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Prevalence of Adiposity and Associated Cardiometabolic Risk Factors in the Samoan Genome-Wide Association Study

Identifieur interne : 001728 ( Pmc/Corpus ); précédent : 001727; suivant : 001729

Prevalence of Adiposity and Associated Cardiometabolic Risk Factors in the Samoan Genome-Wide Association Study

Auteurs : Nicola L. Hawley ; Ryan L. Minster ; Daniel E. Weeks ; Satupaitea Viali ; Muagututia Sefuiva Reupena ; Guangyun Sun ; Hong Cheng ; Ranjan Deka ; Stephen T. Mcgarvey

Source :

RBID : PMC:4292846

Abstract

Objective

To describe the prevalence of obesity-related noncommunicable diseases (NCDs) and associated risk factors in a sample of Samoan adults studied in 2010 as part of a genome-wide assocation study (GWAS) for obesity related traits.

Methods

Anthropometric and biochemical data collected from n = 3,475 participants (n = 1,437 male; n = 2,038 female) aged 24.5 to <65 years were used to describe the prevalence of obesity, diabetes, hypertension, and dyslipidemia within the study sample. One way analysis of variance, χ2 tests, and binary logistic regression were used to identify differences in disease and risk factor prevalence by 10-year age group, gender, or by census region of residence.

Results

Obesity was highly prevalent among the study sample; 64.6% of females and 41.2% of males were obese according to Polynesian cutoffs (BMI ≥ 32 kg/m2). Females were less likely than males to have hypertension (31.7% vs. 36.7%) but equally likely to have diabetes (17.8% vs. 16.4%). With the exception of obesity and low HDL-cholesterol in females only, there were significant differences in the prevalence of all NCDs and associated risk factors by age group, with the oldest age group (55 to <65 years) most affected. In both sexes, residents of the Apia Urban Area were at significantly greater risk of obesity, diabetes, low HDL-cholesterol, and high triglycerides than residents of the more rural Savaii region.

Conclusions

The phenotypic characteristics of this sample provide evidence of a continuation of previously reported temporal trends toward obesity and its associated disorders. Attention must be paid to the critical NCD situation in Samoa.


Url:
DOI: 10.1002/ajhb.22553
PubMed: 24799123
PubMed Central: 4292846

Links to Exploration step

PMC:4292846

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<title>Conclusions</title>
<p id="P4">The phenotypic characteristics of this sample provide evidence of a continuation of previously reported temporal trends toward obesity and its associated disorders. Attention must be paid to the critical NCD situation in Samoa.</p>
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<article-title>Prevalence of Adiposity and Associated Cardiometabolic Risk Factors in the Samoan Genome-Wide Association Study</article-title>
</title-group>
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<contrib contrib-type="author">
<name>
<surname>HAWLEY</surname>
<given-names>NICOLA L.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>MINSTER</surname>
<given-names>RYAN L.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>WEEKS</surname>
<given-names>DANIEL E.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>VIALI</surname>
<given-names>SATUPAITEA</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>REUPENA</surname>
<given-names>MUAGUTUTIA SEFUIVA</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>SUN</surname>
<given-names>GUANGYUN</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
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<contrib contrib-type="author">
<name>
<surname>CHENG</surname>
<given-names>HONG</given-names>
</name>
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<surname>DEKA</surname>
<given-names>RANJAN</given-names>
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<xref ref-type="aff" rid="A7">7</xref>
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<xref ref-type="corresp" rid="CR1">*</xref>
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<aff id="A1">
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Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, Rhode Island</aff>
<aff id="A2">
<label>2</label>
The Alpert Medical School, Brown University, Providence, Rhode Island</aff>
<aff id="A3">
<label>3</label>
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania</aff>
<aff id="A4">
<label>4</label>
Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania</aff>
<aff id="A5">
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Ministry of Health, Government of Samoa, Samoa</aff>
<aff id="A6">
<label>6</label>
Samoa Bureau of Statistics, Samoa</aff>
<aff id="A7">
<label>7</label>
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio</aff>
<aff id="A8">
<label>8</label>
International Health Institute, Department of Epidemiology, Brown University, Providence, Rhode Island</aff>
<author-notes>
<corresp id="CR1">
<label>*</label>
Correspondence to: Stephen T. McGarvey, International Health Institute, Department of Epidemiology, Box G-S121-2, Brown University, Providence, RI 02912, USA.
<email>Stephen_McGarvey@brown.edu</email>
</corresp>
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<pub-date pub-type="nihms-submitted">
<day>7</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>05</day>
<month>5</month>
<year>2014</year>
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<pub-date pub-type="ppub">
<season>Jul-Aug</season>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>13</day>
<month>1</month>
<year>2015</year>
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<volume>26</volume>
<issue>4</issue>
<fpage>491</fpage>
<lpage>501</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/ajhb.22553</pmc-comment>
<permissions>
<copyright-statement>© 2014 Wiley Periodicals, Inc.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract>
<sec id="S1">
<title>Objective</title>
<p id="P1">To describe the prevalence of obesity-related noncommunicable diseases (NCDs) and associated risk factors in a sample of Samoan adults studied in 2010 as part of a genome-wide assocation study (GWAS) for obesity related traits.</p>
</sec>
<sec id="S2">
<title>Methods</title>
<p id="P2">Anthropometric and biochemical data collected from
<italic>n</italic>
= 3,475 participants (
<italic>n</italic>
= 1,437 male;
<italic>n</italic>
= 2,038 female) aged 24.5 to <65 years were used to describe the prevalence of obesity, diabetes, hypertension, and dyslipidemia within the study sample. One way analysis of variance, χ
<sup>2</sup>
tests, and binary logistic regression were used to identify differences in disease and risk factor prevalence by 10-year age group, gender, or by census region of residence.</p>
</sec>
<sec id="S3">
<title>Results</title>
<p id="P3">Obesity was highly prevalent among the study sample; 64.6% of females and 41.2% of males were obese according to Polynesian cutoffs (BMI ≥ 32 kg/m
<sup>2</sup>
). Females were less likely than males to have hypertension (31.7% vs. 36.7%) but equally likely to have diabetes (17.8% vs. 16.4%). With the exception of obesity and low HDL-cholesterol in females only, there were significant differences in the prevalence of all NCDs and associated risk factors by age group, with the oldest age group (55 to <65 years) most affected. In both sexes, residents of the Apia Urban Area were at significantly greater risk of obesity, diabetes, low HDL-cholesterol, and high triglycerides than residents of the more rural Savaii region.</p>
</sec>
<sec id="S4">
<title>Conclusions</title>
<p id="P4">The phenotypic characteristics of this sample provide evidence of a continuation of previously reported temporal trends toward obesity and its associated disorders. Attention must be paid to the critical NCD situation in Samoa.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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