tyagi V">V Tyagi</name>
</author>
<author><name sortKey="Philips, Bj" uniqKey="Philips B">BJ Philips</name>
</author>
<author><name sortKey="Su, R" uniqKey="Su R">R Su</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Philips, Bj" uniqKey="Philips B">BJ Philips</name>
</author>
<author><name sortKey="Smaldone, Mc" uniqKey="Smaldone M">MC Smaldone</name>
</author>
<author><name sortKey="Erickson, Vl" uniqKey="Erickson V">VL Erickson</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baker, Sa" uniqKey="Baker S">SA Baker</name>
</author>
<author><name sortKey="Hennig, Gw" uniqKey="Hennig G">GW Hennig</name>
</author>
<author><name sortKey="Han, J" uniqKey="Han J">J Han</name>
</author>
<author><name sortKey="Britton, Fc" uniqKey="Britton F">FC Britton</name>
</author>
<author><name sortKey="Smith, Tk" uniqKey="Smith T">TK Smith</name>
</author>
<author><name sortKey="Koh, Sd" uniqKey="Koh S">SD Koh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beckel, Jm" uniqKey="Beckel J">JM Beckel</name>
</author>
<author><name sortKey="Kanai, A" uniqKey="Kanai A">A Kanai</name>
</author>
<author><name sortKey="Lee, S J" uniqKey="Lee S">S-J Lee</name>
</author>
<author><name sortKey="De Groat, Wc" uniqKey="De Groat W">WC De Groat</name>
</author>
<author><name sortKey="Birder, La" uniqKey="Birder L">LA Birder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Birder, La" uniqKey="Birder L">LA Birder</name>
</author>
<author><name sortKey="Kanai, Aj" uniqKey="Kanai A">AJ Kanai</name>
</author>
<author><name sortKey="De Groat, Wc" uniqKey="De Groat W">WC De Groat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Thomas, Ca" uniqKey="Thomas C">CA Thomas</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanna Mitchell, At" uniqKey="Hanna Mitchell A">AT Hanna-Mitchell</name>
</author>
<author><name sortKey="Beckel, Jm" uniqKey="Beckel J">JM Beckel</name>
</author>
<author><name sortKey="Barbadora, S" uniqKey="Barbadora S">S Barbadora</name>
</author>
<author><name sortKey="Kanai, Aj" uniqKey="Kanai A">AJ Kanai</name>
</author>
<author><name sortKey="De Groat, Wc" uniqKey="De Groat W">WC de Groat</name>
</author>
<author><name sortKey="Birder, La" uniqKey="Birder L">LA Birder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Cp" uniqKey="Smith C">CP Smith</name>
</author>
<author><name sortKey="Gangitano, Da" uniqKey="Gangitano D">DA Gangitano</name>
</author>
<author><name sortKey="Munoz, A" uniqKey="Munoz A">A Munoz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chuang, Y C" uniqKey="Chuang Y">Y-C Chuang</name>
</author>
<author><name sortKey="Thomas, Ca" uniqKey="Thomas C">CA Thomas</name>
</author>
<author><name sortKey="Tyagi, S" uniqKey="Tyagi S">S Tyagi</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Masuda, H" uniqKey="Masuda H">H Masuda</name>
</author>
<author><name sortKey="Miguel, Fd" uniqKey="Miguel F">FD Miguel</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, S" uniqKey="Tyagi S">S Tyagi</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Van Le, S" uniqKey="Van Le S">S Van-le</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
<author><name sortKey="De Miguel, F" uniqKey="De Miguel F">F de Miguel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregoriadis, G" uniqKey="Gregoriadis G">G Gregoriadis</name>
</author>
<author><name sortKey="Ryman, Be" uniqKey="Ryman B">BE Ryman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregoriadis, G" uniqKey="Gregoriadis G">G Gregoriadis</name>
</author>
<author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Papaioannou, I" uniqKey="Papaioannou I">I Papaioannou</name>
</author>
<author><name sortKey="Laing, P" uniqKey="Laing P">P Laing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sapra, P" uniqKey="Sapra P">P Sapra</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Allen, Tm" uniqKey="Allen T">TM Allen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregoriadis, G" uniqKey="Gregoriadis G">G Gregoriadis</name>
</author>
