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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship Between 25-Hydroxyvitamin D and Cognitive Function in Older Adults: The Health ABC Study</title><author><name sortKey="Wilson, Valerie K" sort="Wilson, Valerie K" uniqKey="Wilson V" first="Valerie K." last="Wilson">Valerie K. Wilson</name><affiliation><nlm:aff id="A1">Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author><author><name sortKey="Houston, Denise K" sort="Houston, Denise K" uniqKey="Houston D" first="Denise K." last="Houston">Denise K. Houston</name><affiliation><nlm:aff id="A1">Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author><author><name sortKey="Kilpatrick, Laurel" sort="Kilpatrick, Laurel" uniqKey="Kilpatrick L" first="Laurel" last="Kilpatrick">Laurel Kilpatrick</name><affiliation><nlm:aff id="A2">Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, AL</nlm:aff></affiliation></author><author><name sortKey="Lovato, James" sort="Lovato, James" uniqKey="Lovato J" first="James" last="Lovato">James Lovato</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author><author><name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name><affiliation><nlm:aff id="A4">Departments of Psychiatry, Neurology and Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA</nlm:aff></affiliation></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name><affiliation><nlm:aff id="A5">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A6">Intramural Research Program, National Institute on Aging, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name><affiliation><nlm:aff id="A7">Clinical Research Branch, National Institute on Aging, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Ayonayon, Hilsa N" sort="Ayonayon, Hilsa N" uniqKey="Ayonayon H" first="Hilsa N." last="Ayonayon">Hilsa N. Ayonayon</name><affiliation><nlm:aff id="A8">Department of Epidemiology & Biostatistics, University of California at San Francisco, San Francisco, CA</nlm:aff></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation><nlm:aff id="A1">Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author><author><name sortKey="Sink, Kaycee M" sort="Sink, Kaycee M" uniqKey="Sink K" first="Kaycee M." last="Sink">Kaycee M. Sink</name><affiliation><nlm:aff id="A1">Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24635412</idno><idno type="pmc">3989387</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989387</idno><idno type="RBID">PMC:3989387</idno><idno type="doi">10.1111/jgs.12765</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001316</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001316</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relationship Between 25-Hydroxyvitamin D and Cognitive Function in Older Adults: The Health ABC Study</title><author><name sortKey="Wilson, Valerie K" sort="Wilson, Valerie K" uniqKey="Wilson V" first="Valerie K." last="Wilson">Valerie K. Wilson</name><affiliation><nlm:aff id="A1">Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author><author><name sortKey="Houston, Denise K" sort="Houston, Denise K" uniqKey="Houston D" first="Denise K." last="Houston">Denise K. Houston</name><affiliation><nlm:aff id="A1">Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author><author><name sortKey="Kilpatrick, Laurel" sort="Kilpatrick, Laurel" uniqKey="Kilpatrick L" first="Laurel" last="Kilpatrick">Laurel Kilpatrick</name><affiliation><nlm:aff id="A2">Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, AL</nlm:aff></affiliation></author><author><name sortKey="Lovato, James" sort="Lovato, James" uniqKey="Lovato J" first="James" last="Lovato">James Lovato</name><affiliation><nlm:aff id="A3">Department of Biostatistics, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author><author><name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name><affiliation><nlm:aff id="A4">Departments of Psychiatry, Neurology and Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA</nlm:aff></affiliation></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name><affiliation><nlm:aff id="A5">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A6">Intramural Research Program, National Institute on Aging, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name><affiliation><nlm:aff id="A7">Clinical Research Branch, National Institute on Aging, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Ayonayon, Hilsa