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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews</title><author><name sortKey="Horn, Charles C" sort="Horn, Charles C" uniqKey="Horn C" first="Charles C." last="Horn">Charles C. Horn</name><affiliation><nlm:aff id="aff1">Biobehavioral Medicine in Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Meyers, Kelly" sort="Meyers, Kelly" uniqKey="Meyers K" first="Kelly" last="Meyers">Kelly Meyers</name><affiliation><nlm:aff id="aff1">Biobehavioral Medicine in Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Lim, Audrey" sort="Lim, Audrey" uniqKey="Lim A" first="Audrey" last="Lim">Audrey Lim</name><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Dye, Matthew" sort="Dye, Matthew" uniqKey="Dye M" first="Matthew" last="Dye">Matthew Dye</name><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Pak, Diana" sort="Pak, Diana" uniqKey="Pak D" first="Diana" last="Pak">Diana Pak</name><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Rinaman, Linda" sort="Rinaman, Linda" uniqKey="Rinaman L" first="Linda" last="Rinaman">Linda Rinaman</name><affiliation><nlm:aff id="aff4">Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Yates, Bill J" sort="Yates, Bill J" uniqKey="Yates B" first="Bill J." last="Yates">Bill J. Yates</name><affiliation><nlm:aff id="aff4">Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24430885</idno><idno type="pmc">3949074</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949074</idno><idno type="RBID">PMC:3949074</idno><idno type="doi">10.1152/ajpregu.00413.2013</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000832</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000832</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews</title><author><name sortKey="Horn, Charles C" sort="Horn, Charles C" uniqKey="Horn C" first="Charles C." last="Horn">Charles C. Horn</name><affiliation><nlm:aff id="aff1">Biobehavioral Medicine in Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Meyers, Kelly" sort="Meyers, Kelly" uniqKey="Meyers K" first="Kelly" last="Meyers">Kelly Meyers</name><affiliation><nlm:aff id="aff1">Biobehavioral Medicine in Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Lim, Audrey" sort="Lim, Audrey" uniqKey="Lim A" first="Audrey" last="Lim">Audrey Lim</name><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Dye, Matthew" sort="Dye, Matthew" uniqKey="Dye M" first="Matthew" last="Dye">Matthew Dye</name><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Pak, Diana" sort="Pak, Diana" uniqKey="Pak D" first="Diana" last="Pak">Diana Pak</name><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Rinaman, Linda" sort="Rinaman, Linda" uniqKey="Rinaman L" first="Linda" last="Rinaman">Linda Rinaman</name><affiliation><nlm:aff id="aff4">Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation></author><author><name sortKey="Yates, Bill J" sort="Yates, Bill J" uniqKey="Yates B" first="Bill J." last="Yates">Bill J. Yates</name><affiliation><nlm:aff id="aff4">Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Physiology - Regulatory, Integrative and Comparative Physiology</title><idno type="ISSN">0363-6119</idno><idno type="eISSN">1522-1490</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Signals from the vestibular system, area postrema, and forebrain elicit nausea and vomiting, but gastrointestinal (GI) vagal afferent input arguably plays the most prominent role in defense against food poisoning. It is difficult to determine the contribution of GI vagal afferent input on emesis because various agents (e.g., chemotherapy) often act on multiple sensory pathways. Intragastric copper sulfate (CuSO<sub>4</sub>) potentially provides a specific vagal emetic stimulus, but its actions are not well defined in musk shrews (<italic>Suncus murinus)</italic>, a primary small animal model used to study emesis. The aims of the current study were <italic>1</italic>) to investigate the effects of subdiaphragmatic vagotomy on CuSO<sub>4</sub>-induced emesis and <italic>2</italic>) to conduct preliminary transneuronal tracing of the GI-brain pathways in musk shrews. Vagotomy failed to inhibit the number of emetic episodes produced by optimal emetic doses of CuSO<sub>4</sub> (60 and 120 mg/kg ig), but the effects of lower doses were dependent on an intact vagus (20 and 40 mg/kg). Vagotomy also failed to affect emesis produced by motion (1 Hz, 10 min) or nicotine administration (5 mg/kg sc). Anterograde transport of the H129 strain of herpes simplex virus-1 from the ventral stomach wall identified the following brain regions as receiving inputs from vagal afferents: the nucleus of the solitary tract, area postrema, and lateral parabrachial nucleus. These data indicate that the contribution of vagal pathways to intragastric CuSO<sub>4</sub>-induced emesis is dose dependent in musk shrews. Furthermore, the current neural tracing data suggest brain stem anatomical circuits that are activated by GI signaling in the musk shrew.