Regular Fish Consumption and Age-Related Brain Gray Matter Loss
Identifieur interne : 001639 ( Pmc/Corpus ); précédent : 001638; suivant : 001640Regular Fish Consumption and Age-Related Brain Gray Matter Loss
Auteurs : Cyrus A. Raji ; Kirk I. Erickson ; Oscar Lopez ; Lewis H. Kuller ; H. Michael Gach ; Paul M. Thompson ; Mario Riverol ; James T. BeckerSource :
- American journal of preventive medicine [ 0749-3797 ] ; 2014.
Abstract
Brain health may be affected by modifiable lifestyle factors; consuming fish and anti-oxidative omega-3 fatty acids may reduce brain structural abnormality risk.
To determine whether dietary fish consumption is related to brain structural integrity among cognitively normal elders.
Data were analyzed from 260 cognitively normal individuals from the Cardiovascular Health Study with information on fish consumption from the National Cancer Institute Food Frequency Questionnaire and brain magnetic resonance imaging (MRI). The relationship between fish consumption data collected in 1989–1990 and brain structural MRI obtained in 1998–1999 was assessed using voxel-based morphometry in multiple regression analyses in 2012. Covariates were age, gender, race, education, white matter lesions, MRI-identified infarcts, waist/hip ratio, and physical activity as assessed by the number of city blocks walked in 1 week. Volumetric changes were further modeled with omega-3 fatty acid estimates to better understand the mechanistic link between fish consumption, brain health, and Alzheimer disease.
Weekly consumption of baked or broiled fish was positively associated with gray matter volumes in the hippocampus, precuneus, posterior cingulate, and orbital frontal cortex even after adjusting for covariates. These results did not change when including omega-3 fatty acid estimates in the analysis.
Dietary consumption of baked or broiled fish is related to larger gray matter volumes independent of omega-3 fatty acid content. These findings suggest that a confluence of lifestyle factors influence brain health, adding to the growing body of evidence that prevention strategies for late-life brain health need to begin decades earlier.
Url:
DOI: 10.1016/j.amepre.2014.05.037
PubMed: 25084680
PubMed Central: 4171345
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PMC:4171345Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regular Fish Consumption and Age-Related Brain Gray Matter Loss</title>
<author><name sortKey="Raji, Cyrus A" sort="Raji, Cyrus A" uniqKey="Raji C" first="Cyrus A." last="Raji">Cyrus A. Raji</name>
</author>
<author><name sortKey="Erickson, Kirk I" sort="Erickson, Kirk I" uniqKey="Erickson K" first="Kirk I." last="Erickson">Kirk I. Erickson</name>
</author>
<author><name sortKey="Lopez, Oscar" sort="Lopez, Oscar" uniqKey="Lopez O" first="Oscar" last="Lopez">Oscar Lopez</name>
</author>
<author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name>
</author>
<author><name sortKey="Gach, H Michael" sort="Gach, H Michael" uniqKey="Gach H" first="H. Michael" last="Gach">H. Michael Gach</name>
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<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
</author>
<author><name sortKey="Riverol, Mario" sort="Riverol, Mario" uniqKey="Riverol M" first="Mario" last="Riverol">Mario Riverol</name>
</author>
<author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regular Fish Consumption and Age-Related Brain Gray Matter Loss</title>
<author><name sortKey="Raji, Cyrus A" sort="Raji, Cyrus A" uniqKey="Raji C" first="Cyrus A." last="Raji">Cyrus A. Raji</name>
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<author><name sortKey="Erickson, Kirk I" sort="Erickson, Kirk I" uniqKey="Erickson K" first="Kirk I." last="Erickson">Kirk I. Erickson</name>
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<author><name sortKey="Lopez, Oscar" sort="Lopez, Oscar" uniqKey="Lopez O" first="Oscar" last="Lopez">Oscar Lopez</name>
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<author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name>
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<author><name sortKey="Gach, H Michael" sort="Gach, H Michael" uniqKey="Gach H" first="H. Michael" last="Gach">H. Michael Gach</name>
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<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
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<author><name sortKey="Riverol, Mario" sort="Riverol, Mario" uniqKey="Riverol M" first="Mario" last="Riverol">Mario Riverol</name>
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<author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name>
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<series><title level="j">American journal of preventive medicine</title>
<idno type="ISSN">0749-3797</idno>
<idno type="eISSN">1873-2607</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Brain health may be affected by modifiable lifestyle factors; consuming fish and anti-oxidative omega-3 fatty acids may reduce brain structural abnormality risk.</p>
</sec>
<sec id="S2"><title>Purpose</title>