N" sort="Ayonayon, Hilsa N" uniqKey="Ayonayon H" first="Hilsa N." last="Ayonayon">Hilsa N. Ayonayon</name><affiliation><nlm:aff id="A8">Department of Epidemiology & Biostatistics, University of California at San Francisco, San Francisco, CA</nlm:aff></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation><nlm:aff id="A1">Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author><author><name sortKey="Sink, Kaycee M" sort="Sink, Kaycee M" uniqKey="Sink K" first="Kaycee M." last="Sink">Kaycee M. Sink</name><affiliation><nlm:aff id="A1">Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the American Geriatrics Society</title><idno type="ISSN">0002-8614</idno><idno type="eISSN">1532-5415</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P1">To examine the relationship between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance over time in older adults in the Health, Aging, and Body Composition (Health ABC) study. </p></sec><sec id="S2"><title>Design</title><p id="P2">Prospective cohort study</p></sec><sec id="S3"><title>Setting</title><p id="P3">Community-dwelling participants in Pittsburgh, PA, and Memphis, TN</p></sec><sec id="S4"><title>Participants</title><p id="P4">2,777 well-functioning adults aged 70–79 at baseline with serum 25(OH)D measured at the 12 month follow-up visit and cognitive function measured at baseline and 4-year follow-up visit.</p></sec><sec id="S5"><title>Measurements</title><p id="P5">Vitamin D status was categorized as 25(OH)D levels <20 ng/mL, 20 - <30 ng/mL, or ≥ 30ng/mL. Cognition was measured using the Modified Mini-Mental State Exam (3MS) and Digit Symbol Substitution Test (DSST). Linear regression models adjusting for multiple covariates, including age, education, sex, race, site, season, physical activity, and comorbidities were used in the analysis.</p></sec><sec id="S6"><title>Results</title><p id="P6">Sixty-eight percent of participants had 25(OH)D levels<30 ng/mL. Lower 25(OH)D levels were associated with lower baseline cognitive scores on the 3MS (adjusted means (95% CI): 89.9 (89.4–90.4), 90.8 (90.4–91.3), and 90.6 (90.2–91.1) for <20, 20-<30, and ≥30ng/mL, respectively; p trend =0.02) and the DSST (35.2 (34.5–36.0), 35.9 (35.2–36.6), and 37.0 (36.3–37.8), p trend =0.01). Participants with low 25(OH)D levels had greater declines in 3MS scores over 4 years than those with higher levels (LS mean change (95% CI): −1.0 (−1.5 to −0.6), −0.8 (−1.2 to −0.3), and −0.2 (−0.7 to 0.2) for <20, 20-<30, and ≥30ng/mL, respectively; p=0.05). There was no significant difference in DSST decline by 25(OH)D level.</p></sec><sec id="S7"><title>Conclusion</title><p id="P7">Low 25(OH)D levels were associated with worse global cognitive function and greater decline over time as measured by the 3MS. Intervention trials are needed to determine if vitamin D supplementation can reduce cognitive decline.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7503062</journal-id><journal-id journal-id-type="pubmed-jr-id">4443</journal-id><journal-id journal-id-type="nlm-ta">J Am Geriatr Soc</journal-id><journal-id journal-id-type="iso-abbrev">J Am Geriatr Soc</journal-id><journal-title-group><journal-title>Journal of the American Geriatrics Society</journal-title></journal-title-group><issn pub-type="ppub">0002-8614</issn><issn pub-type="epub">1532-5415</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24635412</article-id><article-id pub-id-type="pmc">3989387</article-id><article-id pub-id-type="doi">10.1111/jgs.12765</article-id><article-id pub-id-type="manuscript">NIHMS558397</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Relationship Between 25-Hydroxyvitamin D and Cognitive Function in Older Adults: The Health ABC Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>Valerie K.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Houston</surname><given-names>Denise K.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kilpatrick</surname><given-names>Laurel</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lovato</surname><given-names>James</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Yaffe</surname><given-names>Kristine</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cauley</surname><given-names>Jane A.</given-names></name><degrees>DrPH</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Tamara B.