<author><name sortKey="Dapergolas, G" uniqKey="Dapergolas G">G Dapergolas</name>
</author>
<author><name sortKey="Neerunjun, Ed" uniqKey="Neerunjun E">ED Neerunjun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregoriadis, G" uniqKey="Gregoriadis G">G Gregoriadis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregoriadis, G" uniqKey="Gregoriadis G">G Gregoriadis</name>
</author>
<author><name sortKey="Allison, Ac" uniqKey="Allison A">AC Allison</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Dausch, S" uniqKey="Dausch S">S Dausch</name>
</author>
<author><name sortKey="Maierhofer, C" uniqKey="Maierhofer C">C Maierhofer</name>
</author>
<author><name sortKey="Dausch, D" uniqKey="Dausch D">D Dausch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dausch, D" uniqKey="Dausch D">D Dausch</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Dausch, S" uniqKey="Dausch S">S Dausch</name>
</author>
<author><name sortKey="Kim, Jc" uniqKey="Kim J">JC Kim</name>
</author>
<author><name sortKey="Schwert, G" uniqKey="Schwert G">G Schwert</name>
</author>
<author><name sortKey="Michelson, W" uniqKey="Michelson W">W Michelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ebrahim, S" uniqKey="Ebrahim S">S Ebrahim</name>
</author>
<author><name sortKey="Peyman, Ga" uniqKey="Peyman G">GA Peyman</name>
</author>
<author><name sortKey="Lee, Pj" uniqKey="Lee P">PJ Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nirmal, J" uniqKey="Nirmal J">J Nirmal</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Dang, L" uniqKey="Dang L">L Dang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frangos, Dn" uniqKey="Frangos D">DN Frangos</name>
</author>
<author><name sortKey="Killion, Jj" uniqKey="Killion J">JJ Killion</name>
</author>
<author><name sortKey="Fan, D" uniqKey="Fan D">D Fan</name>
</author>
<author><name sortKey="Fishbeck, R" uniqKey="Fishbeck R">R Fishbeck</name>
</author>
<author><name sortKey="Von Eschenbach, Ac" uniqKey="Von Eschenbach A">AC Von Eschenbach</name>
</author>
<author><name sortKey="Fidler, Ij" uniqKey="Fidler I">IJ Fidler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Jw" uniqKey="Johnson J">JW Johnson</name>
</author>
<author><name sortKey="Nayar, R" uniqKey="Nayar R">R Nayar</name>
</author>
<author><name sortKey="Killion, Jj" uniqKey="Killion J">JJ Killion</name>
</author>
<author><name sortKey="Von Eschenbach, Ac" uniqKey="Von Eschenbach A">AC Von Eschenbach</name>
</author>
<author><name sortKey="Fidler, Ij" uniqKey="Fidler I">IJ Fidler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chuang, Y C" uniqKey="Chuang Y">Y-C Chuang</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
<author><name sortKey="Seki, S" uniqKey="Seki S">S Seki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaufman, J" uniqKey="Kaufman J">J Kaufman</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fraser, Mo" uniqKey="Fraser M">MO Fraser</name>
</author>
<author><name sortKey="Chuang, Y C" uniqKey="Chuang Y">Y-C Chuang</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Chancellor, M" uniqKey="Chancellor M">M Chancellor</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Chai, Tc" uniqKey="Chai T">TC Chai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bade, Jj" uniqKey="Bade J">JJ Bade</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Hsieh, Vc" uniqKey="Hsieh V">VC Hsieh</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Kaufman, J" uniqKey="Kaufman J">J Kaufman</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, W C" uniqKey="Lee W">W-C Lee</name>
</author>
<author><name sortKey="Chien, C T" uniqKey="Chien C">C-T Chien</name>
</author>
<author><name sortKey="Yu, H J" uniqKey="Yu H">H-J Yu</name>
</author>
<author><name sortKey="Lee, S W" uniqKey="Lee S">S-W Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gillespie, Ji" uniqKey="Gillespie J">JI Gillespie</name>
</author>
<author><name sortKey="Van Koeveringe, Ga" uniqKey="Van Koeveringe G">GA Van Koeveringe</name>
</author>
