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Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk

Identifieur interne : 000F13 ( Pmc/Corpus ); précédent : 000F12; suivant : 000F14

Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk

Auteurs : Susan E. Steck ; Lesley M. Butler ; Temitope Keku ; Samuel Antwi ; Joseph Galanko ; Robert S. Sandler ; Jennifer J. Hu

Source :

Mutation research [ 0027-5107 ] ; 2014.

RBID : PMC:4056032

Abstract

Purpose

Much of the DNA damage from colon cancer-related carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH) from red meat cooked at high temperature, are repaired by the nucleotide excision repair (NER) pathway. Thus, we examined whether NER non-synonymous single nucleotide polymorphisms (nsSNPs) modified the association between red meat intake and colon cancer risk.

Methods

The study consists of 244 African-American and 311 white colon cancer cases and population-based controls (331 African Americans and 544 whites) recruited from 33 counties in North Carolina from 1996 to 2000. Information collected by food frequency questionnaire on meat intake and preparation methods were used to estimate HCA and benzo(a)pyrene (BaP, a PAH) intake. We tested 7 nsSNPs in 5 NER genes: XPC A499V and K939Q, XPD D312N and K751Q, XPF R415Q, XPG D1104H, and RAD23B A249V. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression.

Results

Among African Americans, we observed a statistically significant positive association between colon cancer risk and XPC 499 AV+VV genotype (OR=1.7, 95% CI: 1.1, 2.7, AA as referent), and an inverse association with XPC 939 QQ (OR=0.3, 95%CI: 0.2, 0.8, KK as referent). These associations were not observed among whites. For both races combined, there was interaction between the XPC 939 genotype, well-done red meat intake and colon cancer risk (OR=1.5, 95% CI=1.0, 2.2 for high well-done red meat and KK genotype as compared to low well-done red meat and KK genotype, p_interaction =0.05).

Conclusions

Our data suggest that NER nsSNPs are associated with colon cancer risk and may modify the association between well-done red meat intake and colon cancer risk.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056032

