Cognitive Inhibition in Elderly High-Lethality Suicide Attempters
Identifieur interne : 001664 ( Pmc/Corpus ); précédent : 001663; suivant : 001665Cognitive Inhibition in Elderly High-Lethality Suicide Attempters
Auteurs : Stéphane Richard-Devantoy ; Katalin Szanto ; Meryl A. Butters ; Jan Kalkus ; Alexandre Y. DombrovskiSource :
- International journal of geriatric psychiatry [ 0885-6230 ] ; 2014.
Abstract
People who attempt suicide often display cognitive impairments, particularly poor cognitive control. Could poor cognitive control contribute to high suicide rates in old age? A component of cognitive control, cognitive inhibition – active suppression of task-irrelevant processing – is very sensitive to aging and has been linked to attempted suicide. We investigated cognitive inhibition in older high-lethality suicide attempters, closely resembling suicide victims, as well as low-lethality attempters, and control groups with and without depression and suicidal ideation.
102 participants aged 60+ (17 psychiatrically healthy control subjects, 38 depressed control subjects, 16 suicide ideators, 14 low-lethality suicide attempters, and 17 high-lethality suicide attempters) underwent comprehensive clinical and cognitive assessments. They completed the Delis–Kaplan Executive Function System Color-Word Interference Test, a validated modification of the Stroop test.
High-lethality suicide attempters demonstrated a distinct pattern of cognitive inhibition deficits. Compared to psychiatrically healthy control subjects and suicide ideators, high-lethality attempters took longer to complete inhibition trials, even after accounting for potential confounding factors (age, education, MMSE score, information processing speed, and accuracy). Compared to non-suicidal depressed and healthy control subjects, low-lethality suicide attempters committed more uncorrected errors; however, this difference was not specific to the inhibition condition.
Older suicide attempters are a cognitively heterogeneous group. Poor cognitive control in high-lethality attempters may undermine their ability to solve real-life problems, precipitating a catastrophic accumulation of stressors. Meanwhile, low-lethality attempters' poor performance may reflect a careless approach to the task or faulty monitoring.
Url:
DOI: 10.1002/gps.4138
PubMed: 24816626
PubMed Central: 4229451
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Butters</name><affiliation><nlm:aff id="A3">Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA</nlm:aff></affiliation></author><author><name sortKey="Kalkus, Jan" sort="Kalkus, Jan" uniqKey="Kalkus J" first="Jan" last="Kalkus">Jan Kalkus</name><affiliation><nlm:aff id="A3">Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA</nlm:aff></affiliation></author><author><name sortKey="Dombrovski, Alexandre Y" sort="Dombrovski, Alexandre Y" uniqKey="Dombrovski A" first="Alexandre Y." last="Dombrovski">Alexandre Y. Dombrovski</name><affiliation><nlm:aff id="A3">Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24816626</idno><idno type="pmc">4229451</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229451</idno><idno type="RBID">PMC:4229451</idno><idno type="doi">10.1002/gps.4138</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001664</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001664</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cognitive Inhibition in Elderly High-Lethality Suicide Attempters</title><author><name sortKey="Richard Devantoy, Stephane" sort="Richard Devantoy, Stephane" uniqKey="Richard Devantoy S" first="Stéphane" last="Richard-Devantoy">Stéphane Richard-Devantoy</name><affiliation><nlm:aff id="A1">McGill University, Department of Psychiatry & Douglas Mental Health University Institute, McGill Group for Suicide Studies, Montréal (Québec), Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Laboratoire de Psychologie des Pays de la Loire EA 4638, Université de Nantes et Angers, France</nlm:aff></affiliation></author><author><name sortKey="Szanto, Katalin" sort="Szanto, Katalin" uniqKey="Szanto K" first="Katalin" last="Szanto">Katalin Szanto</name><affiliation><nlm:aff id="A3">Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA</nlm:aff></affiliation></author><author><name sortKey="Butters, Meryl A" sort="Butters, Meryl A" uniqKey="Butters M" first="Meryl A." last="Butters">Meryl A. Butters</name><affiliation><nlm:aff id="A3">Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA</nlm:aff></affiliation></author><author><name sortKey="Kalkus, Jan" sort="Kalkus, Jan" uniqKey="Kalkus J" first="Jan" last="Kalkus">Jan Kalkus</name><affiliation><nlm:aff id="A3">Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA</nlm:aff></affiliation></author><author><name sortKey="Dombrovski, Alexandre Y" sort="Dombrovski, Alexandre Y" uniqKey="Dombrovski A" first="Alexandre Y." last="Dombrovski">Alexandre Y. Dombrovski</name><affiliation><nlm:aff id="A3">Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of geriatric psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">People who attempt suicide often display cognitive impairments, particularly poor cognitive control. Could poor cognitive control contribute to high suicide rates in old age? A component of cognitive control, cognitive inhibition – active suppression of task-irrelevant processing – is very sensitive to aging and has been linked to attempted suicide. We investigated cognitive inhibition in older high-lethality suicide attempters, closely resembling suicide victims, as well as low-lethality attempters, and control groups with and without depression and suicidal ideation.