Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients
Identifieur interne : 000888 ( Pmc/Curation ); précédent : 000887; suivant : 000889Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients
Auteurs : Joseph K. Lim [États-Unis] ; Janet P. Tate [États-Unis] ; Shawn L. Fultz ; Joseph L. Goulet [États-Unis] ; Joseph Conigliaro [États-Unis] ; Kendall J. Bryant [États-Unis] ; Adam J. Gordon ; Cynthia Gibert ; David Rimland ; Matthew Bidwell Goetz [États-Unis] ; Marina B. Klein [Canada] ; David A. Fiellin [États-Unis] ; Amy C. Justice [États-Unis] ; Vincent Lo ReSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2014.
Abstract
Advanced hepatic fibrosis was present with nonhazardous alcohol consumption and increased with higher alcohol use categories across groups stratified by HIV and chronic hepatitis C virus (HCV) status. All alcohol use categories were strongly associated with advanced hepatic fibrosis in HIV/HCV-coinfected patients.
Url:
DOI: 10.1093/cid/ciu097
PubMed: 24569533
PubMed Central: 4001286
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients</title><author><name sortKey="Lim, Joseph K" sort="Lim, Joseph K" uniqKey="Lim J" first="Joseph K." last="Lim">Joseph K. Lim</name><affiliation><nlm:aff id="af1"><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Tate, Janet P" sort="Tate, Janet P" uniqKey="Tate J" first="Janet P." last="Tate">Janet P. Tate</name><affiliation><nlm:aff id="af1"><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Fultz, Shawn L" sort="Fultz, Shawn L" uniqKey="Fultz S" first="Shawn L." last="Fultz">Shawn L. Fultz</name><affiliation><nlm:aff id="af3"><institution>Center for Tobacco Products, US Food and Drug Administration</institution>,<addr-line>Washington D.C.</addr-line></nlm:aff></affiliation></author><author><name sortKey="Goulet, Joseph L" sort="Goulet, Joseph L" uniqKey="Goulet J" first="Joseph L." last="Goulet">Joseph L. Goulet</name><affiliation><nlm:aff id="af1"><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Conigliaro, Joseph" sort="Conigliaro, Joseph" uniqKey="Conigliaro J" first="Joseph" last="Conigliaro">Joseph Conigliaro</name><affiliation wicri:level="2"><nlm:aff id="af4"><institution>Hofstra North Shore–LIJ School of Medicine and North Shore–LIJ Health System</institution>,<addr-line>Lake Success, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Lake Success</wicri:cityArea></affiliation></author><author><name sortKey="Bryant, Kendall J" sort="Bryant, Kendall J" uniqKey="Bryant K" first="Kendall J." last="Bryant">Kendall J. Bryant</name><affiliation wicri:level="2"><nlm:aff id="af5"><institution>National Institute on Alcohol Abuse and Alcoholism</institution>,<addr-line>Bethesda, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gordon, Adam J" sort="Gordon, Adam J" uniqKey="Gordon A" first="Adam J." last="Gordon">Adam J. Gordon</name><affiliation><nlm:aff id="af6"><institution>University of Pittsburgh and Pittsburgh VA Medical Center</institution>,<addr-line>Pennsylvania</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gibert, Cynthia" sort="Gibert, Cynthia" uniqKey="Gibert C" first="Cynthia" last="Gibert">Cynthia Gibert</name><affiliation><nlm:aff id="af7"><institution>Washington, DC, VA Medical Center and George Washington University Medical Center</institution></nlm:aff></affiliation></author><author><name sortKey="Rimland, David" sort="Rimland, David" uniqKey="Rimland D" first="David" last="Rimland">David Rimland</name><affiliation><nlm:aff id="af8"><institution>Atlanta VA Medical Center and Emory University School of Medicine</institution>,<addr-line>Georgia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bidwell Goetz, Matthew" sort="Bidwell Goetz, Matthew" uniqKey="Bidwell Goetz M" first="Matthew" last="Bidwell Goetz">Matthew Bidwell Goetz</name><affiliation wicri:level="2"><nlm:aff id="af9"><institution>VA Greater Los Angeles Healthcare System and David Geffen School of Medicine at UCLA</institution>,<addr-line>Los Angeles, California</addr-line></nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Klein, Marina B" sort="Klein, Marina B" uniqKey="Klein M" first="Marina B." last="Klein">Marina B. Klein</name><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Chronic Viral Illness Service</addr-line>,<institution>McGill University Health Centre</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fiellin, David A" sort="Fiellin, David A" uniqKey="Fiellin D" first="David