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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of a Novel Polyomavirus in a Pancreatic Transplant Recipient With Retinal Blindness and Vasculitic Myopathy</title><author><name sortKey="Mishra, Nischay" sort="Mishra, Nischay" uniqKey="Mishra N" first="Nischay" last="Mishra">Nischay Mishra</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pereira, Marcus" sort="Pereira, Marcus" uniqKey="Pereira M" first="Marcus" last="Pereira">Marcus Pereira</name><affiliation><nlm:aff id="af2"><addr-line>Division of Infectious Diseases</addr-line>,<institution>Columbia University</institution>,<addr-line>New York, New York</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rhodes, Roy H" sort="Rhodes, Roy H" uniqKey="Rhodes R" first="Roy H." last="Rhodes">Roy H. Rhodes</name><affiliation><nlm:aff id="af3"><addr-line>Pathology and Laboratory Medicine</addr-line>,<institution>Rutgers University</institution>,<addr-line>New Brunswick, New Jersey</addr-line></nlm:aff></affiliation></author><author><name sortKey="An, Ping" sort="An, Ping" uniqKey="An P" first="Ping" last="An">Ping An</name><affiliation><nlm:aff id="af4"><addr-line>Department of Biological Sciences</addr-line>,<institution>University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pipas, James M" sort="Pipas, James M" uniqKey="Pipas J" first="James M." last="Pipas">James M. Pipas</name><affiliation><nlm:aff id="af4"><addr-line>Department of Biological Sciences</addr-line>,<institution>University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jain, Komal" sort="Jain, Komal" uniqKey="Jain K" first="Komal" last="Jain">Komal Jain</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kapoor, Amit" sort="Kapoor, Amit" uniqKey="Kapoor A" first="Amit" last="Kapoor">Amit Kapoor</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author><author><name sortKey="Briese, Thomas" sort="Briese, Thomas" uniqKey="Briese T" first="Thomas" last="Briese">Thomas Briese</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author><author><name sortKey="Faust, Phyllis L" sort="Faust, Phyllis L" uniqKey="Faust P" first="Phyllis L." last="Faust">Phyllis L. Faust</name><affiliation><nlm:aff id="af5"><institution>Pathology and Cell Biology, Columbia University</institution>,<addr-line>New York, New York</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lipkin, W Ian" sort="Lipkin, W Ian" uniqKey="Lipkin W" first="W. Ian" last="Lipkin">W. Ian Lipkin</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24795478</idno><idno type="pmc">4334791</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334791</idno><idno type="RBID">PMC:4334791</idno><idno type="doi">10.1093/infdis/jiu250</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A99</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of a Novel Polyomavirus in a Pancreatic Transplant Recipient With Retinal Blindness and Vasculitic Myopathy</title><author><name sortKey="Mishra, Nischay" sort="Mishra, Nischay" uniqKey="Mishra N" first="Nischay" last="Mishra">Nischay Mishra</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pereira, Marcus" sort="Pereira, Marcus" uniqKey="Pereira M" first="Marcus" last="Pereira">Marcus Pereira</name><affiliation><nlm:aff id="af2"><addr-line>Division of Infectious Diseases</addr-line>,<institution>Columbia University</institution>,<addr-line>New York, New York</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rhodes, Roy H" sort="Rhodes, Roy H" uniqKey="Rhodes R" first="Roy H." last="Rhodes">Roy H. Rhodes</name><affiliation><nlm:aff id="af3"><addr-line>Pathology and Laboratory Medicine</addr-line>,<institution>Rutgers University</institution>,<addr-line>New Brunswick, New Jersey</addr-line></nlm:aff></affiliation></author><author><name sortKey="An, Ping" sort="An, Ping" uniqKey="An P" first="Ping" last="An">Ping An</name><affiliation><nlm:aff id="af4"><addr-line>Department of Biological Sciences</addr-line>,<institution>University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pipas, James M" sort="Pipas, James M" uniqKey="Pipas J" first="James M." last="Pipas">James M. Pipas</name><affiliation><nlm:aff id="af4"><addr-line>Department of Biological Sciences</addr-line>,<institution>University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jain, Komal" sort="Jain, Komal" uniqKey="Jain K" first="Komal" last="Jain">Komal Jain</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kapoor, Amit" sort="Kapoor, Amit" uniqKey="Kapoor A" first="Amit" last="Kapoor">Amit Kapoor</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author><author><name sortKey="Briese, Thomas" sort="Briese, Thomas" uniqKey="Briese T" first="Thomas" last="Briese">Thomas Briese</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author><author><name sortKey="Faust, Phyllis L" sort="Faust, Phyllis L" uniqKey="Faust P" first="Phyllis L." last="Faust">Phyllis L. Faust</name><affiliation><nlm:aff id="af5"><institution>Pathology and Cell Biology, Columbia University</institution>,<addr-line>New York, New York</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lipkin, W Ian" sort="Lipkin, W Ian" uniqKey="Lipkin W" first="W. Ian" last="Lipkin">W. Ian Lipkin</name><affiliation><nlm:aff id="af1"><addr-line>Center for Infection and Immunity</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold><italic>Background.