<author><name sortKey="De Wachter, Sg" uniqKey="De Wachter S">SG De Wachter</name>
</author>
<author><name sortKey="De Vente, J" uniqKey="De Vente J">J De Vente</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Wc" uniqKey="Lee W">WC Lee</name>
</author>
<author><name sortKey="Chiang, Ph" uniqKey="Chiang P">PH Chiang</name>
</author>
<author><name sortKey="Tain, Yl" uniqKey="Tain Y">YL Tain</name>
</author>
<author><name sortKey="Wu, Cc" uniqKey="Wu C">CC Wu</name>
</author>
<author><name sortKey="Chuang, Yc" uniqKey="Chuang Y">YC Chuang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chuang, Y C" uniqKey="Chuang Y">Y-C Chuang</name>
</author>
<author><name sortKey="Lee, W C" uniqKey="Lee W">W-C Lee</name>
</author>
<author><name sortKey="Lee, W C" uniqKey="Lee W">W-C Lee</name>
</author>
<author><name sortKey="Chiang, P H" uniqKey="Chiang P">P-H Chiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, W C" uniqKey="Lee W">W-C Lee</name>
</author>
<author><name sortKey="Chuang, Y C" uniqKey="Chuang Y">Y-C Chuang</name>
</author>
<author><name sortKey="Lee, W C" uniqKey="Lee W">W-C Lee</name>
</author>
<author><name sortKey="Chiang, P H" uniqKey="Chiang P">P-H Chiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Truschel, St" uniqKey="Truschel S">ST Truschel</name>
</author>
<author><name sortKey="Wang, E" uniqKey="Wang E">E Wang</name>
</author>
<author><name sortKey="Ruiz, Wg" uniqKey="Ruiz W">WG Ruiz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
<author><name sortKey="De Groat, Wc" uniqKey="De Groat W">WC De Groat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Byrne, Ds" uniqKey="Byrne D">DS Byrne</name>
</author>
<author><name sortKey="Das, A" uniqKey="Das A">A Das</name>
</author>
<author><name sortKey="Sedor, J" uniqKey="Sedor J">J Sedor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mandal, M" uniqKey="Mandal M">M Mandal</name>
</author>
<author><name sortKey="Lee, K D" uniqKey="Lee K">K-D Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chuang, Y C" uniqKey="Chuang Y">Y-C Chuang</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Huang, C C" uniqKey="Huang C">C-C Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chuang, Y C" uniqKey="Chuang Y">Y-C Chuang</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Huang, C C" uniqKey="Huang C">C-C Huang</name>
</author>
<author><name sortKey="Chiang, P H" uniqKey="Chiang P">P-H Chiang</name>
</author>
<author><name sortKey="Chancellor, Mb" uniqKey="Chancellor M">MB Chancellor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petrou, Sp" uniqKey="Petrou S">SP Petrou</name>
</author>
<author><name sortKey="Parker, As" uniqKey="Parker A">AS Parker</name>
</author>
<author><name sortKey="Crook, Je" uniqKey="Crook J">JE Crook</name>
</author>
<author><name sortKey="Rogers, A" uniqKey="Rogers A">A Rogers</name>
</author>
<author><name sortKey="Metz Kudashick, D" uniqKey="Metz Kudashick D">D Metz-Kudashick</name>
</author>
<author><name sortKey="Thiel, Dd" uniqKey="Thiel D">DD Thiel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caccin, P" uniqKey="Caccin P">P Caccin</name>
</author>
<author><name sortKey="Rossetto, O" uniqKey="Rossetto O">O Rossetto</name>
</author>
<author><name sortKey="Rigoni, M" uniqKey="Rigoni M">M Rigoni</name>
</author>
<author><name sortKey="Johnson, E" uniqKey="Johnson E">E Johnson</name>
</author>
<author><name sortKey="Schiavo, G" uniqKey="Schiavo G">G Schiavo</name>
</author>
<author><name sortKey="Montecucco, C" uniqKey="Montecucco C">C Montecucco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stephenson, Ml" uniqKey="Stephenson M">ML Stephenson</name>
</author>
<author><name sortKey="Zamecnik, Pc" uniqKey="Zamecnik P">PC Zamecnik</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dadgostar, H" uniqKey="Dadgostar H">H Dadgostar</name>
</author>
<author><name sortKey="Waheed, N" uniqKey="Waheed N">N Waheed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gebhard, C" uniqKey="Gebhard C">C Gebhard</name>
</author>
