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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lupus Nephritis Susceptibility Loci in Women with Systemic Lupus Erythematosus</title><author><name sortKey="Chung, Sharon A" sort="Chung, Sharon A" uniqKey="Chung S" first="Sharon A." last="Chung">Sharon A. Chung</name><affiliation><nlm:aff id="aff1">Division of Rheumatology, Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, University of California, San Francisco, California;</nlm:aff></affiliation></author><author><name sortKey="Brown, Elizabeth E" sort="Brown, Elizabeth E" uniqKey="Brown E" first="Elizabeth E." last="Brown">Elizabeth E. Brown</name><affiliation><nlm:aff id="aff2">Department of Epidemiology, University of Alabama, Birmingham, Alabama;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, Alabama;</nlm:aff></affiliation></author><author><name sortKey="Williams, Adrienne H" sort="Williams, Adrienne H" uniqKey="Williams A" first="Adrienne H." last="Williams">Adrienne H. Williams</name><affiliation><nlm:aff id="aff4">Department of Biostatistical Sciences, Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Ramos, Paula S" sort="Ramos, Paula S" uniqKey="Ramos P" first="Paula S." last="Ramos">Paula S. Ramos</name><affiliation><nlm:aff id="aff5">Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina;</nlm:aff></affiliation></author><author><name sortKey="Berthier, Celine C" sort="Berthier, Celine C" uniqKey="Berthier C" first="Celine C." last="Berthier">Celine C. Berthier</name><affiliation><nlm:aff id="aff6">Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan;</nlm:aff></affiliation></author><author><name sortKey="Bhangale, Tushar" sort="Bhangale, Tushar" uniqKey="Bhangale T" first="Tushar" last="Bhangale">Tushar Bhangale</name><affiliation><nlm:aff wicri:cut=", and" id="aff23">Department of Bioinformatics and Computational Biology</nlm:aff></affiliation></author><author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E." last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">Human DNA Variability Area, Pfizer–University of Granada–Andalusian Government Centre for Genomics and Oncological Research, Granada, Spain;</nlm:aff></affiliation></author><author><name sortKey="Behrens, Timothy W" sort="Behrens, Timothy W" uniqKey="Behrens T" first="Timothy W." last="Behrens">Timothy W. Behrens</name><affiliation><nlm:aff id="aff9">Immunology Tissue Growth and Repair Human Genetics Group, Genentech Inc., South San Francisco, California;</nlm:aff></affiliation></author><author><name sortKey="Criswell, Lindsey A" sort="Criswell, Lindsey A" uniqKey="Criswell L" first="Lindsey A." last="Criswell">Lindsey A. Criswell</name><affiliation><nlm:aff id="aff1">Division of Rheumatology, Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, University of California, San Francisco, California;</nlm:aff></affiliation></author><author><name sortKey="Graham, Deborah Cunninghame" sort="Graham, Deborah Cunninghame" uniqKey="Graham D" first="Deborah Cunninghame" last="Graham">Deborah Cunninghame Graham</name><affiliation><nlm:aff id="aff10">Divisions of Genetics and Molecular Medicine and Immunology, Infection, and Inflammatory Disease, Kings College, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Demirci, F Yesim" sort="Demirci, F Yesim" uniqKey="Demirci F" first="F. Yesim" last="Demirci">F. Yesim Demirci</name><affiliation><nlm:aff id="aff11">Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Edberg, Jeffrey C" sort="Edberg, Jeffrey C" uniqKey="Edberg J" first="Jeffrey C." last="Edberg">Jeffrey C. Edberg</name><affiliation><nlm:aff id="aff3">Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, Alabama;</nlm:aff></affiliation></author><author><name sortKey="Gaffney, Patrick M" sort="Gaffney, Patrick M" uniqKey="Gaffney P" first="Patrick M." last="Gaffney">Patrick M. Gaffney</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation></author><author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B." last="Harley">John B. Harley</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation><affiliation><nlm:aff id="aff12">Division of Rheumatology, Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio;</nlm:aff></affiliation><affiliation><nlm:aff id="aff13">University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma;</nlm:aff></affiliation></author><author><name