A." last="Fiellin">David A. Fiellin</name><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="af11"><addr-line>Yale Center for Interdisciplinary Research on AIDS</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Justice, Amy C" sort="Justice, Amy C" uniqKey="Justice A" first="Amy C." last="Justice">Amy C. Justice</name><affiliation><nlm:aff id="af1"><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="af11"><addr-line>Yale Center for Interdisciplinary Research on AIDS</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Lo Re, Vincent" sort="Lo Re, Vincent" uniqKey="Lo Re V" first="Vincent" last="Lo Re">Vincent Lo Re</name><affiliation><nlm:aff id="af12"><addr-line>Philadelphia VA Medical Center and Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24569533</idno><idno type="pmc">4001286</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001286</idno><idno type="RBID">PMC:4001286</idno><idno type="doi">10.1093/cid/ciu097</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000912</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000912</idno><idno type="wicri:Area/Pmc/Curation">000888</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients</title><author><name sortKey="Lim, Joseph K" sort="Lim, Joseph K" uniqKey="Lim J" first="Joseph K." last="Lim">Joseph K. Lim</name><affiliation><nlm:aff id="af1"><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Tate, Janet P" sort="Tate, Janet P" uniqKey="Tate J" first="Janet P." last="Tate">Janet P. Tate</name><affiliation><nlm:aff id="af1"><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Fultz, Shawn L" sort="Fultz, Shawn L" uniqKey="Fultz S" first="Shawn L." last="Fultz">Shawn L. Fultz</name><affiliation><nlm:aff id="af3"><institution>Center for Tobacco Products, US Food and Drug Administration</institution>,<addr-line>Washington D.C.</addr-line></nlm:aff></affiliation></author><author><name sortKey="Goulet, Joseph L" sort="Goulet, Joseph L" uniqKey="Goulet J" first="Joseph L." last="Goulet">Joseph L. Goulet</name><affiliation><nlm:aff id="af1"><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Conigliaro, Joseph" sort="Conigliaro, Joseph" uniqKey="Conigliaro J" first="Joseph" last="Conigliaro">Joseph Conigliaro</name><affiliation wicri:level="2"><nlm:aff id="af4"><institution>Hofstra North Shore–LIJ School of Medicine and North Shore–LIJ Health System</institution>,<addr-line>Lake Success, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Lake Success</wicri:cityArea></affiliation></author><author><name sortKey="Bryant, Kendall J" sort="Bryant, Kendall J" uniqKey="Bryant K" first="Kendall J." last="Bryant">Kendall J. Bryant</name><affiliation wicri:level="2"><nlm:aff id="af5"><institution>National Institute on Alcohol Abuse and Alcoholism</institution>,<addr-line>Bethesda, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gordon, Adam J" sort="Gordon, Adam J" uniqKey="Gordon A" first="Adam J." last="Gordon">Adam J. Gordon</name><affiliation><nlm:aff id="af6"><institution>University of Pittsburgh and Pittsburgh VA Medical Center</institution>,<addr-line>Pennsylvania</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gibert, Cynthia" sort="Gibert, Cynthia" uniqKey="Gibert C" first="Cynthia" last="Gibert">Cynthia Gibert</name><affiliation><nlm:aff id="af7"><institution>Washington, DC, VA Medical Center and George Washington University Medical Center</institution></nlm:aff></affiliation></author><author><name sortKey="Rimland, David" sort="Rimland, David" uniqKey="Rimland D" first="David" last="Rimland">David Rimland</name><affiliation><nlm:aff id="af8"><institution>Atlanta VA Medical Center and Emory University School of Medicine</institution>,<addr-line>Georgia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bidwell Goetz, Matthew" sort="Bidwell Goetz, Matthew" uniqKey="Bidwell Goetz M" first="Matthew" last="Bidwell Goetz">Matthew Bidwell Goetz</name><affiliation wicri:level="2"><nlm:aff id="af9"><institution>VA Greater Los Angeles Healthcare System and David Geffen School of Medicine at UCLA</institution>,<addr-line>Los Angeles, California</addr-line></nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Klein, Marina B" sort="Klein, Marina B" uniqKey="Klein M" first="Marina B." last="Klein">Marina B. Klein</name><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Chronic Viral Illness Service</addr-line>,<institution>McGill University Health Centre</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fiellin, David