<author><name sortKey="Huard, G" uniqKey="Huard G">G Huard</name>
</author>
<author><name sortKey="Kritikou, Ea" uniqKey="Kritikou E">EA Kritikou</name>
</author>
<author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yokota, T" uniqKey="Yokota T">T Yokota</name>
</author>
<author><name sortKey="Hoffman, E" uniqKey="Hoffman E">E Hoffman</name>
</author>
<author><name sortKey="Takeda, S" uniqKey="Takeda S">S Takeda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jacobs, Bl" uniqKey="Jacobs B">BL Jacobs</name>
</author>
<author><name sortKey="Smaldone, Mc" uniqKey="Smaldone M">MC Smaldone</name>
</author>
<author><name sortKey="Tyagi, V" uniqKey="Tyagi V">V Tyagi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, H T" uniqKey="Liu H">H-T Liu</name>
</author>
<author><name sortKey="Kuo, H C" uniqKey="Kuo H">H-C Kuo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Ht" uniqKey="Liu H">HT Liu</name>
</author>
<author><name sortKey="Kuo, Hc" uniqKey="Kuo H">HC Kuo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Bennett, Ne" uniqKey="Bennett N">NE Bennett</name>
</author>
<author><name sortKey="Hayashi, Y" uniqKey="Hayashi Y">Y Hayashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seki, S" uniqKey="Seki S">S Seki</name>
</author>
<author><name sortKey="Sasaki, K" uniqKey="Sasaki K">K Sasaki</name>
</author>
<author><name sortKey="Igawa, Y" uniqKey="Igawa Y">Y Igawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Evans, Rj" uniqKey="Evans R">RJ Evans</name>
</author>
<author><name sortKey="Moldwin, Rm" uniqKey="Moldwin R">RM Moldwin</name>
</author>
<author><name sortKey="Cossons, N" uniqKey="Cossons N">N Cossons</name>
</author>
<author><name sortKey="Darekar, A" uniqKey="Darekar A">A Darekar</name>
</author>
<author><name sortKey="Mills, Iw" uniqKey="Mills I">IW Mills</name>
</author>
<author><name sortKey="Scholfield, D" uniqKey="Scholfield D">D Scholfield</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Banerjee, R" uniqKey="Banerjee R">R Banerjee</name>
</author>
<author><name sortKey="Basu, S" uniqKey="Basu S">S Basu</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Chancellor, M" uniqKey="Chancellor M">M Chancellor</name>
</author>
<author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Molliver, Dc" uniqKey="Molliver D">DC Molliver</name>
</author>
<author><name sortKey="Wright, De" uniqKey="Wright D">DE Wright</name>
</author>
<author><name sortKey="Leitner, Ml" uniqKey="Leitner M">ML Leitner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, M" uniqKey="Tyagi M">M Tyagi</name>
</author>
<author><name sortKey="Rusnati, M" uniqKey="Rusnati M">M Rusnati</name>
</author>
<author><name sortKey="Presta, M" uniqKey="Presta M">M Presta</name>
</author>
<author><name sortKey="Giacca, M" uniqKey="Giacca M">M Giacca</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uhlmann, E" uniqKey="Uhlmann E">E Uhlmann</name>
</author>
<author><name sortKey="Ryte, A" uniqKey="Ryte A">A Ryte</name>
</author>
<author><name sortKey="Peyman, A" uniqKey="Peyman A">A Peyman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nogawa, M" uniqKey="Nogawa M">M Nogawa</name>
</author>
<author><name sortKey="Yuasa, T" uniqKey="Yuasa T">T Yuasa</name>
</author>
<author><name sortKey="Kimura, S" uniqKey="Kimura S">S Kimura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kashyap, M" uniqKey="Kashyap M">M Kashyap</name>
</author>
<author><name sortKey="Kawamorita, N" uniqKey="Kawamorita N">N Kawamorita</name>
</author>
<author><name sortKey="Tyagi, V" uniqKey="Tyagi V">V Tyagi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arum, C J" uniqKey="Arum C">C-J Arum</name>
</author>
<author><name sortKey="Kodama, Y" uniqKey="Kodama Y">Y Kodama</name>
</author>
<author><name sortKey="Rolim, N" uniqKey="Rolim N">N Rolim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blietz, Ce" uniqKey="Blietz C">CE Blietz</name>
</author>
<author><name sortKey="Thode, B" uniqKey="Thode B">B Thode</name>
</author>
