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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults</title><author><name sortKey="Tian, Qu" sort="Tian, Qu" uniqKey="Tian Q" first="Qu" last="Tian">Qu Tian</name><affiliation><nlm:aff wicri:cut=" and" id="AF0001"><institution>Department of Epidemiology, Graduate School of Public Health</institution></nlm:aff></affiliation></author><author><name sortKey="Erickson, Kirk I" sort="Erickson, Kirk I" uniqKey="Erickson K" first="Kirk I." last="Erickson">Kirk I. Erickson</name><affiliation><nlm:aff id="AF0002"><institution>Department of Psychology, University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name><affiliation><nlm:aff id="AF0003"><institution>Translational Gerontology Branch, Intramural Research Program, National Institute on Aging</institution>,<addr-line>Baltimore, Maryland</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J." last="Aizenstein">Howard J. Aizenstein</name><affiliation><nlm:aff id="AF0004"><institution>Department of Psychiatry, University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Glynn, Nancy W" sort="Glynn, Nancy W" uniqKey="Glynn N" first="Nancy W." last="Glynn">Nancy W. Glynn</name><affiliation><nlm:aff id="AF0005"><institution>Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine</institution>,<addr-line>Winston Salem, North Carolina</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name><affiliation><nlm:aff id="AF0006"><institution>Department of Psychiatry, Neurology and Epidemiology, University of California</institution>,<addr-line>San Francisco</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><affiliation><nlm:aff wicri:cut=" and" id="AF0001"><institution>Department of Epidemiology, Graduate School of Public Health</institution></nlm:aff></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation><nlm:aff id="AF0005"><institution>Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine</institution>,<addr-line>Winston Salem, North Carolina</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name><affiliation><nlm:aff id="AF0006"><institution>Department of Psychiatry, Neurology and Epidemiology, University of California</institution>,<addr-line>San Francisco</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="AF0007"><institution>Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging</institution>,<addr-line>Bethesda, Maryland</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name><affiliation><nlm:aff wicri:cut=" and" id="AF0001"><institution>Department of Epidemiology, Graduate School of Public Health</institution></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24474004</idno><idno type="pmc">4172036</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172036</idno><idno type="RBID">PMC:4172036</idno><idno type="doi">10.1093/gerona/glt287</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults</title><author><name sortKey="Tian, Qu" sort="Tian, Qu" uniqKey="Tian Q" first="Qu" last="Tian">Qu Tian</name><affiliation><nlm:aff wicri:cut=" and" id="AF0001"><institution>Department of Epidemiology, Graduate School of Public Health</institution></nlm:aff></affiliation></author><author><name sortKey="Erickson, Kirk I" sort="Erickson, Kirk I" uniqKey="Erickson K" first="Kirk I." last="Erickson">Kirk I. Erickson</name><affiliation><nlm:aff id="AF0002"><institution>Department of Psychology, University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name><affiliation><nlm:aff id="AF0003"><institution>Translational Gerontology Branch, Intramural Research Program, National Institute on Aging</institution>,<addr-line>Baltimore, Maryland</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J." last="Aizenstein">Howard J. Aizenstein</name><affiliation><nlm:aff id="AF0004"><institution>Department of Psychiatry, University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Glynn, Nancy W" sort="Glynn, Nancy W" uniqKey="Glynn N" first="Nancy W." last="Glynn">Nancy W. Glynn</name><affiliation><nlm:aff id="AF0005"><institution>Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine</institution>,<addr-line>Winston Salem, North Carolina</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name><affiliation><nlm:aff id="AF0006"><institution>Department of Psychiatry, Neurology and Epidemiology, University of California</institution>,<addr-line>San Francisco</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><affiliation><nlm:aff wicri:cut=" and" id="AF0001"><institution>Department of Epidemiology, Graduate School of Public Health</institution></nlm:aff></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation><nlm:aff id="AF0005"><institution>Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine</institution>,<addr-line>Winston Salem, North Carolina</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name><affiliation><nlm:aff id="AF0006"><institution>Department of Psychiatry, Neurology and Epidemiology, University of California</institution>,<addr-line>San Francisco</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="AF0007"><institution>Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging</institution>,<addr-line>Bethesda, Maryland</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name><affiliation><nlm:aff wicri:cut=" and" id="AF0001"><institution>Department of Epidemiology, Graduate School of Public Health</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</title><idno type="ISSN">1079-5006</idno><idno type="eISSN">1758-535X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background.</title><p>Although the beneficial effects of physical activity (PA) on memory and executive function are well established in older adults, little is known about the relationship between PA and brain microstructure and the contributions of physical functional limitations and chronic diseases. This study examined whether higher PA would be longitudinally associated with greater microstructural integrity in memory- and executive function-related networks and whether these associations would be independent of physical function and chronic diseases.</p></sec><sec><title>Methods.</title><p>Diffusion tensor imaging was obtained in 2006–2008 in 276 participants (mean age = 83.0 years, 58.7% female, 41.3% black) with PA (sedentary, lifestyle active, and exercise active) measured in 1997–1998. Gait speed, cognition, depressive symptoms, cardiovascular and pulmonary diseases, hypertension, stroke, and diabetes were measured at both time points. Mean diffusivity and fractional anisotropy were computed from normal-appearing gray and white matter in frontoparietal and subcortical networks. Moderating effects of physical function and chronic diseases were tested using hierarchical regression models.</p></sec><sec><title>Results.