sortKey="Jacob, Chaim O" sort="Jacob, Chaim O" uniqKey="Jacob C" first="Chaim O." last="Jacob">Chaim O. Jacob</name><affiliation><nlm:aff id="aff15">Department of Medicine, University of Southern California, Los Angeles, California;</nlm:aff></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><affiliation><nlm:aff id="aff11">Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A." last="Kelly">Jennifer A. Kelly</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation></author><author><name sortKey="Manzi, Susan" sort="Manzi, Susan" uniqKey="Manzi S" first="Susan" last="Manzi">Susan Manzi</name><affiliation><nlm:aff id="aff16">Department of Medicine, West Penn Allegheny Health System, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff17">Temple University School of Medicine, Philadelphia, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Moser Sivils, Kathy L" sort="Moser Sivils, Kathy L" uniqKey="Moser Sivils K" first="Kathy L." last="Moser-Sivils">Kathy L. Moser-Sivils</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation><affiliation><nlm:aff id="aff18">College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;</nlm:aff></affiliation></author><author><name sortKey="Russell, Laurie P" sort="Russell, Laurie P" uniqKey="Russell L" first="Laurie P." last="Russell">Laurie P. Russell</name><affiliation><nlm:aff id="aff4">Department of Biostatistical Sciences, Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Petri, Michelle" sort="Petri, Michelle" uniqKey="Petri M" first="Michelle" last="Petri">Michelle Petri</name><affiliation><nlm:aff id="aff19">Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Tsao, Betty P" sort="Tsao, Betty P" uniqKey="Tsao B" first="Betty P." last="Tsao">Betty P. Tsao</name><affiliation><nlm:aff id="aff20">Division of Rheumatology, Department of Medicine, University of California, Los Angeles, California;</nlm:aff></affiliation></author><author><name sortKey="Vyse, Tim J" sort="Vyse, Tim J" uniqKey="Vyse T" first="Tim J." last="Vyse">Tim J. Vyse</name><affiliation><nlm:aff id="aff10">Divisions of Genetics and Molecular Medicine and Immunology, Infection, and Inflammatory Disease, Kings College, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Zidovetzki, Raphael" sort="Zidovetzki, Raphael" uniqKey="Zidovetzki R" first="Raphael" last="Zidovetzki">Raphael Zidovetzki</name><affiliation><nlm:aff wicri:cut="; and" id="aff21">Department of Cell Biology and Neuroscience, University of California, Riverside, California</nlm:aff></affiliation></author><author><name sortKey="Kretzler, Matthias" sort="Kretzler, Matthias" uniqKey="Kretzler M" first="Matthias" last="Kretzler">Matthias Kretzler</name><affiliation><nlm:aff id="aff6">Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan;</nlm:aff></affiliation></author><author><name sortKey="Kimberly, Robert P" sort="Kimberly, Robert P" uniqKey="Kimberly R" first="Robert P." last="Kimberly">Robert P. Kimberly</name><affiliation><nlm:aff id="aff3">Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, Alabama;</nlm:aff></affiliation></author><author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><affiliation><nlm:aff id="aff22">Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Graham, Robert R" sort="Graham, Robert R" uniqKey="Graham R" first="Robert R." last="Graham">Robert R. Graham</name><affiliation><nlm:aff id="aff9">Immunology Tissue Growth and Repair Human Genetics Group, Genentech Inc., South San Francisco, California;</nlm:aff></affiliation></author><author><name sortKey="Langefeld, Carl D" sort="Langefeld, Carl D" uniqKey="Langefeld C" first="Carl D." last="Langefeld">Carl D. Langefeld</name><affiliation><nlm:aff id="aff4">Department of Biostatistical Sciences, Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24925725</idno><idno type="pmc">4243339</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243339</idno><idno type="RBID">PMC:4243339</idno><idno type="doi">10.1681/ASN.2013050446</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000983</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000983</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lupus Nephritis Susceptibility Loci in Women with Systemic Lupus Erythematosus</title><author><name sortKey="Chung, Sharon A" sort="Chung, Sharon