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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebellar Volume in Schizophrenia and Bipolar I Disorder with and without Psychotic Features</title><author><name sortKey="Laidi, Charles" sort="Laidi, Charles" uniqKey="Laidi C" first="Charles" last="Laidi">Charles Laidi</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Faculté de médecine, Université Paris Est, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</nlm:aff></affiliation></author><author><name sortKey="D Lbis, Marc Antoine" sort="D Lbis, Marc Antoine" uniqKey="D Lbis M" first="Marc-Antoine" last="D Lbis">Marc-Antoine D Lbis</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Faculté de médecine, Université Paris Est, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Wessa, Michele" sort="Wessa, Michele" uniqKey="Wessa M" first="Michèle" last="Wessa">Michèle Wessa</name><affiliation><nlm:aff id="A6">Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Center For Psychosocial Medicine, Heidelberg University, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Linke, Julia" sort="Linke, Julia" uniqKey="Linke J" first="Julia" last="Linke">Julia Linke</name><affiliation><nlm:aff id="A6">Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Center For Psychosocial Medicine, Heidelberg University, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Phillips, Mary" sort="Phillips, Mary" uniqKey="Phillips M" first="Mary" last="Phillips">Mary Phillips</name><affiliation><nlm:aff id="A7">Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Delavest, Marine" sort="Delavest, Marine" uniqKey="Delavest M" first="Marine" last="Delavest">Marine Delavest</name><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">AP-HP, Groupe Saint-Louis, Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">AP-HP, Groupe Saint-Louis, Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Versace, Amelia" sort="Versace, Amelia" uniqKey="Versace A" first="Amelia" last="Versace">Amelia Versace</name><affiliation><nlm:aff id="A7">Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Almeida, Jorge" sort="Almeida, Jorge" uniqKey="Almeida J" first="Jorge" last="Almeida">Jorge Almeida</name><affiliation><nlm:aff id="A7">Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Sarrazin, Samuel" sort="Sarrazin, Samuel" uniqKey="Sarrazin S" first="Samuel" last="Sarrazin">Samuel Sarrazin</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Faculté de médecine, Université Paris Est, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Poupon, Cyril" sort="Poupon, Cyril" uniqKey="Poupon C" first="Cyril" last="Poupon">Cyril Poupon</name><affiliation><nlm:aff id="A9">UNIRS, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Le Dudal, Katia" sort="Le Dudal, Katia" uniqKey="Le Dudal K" first="Katia" last="Le Dudal">Katia Le Dudal</name><affiliation><nlm:aff id="A10">Centre d’Investigation Clinique 1430 et Plateforme de Ressources Biologiques, Hôpital Henri Mondor, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Daban, Claire" sort="Daban, Claire" uniqKey="Daban C" first="Claire" last="Daban">Claire Daban</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Hamdani, Nora" sort="Hamdani, Nora" uniqKey="Hamdani N" first="Nora" last="Hamdani">Nora Hamdani</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Faculté de médecine, Université Paris Est, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Houenou, Josselin" sort="Houenou, Josselin" uniqKey="Houenou J" first="Josselin" last="Houenou">Josselin Houenou</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25430729</idno><idno type="pmc">4329064</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329064</idno><idno type="RBID">PMC:4329064</idno><idno type="doi">10.1111/acps.12363</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000E18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cerebellar Volume in Schizophrenia and Bipolar I Disorder with and without Psychotic Features</title><author><name sortKey="Laidi, Charles" sort="Laidi, Charles" uniqKey="Laidi C" first="Charles" last="Laidi">Charles Laidi</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Faculté de médecine, Université Paris Est, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</nlm:aff></affiliation></author><author><name sortKey="D Lbis, Marc Antoine" sort="D Lbis, Marc Antoine" uniqKey="D Lbis M" first="Marc-Antoine" last="D Lbis">Marc-Antoine D Lbis</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Faculté de médecine, Université Paris Est, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Wessa, Michele" sort="Wessa, Michele" uniqKey="Wessa M" first="Michèle" last="Wessa">Michèle Wessa</name><affiliation><nlm:aff id="A6">Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Center For Psychosocial Medicine, Heidelberg University, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Linke, Julia" sort="Linke, Julia" uniqKey="Linke J" first="Julia" last="Linke">Julia Linke</name><affiliation><nlm:aff id="A6">Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Center