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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevents Host Invasion of Divergent Plasmodial Species</title><author><name sortKey="Chandramohanadas, Rajesh" sort="Chandramohanadas, Rajesh" uniqKey="Chandramohanadas R" first="Rajesh" last="Chandramohanadas">Rajesh Chandramohanadas</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><institution>Singapore University of Technology and Design</institution>,<addr-line>20 Dover Drive</addr-line></nlm:aff></affiliation></author><author><name sortKey="Russell, Bruce" sort="Russell, Bruce" uniqKey="Russell B" first="Bruce" last="Russell">Bruce Russell</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Microbiology, Yong Loo Lin School of Medicine</addr-line>,<institution>National University of Singapore</institution></nlm:aff></affiliation></author><author><name sortKey="Liew, Kingsley" sort="Liew, Kingsley" uniqKey="Liew K" first="Kingsley" last="Liew">Kingsley Liew</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation></author><author><name sortKey="Yau, Yin Hoe" sort="Yau, Yin Hoe" uniqKey="Yau Y" first="Yin Hoe" last="Yau">Yin Hoe Yau</name><affiliation><nlm:aff id="af4"><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chong, Alvin" sort="Chong, Alvin" uniqKey="Chong A" first="Alvin" last="Chong">Alvin Chong</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation></author><author><name sortKey="Liu, Min" sort="Liu, Min" uniqKey="Liu M" first="Min" last="Liu">Min Liu</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation></author><author><name sortKey="Gunalan, Karthigayan" sort="Gunalan, Karthigayan" uniqKey="Gunalan K" first="Karthigayan" last="Gunalan">Karthigayan Gunalan</name><affiliation><nlm:aff id="af4"><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Raman, Rahul" sort="Raman, Rahul" uniqKey="Raman R" first="Rahul" last="Raman">Rahul Raman</name><affiliation><nlm:aff id="af5"><addr-line>Department of Biological Engineering</addr-line>,<institution>Massachusetts Institute of Technology</institution>,<addr-line>Cambridge, Massachusetts</addr-line></nlm:aff></affiliation></author><author><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Renia">Laurent Renia</name><affiliation><nlm:aff id="af6"><addr-line>Singapore Immunology Network (SIgN)</addr-line>,<institution>Agency for Science, Technology and Research (A*STAR)</institution></nlm:aff></affiliation></author><author><name sortKey="Nosten, Francois" sort="Nosten, Francois" uniqKey="Nosten F" first="Francois" last="Nosten">Francois Nosten</name><affiliation><nlm:aff id="af7"><addr-line>Shoklo Malaria Research Unit, Mae Sot,</addr-line><country>Thailand</country></nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Shochat, Susana Geifman" sort="Shochat, Susana Geifman" uniqKey="Shochat S" first="Susana Geifman" last="Shochat">Susana Geifman Shochat</name><affiliation><nlm:aff id="af4"><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dao, Ming" sort="Dao, Ming" uniqKey="Dao M" first="Ming" last="Dao">Ming Dao</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af9"><addr-line>Department of Materials Science and Engineering</addr-line>,<institution>Massachusetts Institute of Technology</institution>,<addr-line>Cambridge</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Sasisekharan, Ram" sort="Sasisekharan, Ram" uniqKey="Sasisekharan R" first="Ram" last="Sasisekharan">Ram Sasisekharan</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Department of Biological Engineering</addr-line>,<institution>Massachusetts Institute of Technology</institution>,<addr-line>Cambridge, Massachusetts</addr-line></nlm:aff></affiliation></author><author><name sortKey="Suresh, Subra" sort="Suresh, Subra" uniqKey="Suresh S" first="Subra" last="Suresh">Subra Suresh</name><affiliation><nlm:aff id="af10"><addr-line>Department of Biomedical Engineering and Department of Materials Science and Engineering</addr-line>,<institution>Carnegie Mellon University</institution>,<addr-line>Pittsburgh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Preiser, Peter" sort="Preiser, Peter" uniqKey="Preiser P" first="Peter" last="Preiser">Peter Preiser</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24864124</idno><idno type="pmc">4334792</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334792</idno><idno type="RBID">PMC:4334792</idno><idno type="doi">10.1093/infdis/jiu296</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000B00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevents Host Invasion of Divergent Plasmodial Species</title><author><name sortKey="Chandramohanadas, Rajesh" sort="Chandramohanadas, Rajesh" uniqKey="Chandramohanadas R" first="Rajesh" last="Chandramohanadas">Rajesh Chandramohanadas</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><institution>Singapore University of Technology and Design</institution>,<addr-line>20 Dover Drive</addr-line></nlm:aff></affiliation></author><author><name sortKey="Russell, Bruce" sort="Russell, Bruce" uniqKey="Russell B" first="Bruce" last="Russell">Bruce Russell</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Microbiology, Yong Loo Lin School of Medicine</addr-line>,<institution>National University of Singapore</institution></nlm:aff></affiliation></author><author><name sortKey="Liew, Kingsley" sort="Liew, Kingsley" uniqKey="Liew K" first="Kingsley" last="Liew">Kingsley Liew</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation></author><author><name sortKey="Yau, Yin