A" uniqKey="Chung S" first="Sharon A." last="Chung">Sharon A. Chung</name><affiliation><nlm:aff id="aff1">Division of Rheumatology, Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, University of California, San Francisco, California;</nlm:aff></affiliation></author><author><name sortKey="Brown, Elizabeth E" sort="Brown, Elizabeth E" uniqKey="Brown E" first="Elizabeth E." last="Brown">Elizabeth E. Brown</name><affiliation><nlm:aff id="aff2">Department of Epidemiology, University of Alabama, Birmingham, Alabama;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, Alabama;</nlm:aff></affiliation></author><author><name sortKey="Williams, Adrienne H" sort="Williams, Adrienne H" uniqKey="Williams A" first="Adrienne H." last="Williams">Adrienne H. Williams</name><affiliation><nlm:aff id="aff4">Department of Biostatistical Sciences, Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Ramos, Paula S" sort="Ramos, Paula S" uniqKey="Ramos P" first="Paula S." last="Ramos">Paula S. Ramos</name><affiliation><nlm:aff id="aff5">Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina;</nlm:aff></affiliation></author><author><name sortKey="Berthier, Celine C" sort="Berthier, Celine C" uniqKey="Berthier C" first="Celine C." last="Berthier">Celine C. Berthier</name><affiliation><nlm:aff id="aff6">Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan;</nlm:aff></affiliation></author><author><name sortKey="Bhangale, Tushar" sort="Bhangale, Tushar" uniqKey="Bhangale T" first="Tushar" last="Bhangale">Tushar Bhangale</name><affiliation><nlm:aff wicri:cut=", and" id="aff23">Department of Bioinformatics and Computational Biology</nlm:aff></affiliation></author><author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E." last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">Human DNA Variability Area, Pfizer–University of Granada–Andalusian Government Centre for Genomics and Oncological Research, Granada, Spain;</nlm:aff></affiliation></author><author><name sortKey="Behrens, Timothy W" sort="Behrens, Timothy W" uniqKey="Behrens T" first="Timothy W." last="Behrens">Timothy W. Behrens</name><affiliation><nlm:aff id="aff9">Immunology Tissue Growth and Repair Human Genetics Group, Genentech Inc., South San Francisco, California;</nlm:aff></affiliation></author><author><name sortKey="Criswell, Lindsey A" sort="Criswell, Lindsey A" uniqKey="Criswell L" first="Lindsey A." last="Criswell">Lindsey A. Criswell</name><affiliation><nlm:aff id="aff1">Division of Rheumatology, Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, University of California, San Francisco, California;</nlm:aff></affiliation></author><author><name sortKey="Graham, Deborah Cunninghame" sort="Graham, Deborah Cunninghame" uniqKey="Graham D" first="Deborah Cunninghame" last="Graham">Deborah Cunninghame Graham</name><affiliation><nlm:aff id="aff10">Divisions of Genetics and Molecular Medicine and Immunology, Infection, and Inflammatory Disease, Kings College, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Demirci, F Yesim" sort="Demirci, F Yesim" uniqKey="Demirci F" first="F. Yesim" last="Demirci">F. Yesim Demirci</name><affiliation><nlm:aff id="aff11">Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Edberg, Jeffrey C" sort="Edberg, Jeffrey C" uniqKey="Edberg J" first="Jeffrey C." last="Edberg">Jeffrey C. Edberg</name><affiliation><nlm:aff id="aff3">Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, Alabama;</nlm:aff></affiliation></author><author><name sortKey="Gaffney, Patrick M" sort="Gaffney, Patrick M" uniqKey="Gaffney P" first="Patrick M." last="Gaffney">Patrick M. Gaffney</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation></author><author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B." last="Harley">John B. Harley</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation><affiliation><nlm:aff id="aff12">Division of Rheumatology, Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio;</nlm:aff></affiliation><affiliation><nlm:aff id="aff13">University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma;</nlm:aff></affiliation></author><author><name sortKey="Jacob, Chaim O" sort="Jacob, Chaim O" uniqKey="Jacob C" first="Chaim O." last="Jacob">Chaim O. Jacob</name><affiliation><nlm:aff id="aff15">Department of Medicine, University of Southern California, Los