<p id="P2">To determine whether dietary fish consumption is related to brain structural integrity among cognitively normal elders.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">Data were analyzed from 260 cognitively normal individuals from the Cardiovascular Health Study with information on fish consumption from the National Cancer Institute Food Frequency Questionnaire and brain magnetic resonance imaging (MRI). The relationship between fish consumption data collected in 1989–1990 and brain structural MRI obtained in 1998–1999 was assessed using voxel-based morphometry in multiple regression analyses in 2012. Covariates were age, gender, race, education, white matter lesions, MRI-identified infarcts, waist/hip ratio, and physical activity as assessed by the number of city blocks walked in 1 week. Volumetric changes were further modeled with omega-3 fatty acid estimates to better understand the mechanistic link between fish consumption, brain health, and Alzheimer disease.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">Weekly consumption of baked or broiled fish was positively associated with gray matter volumes in the hippocampus, precuneus, posterior cingulate, and orbital frontal cortex even after adjusting for covariates. These results did not change when including omega-3 fatty acid estimates in the analysis.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">Dietary consumption of baked or broiled fish is related to larger gray matter volumes independent of omega-3 fatty acid content. These findings suggest that a confluence of lifestyle factors influence brain health, adding to the growing body of evidence that prevention strategies for late-life brain health need to begin decades earlier.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8704773</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1656</journal-id>
<journal-id journal-id-type="nlm-ta">Am J Prev Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Am J Prev Med</journal-id>
<journal-title-group><journal-title>American journal of preventive medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">0749-3797</issn>
<issn pub-type="epub">1873-2607</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25084680</article-id>
<article-id pub-id-type="pmc">4171345</article-id>
<article-id pub-id-type="doi">10.1016/j.amepre.2014.05.037</article-id>
<article-id pub-id-type="manuscript">NIHMS602806</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Regular Fish Consumption and Age-Related Brain Gray Matter Loss</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Raji</surname>
<given-names>Cyrus A.</given-names>
</name>
<degrees>MD, PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Erickson</surname>
<given-names>Kirk I.</given-names>
</name>
<degrees>PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Lopez</surname>
<given-names>Oscar</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Kuller</surname>
<given-names>Lewis H.</given-names>
</name>
<degrees>MD, DrPH</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Gach</surname>
<given-names>H. Michael</given-names>
</name>
<degrees>PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Thompson</surname>
<given-names>Paul M.</given-names>
</name>
<degrees>PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Riverol</surname>
<given-names>Mario</given-names>
</name>
<degrees>MD, PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Becker</surname>
<given-names>James T.</given-names>
</name>
<degrees>PhD</degrees>
</contrib>
<aff id="A1">Department of Radiology (Raji), University of California, Los Angeles Medical Center; Laboratory of Neuroimaging (Thompson), University of Southern California, Los Angeles, Los Angeles, California; Department of Radiology (Raji), Department of Psychology (Erickson, Gach, Becker), Department of Neurology (Lopez, Becker), Department of Psychiatry (Becker), Department of Epidemiology (Kuller), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania; and the Department of Neurology (Riverol), University of Navarra, Pamplona, Spain</aff>
</contrib-group>
<author-notes><corresp id="FN1">Address correspondence to: James T. Becker, PhD, Department of Psychiatry, University of Pittsburgh, Suite 830, 3501 Forbes Avenue, Pittsburgh PA 15213. <email>beckerjt@upmc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>12</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>7</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>10</month>
<year>2015</year>
</pub-date>
<volume>47</volume>
<issue>4</issue>
<fpage>444</fpage>
<lpage>451</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.amepre.2014.05.037</pmc-comment>
<permissions><copyright-statement>© 2014 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">Brain health may be affected by modifiable lifestyle factors; consuming fish and anti-oxidative omega-3 fatty acids may reduce brain structural abnormality risk.</p>
</sec>
<sec id="S2"><title>Purpose</title>
<p id="P2">To determine whether dietary fish consumption is related to brain structural integrity among cognitively normal elders.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">Data were analyzed from 260 cognitively normal individuals from the Cardiovascular Health Study with information on fish consumption from the National Cancer Institute Food Frequency Questionnaire and brain magnetic resonance imaging (MRI). The relationship between fish consumption data collected in 1989–1990 and brain structural MRI obtained in 1998–1999 was assessed using voxel-based morphometry in multiple regression analyses in 2012. Covariates were age, gender, race, education, white matter lesions, MRI-identified infarcts, waist/hip ratio, and physical activity as assessed by the number of city blocks walked in 1 week. Volumetric changes were further modeled with omega-3 fatty acid estimates to better understand the mechanistic link between fish consumption, brain health, and Alzheimer disease.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">Weekly consumption of baked or broiled fish was positively associated with gray matter volumes in the hippocampus, precuneus, posterior cingulate, and orbital frontal cortex even after adjusting for covariates. These results did not change when including omega-3 fatty acid estimates in the analysis.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">Dietary consumption of baked or broiled fish is related to larger gray matter volumes independent of omega-3 fatty acid content. These findings suggest that a confluence of lifestyle factors influence brain health, adding to the growing body of evidence that prevention strategies for late-life brain health need to begin decades earlier.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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