Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure
Identifieur interne : 000E14 ( Pmc/Curation ); précédent : 000E13; suivant : 000E15Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure
Auteurs : P. G. Sanfilippo [Australie] ; J. L. Grimm [États-Unis] ; J. G. Flanagan [Canada] ; K. L. Lathrop [États-Unis] ; I. A. Sigal [États-Unis]Source :
- Experimental eye research [ 0014-4835 ] ; 2014.
Abstract
The lamina cribrosa (LC) plays an important biomechanical role in the optic nerve head (ONH). We developed a statistical shape model of the LC and tested if the shape varies with age or IOP. The ONHs of 18 donor eyes (47 to 91 years, mean 76 years) fixed at either 5 or 50 mm Hg of IOP were sectioned, stained, and imaged under a microscope. A 3D model of each ONH was reconstructed and the outline of the vertical sagittal section closest to the geometric centre of the LC extracted. The outline shape was described using elliptic Fourier analysis, and principal components analysis (PCA) employed to identify the primary modes of LC shape variation. Linear mixed effect models were used to determine if the shape measurements were associated with age or IOP. The analysis revealed several modes of shape variation: thickness and depth directly (PC1), or inversely (PC2) related, and superior-inferior asymmetry (PC3). Only PC3 was associated with IOP, with higher IOP correlating with greater curvature of the LC superiorly compared to inferiorly. Our analysis enabled a concise and complete characterization of LC shape, revealing variations without defining them
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DOI: 10.1016/j.exer.2014.08.013
PubMed: 25193035
PubMed Central: 4252246
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G." last="Sanfilippo">P. G. Sanfilippo</name><affiliation wicri:level="3"><nlm:aff id="A5">Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne</nlm:aff><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><wicri:orgArea>Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne</wicri:orgArea></affiliation></author><author><name sortKey="Grimm, J L" sort="Grimm, J L" uniqKey="Grimm J" first="J. L." last="Grimm">J. L. Grimm</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA</wicri:regionArea></affiliation></author><author><name sortKey="Flanagan, J G" sort="Flanagan, J G" uniqKey="Flanagan J" first="J. G." last="Flanagan">J. G. Flanagan</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Optometry and Vision Science, University of Waterloo, Waterloo, ON</wicri:regionArea></affiliation></author><author><name sortKey="Lathrop, K L" sort="Lathrop, K L" uniqKey="Lathrop K" first="K. L." last="Lathrop">K. L. Lathrop</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Bioengineering, University of Pittsburgh, Pittsburgh PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh PA</wicri:regionArea></affiliation></author><author><name sortKey="Sigal, I A" sort="Sigal, I A" uniqKey="Sigal I" first="I. A." last="Sigal">I. A. Sigal</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Bioengineering, University of Pittsburgh, Pittsburgh PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh PA</wicri:regionArea></affiliation></author></analytic><series><title level="j">Experimental eye research</title><idno type="ISSN">0014-4835</idno><idno type="eISSN">1096-0007</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The lamina cribrosa (LC) plays an important biomechanical role in the optic nerve head (ONH). We developed a statistical shape model of the LC and tested if the shape varies with age or IOP. The ONHs of 18 donor eyes (47 to 91 years, mean 76 years) fixed at either 5 or 50 mm Hg of IOP were sectioned, stained, and imaged under a microscope. A 3D model of each ONH was reconstructed and the outline of the vertical sagittal section closest to the geometric centre of the LC extracted. The outline shape was described using elliptic Fourier analysis, and principal components analysis (PCA) employed to identify the primary modes of LC shape variation. Linear mixed effect models were used to determine if the shape measurements were associated with age or IOP. The analysis revealed several modes of shape variation: thickness and depth directly (PC1), or inversely (PC2) related, and superior-inferior asymmetry (PC3). Only PC3 was associated with IOP, with higher IOP correlating with greater curvature of the LC superiorly compared to inferiorly. Our analysis enabled a concise and complete characterization of LC shape, revealing variations without defining them <italic>a priori</italic>. No association between LC shape and age was found for the relatively old population studied. Superior-inferior asymmetry of LC shape was associated with IOP, with more asymmetry at higher IOP. Increased IOP was not associated with LC thickness or depth.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370707</journal-id><journal-id journal-id-type="pubmed-jr-id">3647</journal-id><journal-id journal-id-type="nlm-ta">Exp Eye Res</journal-id><journal-id journal-id-type="iso-abbrev">Exp. Eye Res.</journal-id><journal-title-group><journal-title>Experimental eye research</journal-title></journal-title-group><issn pub-type="ppub">0014-4835</issn><issn pub-type="epub">1096-0007</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25193035</article-id><article-id pub-id-type="pmc">4252246</article-id><article-id pub-id-type="doi">10.1016/j.exer.2014.08.013</article-id><article-id pub-id-type="manuscript">NIHMS625304</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sanfilippo</surname><given-names>P.G.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Grimm</surname><given-names>J.L.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Flanagan</surname><given-names>J.G.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lathrop</surname><given-names>K.L.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Sigal</surname><given-names>I.A.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA, USA</aff><aff id="A2"><label>2</label>Department of Bioengineering, University of Pittsburgh, Pittsburgh PA, USA</aff><aff id="A3"><label>3</label>Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada</aff><aff id="A4"><label>4</label>School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada</aff><aff id="A5"><label>5</label>Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence: Ian A. Sigal, Ph.D., Laboratory of Ocular Biomechanics, Department of Ophthalmology, University of Pittsburgh Medical Center, Eye & Ear Institute, 203 Lothrop St. Rm. 930, Pittsburgh, PA, USA. 15213, Phone: (412) 864-2220; fax: (412) 647-5880; <email>sigalia@upmc.edu</email>, <ext-link ext-link-type="uri" xlink:href="http://www.ocularbiomechanics.org">http://www.ocularbiomechanics.org</ext-link></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>02</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2015</year></pub-date><volume>128</volume><fpage>1</fpage><lpage>7</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.exer.2014.08.013</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P2">The lamina cribrosa (LC) plays an important biomechanical role in the optic nerve head (ONH). We developed a statistical shape model of the LC and tested if the shape varies with age or IOP. The ONHs of 18 donor eyes (47 to 91 years, mean 76 years) fixed at either 5 or 50 mm Hg of IOP were sectioned, stained, and imaged under a microscope. A 3D model of each ONH was reconstructed and the outline of the vertical sagittal section closest to the geometric centre of the LC extracted. The outline shape was described using elliptic Fourier analysis, and principal components analysis (PCA) employed to identify the primary modes of LC shape variation. Linear mixed effect models were used to determine if the shape measurements were associated with age or IOP. The analysis revealed several modes of shape variation: thickness and depth directly (PC1), or inversely (PC2) related, and superior-inferior asymmetry (PC3). Only PC3 was associated with IOP, with higher IOP correlating with greater curvature of the LC superiorly compared to inferiorly. Our analysis enabled a concise and complete characterization of LC shape, revealing variations without defining them <italic>a priori</italic>. No association between LC shape and age was found for the relatively old population studied. Superior-inferior asymmetry of LC shape was associated with IOP, with more asymmetry at higher IOP. Increased IOP was not associated with LC thickness or depth.</p></abstract><kwd-group><kwd>Optic Nerve Head</kwd><kwd>Lamina Cribrosa</kwd><kwd>Morphometry</kwd><kwd>Glaucoma</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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