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Physiol Regul Integr Comp Physiol</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Physiol. Regul. Integr. Comp. Physiol</journal-id><journal-id journal-id-type="hwp">ajpregu</journal-id><journal-id journal-id-type="pmc">ajpregu</journal-id><journal-id journal-id-type="publisher-id">AJPREGU</journal-id><journal-title-group><journal-title>American Journal of Physiology - Regulatory, Integrative and Comparative Physiology</journal-title></journal-title-group><issn pub-type="ppub">0363-6119</issn><issn pub-type="epub">1522-1490</issn><publisher><publisher-name>American Physiological Society</publisher-name><publisher-loc>Bethesda, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24430885</article-id><article-id pub-id-type="pmc">3949074</article-id><article-id pub-id-type="publisher-id">R-00413-2013</article-id><article-id pub-id-type="doi">10.1152/ajpregu.00413.2013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neural Control</subject></subj-group><subj-group subj-group-type="heading"><subject>Obesity, Diabetes and Energy Homeostasis</subject></subj-group></article-categories><title-group><article-title>Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Horn</surname><given-names>Charles C.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Meyers</surname><given-names>Kelly</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Audrey</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dye</surname><given-names>Matthew</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pak</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rinaman</surname><given-names>Linda</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yates</surname><given-names>Bill J.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><aff id="aff1"><sup>1</sup>Biobehavioral Medicine in Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania;</aff><aff id="aff2"><sup>2</sup>Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;</aff><aff id="aff3"><sup>3</sup>Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;</aff><aff id="aff4"><sup>4</sup>Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</aff><aff id="aff5"><sup>5</sup>Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania;</aff><aff id="aff6"><sup>6</sup>Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</aff></contrib-group><author-notes><corresp id="cor1">Address for reprint requests and other correspondence: C. C. Horn, <addr-line>Univ. of Pittsburgh Cancer Institute, Hillman Cancer Center-Research Pavilion, G.17b, 5117 Centre Ave., Pittsburgh, PA 15213</addr-line> (<email>chorn@pitt.edu</email>).</corresp></author-notes><pub-date pub-type="epub"><day>15</day><month>1</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>3</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>306</volume><issue>5</issue><fpage>R341</fpage><lpage>R351</lpage><history><date date-type="received"><day>29</day><month>8</month><year>2013</year></date><date date-type="accepted"><day>30</day><month>12</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2014 the American Physiological Society</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>American Physiological Society</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh600514000341.pdf"></self-uri><abstract><p>Signals from the vestibular system, area postrema, and forebrain elicit nausea and vomiting, but gastrointestinal (GI) vagal afferent input arguably plays the most prominent role in defense against food poisoning. It is difficult to determine the contribution of GI vagal afferent input on emesis because various agents (e.g., chemotherapy) often act on multiple sensory pathways. Intragastric copper sulfate (CuSO<sub>4</sub>) potentially provides a specific vagal emetic stimulus, but its actions are not well defined in musk shrews (<italic>Suncus murinus)</italic>, a primary small animal model used to study emesis. The aims of the current study were <italic>1</italic>) to investigate the effects of subdiaphragmatic vagotomy on CuSO<sub>4</sub>-induced emesis and <italic>2</italic>) to conduct preliminary transneuronal tracing of the GI-brain pathways in musk shrews. Vagotomy failed to inhibit the number of emetic episodes produced by optimal emetic doses of CuSO<sub>4</sub> (60 and 120 mg/kg ig), but the effects of lower doses were dependent on an intact vagus (20 and 40 mg/kg). Vagotomy also failed to affect emesis produced by motion (1 Hz, 10 min) or nicotine administration (5 mg/kg sc). Anterograde transport of the H129 strain of herpes simplex virus-1 from the ventral stomach wall identified the following brain regions as receiving inputs from vagal afferents: the nucleus of the solitary tract, area postrema, and lateral parabrachial nucleus. These data indicate that the contribution of vagal pathways to intragastric CuSO<sub>4</sub>-induced emesis is dose dependent in musk shrews. Furthermore, the current neural tracing data suggest brain stem anatomical circuits that are activated by GI signaling in the musk shrew.</p></abstract><kwd-group><kwd>taste aversion</kwd><kwd>pica</kwd><kwd>vagus</kwd><kwd><italic>Suncus murinus</italic></kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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