<author><name sortKey="Hauses, M" uniqKey="Hauses M">M Hauses</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oddiah, D" uniqKey="Oddiah D">D Oddiah</name>
</author>
<author><name sortKey="Anand, P" uniqKey="Anand P">P Anand</name>
</author>
<author><name sortKey="Mcmahon, Sb" uniqKey="Mcmahon S">SB McMahon</name>
</author>
<author><name sortKey="Rattray, M" uniqKey="Rattray M">M Rattray</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saban, Mr" uniqKey="Saban M">MR Saban</name>
</author>
<author><name sortKey="Hellmich, H" uniqKey="Hellmich H">H Hellmich</name>
</author>
<author><name sortKey="Nguyen, Nb" uniqKey="Nguyen N">NB Nguyen</name>
</author>
<author><name sortKey="Winston, J" uniqKey="Winston J">J Winston</name>
</author>
<author><name sortKey="Hammond, Tg" uniqKey="Hammond T">TG Hammond</name>
</author>
<author><name sortKey="Saban, R" uniqKey="Saban R">R Saban</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schnegelsberg, B" uniqKey="Schnegelsberg B">B Schnegelsberg</name>
</author>
<author><name sortKey="Sun, Tt" uniqKey="Sun T">TT Sun</name>
</author>
<author><name sortKey="Cain, G" uniqKey="Cain G">G Cain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cardenas, S" uniqKey="Cardenas S">S Cardenas</name>
</author>
<author><name sortKey="Scuri, M" uniqKey="Scuri M">M Scuri</name>
</author>
<author><name sortKey="Samsell, L" uniqKey="Samsell L">L Samsell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K Nakamura</name>
</author>
<author><name sortKey="Tan, F" uniqKey="Tan F">F Tan</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
<author><name sortKey="Thiele, Cj" uniqKey="Thiele C">CJ Thiele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Othumpangat, S" uniqKey="Othumpangat S">S Othumpangat</name>
</author>
<author><name sortKey="Regier, M" uniqKey="Regier M">M Regier</name>
</author>
<author><name sortKey="Piedimonte, G" uniqKey="Piedimonte G">G Piedimonte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jung, H" uniqKey="Jung H">H Jung</name>
</author>
<author><name sortKey="Toth, Pt" uniqKey="Toth P">PT Toth</name>
</author>
<author><name sortKey="White, Fa" uniqKey="White F">FA White</name>
</author>
<author><name sortKey="Miller, Rj" uniqKey="Miller R">RJ Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, Fa" uniqKey="White F">FA White</name>
</author>
<author><name sortKey="Jung, H" uniqKey="Jung H">H Jung</name>
</author>
<author><name sortKey="Miller, Rj" uniqKey="Miller R">RJ Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Banisadr, G" uniqKey="Banisadr G">G Banisadr</name>
</author>
<author><name sortKey="Gosselin, R D" uniqKey="Gosselin R">R-D Gosselin</name>
</author>
<author><name sortKey="Mechighel, P" uniqKey="Mechighel P">P Mechighel</name>
</author>
<author><name sortKey="Rostene, W" uniqKey="Rostene W">W Rostène</name>
</author>
<author><name sortKey="Kitabgi, P" uniqKey="Kitabgi P">P Kitabgi</name>
</author>
<author><name sortKey="Parsadaniantz, Sm" uniqKey="Parsadaniantz S">SM Parsadaniantz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bhangoo, S" uniqKey="Bhangoo S">S Bhangoo</name>
</author>
<author><name sortKey="Ren, D" uniqKey="Ren D">D Ren</name>
</author>
<author><name sortKey="Miller, Rj" uniqKey="Miller R">RJ Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maeda, T" uniqKey="Maeda T">T Maeda</name>
</author>
<author><name sortKey="Kiguchi, N" uniqKey="Kiguchi N">N Kiguchi</name>
</author>
<author><name sortKey="Kobayashi, Y" uniqKey="Kobayashi Y">Y Kobayashi</name>
</author>
<author><name sortKey="Ikuta, T" uniqKey="Ikuta T">T Ikuta</name>
</author>
<author><name sortKey="Ozaki, M" uniqKey="Ozaki M">M Ozaki</name>
</author>
<author><name sortKey="Kishioka, S" uniqKey="Kishioka S">S Kishioka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kajiwara, H" uniqKey="Kajiwara H">H Kajiwara</name>
</author>
<author><name sortKey="Yasuda, M" uniqKey="Yasuda M">M Yasuda</name>
</author>
<author><name sortKey="Kumaki, N" uniqKey="Kumaki N">N Kumaki</name>
</author>