Hoe" sort="Yau, Yin Hoe" uniqKey="Yau Y" first="Yin Hoe" last="Yau">Yin Hoe Yau</name><affiliation><nlm:aff id="af4"><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chong, Alvin" sort="Chong, Alvin" uniqKey="Chong A" first="Alvin" last="Chong">Alvin Chong</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation></author><author><name sortKey="Liu, Min" sort="Liu, Min" uniqKey="Liu M" first="Min" last="Liu">Min Liu</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation></author><author><name sortKey="Gunalan, Karthigayan" sort="Gunalan, Karthigayan" uniqKey="Gunalan K" first="Karthigayan" last="Gunalan">Karthigayan Gunalan</name><affiliation><nlm:aff id="af4"><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Raman, Rahul" sort="Raman, Rahul" uniqKey="Raman R" first="Rahul" last="Raman">Rahul Raman</name><affiliation><nlm:aff id="af5"><addr-line>Department of Biological Engineering</addr-line>,<institution>Massachusetts Institute of Technology</institution>,<addr-line>Cambridge, Massachusetts</addr-line></nlm:aff></affiliation></author><author><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Renia">Laurent Renia</name><affiliation><nlm:aff id="af6"><addr-line>Singapore Immunology Network (SIgN)</addr-line>,<institution>Agency for Science, Technology and Research (A*STAR)</institution></nlm:aff></affiliation></author><author><name sortKey="Nosten, Francois" sort="Nosten, Francois" uniqKey="Nosten F" first="Francois" last="Nosten">Francois Nosten</name><affiliation><nlm:aff id="af7"><addr-line>Shoklo Malaria Research Unit, Mae Sot,</addr-line><country>Thailand</country></nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Shochat, Susana Geifman" sort="Shochat, Susana Geifman" uniqKey="Shochat S" first="Susana Geifman" last="Shochat">Susana Geifman Shochat</name><affiliation><nlm:aff id="af4"><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dao, Ming" sort="Dao, Ming" uniqKey="Dao M" first="Ming" last="Dao">Ming Dao</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af9"><addr-line>Department of Materials Science and Engineering</addr-line>,<institution>Massachusetts Institute of Technology</institution>,<addr-line>Cambridge</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Sasisekharan, Ram" sort="Sasisekharan, Ram" uniqKey="Sasisekharan R" first="Ram" last="Sasisekharan">Ram Sasisekharan</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Department of Biological Engineering</addr-line>,<institution>Massachusetts Institute of Technology</institution>,<addr-line>Cambridge, Massachusetts</addr-line></nlm:aff></affiliation></author><author><name sortKey="Suresh, Subra" sort="Suresh, Subra" uniqKey="Suresh S" first="Subra" last="Suresh">Subra Suresh</name><affiliation><nlm:aff id="af10"><addr-line>Department of Biomedical Engineering and Department of Materials Science and Engineering</addr-line>,<institution>Carnegie Mellon University</institution>,<addr-line>Pittsburgh</addr-line></nlm:aff></affiliation></author><author><name sortKey="Preiser, Peter" sort="Preiser, Peter" uniqKey="Preiser P" first="Peter" last="Preiser">Peter Preiser</name><affiliation><nlm:aff id="af1"><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Malaria causes nearly 1 million deaths annually. Recent emergence of multidrug resistance highlights the need to develop novel therapeutic interventions against human malaria. Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to identify such proteins as targets of small glycans. Combining multidisciplinary approaches, we report the discovery of a small molecule inhibitor, NIC, capable of inhibiting host invasion through interacting with a major invasion-related protein, merozoite surface protein-1 (MSP-1). This interaction was validated through computational, biochemical, and biophysical tools. Importantly, treatment with NIC prevented host invasion by <italic>Plasmodium falciparum</italic> and <italic>Plasmodium vivax—</italic>major causative organisms of human malaria. MSP-1, an indispensable antigen critical for invasion and suitably localized in abundance on the merozoite surface represents an ideal target for antimalarial development. The ability to target merozoite invasion proteins with specific small inhibitors opens up a new avenue to target this important pathogen.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-id journal-id-type="hwp">jinfdis</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24864124</article-id><article-id pub-id-type="pmc">4334792</article-id><article-id pub-id-type="doi">10.1093/infdis/jiu296</article-id><article-id pub-id-type="publisher-id">jiu296</article-id><article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject><subj-group subj-group-type="heading"><subject>Parasites</subject></subj-group></subj-group></article-categories><title-group><article-title>Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevents Host Invasion of Divergent Plasmodial Species</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chandramohanadas</surname><given-names>Rajesh</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Basappa</surname><given-names></given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Russell</surname><given-names>Bruce</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Liew</surname><given-names>Kingsley</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yau</surname><given-names>Yin