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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sequential Gene Silencing Using Wavelength-Selective Caged Morpholinos<sup><xref ref-type="fn" rid="FN2">**</xref>
</sup>
</title>
<author><name sortKey="Yamazoe, Sayumi" sort="Yamazoe, Sayumi" uniqKey="Yamazoe S" first="Sayumi" last="Yamazoe">Sayumi Yamazoe</name>
</author>
<author><name sortKey="Liu, Qingyang" sort="Liu, Qingyang" uniqKey="Liu Q" first="Qingyang" last="Liu">Qingyang Liu</name>
</author>
<author><name sortKey="Mcquade, Lindsey E" sort="Mcquade, Lindsey E" uniqKey="Mcquade L" first="Lindsey E." last="Mcquade">Lindsey E. Mcquade</name>
</author>
<author><name sortKey="Deiters, Alexander" sort="Deiters, Alexander" uniqKey="Deiters A" first="Alexander" last="Deiters">Alexander Deiters</name>
</author>
<author><name sortKey="Chen, James K" sort="Chen, James K" uniqKey="Chen J" first="James K." last="Chen">James K. Chen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25130695</idno>
<idno type="pmc">4206551</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206551</idno>
<idno type="RBID">PMC:4206551</idno>
<idno type="doi">10.1002/anie.201405355</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000E36</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E36</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sequential Gene Silencing Using Wavelength-Selective Caged Morpholinos<sup><xref ref-type="fn" rid="FN2">**</xref>
</sup>
</title>
<author><name sortKey="Yamazoe, Sayumi" sort="Yamazoe, Sayumi" uniqKey="Yamazoe S" first="Sayumi" last="Yamazoe">Sayumi Yamazoe</name>
</author>
<author><name sortKey="Liu, Qingyang" sort="Liu, Qingyang" uniqKey="Liu Q" first="Qingyang" last="Liu">Qingyang Liu</name>
</author>
<author><name sortKey="Mcquade, Lindsey E" sort="Mcquade, Lindsey E" uniqKey="Mcquade L" first="Lindsey E." last="Mcquade">Lindsey E. Mcquade</name>
</author>
<author><name sortKey="Deiters, Alexander" sort="Deiters, Alexander" uniqKey="Deiters A" first="Alexander" last="Deiters">Alexander Deiters</name>
</author>
<author><name sortKey="Chen, James K" sort="Chen, James K" uniqKey="Chen J" first="James K." last="Chen">James K. Chen</name>
</author>
</analytic>
<series><title level="j">Angewandte Chemie (International ed. in English)</title>
<idno type="ISSN">1433-7851</idno>
<idno type="eISSN">1521-3773</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Sequential gene silencing in zebrafish embryos has been achieved using caged morpholino oligonucleotides with spectrally distinct triggers. Using these optochemical tools, the genetic interactions that dynamically regulate mesoderm patterning have been examined.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370543</journal-id>
<journal-id journal-id-type="pubmed-jr-id">537</journal-id>
<journal-id journal-id-type="nlm-ta">Angew Chem Int Ed Engl</journal-id>
<journal-id journal-id-type="iso-abbrev">Angew. Chem. Int. Ed. Engl.</journal-id>
<journal-title-group><journal-title>Angewandte Chemie (International ed. in English)</journal-title>
</journal-title-group>
<issn pub-type="ppub">1433-7851</issn>
<issn pub-type="epub">1521-3773</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25130695</article-id>
<article-id pub-id-type="pmc">4206551</article-id>
<article-id pub-id-type="doi">10.1002/anie.201405355</article-id>
<article-id pub-id-type="manuscript">NIHMS633807</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Sequential Gene Silencing Using Wavelength-Selective Caged Morpholinos<sup><xref ref-type="fn" rid="FN2">**</xref>
</sup>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Yamazoe</surname>
<given-names>Sayumi</given-names>
<prefix>Dr.</prefix>
</name>
<xref rid="FN1" ref-type="author-notes">+</xref>
<aff id="A1">Departments of Chemical and Systems Biology and Developmental Biology, Stanford University School of Medicine 269 Campus Drive, CCSR 3155, Stanford, CA 94305 (USA)</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Qingyang</given-names>
</name>
<xref rid="FN1" ref-type="author-notes">+</xref>
<aff id="A2">Department of Chemistry, University of Pittsburgh Chevron Science Center, 219 Parkman Avenue, Pittsburgh, PA 15260 (USA)</aff>
</contrib>
<contrib contrib-type="author"><name><surname>McQuade</surname>
<given-names>Lindsey E.</given-names>
<prefix>Dr.</prefix>
</name>
<aff id="A3">Departments of Chemical and Systems Biology and Developmental Biology, Stanford University School of Medicine 269 Campus Drive, CCSR 3155, Stanford, CA 94305 (USA)</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Deiters</surname>
<given-names>Alexander</given-names>
<prefix>Prof. Dr.</prefix>
</name>
<aff id="A4">Department of Chemistry, University of Pittsburgh Chevron Science Center, 219 Parkman Avenue, Pittsburgh, PA 15260 (USA), Homepage:<ext-link ext-link-type="uri" xlink:href="http://www.pitt.edu/~deiters">http://www.pitt.edu/~deiters</ext-link>
</aff>
<email>deiters@pitt.edu</email>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Chen</surname>
<given-names>James K.</given-names>
<prefix>Prof. Dr.</prefix>
</name>
<aff id="A5">Departments of Chemical and Systems Biology and Developmental Biology, Stanford University School of Medicine 269 Campus Drive, CCSR 3155, Stanford, CA 94305 (USA), Homepage:<ext-link ext-link-type="uri" xlink:href="http://chen.stanford.edu">http://chen.stanford.edu</ext-link>
</aff>
<email>jameschen@stanford.edu</email>
</contrib>
</contrib-group>
<author-notes><fn id="FN1" fn-type="equal"><label>+</label>
<p>These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>8</day>
<month>10</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>01</day>
<month>8</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>9</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>9</month>
<year>2015</year>
</pub-date>
<volume>53</volume>
<issue>38</issue>
<fpage>10114</fpage>
<lpage>10118</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/anie.201405355</pmc-comment>
<permissions><copyright-statement>© 2013 Wiley VCH Verlag GmbH & Co. KGaA, We inheim</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p id="P2">Sequential gene silencing in zebrafish embryos has been achieved using caged morpholino oligonucleotides with spectrally distinct triggers. Using these optochemical tools, the genetic interactions that dynamically regulate mesoderm patterning have been examined.</p>
</abstract>
<kwd-group><kwd>antisense oligonucleotides</kwd>
<kwd>caged compounds</kwd>
<kwd>gene expression</kwd>
<kwd>developmental biology</kwd>
<kwd>zebrafish</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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