</p></sec><sec id="S2"><title>Methods</title><p id="P2">102 participants aged 60+ (17 psychiatrically healthy control subjects, 38 depressed control subjects, 16 suicide ideators, 14 low-lethality suicide attempters, and 17 high-lethality suicide attempters) underwent comprehensive clinical and cognitive assessments. They completed the Delis–Kaplan Executive Function System Color-Word Interference Test, a validated modification of the Stroop test.</p></sec><sec id="S3"><title>Results</title><p id="P3">High-lethality suicide attempters demonstrated a distinct pattern of cognitive inhibition deficits. Compared to psychiatrically healthy control subjects and suicide ideators, high-lethality attempters took longer to complete inhibition trials, even after accounting for potential confounding factors (age, education, MMSE score, information processing speed, and accuracy). Compared to non-suicidal depressed and healthy control subjects, low-lethality suicide attempters committed more uncorrected errors; however, this difference was not specific to the inhibition condition.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Older suicide attempters are a cognitively heterogeneous group. Poor cognitive control in high-lethality attempters may undermine their ability to solve real-life problems, precipitating a catastrophic accumulation of stressors. Meanwhile, low-lethality attempters' poor performance may reflect a careless approach to the task or faulty monitoring.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8710629</journal-id><journal-id journal-id-type="pubmed-jr-id">20512</journal-id><journal-id journal-id-type="nlm-ta">Int J Geriatr Psychiatry</journal-id><journal-id journal-id-type="iso-abbrev">Int J Geriatr Psychiatry</journal-id><journal-title-group><journal-title>International journal of geriatric psychiatry</journal-title></journal-title-group><issn pub-type="ppub">0885-6230</issn><issn pub-type="epub">1099-1166</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24816626</article-id><article-id pub-id-type="pmc">4229451</article-id><article-id pub-id-type="doi">10.1002/gps.4138</article-id><article-id pub-id-type="manuscript">NIHMS595533</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Cognitive Inhibition in Elderly High-Lethality Suicide Attempters</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Richard-Devantoy</surname><given-names>Stéphane</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Szanto</surname><given-names>Katalin</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Butters</surname><given-names>Meryl A.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kalkus</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Dombrovski</surname><given-names>Alexandre Y.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>McGill University, Department of Psychiatry & Douglas Mental Health University Institute, McGill Group for Suicide Studies, Montréal (Québec), Canada</aff><aff id="A2"><label>2</label>Laboratoire de Psychologie des Pays de la Loire EA 4638, Université de Nantes et Angers, France</aff><aff id="A3"><label>3</label>Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA</aff><author-notes><corresp id="FN1">Correspondence to: Alexandre Y. Dombrovski; Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara Street, BT 754, Pittsburgh, PA 15217, USA. <email>dombax@upmc.edu</email>; phone: 412-246-6143; fax: 412-246-6030</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2016</year></pub-date><volume>30</volume><issue>3</issue><fpage>274</fpage><lpage>283</lpage><pmc-comment>elocation-id from pubmed: 10.1002/gps.4138</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">People who attempt suicide often display cognitive impairments, particularly poor cognitive control. Could poor cognitive control contribute to high suicide rates in old age? A component of cognitive control, cognitive inhibition – active suppression of task-irrelevant processing – is very sensitive to aging and has been linked to attempted suicide. We investigated cognitive inhibition in older high-lethality suicide attempters, closely resembling suicide victims, as well as low-lethality attempters, and control groups with and without depression and suicidal ideation.</p></sec><sec id="S2"><title>Methods</title><p id="P2">102 participants aged 60+ (17 psychiatrically healthy control subjects, 38 depressed control subjects, 16 suicide ideators, 14 low-lethality suicide attempters, and 17 high-lethality suicide attempters) underwent comprehensive clinical and cognitive assessments. They completed the Delis–Kaplan Executive Function System Color-Word Interference Test, a validated modification of the Stroop test.</p></sec><sec id="S3"><title>Results</title><p id="P3">High-lethality suicide attempters demonstrated a distinct pattern of cognitive inhibition deficits. Compared to psychiatrically healthy control subjects and suicide ideators, high-lethality attempters took longer to complete inhibition trials, even after accounting for potential confounding factors (age, education, MMSE score, information processing speed, and accuracy). Compared to non-suicidal depressed and healthy control subjects, low-lethality suicide attempters committed more uncorrected errors; however, this difference was not specific to the inhibition condition.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Older suicide attempters are a cognitively heterogeneous group. Poor cognitive control in high-lethality attempters may undermine their ability to solve real-life problems, precipitating a catastrophic accumulation of stressors. Meanwhile, low-lethality attempters' poor performance may reflect a careless approach to the task or faulty monitoring.</p></sec></abstract><kwd-group><kwd>Suicidal behavior</kwd><kwd>Stroop</kwd><kwd>Neuropsychology</kwd><kwd>Cognitive Control</kwd><kwd>Mood Disorders</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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