<author><name sortKey="Shibayama, T" uniqKey="Shibayama T">T Shibayama</name>
</author>
<author><name sortKey="Osamura, Y" uniqKey="Osamura Y">Y Osamura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assreuy, Ams" uniqKey="Assreuy A">AMS Assreuy</name>
</author>
<author><name sortKey="Martins, Gj" uniqKey="Martins G">GJ Martins</name>
</author>
<author><name sortKey="Moreira, Mef" uniqKey="Moreira M">MEF Moreira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vinson, Sm" uniqKey="Vinson S">SM Vinson</name>
</author>
<author><name sortKey="Rickard, A" uniqKey="Rickard A">A Rickard</name>
</author>
<author><name sortKey="Ryerse, Js" uniqKey="Ryerse J">JS Ryerse</name>
</author>
<author><name sortKey="Mchowat, J" uniqKey="Mchowat J">J McHowat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Green, M" uniqKey="Green M">M Green</name>
</author>
<author><name sortKey="Filippou, A" uniqKey="Filippou A">A Filippou</name>
</author>
<author><name sortKey="Sant, G" uniqKey="Sant G">G Sant</name>
</author>
<author><name sortKey="Theoharides, Tc" uniqKey="Theoharides T">TC Theoharides</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leppilahti, M" uniqKey="Leppilahti M">M Leppilahti</name>
</author>
<author><name sortKey="Hellstrom, P" uniqKey="Hellstrom P">P Hellström</name>
</author>
<author><name sortKey="Tammela, Tlj" uniqKey="Tammela T">TLJ Tammela</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corcoran, At" uniqKey="Corcoran A">AT Corcoran</name>
</author>
<author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name>
</author>
<author><name sortKey="Tyagi, V" uniqKey="Tyagi V">V Tyagi</name>
</author>
<author><name sortKey="Jacobs, B" uniqKey="Jacobs B">B Jacobs</name>
</author>
<author><name sortKey="Leng, W" uniqKey="Leng W">W Leng</name>
</author>
<author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
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<biblStruct><analytic><author><name sortKey="Garrean, S" uniqKey="Garrean S">S Garrean</name>
</author>
<author><name sortKey="Gao, X P" uniqKey="Gao X">X-P Gao</name>
</author>
<author><name sortKey="Brovkovych, V" uniqKey="Brovkovych V">V Brovkovych</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, Mr" uniqKey="Kang M">MR Kang</name>
</author>
<author><name sortKey="Yang, G" uniqKey="Yang G">G Yang</name>
</author>
<author><name sortKey="Place, Rf" uniqKey="Place R">RF Place</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Barclay, D" uniqKey="Barclay D">D Barclay</name>
</author>
<author><name sortKey="Zamora, R" uniqKey="Zamora R">R Zamora</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Jacobs, Bl" uniqKey="Jacobs B">BL Jacobs</name>
</author>
<author><name sortKey="Barcaly, D" uniqKey="Barcaly D">D Barcaly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Tyagi, V" uniqKey="Tyagi V">V Tyagi</name>
</author>
<author><name sortKey="Bui, D" uniqKey="Bui D">D Bui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name>
</author>
<author><name sortKey="Nikolavsky, D" uniqKey="Nikolavsky D">D Nikolavsky</name>
</author>
<author><name sortKey="Vodovotz, Y" uniqKey="Vodovotz Y">Y Vodovotz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weissleder, R" uniqKey="Weissleder R">R Weissleder</name>
</author>
<author><name sortKey="Ntziachristos, V" uniqKey="Ntziachristos V">V Ntziachristos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bremer, C" uniqKey="Bremer C">C Bremer</name>
</author>
<author><name sortKey="Ntziachristos, V" uniqKey="Ntziachristos V">V Ntziachristos</name>
</author>
<author><name sortKey="Weissleder, R" uniqKey="Weissleder R">R Weissleder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahmood, U" uniqKey="Mahmood U">U Mahmood</name>
</author>
<author><name sortKey="Weissleder, R" uniqKey="Weissleder R">R Weissleder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaufman, J" uniqKey="Kaufman J">J Kaufman</name>
</author>
<author><name sortKey="Hensley, H" uniqKey="Hensley H">H Hensley</name>
</author>
