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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Association of Cord Serum Cytokines with Neurodevelopmental Outcomes</title><author><name sortKey="Varner, Michael W" sort="Varner, Michael W" uniqKey="Varner M" first="Michael W." last="Varner">Michael W. Varner</name></author><author><name sortKey="Marshall, Nicole E" sort="Marshall, Nicole E" uniqKey="Marshall N" first="Nicole E." last="Marshall">Nicole E. Marshall</name></author><author><name sortKey="Rouse, Dwight J" sort="Rouse, Dwight J" uniqKey="Rouse D" first="Dwight J." last="Rouse">Dwight J. Rouse</name></author><author><name sortKey="Jablonski, Kathleen A" sort="Jablonski, Kathleen A" uniqKey="Jablonski K" first="Kathleen A." last="Jablonski">Kathleen A. Jablonski</name></author><author><name sortKey="Leveno, Kenneth J" sort="Leveno, Kenneth J" uniqKey="Leveno K" first="Kenneth J." last="Leveno">Kenneth J. Leveno</name></author><author><name sortKey="Reddy, Uma M" sort="Reddy, Uma M" uniqKey="Reddy U" first="Uma M." last="Reddy">Uma M. Reddy</name></author><author><name sortKey="Mercer, Brian M" sort="Mercer, Brian M" uniqKey="Mercer B" first="Brian M." last="Mercer">Brian M. Mercer</name></author><author><name sortKey="Iams, Jay D" sort="Iams, Jay D" uniqKey="Iams J" first="Jay D." last="Iams">Jay D. Iams</name></author><author><name sortKey="Wapner, Ronald J" sort="Wapner, Ronald J" uniqKey="Wapner R" first="Ronald J." last="Wapner">Ronald J. Wapner</name></author><author><name sortKey="Sorokin, Yoram" sort="Sorokin, Yoram" uniqKey="Sorokin Y" first="Yoram" last="Sorokin">Yoram Sorokin</name></author><author><name sortKey="Thorp, John M" sort="Thorp, John M" uniqKey="Thorp J" first="John M." last="Thorp">John M. Thorp</name></author><author><name sortKey="Malone, Fergal D" sort="Malone, Fergal D" uniqKey="Malone F" first="Fergal D." last="Malone">Fergal D. Malone</name></author><author><name sortKey="Carpenter, Marshall" sort="Carpenter, Marshall" uniqKey="Carpenter M" first="Marshall" last="Carpenter">Marshall Carpenter</name></author><author><name sortKey="O Ullivan, Mary J" sort="O Ullivan, Mary J" uniqKey="O Ullivan M" first="Mary J." last="O Ullivan">Mary J. O Ullivan</name></author><author><name sortKey="Peaceman, Alan M" sort="Peaceman, Alan M" uniqKey="Peaceman A" first="Alan M." last="Peaceman">Alan M. Peaceman</name></author><author><name sortKey="Hankins, Gary D V" sort="Hankins, Gary D V" uniqKey="Hankins G" first="Gary D. V." last="Hankins">Gary D. V. Hankins</name></author><author><name sortKey="Dudley, Donald J" sort="Dudley, Donald J" uniqKey="Dudley D" first="Donald J." last="Dudley">Donald J. Dudley</name></author><author><name sortKey="Caritis, Steve N" sort="Caritis, Steve N" uniqKey="Caritis S" first="Steve N." last="Caritis">Steve N. Caritis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24936937</idno><idno type="pmc">4269581</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269581</idno><idno type="RBID">PMC:4269581</idno><idno type="doi">10.1055/s-0034-1376185</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001560</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001560</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Association of Cord Serum Cytokines with Neurodevelopmental Outcomes</title><author><name sortKey="Varner, Michael W" sort="Varner, Michael W" uniqKey="Varner M" first="Michael W." last="Varner">Michael W. Varner</name></author><author><name sortKey="Marshall, Nicole E" sort="Marshall, Nicole E" uniqKey="Marshall N" first="Nicole E." last="Marshall">Nicole E. Marshall</name></author><author><name sortKey="Rouse, Dwight J" sort="Rouse, Dwight J" uniqKey="Rouse D" first="Dwight J." last="Rouse">Dwight J. Rouse</name></author><author><name sortKey="Jablonski, Kathleen A" sort="Jablonski, Kathleen A" uniqKey="Jablonski K" first="Kathleen A." last="Jablonski">Kathleen A. Jablonski</name></author><author><name sortKey="Leveno, Kenneth J" sort="Leveno, Kenneth J" uniqKey="Leveno K" first="Kenneth J." last="Leveno">Kenneth J. Leveno</name></author><author><name sortKey="Reddy, Uma M" sort="Reddy, Uma M" uniqKey="Reddy U" first="Uma M." last="Reddy">Uma M. Reddy</name></author><author><name sortKey="Mercer, Brian M" sort="Mercer, Brian M" uniqKey="Mercer B" first="Brian M." last="Mercer">Brian M. Mercer</name></author><author><name sortKey="Iams, Jay D" sort="Iams, Jay D" uniqKey="Iams J" first="Jay D." last="Iams">Jay D. Iams</name></author><author><name sortKey="Wapner, Ronald J" sort="Wapner, Ronald J" uniqKey="Wapner R" first="Ronald J." last="Wapner">Ronald