For Psychosocial Medicine, Heidelberg University, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Phillips, Mary" sort="Phillips, Mary" uniqKey="Phillips M" first="Mary" last="Phillips">Mary Phillips</name><affiliation><nlm:aff id="A7">Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Delavest, Marine" sort="Delavest, Marine" uniqKey="Delavest M" first="Marine" last="Delavest">Marine Delavest</name><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">AP-HP, Groupe Saint-Louis, Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">AP-HP, Groupe Saint-Louis, Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Versace, Amelia" sort="Versace, Amelia" uniqKey="Versace A" first="Amelia" last="Versace">Amelia Versace</name><affiliation><nlm:aff id="A7">Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Almeida, Jorge" sort="Almeida, Jorge" uniqKey="Almeida J" first="Jorge" last="Almeida">Jorge Almeida</name><affiliation><nlm:aff id="A7">Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Sarrazin, Samuel" sort="Sarrazin, Samuel" uniqKey="Sarrazin S" first="Samuel" last="Sarrazin">Samuel Sarrazin</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Faculté de médecine, Université Paris Est, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Poupon, Cyril" sort="Poupon, Cyril" uniqKey="Poupon C" first="Cyril" last="Poupon">Cyril Poupon</name><affiliation><nlm:aff id="A9">UNIRS, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Le Dudal, Katia" sort="Le Dudal, Katia" uniqKey="Le Dudal K" first="Katia" last="Le Dudal">Katia Le Dudal</name><affiliation><nlm:aff id="A10">Centre d’Investigation Clinique 1430 et Plateforme de Ressources Biologiques, Hôpital Henri Mondor, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Daban, Claire" sort="Daban, Claire" uniqKey="Daban C" first="Claire" last="Daban">Claire Daban</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Hamdani, Nora" sort="Hamdani, Nora" uniqKey="Hamdani N" first="Nora" last="Hamdani">Nora Hamdani</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Faculté de médecine, Université Paris Est, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Houenou, Josselin" sort="Houenou, Josselin" uniqKey="Houenou J" first="Josselin" last="Houenou">Josselin Houenou</name><affiliation><nlm:aff id="A1">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fondation Fondamental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</nlm:aff></affiliation></author></analytic><series><title level="j">Acta psychiatrica Scandinavica</title><idno type="ISSN">0001-690X</idno><idno type="eISSN">1600-0447</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">There is growing evidence that cerebellum plays a crucial role in cognition and emotional regulation. Cerebellum is likely to be involved in the physiopathology of both bipolar disorder and schizophrenia. The objective of our study was to compare cerebellar size between patients with bipolar disorder patients with schizophrenia and healthy controls in a multicenter sample. In addition, we studied the influence of psychotic features on cerebellar size in bipolar patients.</p></sec><sec id="S2"><title>Method</title><p id="P2">One hundred and fifteen bipolar I patients, thirty-two patients with schizophrenia and fifty-two healthy controls underwent 3 Tesla MRI. Automated segmentation of cerebellum was performed using FreeSurfer software. Volumes of cerebellar cortex and white matter were extracted. Analyses of covariance were conducted and age, sex and intracranial volume were considered as covariates.</p></sec><sec id="S3"><title>Results</title><p id="P3">Bilateral cerebellar cortical volumes were smaller in patients with schizophrenia compared to patients with bipolar I disorder and healthy controls. We found no significant difference of cerebellar volume between bipolar patients with and without psychotic features. No change was evidenced in white matter.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Our results suggest that reduction of cerebellar cortical volume is specific to schizophrenia. Cerebellar dysfunction in bipolar disorder, if present, appears to be more subtle than a reduction in cerebellar volume.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370364</journal-id><journal-id journal-id-type="pubmed-jr-id">192</journal-id><journal-id journal-id-type="nlm-ta">Acta Psychiatr Scand</journal-id><journal-id journal-id-type="iso-abbrev">Acta Psychiatr Scand</journal-id><journal-title-group><journal-title>Acta psychiatrica Scandinavica</journal-title></journal-title-group><issn pub-type="ppub">0001-690X</issn><issn pub-type="epub">1600-0447</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25430729</article-id><article-id pub-id-type="pmc">4329064</article-id><article-id pub-id-type="doi">10.1111/acps.12363</article-id><article-id pub-id-type="manuscript">NIHMS635594</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Cerebellar Volume in Schizophrenia and Bipolar I Disorder with and without Psychotic