Angeles, California;</nlm:aff></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><affiliation><nlm:aff id="aff11">Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A." last="Kelly">Jennifer A. Kelly</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation></author><author><name sortKey="Manzi, Susan" sort="Manzi, Susan" uniqKey="Manzi S" first="Susan" last="Manzi">Susan Manzi</name><affiliation><nlm:aff id="aff16">Department of Medicine, West Penn Allegheny Health System, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff17">Temple University School of Medicine, Philadelphia, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Moser Sivils, Kathy L" sort="Moser Sivils, Kathy L" uniqKey="Moser Sivils K" first="Kathy L." last="Moser-Sivils">Kathy L. Moser-Sivils</name><affiliation><nlm:aff id="aff7">Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</nlm:aff></affiliation><affiliation><nlm:aff id="aff18">College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;</nlm:aff></affiliation></author><author><name sortKey="Russell, Laurie P" sort="Russell, Laurie P" uniqKey="Russell L" first="Laurie P." last="Russell">Laurie P. Russell</name><affiliation><nlm:aff id="aff4">Department of Biostatistical Sciences, Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Petri, Michelle" sort="Petri, Michelle" uniqKey="Petri M" first="Michelle" last="Petri">Michelle Petri</name><affiliation><nlm:aff id="aff19">Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Tsao, Betty P" sort="Tsao, Betty P" uniqKey="Tsao B" first="Betty P." last="Tsao">Betty P. Tsao</name><affiliation><nlm:aff id="aff20">Division of Rheumatology, Department of Medicine, University of California, Los Angeles, California;</nlm:aff></affiliation></author><author><name sortKey="Vyse, Tim J" sort="Vyse, Tim J" uniqKey="Vyse T" first="Tim J." last="Vyse">Tim J. Vyse</name><affiliation><nlm:aff id="aff10">Divisions of Genetics and Molecular Medicine and Immunology, Infection, and Inflammatory Disease, Kings College, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Zidovetzki, Raphael" sort="Zidovetzki, Raphael" uniqKey="Zidovetzki R" first="Raphael" last="Zidovetzki">Raphael Zidovetzki</name><affiliation><nlm:aff wicri:cut="; and" id="aff21">Department of Cell Biology and Neuroscience, University of California, Riverside, California</nlm:aff></affiliation></author><author><name sortKey="Kretzler, Matthias" sort="Kretzler, Matthias" uniqKey="Kretzler M" first="Matthias" last="Kretzler">Matthias Kretzler</name><affiliation><nlm:aff id="aff6">Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan;</nlm:aff></affiliation></author><author><name sortKey="Kimberly, Robert P" sort="Kimberly, Robert P" uniqKey="Kimberly R" first="Robert P." last="Kimberly">Robert P. Kimberly</name><affiliation><nlm:aff id="aff3">Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, Alabama;</nlm:aff></affiliation></author><author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><affiliation><nlm:aff id="aff22">Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Graham, Robert R" sort="Graham, Robert R" uniqKey="Graham R" first="Robert R." last="Graham">Robert R. Graham</name><affiliation><nlm:aff id="aff9">Immunology Tissue Growth and Repair Human Genetics Group, Genentech Inc., South San Francisco, California;</nlm:aff></affiliation></author><author><name sortKey="Langefeld, Carl D" sort="Langefeld, Carl D" uniqKey="Langefeld C" first="Carl D." last="Langefeld">Carl D. Langefeld</name><affiliation><nlm:aff id="aff4">Department of Biostatistical Sciences, Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the American Society of Nephrology : JASN</title><idno type="ISSN">1046-6673</idno><idno type="eISSN">1533-3450</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. Lupus nephritis demonstrates familial aggregation and accounts for significant morbidity and mortality. We completed a meta-analysis of three genome-wide association studies of SLE to identify lupus nephritis–predisposing loci. Through genotyping and imputation, >1.6 million markers were assessed in 2000 unrelated women of European descent with SLE (588 patients with lupus nephritis and 1412 patients with lupus without nephritis). Tests of association were computed using logistic regression adjusting for population substructure. The