J. Wapner</name></author><author><name sortKey="Sorokin, Yoram" sort="Sorokin, Yoram" uniqKey="Sorokin Y" first="Yoram" last="Sorokin">Yoram Sorokin</name></author><author><name sortKey="Thorp, John M" sort="Thorp, John M" uniqKey="Thorp J" first="John M." last="Thorp">John M. Thorp</name></author><author><name sortKey="Malone, Fergal D" sort="Malone, Fergal D" uniqKey="Malone F" first="Fergal D." last="Malone">Fergal D. Malone</name></author><author><name sortKey="Carpenter, Marshall" sort="Carpenter, Marshall" uniqKey="Carpenter M" first="Marshall" last="Carpenter">Marshall Carpenter</name></author><author><name sortKey="O Ullivan, Mary J" sort="O Ullivan, Mary J" uniqKey="O Ullivan M" first="Mary J." last="O Ullivan">Mary J. O Ullivan</name></author><author><name sortKey="Peaceman, Alan M" sort="Peaceman, Alan M" uniqKey="Peaceman A" first="Alan M." last="Peaceman">Alan M. Peaceman</name></author><author><name sortKey="Hankins, Gary D V" sort="Hankins, Gary D V" uniqKey="Hankins G" first="Gary D. V." last="Hankins">Gary D. V. Hankins</name></author><author><name sortKey="Dudley, Donald J" sort="Dudley, Donald J" uniqKey="Dudley D" first="Donald J." last="Dudley">Donald J. Dudley</name></author><author><name sortKey="Caritis, Steve N" sort="Caritis, Steve N" uniqKey="Caritis S" first="Steve N." last="Caritis">Steve N. Caritis</name></author></analytic><series><title level="j">American journal of perinatology</title><idno type="ISSN">0735-1631</idno><idno type="eISSN">1098-8785</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>OBJECTIVE</title><p id="P1">To test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD).</p></sec><sec id="S2"><title>STUDY DESIGN</title><p id="P2">Nested case-control analysis within a clinical trial of antenatal magnesium sulfate (MgSO4) before anticipated PTB for prevention of CP, with evaluation of surviving children at age 2. NDD was defined as a Bayley Psychomotor Developmental Index (PDI) and/or Mental Developmental Index (MDI) <70. Controls, defined as surviving children without CP and with Bayley PDI and MDI ≥85, were matched by race and gestational age. Cord serum was analyzed for IL-8, IL-1 β and TNF-α levels. Elevated cytokine levels were defined as ≥75th percentile in placebo-exposed controls. Analyses compared case/control cytokine levels, adjusting for MgSO4 exposure, gestational age, race/ethnicity and sociodemographic differences.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">Logistic regression analysis with 339 cases and 276 controls showed that elevated IL-8 and IL-1β were more common in cord blood serum from infants with subsequent low MDI compared with controls. After adjusting for additional confounders, the significant differences were no longer evident. Cytokine levels (IL-8, IL-1β, and TNF-α) were not elevated with CP or low PDI.</p></sec><sec id="S4"><title>CONCLUSION</title><p id="P4">Cord serum IL-8, IL-1β, and TNF-α levels in preterm infants are not associated with subsequent CP or NDD.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8405212</journal-id><journal-id journal-id-type="pubmed-jr-id">1287</journal-id><journal-id journal-id-type="nlm-ta">Am J Perinatol</journal-id><journal-id journal-id-type="iso-abbrev">Am J Perinatol</journal-id><journal-title-group><journal-title>American journal of perinatology</journal-title></journal-title-group><issn pub-type="ppub">0735-1631</issn><issn pub-type="epub">1098-8785</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24936937</article-id><article-id pub-id-type="pmc">4269581</article-id><article-id pub-id-type="doi">10.1055/s-0034-1376185</article-id><article-id pub-id-type="manuscript">NIHMS584271</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Association of Cord Serum Cytokines with Neurodevelopmental Outcomes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Varner</surname><given-names>Michael W.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Marshall</surname><given-names>Nicole E.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Rouse</surname><given-names>Dwight J.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Jablonski</surname><given-names>Kathleen A.</given-names></name><degrees>Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Leveno</surname><given-names>Kenneth J.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Reddy</surname><given-names>Uma M.</given-names></name><degrees>M.D., M.P.H.</degrees></contrib><contrib contrib-type="author"><name><surname>Mercer</surname><given-names>Brian M.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Iams</surname><given-names>Jay D.