</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Simonsick</surname><given-names>Eleanor M.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Ayonayon</surname><given-names>Hilsa N.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Kritchevsky</surname><given-names>Stephen B.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sink</surname><given-names>Kaycee M.</given-names></name><degrees>MD, MAS</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><collab>for the Health ABC study</collab></contrib></contrib-group><aff id="A1"><label>1</label>Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC</aff><aff id="A2"><label>2</label>Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, AL</aff><aff id="A3"><label>3</label>Department of Biostatistics, Wake Forest School of Medicine, Winston Salem, NC</aff><aff id="A4"><label>4</label>Departments of Psychiatry, Neurology and Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA</aff><aff id="A5"><label>5</label>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</aff><aff id="A6"><label>6</label>Intramural Research Program, National Institute on Aging, Bethesda, MD</aff><aff id="A7"><label>7</label>Clinical Research Branch, National Institute on Aging, Baltimore, MD</aff><aff id="A8"><label>8</label>Department of Epidemiology & Biostatistics, University of California at San Francisco, San Francisco, CA</aff><author-notes><corresp id="cor1"><bold>Corresponding Author</bold>: Valerie K. Wilson, MD, Sticht Center on Aging, Medical Center Blvd, Winston-Salem, NC 27157, Office number: 336-713-8250, Fax number: 336-713-8252, <email>vwilson@wakehealth.edu</email></corresp><corresp id="cor2"><bold>Alternate Corresponding Author:</bold> Kaycee M. Sink, MD, MAS, <email>kmsink@wakehealth.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>17</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2015</year></pub-date><volume>62</volume><issue>4</issue><fpage>636</fpage><lpage>641</lpage><pmc-comment>elocation-id from pubmed: 10.1111/jgs.12765</pmc-comment>
<abstract><sec id="S1"><title>Objectives</title><p id="P1">To examine the relationship between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance over time in older adults in the Health, Aging, and Body Composition (Health ABC) study. </p></sec><sec id="S2"><title>Design</title><p id="P2">Prospective cohort study</p></sec><sec id="S3"><title>Setting</title><p id="P3">Community-dwelling participants in Pittsburgh, PA, and Memphis, TN</p></sec><sec id="S4"><title>Participants</title><p id="P4">2,777 well-functioning adults aged 70–79 at baseline with serum 25(OH)D measured at the 12 month follow-up visit and cognitive function measured at baseline and 4-year follow-up visit.</p></sec><sec id="S5"><title>Measurements</title><p id="P5">Vitamin D status was categorized as 25(OH)D levels <20 ng/mL, 20 - <30 ng/mL, or ≥ 30ng/mL. Cognition was measured using the Modified Mini-Mental State Exam (3MS) and Digit Symbol Substitution Test (DSST). Linear regression models adjusting for multiple covariates, including age, education, sex, race, site, season, physical activity, and comorbidities were used in the analysis.</p></sec><sec id="S6"><title>Results</title><p id="P6">Sixty-eight percent of participants had 25(OH)D levels<30 ng/mL. Lower 25(OH)D levels were associated with lower baseline cognitive scores on the 3MS (adjusted means (95% CI): 89.9 (89.4–90.4), 90.8 (90.4–91.3), and 90.6 (90.2–91.1) for <20, 20-<30, and ≥30ng/mL, respectively; p trend =0.02) and the DSST (35.2 (34.5–36.0), 35.9 (35.2–36.6), and 37.0 (36.3–37.8), p trend =0.01). Participants with low 25(OH)D levels had greater declines in 3MS scores over 4 years than those with higher levels (LS mean change (95% CI): −1.0 (−1.5 to −0.6), −0.8 (−1.2 to −0.3), and −0.2 (−0.7 to 0.2) for <20, 20-<30, and ≥30ng/mL, respectively; p=0.05). There was no significant difference in DSST decline by 25(OH)D level.</p></sec><sec id="S7"><title>Conclusion</title><p id="P7">Low 25(OH)D levels were associated with worse global cognitive function and greater decline over time as measured by the 3MS. Intervention trials are needed to determine if vitamin D supplementation can reduce cognitive decline.</p></sec></abstract><kwd-group><kwd>Vitamin D</kwd><kwd>cognition</kwd><kwd>cognitive function</kwd><kwd>memory</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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