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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Does stress mediate the development of substance use disorders among youth transitioning to young adulthood?</title><author><name sortKey="Cornelius, Jack" sort="Cornelius, Jack" uniqKey="Cornelius J" first="Jack" last="Cornelius">Jack Cornelius</name></author><author><name sortKey="Kirisci, Levent" sort="Kirisci, Levent" uniqKey="Kirisci L" first="Levent" last="Kirisci">Levent Kirisci</name></author><author><name sortKey="Reynolds, Maureen" sort="Reynolds, Maureen" uniqKey="Reynolds M" first="Maureen" last="Reynolds">Maureen Reynolds</name></author><author><name sortKey="Tarter, Ralph" sort="Tarter, Ralph" uniqKey="Tarter R" first="Ralph" last="Tarter">Ralph Tarter</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24735415</idno><idno type="pmc">4044823</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044823</idno><idno type="RBID">PMC:4044823</idno><idno type="doi">10.3109/00952990.2014.895833</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001305</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001305</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Does stress mediate the development of substance use disorders among youth transitioning to young adulthood?</title><author><name sortKey="Cornelius, Jack" sort="Cornelius, Jack" uniqKey="Cornelius J" first="Jack" last="Cornelius">Jack Cornelius</name></author><author><name sortKey="Kirisci, Levent" sort="Kirisci, Levent" uniqKey="Kirisci L" first="Levent" last="Kirisci">Levent Kirisci</name></author><author><name sortKey="Reynolds, Maureen" sort="Reynolds, Maureen" uniqKey="Reynolds M" first="Maureen" last="Reynolds">Maureen Reynolds</name></author><author><name sortKey="Tarter, Ralph" sort="Tarter, Ralph" uniqKey="Tarter R" first="Ralph" last="Tarter">Ralph Tarter</name></author></analytic><series><title level="j">The American journal of drug and alcohol abuse</title><idno type="ISSN">0095-2990</idno><idno type="eISSN">1097-9891</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Stress is a well-documented factor in the development of addiction. However, no longitudinal studies to date have assessed the role of stress in mediating the development of substance use disorders (SUD). Our previous results have demonstrated that a measure called Transmissible Liability Index (TLI) assessed during pre-adolescent years serves a significant predictor of risk for substance use disorder among young adults. However, it remains unclear whether life stress mediates the relationship between TLI and SUD, or whether stress predicts SUD.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We conducted a longitudinal study involving 191 male subjects to assess whether life stress mediates the relationship between TLI as assessed at age 10–12 and subsequent development of SUD at age 22, after controlling for other relevant factors.</p></sec><sec id="S3"><title>Results</title><p id="P3">Logistic regression demonstrated that the development of SUD at age 22 was associated with stress at age 19. A path analysis demonstrated that stress at age 19 significantly predicted SUD at age 22. However, stress did not mediate the relationship between the TLI assessed at age 10–12 and SUD in young adulthood.</p></sec><sec id="S4"><title>Conclusions and scientific significance</title><p id="P4">These findings confirm that stress plays a role in the development of SUD, but also shows that stress does not mediate the development of SUD. Further studies are warranted to clarify the role of stress in the etiology of SUD.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7502510</journal-id><journal-id journal-id-type="pubmed-jr-id">420</journal-id><journal-id journal-id-type="nlm-ta">Am J Drug Alcohol Abuse</journal-id><journal-id journal-id-type="iso-abbrev">Am J Drug Alcohol Abuse</journal-id><journal-title-group><journal-title>The American journal of drug and alcohol abuse</journal-title></journal-title-group><issn pub-type="ppub">0095-2990</issn><issn pub-type="epub">1097-9891</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24735415</article-id><article-id pub-id-type="pmc">4044823</article-id><article-id pub-id-type="doi">10.3109/00952990.2014.895833</article-id><article-id pub-id-type="manuscript">NIHMS581114</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Does stress mediate the development of substance use disorders among youth transitioning to young adulthood?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cornelius</surname><given-names>Jack</given-names></name><degrees>MD, MPH</degrees></contrib><contrib contrib-type="author"><name><surname>Kirisci</surname><given-names>Levent</given-names></name></contrib><contrib contrib-type="author"><name><surname>Reynolds</surname><given-names>Maureen</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tarter</surname><given-names>Ralph</given-names></name></contrib><aff id="A1">Center for Education and Drug Abuse Research (CEDAR), University of Pittsburgh, Pittsburgh, PA 15213, USA</aff></contrib-group><author-notes><corresp id="FN1">Address correspondence to Jack R. Cornelius, MD, MPH, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O’Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA. Tel: +1 412 246 5186. <email>corneliusjr@upmc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>6</month><year>2014</year></pub-date><volume>40</volume><issue>3</issue><fpage>225</fpage><lpage>229</lpage><pmc-comment>elocation-id from pubmed: 10.3109/00952990.2014.895833</pmc-comment>
<permissions><copyright-statement>© 2014 Informa Healthcare USA, Inc.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><sec id="S1"><title>Background</title><p id="P1">Stress is a well-documented factor in the development of addiction. However, no longitudinal studies to date have assessed the role of stress in mediating the development of substance use disorders (SUD). Our previous results have demonstrated that a measure called Transmissible Liability Index (TLI) assessed during pre-adolescent years serves a significant predictor of risk for substance use disorder among young adults. However, it remains unclear whether life stress mediates the relationship between TLI and SUD, or whether stress predicts SUD.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We conducted a longitudinal study involving 191 male subjects to assess whether life stress mediates the relationship between TLI as assessed at age 10–12 and subsequent development of SUD at age 22, after controlling for other relevant factors.</p></sec><sec id="S3"><title>Results</title><p id="P3">Logistic regression demonstrated that the development of SUD at age 22 was associated with stress at age 19. A path analysis demonstrated that stress at age 19 significantly predicted SUD at age 22. However, stress did not mediate the relationship between the TLI assessed at age 10–12 and SUD in young adulthood.</p></sec><sec id="S4"><title>Conclusions and scientific significance</title><p id="P4">These findings confirm that stress plays a role in the development of SUD, but also shows that stress does not mediate the development of SUD. Further studies are warranted to clarify the role of stress in the etiology of SUD.</p></sec></abstract><kwd-group><kwd>Stress</kwd><kwd>substance use disorders</kwd><kwd>youth</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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