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Wapner</surname><given-names>Ronald J.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Sorokin</surname><given-names>Yoram</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Thorp</surname><given-names>John M.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Malone</surname><given-names>Fergal D.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Carpenter</surname><given-names>Marshall</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>O’Sullivan</surname><given-names>Mary J.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Peaceman</surname><given-names>Alan M.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Hankins</surname><given-names>Gary D.V.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Dudley</surname><given-names>Donald J.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Caritis</surname><given-names>Steve N.</given-names></name><degrees>M.D.</degrees></contrib><on-behalf-of>for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network</on-behalf-of><xref rid="FN2" ref-type="author-notes">*</xref><aff id="A1">University of Utah, Salt Lake City (M.W.V.); Oregon Health & Science University, Portland, OR (N.E.M.), University of Alabama at Birmingham, Birmingham, AL (D.J.R.); University of Texas Southwestern Medical Center, Dallas, TX (K.J.L.) Case Western Reserve University-MetroHealth Medical Center, Cleveland, OH and University of Tennessee, Memphis, TN (B.M.M.); The Ohio State University, Columbus, OH (J.D.I.); Thomas Jefferson University and Drexel University, Philadelphia, PA (R.J.W.) Wayne State University, Detroit, MI (Y.S.); University of North Carolina at Chapel Hill, Chapel Hill, NC (J.M.T.), Columbia University, New York, NY (F.D.M.); Brown University, Providence, RI (M.C.), University of Miami, Miami, FL (M.J.O.), Northwestern University, Chicago, IL (A.M.P.), University of Texas Medical Branch, Galveston, TX (G.D.V.H.), University of Pittsburgh, Pittsburgh, PA (S.N.C.) and; and the George Washington University Biostatistics Center, Washington, DC (K.A.J.) and the<italic>Eunice Kennedy</italic> Shriver National Institute of Child Health and Human Development (U.M.R.)</aff></contrib-group><author-notes><corresp id="FN1">Corresponding Author: Michael W. Varner, M.D., Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Utah Health Sciences Center, 30 North 1900 East, Room 2A226, Salt Lake City, Utah 84132, PH: 801-585-5156, FAX: 801-585-2594, <email>michael.varner@hsc.utah.edu</email></corresp><fn id="FN2"><label>*</label><p>Other members of the <italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>17</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2015</year></pub-date><volume>30</volume><issue>2</issue><fpage>115</fpage><lpage>122</lpage><pmc-comment>elocation-id from pubmed: 10.1055/s-0034-1376185</pmc-comment>
<abstract><sec id="S1"><title>OBJECTIVE</title><p id="P1">To test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD).</p></sec><sec id="S2"><title>STUDY DESIGN</title><p id="P2">Nested case-control analysis within a clinical trial of antenatal magnesium sulfate (MgSO4) before anticipated PTB for prevention of CP, with evaluation of surviving children at age 2. NDD was defined as a Bayley Psychomotor Developmental Index (PDI) and/or Mental Developmental Index (MDI) <70. Controls, defined as surviving children without CP and with Bayley PDI and MDI ≥85, were matched by race and gestational age. Cord serum was analyzed for IL-8, IL-1 β and TNF-α levels. Elevated cytokine levels were defined as ≥75th percentile in placebo-exposed controls. Analyses compared case/control cytokine levels, adjusting for MgSO4 exposure, gestational age, race/ethnicity and sociodemographic differences.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">Logistic regression analysis with 339 cases and 276 controls showed that elevated IL-8 and IL-1β were more common in cord blood serum from infants with subsequent low MDI compared with controls. After adjusting for additional confounders, the significant differences were no longer evident. Cytokine levels (IL-8, IL-1β, and TNF-α) were not elevated with CP or low PDI.</p></sec><sec id="S4"><title>CONCLUSION</title><p id="P4">Cord serum IL-8, IL-1β, and TNF-α levels in preterm infants are not associated with subsequent CP or NDD.</p></sec></abstract><kwd-group><kwd>Cytokines</kwd><kwd>Cerebral Palsy</kwd><kwd>Neurodevelopmental Outcomes</kwd><kwd>Prematurity</kwd><kwd>Magnesium Sulfate</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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