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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Follicle stimulating hormone receptor in mesenchymal stem cells integrates effects of glycoprotein reproductive hormones</title><author><name sortKey="Tourkova, Irina L" sort="Tourkova, Irina L" uniqKey="Tourkova I" first="Irina L." last="Tourkova">Irina L. Tourkova</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Witt, Michelle R" sort="Witt, Michelle R" uniqKey="Witt M" first="Michelle R." last="Witt">Michelle R. Witt</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Li, La" sort="Li, La" uniqKey="Li L" first="La" last="Li">La Li</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Larrouture, Quitterie" sort="Larrouture, Quitterie" uniqKey="Larrouture Q" first="Quitterie" last="Larrouture">Quitterie Larrouture</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Luo, Jianhua" sort="Luo, Jianhua" uniqKey="Luo J" first="Jianhua" last="Luo">Jianhua Luo</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Robinson, Lisa J" sort="Robinson, Lisa J" uniqKey="Robinson L" first="Lisa J." last="Robinson">Lisa J. Robinson</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Blair, Harry C" sort="Blair, Harry C" uniqKey="Blair H" first="Harry C." last="Blair">Harry C. Blair</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Pittsburgh VA Medical Center Pittsburgh, Pennsylvania</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25118101</idno><idno type="pmc">4289445</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289445</idno><idno type="RBID">PMC:4289445</idno><idno type="doi">10.1111/nyas.12502</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001334</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001334</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Follicle stimulating hormone receptor in mesenchymal stem cells integrates effects of glycoprotein reproductive hormones</title><author><name sortKey="Tourkova, Irina L" sort="Tourkova, Irina L" uniqKey="Tourkova I" first="Irina L." last="Tourkova">Irina L. Tourkova</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Witt, Michelle R" sort="Witt, Michelle R" uniqKey="Witt M" first="Michelle R." last="Witt">Michelle R. Witt</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Li, La" sort="Li, La" uniqKey="Li L" first="La" last="Li">La Li</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Larrouture, Quitterie" sort="Larrouture, Quitterie" uniqKey="Larrouture Q" first="Quitterie" last="Larrouture">Quitterie Larrouture</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Luo, Jianhua" sort="Luo, Jianhua" uniqKey="Luo J" first="Jianhua" last="Luo">Jianhua Luo</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Robinson, Lisa J" sort="Robinson, Lisa J" uniqKey="Robinson L" first="Lisa J." last="Robinson">Lisa J. Robinson</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation></author><author><name sortKey="Blair, Harry C" sort="Blair, Harry C" uniqKey="Blair H" first="Harry C." last="Blair">Harry C. Blair</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Pittsburgh, Pennsylvania</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Pittsburgh VA Medical Center Pittsburgh, Pennsylvania</nlm:aff></affiliation></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Previously we reported that follicle stimulating hormone (FSH) affects bone degradation in human cells and in FSH-R null mice. Here we describe a FSH-R knockout bone formation phenotype. We used mesenchymal stem cells (MSCs), osteoblast precursors that express follicle stimulating hormone receptor (FSH-R), to determine whether FSH regulates bone formation. FSH stimulates MSC cell adhesion 1–3 h and proliferation at 24 h after addition. On the basis of phylogenetic and clinical precedents, we also examined effects of pregnant levels of human chorionic gonadotropin (hCG) on MSCs. We found effects similar to those of FSH, and RNAi knockdown of FSH-R abrogated both FSH and hCG effects on MSCs. In contrast to effects on MSCs, neither FSH nor hCG had significant effects on osteoblast maturation. Also in MSCs, short term treatment by FSH and hCG altered signaling pathways for proliferation, including Erk1/2 phosphorylation. Our results show augmentation of MSC proliferation by either FSH at menopausal levels or hCG at normal pregnant levels. We conclude that FSH-R participates in regulation of MSC precursor pools in response to either FSH or hCG, integrating the effects of these two glycoprotein hormones.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7506858</journal-id><journal-id journal-id-type="pubmed-jr-id">611</journal-id><journal-id journal-id-type="nlm-ta">Ann N Y Acad Sci</journal-id><journal-id journal-id-type="iso-abbrev">Ann. N. Y. Acad. Sci.</journal-id><journal-title-group><journal-title>Annals of the New York Academy of Sciences</journal-title></journal-title-group><issn pub-type="ppub">0077-8923</issn><issn pub-type="epub">1749-6632</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25118101</article-id><article-id pub-id-type="pmc">4289445</article-id><article-id pub-id-type="doi">10.1111/nyas.12502</article-id><article-id pub-id-type="manuscript">NIHMS615483</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Follicle stimulating hormone receptor in mesenchymal stem cells integrates effects of glycoprotein reproductive hormones</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tourkova</surname><given-names>Irina L.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Witt</surname><given-names>Michelle R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>La</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Larrouture</surname><given-names>Quitterie</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Luo</surname><given-names>Jianhua</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Robinson</surname><given-names>Lisa J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Blair</surname><given-names>Harry C.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Pathology, University of Pittsburgh, Pennsylvania</aff><aff id="A2"><label>2</label>Pittsburgh VA Medical Center Pittsburgh, Pennsylvania</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Harry C. Blair, 705 Scaife Hall, University of Pittsburgh, Pittsburgh, PA 15261. <email>hcblair@imap.pitt.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2016</year></pub-date><volume>1335</volume><issue>1</issue><fpage>100</fpage><lpage>109</lpage><pmc-comment>elocation-id from pubmed: 10.1111/nyas.12502</pmc-comment>
<abstract><p id="P1">Previously we reported that follicle stimulating hormone (FSH) affects bone degradation in human cells and in FSH-R null mice. Here we describe a FSH-R knockout bone formation phenotype. We used mesenchymal stem cells (MSCs), osteoblast precursors that express follicle stimulating hormone receptor (FSH-R), to determine whether FSH regulates bone formation. FSH stimulates MSC cell adhesion 1–3 h and proliferation at 24 h after addition. On the basis of phylogenetic and clinical precedents, we also examined effects of pregnant levels of human chorionic gonadotropin (hCG) on MSCs. We found effects similar to those of FSH, and RNAi knockdown of FSH-R abrogated both FSH and hCG effects on MSCs. In contrast to effects on MSCs, neither FSH nor hCG had significant effects on osteoblast maturation. Also in MSCs, short term treatment by FSH and hCG altered signaling pathways for proliferation, including Erk1/2 phosphorylation. Our results show augmentation of MSC proliferation by either FSH at menopausal levels or hCG at normal pregnant levels. We conclude that FSH-R participates in regulation of MSC precursor pools in response to either FSH or hCG, integrating the effects of these two glycoprotein hormones.</p></abstract><kwd-group><kwd>FSH</kwd><kwd>hCG</kwd><kwd>Erk1/2</kwd><kwd>osteoporosis</kwd><kwd>osteoblast</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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