strongest evidence for association was observed outside the MHC and included markers localized to 4q11-q13 (<italic>PDGFRA, GSX2</italic>; <italic>P</italic>=4.5×10<sup>−7</sup>), 16p12 (<italic>SLC5A11</italic>; <italic>P</italic>=5.1×10<sup>−7</sup>), 6p22 (<italic>ID4</italic>; <italic>P</italic>=7.4×10<sup>−7</sup>), and 8q24.12 (<italic>HAS2, SNTB1</italic>; <italic>P</italic>=1.1×10<sup>−6</sup>). Both <italic>HLA-DR2</italic> and <italic>HLA-DR3</italic>, two well established lupus susceptibility loci, showed evidence of association with lupus nephritis (<italic>P</italic>=0.06 and <italic>P</italic>=3.7×10<sup>−5</sup>, respectively). Within the class I region, rs9263871 (<italic>C6orf15-HCG22</italic>) had the strongest evidence of association with lupus nephritis independent of <italic>HLA-DR2</italic> and <italic>HLA-DR3</italic> (<italic>P</italic>=8.5×10<sup>−6</sup>). Consistent with a functional role in lupus nephritis, intra-renal mRNA levels of <italic>PDGFRA</italic> and associated pathway members showed significant enrichment in patients with lupus nephritis (<italic>n</italic>=32) compared with controls (<italic>n</italic>=15). Results from this large-scale genome-wide investigation of lupus nephritis provide evidence of multiple biologically relevant lupus nephritis susceptibility loci.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Am Soc Nephrol</journal-id><journal-id journal-id-type="iso-abbrev">J. Am. Soc. Nephrol</journal-id><journal-id journal-id-type="hwp">jnephrol</journal-id><journal-id journal-id-type="pmc">jnephrol</journal-id><journal-id journal-id-type="publisher-id">ASN</journal-id><journal-title-group><journal-title>Journal of the American Society of Nephrology : JASN</journal-title></journal-title-group><issn pub-type="ppub">1046-6673</issn><issn pub-type="epub">1533-3450</issn><publisher><publisher-name>American Society of Nephrology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24925725</article-id><article-id pub-id-type="pmc">4243339</article-id><article-id pub-id-type="publisher-id">2013050446</article-id><article-id pub-id-type="doi">10.1681/ASN.2013050446</article-id><article-categories><subj-group subj-group-type="heading"><subject>Basic Research</subject></subj-group></article-categories><title-group><article-title>Lupus Nephritis Susceptibility Loci in Women with Systemic Lupus Erythematosus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chung</surname><given-names>Sharon A.</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Elizabeth E.</given-names></name><xref ref-type="aff" rid="aff2"><sup>†</sup></xref><xref ref-type="aff" rid="aff3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>Adrienne H.</given-names></name><xref ref-type="aff" rid="aff4"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ramos</surname><given-names>Paula S.</given-names></name><xref ref-type="aff" rid="aff5"><sup>‖</sup></xref></contrib><contrib contrib-type="author"><name><surname>Berthier</surname><given-names>Celine C.</given-names></name><xref ref-type="aff" rid="aff6"><sup>¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bhangale</surname><given-names>Tushar</given-names></name><xref ref-type="aff" rid="aff23">**</xref></contrib><contrib contrib-type="author"><name><surname>Alarcon-Riquelme</surname><given-names>Marta E.</given-names></name><xref ref-type="aff" rid="aff7"><sup>††</sup></xref><xref ref-type="aff" rid="aff8"><sup>‡‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Behrens</surname><given-names>Timothy W.</given-names></name><xref ref-type="aff" rid="aff9"><sup>§§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Criswell</surname><given-names>Lindsey A.</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Graham</surname><given-names>Deborah Cunninghame</given-names></name><xref ref-type="aff" rid="aff10"><sup>‖‖</sup></xref></contrib><contrib contrib-type="author"><name><surname>Demirci</surname><given-names>F. Yesim</given-names></name><xref ref-type="aff" rid="aff11"><sup>¶¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Edberg</surname><given-names>Jeffrey C.</given-names></name><xref ref-type="aff" rid="aff3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gaffney</surname><given-names>Patrick M.