DOI: 10.1016/j.mrfmmm.2014.02.004
PubMed: 24607854
PubMed Central: 4056032

Links to Exploration step

PMC:4056032

Le document en format XML

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<author><name sortKey="Steck, Susan E" sort="Steck, Susan E" uniqKey="Steck S" first="Susan E." last="Steck">Susan E. Steck</name>
<affiliation><nlm:aff id="A1">915 Greene Street, RM 236, Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA;<email>ssteck@sc.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M." last="Butler">Lesley M. Butler</name>
<affiliation><nlm:aff id="A2">UPMC Cancer Pavilion, Suite 4C-466, 5150 Centre Avenue, Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15232, USA;<email>BUTLERL3@upmc.edu</email>
</nlm:aff>
</affiliation>
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<author><name sortKey="Keku, Temitope" sort="Keku, Temitope" uniqKey="Keku T" first="Temitope" last="Keku">Temitope Keku</name>
<affiliation><nlm:aff id="A3">103 Mason Farm Road, 7340-C Medical Biomolecular Research Building, University of North Carolina, CB#7032, Chapel Hill, NC 27599-7032, USA;<email>tokeku@med.unc.edu</email>
</nlm:aff>
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<author><name sortKey="Antwi, Samuel" sort="Antwi, Samuel" uniqKey="Antwi S" first="Samuel" last="Antwi">Samuel Antwi</name>
<affiliation><nlm:aff id="A1">915 Greene Street, RM 236, Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA;<email>ssteck@sc.edu</email>
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<author><name sortKey="Galanko, Joseph" sort="Galanko, Joseph" uniqKey="Galanko J" first="Joseph" last="Galanko">Joseph Galanko</name>
<affiliation><nlm:aff id="A4">CB#7555, 4157 Bioinformatics Building, Department of Epidemiology Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7555, USA</nlm:aff>
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<author><name sortKey="Sandler, Robert S" sort="Sandler, Robert S" uniqKey="Sandler R" first="Robert S." last="Sandler">Robert S. Sandler</name>
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<author><name sortKey="Hu, Jennifer J" sort="Hu, Jennifer J" uniqKey="Hu J" first="Jennifer J." last="Hu">Jennifer J. Hu</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk</title>
<author><name sortKey="Steck, Susan E" sort="Steck, Susan E" uniqKey="Steck S" first="Susan E." last="Steck">Susan E. Steck</name>
<affiliation><nlm:aff id="A1">915 Greene Street, RM 236, Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA;<email>ssteck@sc.edu</email>
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<author><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M." last="Butler">Lesley M. Butler</name>
<affiliation><nlm:aff id="A2">UPMC Cancer Pavilion, Suite 4C-466, 5150 Centre Avenue, Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15232, USA;<email>BUTLERL3@upmc.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keku, Temitope" sort="Keku, Temitope" uniqKey="Keku T" first="Temitope" last="Keku">Temitope Keku</name>
<affiliation><nlm:aff id="A3">103 Mason Farm Road, 7340-C Medical Biomolecular Research Building, University of North Carolina, CB#7032, Chapel Hill, NC 27599-7032, USA;<email>tokeku@med.unc.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Antwi, Samuel" sort="Antwi, Samuel" uniqKey="Antwi S" first="Samuel" last="Antwi">Samuel Antwi</name>
<affiliation><nlm:aff id="A1">915 Greene Street, RM 236, Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA;<email>ssteck@sc.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Galanko, Joseph" sort="Galanko, Joseph" uniqKey="Galanko J" first="Joseph" last="Galanko">Joseph Galanko</name>
<affiliation><nlm:aff id="A4">CB#7555, 4157 Bioinformatics Building, Department of Epidemiology Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7555, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sandler, Robert S" sort="Sandler, Robert S" uniqKey="Sandler R" first="Robert S." last="Sandler">Robert S. Sandler</name>
<affiliation><nlm:aff id="A4">CB#7555, 4157 Bioinformatics Building, Department of Epidemiology Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7555, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hu, Jennifer J" sort="Hu, Jennifer J" uniqKey="Hu J" first="Jennifer J." last="Hu">Jennifer J. Hu</name>
<affiliation><nlm:aff id="A5">Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, 33136, USA;<email>JHu@med.miami.edu</email>
</nlm:aff>
</affiliation>
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<series><title level="j">Mutation research</title>
<idno type="ISSN">0027-5107</idno>
<idno type="eISSN">1873-135X</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">Much of the DNA damage from colon cancer-related carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH) from red meat cooked at high temperature, are repaired by the nucleotide excision repair (NER) pathway. Thus, we examined whether NER non-synonymous single nucleotide polymorphisms (nsSNPs) modified the association between red meat intake and colon cancer risk.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The study consists of 244 African-American and 311 white colon cancer cases and population-based controls (331 African Americans and 544 whites) recruited from 33 counties in North Carolina from 1996 to 2000. Information collected by food frequency questionnaire on meat intake and preparation methods were used to estimate HCA and benzo(a)pyrene (BaP, a PAH) intake. We tested 7 nsSNPs in 5 NER genes: <italic>XPC A499V</italic>
 and <italic>K939Q</italic>
, <italic>XPD D312N</italic>
 and <italic>K751Q, XPF R415Q</italic>
, <italic>XPG D1104H</italic>
, and <italic>RAD23B A249V</italic>
. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among African Americans, we observed a statistically significant positive association between colon cancer risk and <italic>XPC 499 AV+VV</italic>
 genotype (OR=1.7, 95% CI: 1.1, 2.7, <italic>AA</italic>
 as referent), and an inverse association with <italic>XPC 939 QQ</italic>