A" sort="Fiellin, David A" uniqKey="Fiellin D" first="David A." last="Fiellin">David A. Fiellin</name><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="af11"><addr-line>Yale Center for Interdisciplinary Research on AIDS</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Justice, Amy C" sort="Justice, Amy C" uniqKey="Justice A" first="Amy C." last="Justice">Amy C. Justice</name><affiliation><nlm:aff id="af1"><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2"><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="af11"><addr-line>Yale Center for Interdisciplinary Research on AIDS</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven, Connecticut</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Lo Re, Vincent" sort="Lo Re, Vincent" uniqKey="Lo Re V" first="Vincent" last="Lo Re">Vincent Lo Re</name><affiliation><nlm:aff id="af12"><addr-line>Philadelphia VA Medical Center and Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution></nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Advanced hepatic fibrosis was present with nonhazardous alcohol consumption and increased with higher alcohol use categories across groups stratified by HIV and chronic hepatitis C virus (HCV) status. All alcohol use categories were strongly associated with advanced hepatic fibrosis in HIV/HCV-coinfected patients.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-id journal-id-type="hwp">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24569533</article-id><article-id pub-id-type="pmc">4001286</article-id><article-id pub-id-type="doi">10.1093/cid/ciu097</article-id><article-id pub-id-type="publisher-id">ciu097</article-id><article-categories><subj-group subj-group-type="heading"><subject>HIV/AIDS</subject></subj-group></article-categories><title-group><article-title>Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Joseph K.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Tate</surname><given-names>Janet P.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Fultz</surname><given-names>Shawn L.</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Goulet</surname><given-names>Joseph L.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Conigliaro</surname><given-names>Joseph</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bryant</surname><given-names>Kendall J.</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Gordon</surname><given-names>Adam J.</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Gibert</surname><given-names>Cynthia</given-names></name><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Rimland</surname><given-names>David</given-names></name><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bidwell Goetz</surname><given-names>Matthew</given-names></name><xref ref-type="aff" rid="af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Klein</surname><given-names>Marina B.</given-names></name><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Fiellin</surname><given-names>David A.</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Justice</surname><given-names>Amy C.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Lo Re</surname><given-names>Vincent</given-names><suffix>III</suffix></name><xref ref-type="aff" rid="af12">12</xref></contrib></contrib-group><aff id="af1"><label>1</label><institution>Veterans Affairs (VA) Connecticut Healthcare System</institution>,<addr-line>West Haven</addr-line></aff><aff id="af2"><label>2</label><institution>Yale University School of Medicine</institution>,<addr-line>New Haven, Connecticut</addr-line></aff><aff id="af3"><label>3</label><institution>Center for Tobacco Products, US Food and Drug Administration</institution>,<addr-line>Washington D.C.</addr-line></aff><aff id="af4"><label>4</label><institution>Hofstra North Shore–LIJ School of Medicine and North Shore–LIJ Health System</institution>,<addr-line>Lake Success, New York</addr-line></aff><aff id="af5"><label>5</label><institution>National Institute on Alcohol Abuse and Alcoholism</institution>,<addr-line>Bethesda, Maryland</addr-line></aff><aff id="af6"><label>6</label><institution>University of Pittsburgh and Pittsburgh VA Medical Center</institution>,<addr-line>Pennsylvania</addr-line></aff><aff id="af7"><label>7</label><institution>Washington, DC, VA Medical Center and George Washington University Medical Center</institution></aff><aff id="af8"><label>8</label><institution>Atlanta VA Medical Center and