</given-names></name><xref ref-type="aff" rid="aff7"><sup>††</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harley</surname><given-names>John B.</given-names></name><xref ref-type="aff" rid="aff7"><sup>††</sup></xref><xref ref-type="aff" rid="aff12">***</xref><xref ref-type="aff" rid="aff13"><sup>†††</sup></xref><xref ref-type="aff" rid="aff14"><sup>‡‡‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jacob</surname><given-names>Chaim O.</given-names></name><xref ref-type="aff" rid="aff15"><sup>§§§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kamboh</surname><given-names>M. Ilyas</given-names></name><xref ref-type="aff" rid="aff11"><sup>¶¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kelly</surname><given-names>Jennifer A.</given-names></name><xref ref-type="aff" rid="aff7"><sup>††</sup></xref></contrib><contrib contrib-type="author"><name><surname>Manzi</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="aff16"><sup>‖‖‖</sup></xref><xref ref-type="aff" rid="aff17"><sup>¶¶¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Moser-Sivils</surname><given-names>Kathy L.</given-names></name><xref ref-type="aff" rid="aff7"><sup>††</sup></xref><xref ref-type="aff" rid="aff18">****</xref></contrib><contrib contrib-type="author"><name><surname>Russell</surname><given-names>Laurie P.</given-names></name><xref ref-type="aff" rid="aff4"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Petri</surname><given-names>Michelle</given-names></name><xref ref-type="aff" rid="aff19"><sup>††††</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tsao</surname><given-names>Betty P.</given-names></name><xref ref-type="aff" rid="aff20"><sup>‡‡‡‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vyse</surname><given-names>Tim J.</given-names></name><xref ref-type="aff" rid="aff10"><sup>‖‖</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zidovetzki</surname><given-names>Raphael</given-names></name><xref ref-type="aff" rid="aff21"><sup>§§§§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kretzler</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="aff6"><sup>¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kimberly</surname><given-names>Robert P.</given-names></name><xref ref-type="aff" rid="aff3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Freedman</surname><given-names>Barry I.</given-names></name><xref ref-type="aff" rid="aff22"><sup>‖‖‖‖</sup></xref></contrib><contrib contrib-type="author"><name><surname>Graham</surname><given-names>Robert R.</given-names></name><xref ref-type="aff" rid="aff9"><sup>§§</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Langefeld</surname><given-names>Carl D.</given-names></name><xref ref-type="aff" rid="aff4"><sup>§</sup></xref></contrib><on-behalf-of>for the International Consortium for Systemic Lupus Erythematosus Genetics</on-behalf-of><aff id="aff1"><label>*</label>Division of Rheumatology, Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, University of California, San Francisco, California;</aff><aff id="aff2"><label>†</label>Department of Epidemiology, University of Alabama, Birmingham, Alabama;</aff><aff id="aff3"><label>‡</label>Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, Alabama;</aff><aff id="aff4"><label>§</label>Department of Biostatistical Sciences, Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina;</aff><aff id="aff5"><label>‖</label>Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina;</aff><aff id="aff6"><label>¶</label>Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan;</aff><aff id="aff7"><label>††</label>Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;</aff><aff id="aff8"><label>‡‡</label>Human DNA Variability Area, Pfizer–University of Granada–Andalusian Government Centre for Genomics and Oncological Research, Granada, Spain;</aff><aff id="aff23"><label>**</label>Department of Bioinformatics and Computational Biology, and</aff><aff id="aff9"><label>§§</label>Immunology Tissue Growth and Repair Human Genetics Group, Genentech Inc., South San Francisco, California;</aff><aff id="aff10"><label>‖‖</label>Divisions of Genetics and Molecular Medicine and Immunology, Infection, and Inflammatory Disease, Kings College, London, United Kingdom;</aff><aff id="aff11"><label>¶¶</label>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania;</aff><aff id="aff12"><label>***</label>Division of