Features</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Laidi</surname><given-names>Charles</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>d’Albis</surname><given-names>Marc-Antoine</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Wessa</surname><given-names>Michèle</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Linke</surname><given-names>Julia</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Delavest</surname><given-names>Marine</given-names></name><xref ref-type="aff" rid="A4">d</xref><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Bellivier</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="A4">d</xref><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Versace</surname><given-names>Amelia</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Almeida</surname><given-names>Jorge</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Sarrazin</surname><given-names>Samuel</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Poupon</surname><given-names>Cyril</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Le Dudal</surname><given-names>Katia</given-names></name><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Daban</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Hamdani</surname><given-names>Nora</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Leboyer</surname><given-names>Marion</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Houenou</surname><given-names>Josselin</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A4">d</xref><xref ref-type="aff" rid="A5">e</xref><xref rid="FN1" ref-type="author-notes">1</xref></contrib></contrib-group><aff id="A1"><label>a</label>AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil, France</aff><aff id="A2"><label>b</label>INSERM, U955, IMRB, Psychiatrie Génétique, Créteil, France</aff><aff id="A3"><label>c</label>Faculté de médecine, Université Paris Est, Créteil, France</aff><aff id="A4"><label>d</label>Fondation Fondamental, Créteil, France</aff><aff id="A5"><label>e</label>UNIACT, Neurospin, I2BM, CEA Saclay, Gif sur Yvette, France</aff><aff id="A6"><label>f</label>Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Center For Psychosocial Medicine, Heidelberg University, Heidelberg, Germany</aff><aff id="A7"><label>g</label>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</aff><aff id="A8"><label>h</label>AP-HP, Groupe Saint-Louis, Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France</aff><aff id="A9"><label>i</label>UNIRS, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France</aff><aff id="A10"><label>j</label>Centre d’Investigation Clinique 1430 et Plateforme de Ressources Biologiques, Hôpital Henri Mondor, Créteil, France</aff><author-notes><corresp id="FN1"><label>1</label>*Corresponding author: Josselin Houenou, MD, PhD, INSERM U955, Pôle de psychiatrie, Hôpitaux Universitaires Mondor, 40 rue de Mesly 94000 Créteil France, Phone: +33 1 49 81 30 51, Fax: +33 1 49 81 30 59, <email>Josselin.houenou@inserm.fr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>31</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2016</year></pub-date><volume>131</volume><issue>3</issue><fpage>223</fpage><lpage>233</lpage><pmc-comment>elocation-id from pubmed: 10.1111/acps.12363</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">There is growing evidence that cerebellum plays a crucial role in cognition and emotional regulation. Cerebellum is likely to be involved in the physiopathology of both bipolar disorder and schizophrenia. The objective of our study was to compare cerebellar size between patients with bipolar disorder patients with schizophrenia and healthy controls in a multicenter sample. In addition, we studied the influence of psychotic features on cerebellar size in bipolar patients.</p></sec><sec id="S2"><title>Method</title><p id="P2">One hundred and fifteen bipolar I patients, thirty-two patients with schizophrenia and fifty-two healthy controls underwent 3 Tesla MRI. Automated segmentation of cerebellum was performed using FreeSurfer software. Volumes of cerebellar cortex and white matter were extracted. Analyses of covariance were conducted and age, sex and intracranial volume were considered as covariates.</p></sec><sec id="S3"><title>Results</title><p id="P3">Bilateral cerebellar cortical volumes were smaller in patients with schizophrenia compared to patients with bipolar I disorder and healthy controls. We found no significant difference of cerebellar volume between bipolar patients with and without psychotic features. No change was evidenced in white matter.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Our results suggest that reduction of cerebellar cortical volume is specific to schizophrenia. Cerebellar dysfunction in bipolar disorder, if present, appears to be more subtle than a reduction in cerebellar volume.</p></sec></abstract><kwd-group><kwd>Schizophrenia</kwd><kwd>Bipolar disorder</kwd><kwd>Psychosis</kwd><kwd>cerebellum</kwd><kwd>MRI</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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