Emory University School of Medicine</institution>,<addr-line>Georgia</addr-line></aff><aff id="af9"><label>9</label><institution>VA Greater Los Angeles Healthcare System and David Geffen School of Medicine at UCLA</institution>,<addr-line>Los Angeles, California</addr-line></aff><aff id="af10"><label>10</label><addr-line>Chronic Viral Illness Service</addr-line>,<institution>McGill University Health Centre</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country></aff><aff id="af11"><label>11</label><addr-line>Yale Center for Interdisciplinary Research on AIDS</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven, Connecticut</addr-line></aff><aff id="af12"><label>12</label><addr-line>Philadelphia VA Medical Center and Perelman School of Medicine</addr-line>,<institution>University of Pennsylvania</institution></aff><author-notes><corresp>Correspondence: Vincent Lo Re III, MD, MSCE, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, 836 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021 (<email>vincentl@mail.med.upenn.edu</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>25</day><month>2</month><year>2014</year></pub-date><volume>58</volume><issue>10</issue><fpage>1449</fpage><lpage>1458</lpage><history><date date-type="received"><day>21</day><month>9</month><year>2013</year></date><date date-type="accepted"><day>27</day><month>1</month><year>2014</year></date></history><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: <email>journals.permissions@oup.com</email>.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="ciu097.pdf"></self-uri><abstract abstract-type="precis"><p>Advanced hepatic fibrosis was present with nonhazardous alcohol consumption and increased with higher alcohol use categories across groups stratified by HIV and chronic hepatitis C virus (HCV) status. All alcohol use categories were strongly associated with advanced hepatic fibrosis in HIV/HCV-coinfected patients.</p></abstract><abstract><p><bold><italic>Background.</italic></bold> It is unclear if the risk of liver disease associated with different levels of alcohol consumption is higher for patients infected with human immunodeficiency virus (HIV) or chronic hepatitis C virus (HCV). We evaluated associations between alcohol use categories and advanced hepatic fibrosis, by HIV and chronic HCV status.</p><p><bold><italic>Methods.</italic></bold> We performed a cross-sectional study among participants in the Veterans Aging Cohort Study who reported alcohol consumption at enrollment (701 HIV/HCV-coinfected; 1410 HIV-monoinfected; 296 HCV-monoinfected; 1158 HIV/HCV-uninfected). Alcohol use category was determined by the Alcohol Use Disorders Identification Test–Consumption (AUDIT-C) questionnaire and alcohol-related diagnoses and was classified as nonhazardous drinking, hazardous/binge drinking, or alcohol-related diagnosis. Advanced hepatic fibrosis was defined by FIB-4 index >3.25.</p><p><bold><italic>Results.</italic></bold> Within each HIV/HCV group, the prevalence of advanced hepatic fibrosis increased as alcohol use category increased. For each alcohol use category, advanced hepatic fibrosis was more common among HIV-infected than uninfected (nonhazardous: 6.7% vs 1.4%; hazardous/binge: 9.5% vs 3.0%; alcohol-related diagnosis: 19.0% vs 8.6%; <italic>P</italic> < .01) and chronic HCV-infected than uninfected (nonhazardous: 13.6% vs 2.5%; hazardous/binge: 18.2% vs 3.1%; alcohol-related diagnosis: 22.1% vs 6.5%; <italic>P</italic> < .01) participants. Strong associations with advanced hepatic fibrosis (adjusted odds ratio [95% confidence interval]) were observed among HIV/HCV-coinfected patients with nonhazardous drinking (14.2 [5.91–34.0]), hazardous/binge drinking (18.9 [7.98–44.8]), and alcohol-related diagnoses (25.2 [10.6–59.7]) compared with uninfected nonhazardous drinkers.</p><p><bold><italic>Conclusions.</italic></bold> Advanced hepatic fibrosis was present at low levels of alcohol consumption, increased with higher alcohol use categories, and was more prevalent among HIV-infected and chronic HCV-infected patients than uninfected individuals. All alcohol use categories were strongly associated with advanced hepatic fibrosis in HIV/HCV-coinfected patients.</p></abstract><kwd-group><kwd>alcohol</kwd><kwd>liver fibrosis</kwd><kwd>HIV</kwd><kwd>hepatitis C</kwd><kwd>FIB-4</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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