Rheumatology, Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio;</aff><aff id="aff13"><label>†††</label>University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;</aff><aff id="aff14"><label>‡‡‡</label>US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma;</aff><aff id="aff15"><label>§§§</label>Department of Medicine, University of Southern California, Los Angeles, California;</aff><aff id="aff16"><label>‖‖‖</label>Department of Medicine, West Penn Allegheny Health System, University of Pittsburgh, Pittsburgh, Pennsylvania;</aff><aff id="aff17"><label>¶¶¶</label>Temple University School of Medicine, Philadelphia, Pennsylvania;</aff><aff id="aff18"><label>****</label>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;</aff><aff id="aff19"><label>††††</label>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;</aff><aff id="aff20"><label>‡‡‡‡</label>Division of Rheumatology, Department of Medicine, University of California, Los Angeles, California;</aff><aff id="aff21"><label>§§§§</label>Department of Cell Biology and Neuroscience, University of California, Riverside, California; and</aff><aff id="aff22"><label>‖‖‖‖</label>Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina</aff></contrib-group><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Dr. Carl D. Langefeld, <addr-line>Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157</addr-line>. Email: <email>clangefe@wakehealth.edu</email></corresp><fn id="fn1" fn-type="other"><p>S.A.C. and E.E.B. are co-first authors.</p></fn></author-notes><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>6</month><year>2014</year></pub-date><volume>25</volume><issue>12</issue><fpage>2859</fpage><lpage>2870</lpage><history><date date-type="received"><day>2</day><month>5</month><year>2013</year></date><date date-type="accepted"><day>14</day><month>3</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 by the American Society of Nephrology</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="ASN.2013050446.pdf"></self-uri><abstract><p>Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. Lupus nephritis demonstrates familial aggregation and accounts for significant morbidity and mortality. We completed a meta-analysis of three genome-wide association studies of SLE to identify lupus nephritis–predisposing loci. Through genotyping and imputation, >1.6 million markers were assessed in 2000 unrelated women of European descent with SLE (588 patients with lupus nephritis and 1412 patients with lupus without nephritis). Tests of association were computed using logistic regression adjusting for population substructure. The strongest evidence for association was observed outside the MHC and included markers localized to 4q11-q13 (<italic>PDGFRA, GSX2</italic>; <italic>P</italic>=4.5×10<sup>−7</sup>), 16p12 (<italic>SLC5A11</italic>; <italic>P</italic>=5.1×10<sup>−7</sup>), 6p22 (<italic>ID4</italic>; <italic>P</italic>=7.4×10<sup>−7</sup>), and 8q24.12 (<italic>HAS2, SNTB1</italic>; <italic>P</italic>=1.1×10<sup>−6</sup>). Both <italic>HLA-DR2</italic> and <italic>HLA-DR3</italic>, two well established lupus susceptibility loci, showed evidence of association with lupus nephritis (<italic>P</italic>=0.06 and <italic>P</italic>=3.7×10<sup>−5</sup>, respectively). Within the class I region, rs9263871 (<italic>C6orf15-HCG22</italic>) had the strongest evidence of association with lupus nephritis independent of <italic>HLA-DR2</italic> and <italic>HLA-DR3</italic> (<italic>P</italic>=8.5×10<sup>−6</sup>). Consistent with a functional role in lupus nephritis, intra-renal mRNA levels of <italic>PDGFRA</italic> and associated pathway members showed significant enrichment in patients with lupus nephritis (<italic>n</italic>=32) compared with controls (<italic>n</italic>=15). Results from this large-scale genome-wide investigation of lupus nephritis provide evidence of multiple biologically relevant lupus nephritis susceptibility loci.</p></abstract><kwd-group><kwd>lupus nephritis</kwd><kwd>genetic renal disease</kwd><kwd>epidemiology</kwd><kwd>outcomes</kwd><kwd>SLE</kwd></kwd-group><counts><page-count count="12"></page-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>December 2014</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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