</title><p>Compared with the sedentary, the exercise active group had lower mean diffusivity in the medial temporal lobe and the cingulate cortex (β, <italic>p</italic> values: −.405, .023 and −.497, .006, respectively), independent of age, sex, and race. Associations remained independent of other variables, although they were attenuated after adjustment for diabetes. Associations between PA and other neuroimaging markers were not significant.</p></sec><sec><title>Conclusions.</title><p>Being exercise active predicts greater memory-related microstructural integrity in older adults. Future studies in older adults with diabetes are warranted to examine the neuroprotective effect of PA in these networks.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Gerontol A Biol Sci Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">J. Gerontol. A Biol. Sci. Med. Sci</journal-id><journal-id journal-id-type="hwp">gerona</journal-id><journal-id journal-id-type="publisher-id">gerona</journal-id><journal-title-group><journal-title>The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</journal-title></journal-title-group><issn pub-type="ppub">1079-5006</issn><issn pub-type="epub">1758-535X</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24474004</article-id><article-id pub-id-type="pmc">4172036</article-id><article-id pub-id-type="doi">10.1093/gerona/glt287</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Tian</surname><given-names>Qu</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Erickson</surname><given-names>Kirk I.</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Simonsick</surname><given-names>Eleanor M.</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Aizenstein</surname><given-names>Howard J.</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Glynn</surname><given-names>Nancy W.</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boudreau</surname><given-names>Robert M.</given-names></name><xref ref-type="aff" rid="AF0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Newman</surname><given-names>Anne B.</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kritchevsky</surname><given-names>Stephen B.</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yaffe</surname><given-names>Kristine</given-names></name><xref ref-type="aff" rid="AF0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Tamara B.</given-names></name><xref ref-type="aff" rid="AF0007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rosano</surname><given-names>Caterina</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><aff id="AF0001"><sup>1</sup><institution>Department of Epidemiology, Graduate School of Public Health</institution> and</aff><aff id="AF0002"><sup>2</sup><institution>Department of Psychology, University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>.</aff><aff id="AF0003"><sup>3</sup><institution>Translational Gerontology Branch, Intramural Research Program, National Institute on Aging</institution>,<addr-line>Baltimore, Maryland</addr-line>.</aff><aff id="AF0004"><sup>4</sup><institution>Department of Psychiatry, University of Pittsburgh</institution>,<addr-line>Pennsylvania</addr-line>.</aff><aff id="AF0005"><sup>5</sup><institution>Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine</institution>,<addr-line>Winston Salem, North Carolina</addr-line>.</aff><aff id="AF0006"><sup>6</sup><institution>Department of Psychiatry, Neurology and Epidemiology, University of California</institution>,<addr-line>San Francisco</addr-line>.</aff><aff id="AF0007"><sup>7</sup><institution>Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging</institution>,<addr-line>Bethesda, Maryland</addr-line>.</aff></contrib-group><author-notes><corresp id="c1">Address correspondence to Qu Tian, PhD, MS, Department of Epidemiology, Graduate School of Public Health, 251 Bayview Boulevard, Suite 100, Rm 04B316, Baltimore, MD 21224. Email: <email>qu.tian@nih.gov</email></corresp><fn fn-type="other"><p><italic>Decision Editor: James Goodwin, PhD</italic></p></fn></author-notes><pub-date pub-type="ppub"><month>10</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>1</month><year>2014</year></pub-date><volume>69</volume><issue>10</issue><fpage>1284</fpage><lpage>1290</lpage><history><date date-type="received"><day>25</day><month>5</month><year>2013</year></date><date date-type="accepted"><day>17</day><month>12</month><year>2013</year></date></history><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><sec><title>Background.</title><p>Although the beneficial effects of physical activity (PA) on memory and executive function are well established in older adults, little is known about the relationship between PA and brain microstructure and the contributions of physical functional limitations and chronic diseases. This study examined whether higher PA would be longitudinally associated with greater microstructural integrity in memory- and executive function-related networks and whether these associations would be independent of physical function and chronic diseases.</p></sec><sec><title>Methods.</title><p>Diffusion tensor imaging was obtained in 2006–2008 in 276 participants (mean age = 83.0 years, 58.7% female, 41.3% black) with PA (sedentary, lifestyle active, and exercise active) measured in 1997–1998. Gait speed, cognition, depressive symptoms, cardiovascular and pulmonary diseases, hypertension, stroke, and diabetes were measured at both time points. Mean diffusivity and fractional anisotropy were computed from normal-appearing gray and white matter in frontoparietal and subcortical networks. Moderating effects of physical function and chronic diseases were tested using hierarchical regression models.</p></sec><sec><title>Results.</title><p>Compared with the sedentary, the exercise active group had lower mean diffusivity in the medial temporal lobe and the cingulate cortex (β, <italic>p</italic> values: −.405, .023 and −.497, .006, respectively), independent of age, sex, and race. Associations remained independent of other variables, although they were attenuated after adjustment for diabetes. Associations between PA and other neuroimaging markers were not significant.</p></sec><sec><title>Conclusions.</title><p>Being exercise active predicts greater memory-related microstructural integrity in older adults. Future studies in older adults with diabetes are warranted to examine the neuroprotective effect of PA in these networks.</p></sec></abstract><kwd-group><title>Key Words:</title><kwd>Brain aging</kwd><kwd>Physical activity</kwd><kwd>Neuroimaging</kwd><kwd>Epidemiology.</kwd></kwd-group><counts><page-count count="7"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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