Hoe</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Chong</surname><given-names>Alvin</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Min</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gunalan</surname><given-names>Karthigayan</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Raman</surname><given-names>Rahul</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Renia</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Nosten</surname><given-names>Francois</given-names></name><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Shochat</surname><given-names>Susana Geifman</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Dao</surname><given-names>Ming</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af9">9</xref><xref ref-type="author-notes" rid="AN1">a</xref></contrib><contrib contrib-type="author"><name><surname>Sasisekharan</surname><given-names>Ram</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Suresh</surname><given-names>Subra</given-names></name><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Preiser</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="author-notes" rid="AN1">a</xref></contrib><aff id="af1"><label>1</label><addr-line>Interdisciplinary Research Group of Infectious Diseases</addr-line>,<institution>Singapore MIT Alliance for Research and Technology Centre (SMART)</institution></aff><aff id="af2"><label>2</label><institution>Singapore University of Technology and Design</institution>,<addr-line>20 Dover Drive</addr-line></aff><aff id="af3"><label>3</label><addr-line>Department of Microbiology, Yong Loo Lin School of Medicine</addr-line>,<institution>National University of Singapore</institution> and</aff><aff id="af4"><label>4</label><addr-line>School of Biological Sciences</addr-line>,<institution>Nanyang Technological University</institution>,<addr-line>Singapore</addr-line></aff><aff id="af5"><label>5</label><addr-line>Department of Biological Engineering</addr-line>,<institution>Massachusetts Institute of Technology</institution>,<addr-line>Cambridge, Massachusetts</addr-line></aff><aff id="af6"><label>6</label><addr-line>Singapore Immunology Network (SIgN)</addr-line>,<institution>Agency for Science, Technology and Research (A*STAR)</institution></aff><aff id="af7"><label>7</label><addr-line>Shoklo Malaria Research Unit, Mae Sot,</addr-line><country>Thailand</country></aff><aff id="af8"><label>8</label><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<country>United Kingdom</country></aff><aff id="af9"><label>9</label><addr-line>Department of Materials Science and Engineering</addr-line>,<institution>Massachusetts Institute of Technology</institution>,<addr-line>Cambridge</addr-line>;</aff><aff id="af10"><label>10</label><addr-line>Department of Biomedical Engineering and Department of Materials Science and Engineering</addr-line>,<institution>Carnegie Mellon University</institution>,<addr-line>Pittsburgh</addr-line></aff></contrib-group><author-notes><fn id="AN2" fn-type="con"><p>Presented in part: Molecular Approaches to Malaria (MAM) 2012, Lorne, Australia,19–23 February 2012; ASTMH 62nd Annual Meeting, Marriott Wardman Park Washington, DC, 13–17 November 2013</p></fn><fn id="AN1" fn-type="con"><label>a</label><p>P. P. and M. D. contributed contributed equally to this work and are both corresponding authors.</p></fn><corresp>Correspondence: Peter Rainer Preiser, PhD, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive Singapore 637551, Republic of Singapore (<email>prpreiser@ntu.edu.sg</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>26</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>11</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>210</volume><issue>10</issue><fpage>1616</fpage><lpage>1626</lpage><history><date date-type="received"><day>16</day><month>1</month><year>2014</year></date><date date-type="accepted"><day>5</day><month>5</month><year>2014</year></date></history><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: <email>journals.permissions@oup.com</email>.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="jiu296.pdf"></self-uri><abstract><p>Malaria causes nearly 1 million deaths annually. Recent emergence of multidrug resistance highlights the need to develop novel therapeutic interventions against human malaria. Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to identify such proteins as targets of small glycans. Combining multidisciplinary approaches, we report the discovery of a small molecule inhibitor, NIC, capable of inhibiting host invasion through interacting with a major invasion-related protein, merozoite surface protein-1 (MSP-1). This interaction was validated through computational, biochemical, and biophysical tools. Importantly, treatment with NIC prevented host invasion by <italic>Plasmodium falciparum</italic> and <italic>Plasmodium vivax—</italic>major causative organisms of human malaria. MSP-1, an indispensable antigen critical for invasion and suitably localized in abundance on the merozoite surface represents an ideal target for antimalarial development. The ability to target merozoite invasion proteins with specific small inhibitors opens up a new avenue to target this important pathogen.</p></abstract><kwd-group><kwd>malaria</kwd><kwd><italic>Plasmodium falciparum</italic></kwd><kwd><italic>Plasmodium vivax</italic></kwd><kwd>glycan mimetic small molecules</kwd><kwd>chemical biology</kwd><kwd>mass spectrometry</kwd><kwd>red blood cell</kwd><kwd>host invasion</kwd><kwd>merozoite surface proteins</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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