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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Removal of a small C-terminal region of JCV and SV40 large T antigens has differential effects on transformation</title><author><name sortKey="Seneca, Nicole Tm" sort="Seneca, Nicole Tm" uniqKey="Seneca N" first="Nicole Tm" last="Seneca">Nicole Tm Seneca</name></author><author><name sortKey="Robles, Maria Teresa Saenz" sort="Robles, Maria Teresa Saenz" uniqKey="Robles M" first="Maria Teresa Sáenz" last="Robles">Maria Teresa Sáenz Robles</name></author><author><name sortKey="Pipas, James M" sort="Pipas, James M" uniqKey="Pipas J" first="James M" last="Pipas">James M. Pipas</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25129438</idno><idno type="pmc">4253650</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253650</idno><idno type="RBID">PMC:4253650</idno><idno type="doi">10.1016/j.virol.2014.07.038</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000D07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Removal of a small C-terminal region of JCV and SV40 large T antigens has differential effects on transformation</title><author><name sortKey="Seneca, Nicole Tm" sort="Seneca, Nicole Tm" uniqKey="Seneca N" first="Nicole Tm" last="Seneca">Nicole Tm Seneca</name></author><author><name sortKey="Robles, Maria Teresa Saenz" sort="Robles, Maria Teresa Saenz" uniqKey="Robles M" first="Maria Teresa Sáenz" last="Robles">Maria Teresa Sáenz Robles</name></author><author><name sortKey="Pipas, James M" sort="Pipas, James M" uniqKey="Pipas J" first="James M" last="Pipas">James M. Pipas</name></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The large T antigen (LT) protein of JCV and SV40 polyomaviruses is required to induce tumors in rodents and transform cells in culture. When both LTs are compared side-by-side in cell culture assays, SV40 shows a more robust transformation phenotype even though the LT sequences are highly conserved. A complete understanding of SV40’s enhanced transforming capabilities relative to JCV is lacking. When the least conserved region of the LT proteins, the variable linker and host range region (VHR), was removed, changes in T antigen expression and cellular p53 post-translational modifications occurred, but interaction with the pRB pathway was unaffected. Transformation assessed by growth in low serum was reduced after VHR truncation of the SV40, but not the JCV, T antigen. Conversely, anchorage independent transformation was enhanced only by truncation of the JCV VHR. This is the first report to link the SV40 or JCV VHR region to transformation potential.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110674</journal-id><journal-id journal-id-type="pubmed-jr-id">8015</journal-id><journal-id journal-id-type="nlm-ta">Virology</journal-id><journal-id journal-id-type="iso-abbrev">Virology</journal-id><journal-title-group><journal-title>Virology</journal-title></journal-title-group><issn pub-type="ppub">0042-6822</issn><issn pub-type="epub">1096-0341</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25129438</article-id><article-id pub-id-type="pmc">4253650</article-id><article-id pub-id-type="doi">10.1016/j.virol.2014.07.038</article-id><article-id pub-id-type="manuscript">NIHMS625506</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Removal of a small C-terminal region of JCV and SV40 large T antigens has differential effects on transformation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Seneca</surname><given-names>Nicole TM</given-names></name></contrib><contrib contrib-type="author"><name><surname>Robles</surname><given-names>Maria Teresa Sáenz</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pipas</surname><given-names>James M</given-names></name><xref rid="FN1" ref-type="author-notes">*</xref></contrib><aff id="A1">Department of Biological Sciences. University of Pittsburgh. Pittsburgh, PA, USA 15260</aff></contrib-group><author-notes><corresp id="FN1"><label>*</label>Corresponding Author: James M. Pipas, 570 Crawford Hall, 4249 Fifth Avenue, Pittsburgh, PA 15260, (412) 624-4691, <email>pipas@pitt.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>16</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2015</year></pub-date><volume>0</volume><fpage>47</fpage><lpage>56</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.virol.2014.07.038</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P2">The large T antigen (LT) protein of JCV and SV40 polyomaviruses is required to induce tumors in rodents and transform cells in culture. When both LTs are compared side-by-side in cell culture assays, SV40 shows a more robust transformation phenotype even though the LT sequences are highly conserved. A complete understanding of SV40’s enhanced transforming capabilities relative to JCV is lacking. When the least conserved region of the LT proteins, the variable linker and host range region (VHR), was removed, changes in T antigen expression and cellular p53 post-translational modifications occurred, but interaction with the pRB pathway was unaffected. Transformation assessed by growth in low serum was reduced after VHR truncation of the SV40, but not the JCV, T antigen. Conversely, anchorage independent transformation was enhanced only by truncation of the JCV VHR. This is the first report to link the SV40 or JCV VHR region to transformation potential.</p></abstract><kwd-group><kwd>polyomavirus</kwd><kwd>SV40</kwd><kwd>JCV</kwd><kwd>large T antigen</kwd><kwd>transformation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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