 (OR=0.3, 95%CI: 0.2, 0.8, <italic>KK</italic>
 as referent). These associations were not observed among whites. For both races combined, there was interaction between the <italic>XPC 939</italic>
 genotype, well-done red meat intake and colon cancer risk (OR=1.5, 95% CI=1.0, 2.2 for high well-done red meat and <italic>KK</italic>
 genotype as compared to low well-done red meat and <italic>KK</italic>
 genotype, p<sub><italic>interaction</italic>
</sub>
 =0.05).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Our data suggest that NER nsSNPs are associated with colon cancer risk and may modify the association between well-done red meat intake and colon cancer risk.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0400763</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5976</journal-id>
<journal-id journal-id-type="nlm-ta">Mutat Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Mutat. Res.</journal-id>
<journal-title-group><journal-title>Mutation research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0027-5107</issn>
<issn pub-type="epub">1873-135X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24607854</article-id>
<article-id pub-id-type="pmc">4056032</article-id>
<article-id pub-id-type="doi">10.1016/j.mrfmmm.2014.02.004</article-id>
<article-id pub-id-type="manuscript">NIHMS573729</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Steck</surname>
<given-names>Susan E.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Butler</surname>
<given-names>Lesley M.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Keku</surname>
<given-names>Temitope</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Antwi</surname>
<given-names>Samuel</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Galanko</surname>
<given-names>Joseph</given-names>
</name>
<email>galanko@med.unc.edu</email>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sandler</surname>
<given-names>Robert S.</given-names>
</name>
<email>rsandler@med.unc.edu</email>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hu</surname>
<given-names>Jennifer J.</given-names>
</name>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
915 Greene Street, RM 236, Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA;<email>ssteck@sc.edu</email>
</aff>
<aff id="A2"><label>b</label>
UPMC Cancer Pavilion, Suite 4C-466, 5150 Centre Avenue, Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15232, USA;<email>BUTLERL3@upmc.edu</email>
</aff>
<aff id="A3"><label>c</label>
103 Mason Farm Road, 7340-C Medical Biomolecular Research Building, University of North Carolina, CB#7032, Chapel Hill, NC 27599-7032, USA;<email>tokeku@med.unc.edu</email>
</aff>
<aff id="A4"><label>d</label>
CB#7555, 4157 Bioinformatics Building, Department of Epidemiology Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7555, USA</aff>
<aff id="A5"><label>e</label>
Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, 33136, USA;<email>JHu@med.miami.edu</email>
</aff>
<author-notes><corresp id="cor1"><bold>Corresponding author:</bold>
 Dr. Susan E. Steck, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Room 236, Columbia, SC 29208, USA; phone: (803) 576-5638; fax: (803) 576-5625; <email>ssteck@sc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>07</day>
<month>3</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>4</month>
<year>2015</year>
</pub-date>
<volume>762</volume>
<fpage>24</fpage>
<lpage>31</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.mrfmmm.2014.02.004</pmc-comment>
      <permissions><copyright-statement>© 2014 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Purpose</title>
<p id="P1">Much of the DNA damage from colon cancer-related carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH) from red meat cooked at high temperature, are repaired by the nucleotide excision repair (NER) pathway. Thus, we examined whether NER non-synonymous single nucleotide polymorphisms (nsSNPs) modified the association between red meat intake and colon cancer risk.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The study consists of 244 African-American and 311 white colon cancer cases and population-based controls (331 African Americans and 544 whites) recruited from 33 counties in North Carolina from 1996 to 2000. Information collected by food frequency questionnaire on meat intake and preparation methods were used to estimate HCA and benzo(a)pyrene (BaP, a PAH) intake. We tested 7 nsSNPs in 5 NER genes: <italic>XPC A499V</italic>
 and <italic>K939Q</italic>
, <italic>XPD D312N</italic>
 and <italic>K751Q, XPF R415Q</italic>
, <italic>XPG D1104H</italic>
, and <italic>RAD23B A249V</italic>
. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among African Americans, we observed a statistically significant positive association between colon cancer risk and <italic>XPC 499 AV+VV</italic>
 genotype (OR=1.7, 95% CI: 1.1, 2.7, <italic>AA</italic>
 as referent), and an inverse association with <italic>XPC 939 QQ</italic>
 (OR=0.3, 95%CI: 0.2, 0.8, <italic>KK</italic>
 as referent). These associations were not observed among whites. For both races combined, there was interaction between the <italic>XPC 939</italic>
 genotype, well-done red meat intake and colon cancer risk (OR=1.5, 95% CI=1.0, 2.2 for high well-done red meat and <italic>KK</italic>
 genotype as compared to low well-done red meat and <italic>KK</italic>
 genotype, p<sub><italic>interaction</italic>
</sub>
 =0.05).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Our data suggest that NER nsSNPs are associated with colon cancer risk and may modify the association between well-done red meat intake and colon cancer risk.</p>
</sec>
</abstract>
<kwd-group><kwd>Case-control study</kwd>
<kwd>colon cancer</kwd>
<kwd>diet</kwd>
<kwd>DNA repair</kwd>
<kwd>meat</kwd>
<kwd>polymorphism</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk

Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk

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Abstract

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