</italic></bold> A 33 year-old pancreatic transplant recipient developed weakness, retinal blindness, and necrotic plaques on her face, scalp, and hands.</p><p><bold><italic>Methods.</italic></bold> A muscle biopsy was analyzed by light and electron microscopy and high-throughput nucleic acid sequencing.</p><p><bold><italic>Results.</italic></bold> The biopsy revealed microthrombosis and viral particles in swollen endothelial cell nuclei. High-throughput sequencing of nucleic acid revealed a novel polyomavirus. In situ hybridization confirmed the presence of the polyomavirus in endothelial cells at sites of myositis and cutaneous necrosis.</p><p><bold><italic>Conclusions.</italic></bold> New Jersey polyomavirus (NJPyV-2013) is a novel polyomavirus that may have tropism for vascular endothelial cells.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-id journal-id-type="hwp">jinfdis</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24795478</article-id><article-id pub-id-type="pmc">4334791</article-id><article-id pub-id-type="doi">10.1093/infdis/jiu250</article-id><article-id pub-id-type="publisher-id">jiu250</article-id><article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject><subj-group subj-group-type="heading"><subject>Viruses</subject></subj-group></subj-group></article-categories><title-group><article-title>Identification of a Novel Polyomavirus in a Pancreatic Transplant Recipient With Retinal Blindness and Vasculitic Myopathy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mishra</surname><given-names>Nischay</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pereira</surname><given-names>Marcus</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Rhodes</surname><given-names>Roy H.</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>An</surname><given-names>Ping</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Pipas</surname><given-names>James M.</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Jain</surname><given-names>Komal</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kapoor</surname><given-names>Amit</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Briese</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Faust</surname><given-names>Phyllis L.</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Lipkin</surname><given-names>W. Ian</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><aff id="af1"><label>1</label><addr-line>Center for Infection and Immunity</addr-line></aff><aff id="af2"><label>2</label><addr-line>Division of Infectious Diseases</addr-line>,<institution>Columbia University</institution>,<addr-line>New York, New York</addr-line></aff><aff id="af3"><label>3</label><addr-line>Pathology and Laboratory Medicine</addr-line>,<institution>Rutgers University</institution>,<addr-line>New Brunswick, New Jersey</addr-line></aff><aff id="af4"><label>4</label><addr-line>Department of Biological Sciences</addr-line>,<institution>University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>,</aff><aff id="af5"><label>5</label><institution>Pathology and Cell Biology, Columbia University</institution>,<addr-line>New York, New York</addr-line></aff></contrib-group><author-notes><corresp>Correspondence: W. Ian Lipkin, MD, 722 West 168th St, 17th Fl, New York, NY 10032 (<email>wil2001@columbia.edu</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>01</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>11</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>210</volume><issue>10</issue><fpage>1595</fpage><lpage>1599</lpage><history><date date-type="received"><day>8</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>21</day><month>4</month><year>2014</year></date></history><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: <email>journals.permissions@oup.com</email>.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="jiu250.pdf"></self-uri><abstract><p><bold><italic>Background.</italic></bold> A 33 year-old pancreatic transplant recipient developed weakness, retinal blindness, and necrotic plaques on her face, scalp, and hands.</p><p><bold><italic>Methods.</italic></bold> A muscle biopsy was analyzed by light and electron microscopy and high-throughput nucleic acid sequencing.</p><p><bold><italic>Results.</italic></bold> The biopsy revealed microthrombosis and viral particles in swollen endothelial cell nuclei. High-throughput sequencing of nucleic acid revealed a novel polyomavirus. In situ hybridization confirmed the presence of the polyomavirus in endothelial cells at sites of myositis and cutaneous necrosis.</p><p><bold><italic>Conclusions.</italic></bold> New Jersey polyomavirus (NJPyV-2013) is a novel polyomavirus that may have tropism for vascular endothelial cells.</p></abstract><kwd-group><kwd>virus discovery</kwd><kwd>polyomavirus</kwd><kwd>immunosuppression</kwd><kwd>transplantation</kwd><kwd>vasculitis</kwd><kwd>myositis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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