<author><name sortKey="Jacobs, J" uniqKey="Jacobs J">J Jacobs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y Xj" uniqKey="Wang Y">Y-XJ Wang</name>
</author>
</analytic>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">ISRN Pharmacol</journal-id>
<journal-id journal-id-type="iso-abbrev">ISRN Pharmacol</journal-id>
<journal-id journal-id-type="publisher-id">ISRN.PHARMACOLOGY</journal-id>
<journal-title-group><journal-title>ISRN Pharmacology</journal-title>
</journal-title-group>
<issn pub-type="ppub">2090-5165</issn>
<issn pub-type="epub">2090-5173</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24527221</article-id>
<article-id pub-id-type="pmc">3914518</article-id>
<article-id pub-id-type="doi">10.1155/2014/601653</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Intravesical Liposome and Antisense Treatment for Detrusor Overactivity and Interstitial Cystitis/Painful Bladder Syndrome</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-6586-4545</contrib-id>
<name><surname>Tyagi</surname>
<given-names>Pradeep</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kashyap</surname>
<given-names>Mahendra P.</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kawamorita</surname>
<given-names>Naoki</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yoshizawa</surname>
<given-names>Tsuyoshi</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chancellor</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8070-1664</contrib-id>
<name><surname>Yoshimura</surname>
<given-names>Naoki</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Department of Urology, University of Pittsburgh, PA 15213, USA</aff>
<aff id="I2"><sup>2</sup>
Department of Urology, William Beaumont School of Medicine, Royal oak, MI 48073, USA</aff>
<author-notes><corresp id="cor1">*Pradeep Tyagi: <email>prt18@pitt.edu</email>
</corresp>
<fn fn-type="other"><p>Academic Editors: S. Mingmalairak, T. W. Stone, and S.-N. Wu</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>1</month>
<year>2014</year>
</pub-date>
<volume>2014</volume>
<elocation-id>601653</elocation-id>
<history><date date-type="received"><day>18</day>
<month>7</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>24</day>
<month>10</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 Pradeep Tyagi et al.</copyright-statement>
<copyright-year>2014</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p><italic>Purpose</italic>
. The following review focuses on the recent advancements in intravesical drug delivery, which brings added benefit to the therapy of detrusor overactivity and interstitial cystitis/painful bladder syndrome (IC/PBS). <italic>Results</italic>
. Intravesical route is a preferred route of administration for restricting the action of extremely potent drugs like DMSO for patients of interstitial cystitis/painful bladder syndrome (IC/PBS) and botulinum toxin for detrusor overactivity. Patients who are either refractory to oral treatment or need to mitigate the adverse effects encountered with conventional routes of administration also chose this route. Its usefulness in some cases can be limited by vehicle (carrier) toxicity or short duration of action. Efforts have been underway to overcome these limitations by developing liposome platform for intravesical delivery of biotechnological products including antisense oligonucleotides. <italic>Conclusions</italic>
. Adoption of forward-thinking approaches can achieve advancements in drug delivery systems targeted to future improvement in pharmacotherapy of bladder diseases. Latest developments in the field of nanotechnology can bring this mode of therapy from second line of treatment for refractory cases to the forefront of disease management.</p>
</abstract>
<funding-group><award-group><funding-source>http://dx.doi.org/10.13039/100000002 National Institutes of Health</funding-source>
<award-id>DK057267</award-id>
</award-group>
<award-group><funding-source>http://dx.doi.org/10.13039/100000002 National Institutes of Health</funding-source>
<award-id>DK088836</award-id>
</award-group>
<award-group><funding-source>http://dx.doi.org/10.13039/100000005 U.S. Department of Defense</funding-source>
<award-id>W81XWH-11-1-0763</award-id>
</award-group>
<award-group><funding-source>http://dx.doi.org/10.13039/100000005 U.S. Department of Defense</funding-source>
<award-id>W81XWH-12-1-0565</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Protective effect of liposomes evaluated by histology in rat bladder injured by protamine sulfate. Focal loss of apical layer and ulcerated areas were noted in saline treated rats (a). Liposome post-treatment protected rats from ulceration induced by PS as evident from photograph in (b) taken on bladder harvest at 8 h after liposome instillation.</p>
</caption>
<graphic xlink:href="ISRN.PHARMACOLOGY2014-601653.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p><italic>Ex vivo</italic>
images of rat bladder taken in visible and near-infrared light indicate the coating formed by instilled liposomes on bladder surface. Liposomes carry a trace amount of near-infrared (NIR) lipophilic carbocyanine dye 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR) that fluoresces on exposure to NIR light. Rat bladder filled with urine was tied at the base with thread prior to harvest. Liposomes coating the bladder surface are invisible in visible light photograph (a) but is indicated by blue colored coating on the bladder luminal surface in NIR light (b). NIR imaging <italic>in vivo</italic>
can allow noninvasive repeat objective measurement for bladder residence time of instilled treatments. (c) Schematic illustration of liposome coating the bladder surface. Given the chemical affinity of phospholipids of instilled liposomes with lipids in cells lining the bladder surface, the liposomes form a protective film coating on the injured bladder lumen surface and assist in the repair of leaky and inflamed uroepithelium.</p>
</caption>
<graphic xlink:href="ISRN.PHARMACOLOGY2014-601653.002"></graphic>
</fig>
<fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Scheme for formulation of BoNT into liposomes for bladder instillation. Freeze dried BoNT is resuspended in distilled water and added to vials containing a desiccated liposomal preparation made of phospholipids. This reconstituted suspension is allowed to hydrate at room temperature for 30–60 min before instillation.</p>
</caption>
<graphic xlink:href="ISRN.PHARMACOLOGY2014-601653.003"></graphic>
</fig>
<fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>Illustration of mechanisms for blocking NGF expression by either NGF antibodies or downregulation of NGF mRNA expression. NGF antibody sequesters the freely available NGF and prevents it from binding with the cognate TrkA receptors. NGF antisense selectively binds with NGF mRNA inside the cells to block the translation of corresponding mRNA. siRNA takes advantage of endogenous cellular pathways to degrade NGF mRNA and control the posttranscriptional NGF gene expression.</p>
</caption>
<graphic xlink:href="ISRN.PHARMACOLOGY2014-601653.004"></graphic>
</fig>
<fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label>
<caption><p>Signalling cascades induced by NGF overexpression following exposure to acetic acid. Injury from exposure to acetic sets off the signalling cascades that upregulate the expression of NGF, MCP-1, prostaglandins, CXCL-1, and CXCL-10. Overexpression of NGF drives the expression of VEGF from neurons and leptin from adipocytes covering neurons. NGF and MCP-1 also induce hyperexcitability in neurons by activating TRPV1 receptor. MCP-1, CXCL-1, and CXCL-10 cause chemoattraction of monocytes, neutrophils, and lymphocytes, which requires extravasation across endothelium from blood through the cooperation of adhesion molecules E-selectin and ICAM-1.</p>
</caption>
<graphic xlink:href="ISRN.PHARMACOLOGY2014-601653.005"></graphic>
</fig>
</floats-group>
</pmc>
</record>
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