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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nonesterified Fatty Acids and Spontaneous Preterm Birth: A Factor Analysis for Identification of Risk Patterns</title><author><name sortKey="Catov, Janet M" sort="Catov, Janet M" uniqKey="Catov J" first="Janet M." last="Catov">Janet M. Catov</name></author><author><name sortKey="Bertolet, Marnie" sort="Bertolet, Marnie" uniqKey="Bertolet M" first="Marnie" last="Bertolet">Marnie Bertolet</name></author><author><name sortKey="Chen, Yi Fan" sort="Chen, Yi Fan" uniqKey="Chen Y" first="Yi-Fan" last="Chen">Yi-Fan Chen</name></author><author><name sortKey="Evans, Rhobert W" sort="Evans, Rhobert W" uniqKey="Evans R" first="Rhobert W." last="Evans">Rhobert W. Evans</name></author><author><name sortKey="Hubel, Carl A" sort="Hubel, Carl A" uniqKey="Hubel C" first="Carl A." last="Hubel">Carl A. Hubel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24714724</idno><idno type="pmc">4010188</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010188</idno><idno type="RBID">PMC:4010188</idno><idno type="doi">10.1093/aje/kwu037</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000818</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000818</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nonesterified Fatty Acids and Spontaneous Preterm Birth: A Factor Analysis for Identification of Risk Patterns</title><author><name sortKey="Catov, Janet M" sort="Catov, Janet M" uniqKey="Catov J" first="Janet M." last="Catov">Janet M. Catov</name></author><author><name sortKey="Bertolet, Marnie" sort="Bertolet, Marnie" uniqKey="Bertolet M" first="Marnie" last="Bertolet">Marnie Bertolet</name></author><author><name sortKey="Chen, Yi Fan" sort="Chen, Yi Fan" uniqKey="Chen Y" first="Yi-Fan" last="Chen">Yi-Fan Chen</name></author><author><name sortKey="Evans, Rhobert W" sort="Evans, Rhobert W" uniqKey="Evans R" first="Rhobert W." last="Evans">Rhobert W. Evans</name></author><author><name sortKey="Hubel, Carl A" sort="Hubel, Carl A" uniqKey="Hubel C" first="Carl A." last="Hubel">Carl A. Hubel</name></author></analytic><series><title level="j">American Journal of Epidemiology</title><idno type="ISSN">0002-9262</idno><idno type="eISSN">1476-6256</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We considered that accumulation of nonesterified (free) fatty acids (NEFAs) in the first trimester of pregnancy would mark women at excess risk of spontaneous preterm birth (sPTB) and examined the interplay between NEFAs, lipids, and other markers to explore pathways to sPTB. In a case-control study nested in the Pregnancy Exposures and Preeclampsia Prevention Study (Pittsburgh, Pennsylvania, 1997–2001), we assayed NEFA levels in nonfasting serum collected at a mean gestational week of 9.4 (range, 4–20 weeks) in 115 women with sPTB (<37 weeks) and 222 women with births occurring at ≥37 weeks. C-reactive protein, total cholesterol, low-density lipoprotein and high-density lipoprotein (HDL) cholesterol, triglycerides, and uric acid were also measured. Polytomous logistic regression models were used to evaluate tertiles of NEFA levels and sPTB at <34 weeks and 34–36 weeks; factor analysis was used to characterize patterns of biomarkers. Women with NEFA levels in the highest tertile versus the lowest were 2.02 (95% confidence interval: 1.13, 3.48) times more likely to have sPTB, after adjustment for covariates. Risk of sPTB before 34 weeks was particularly high among women with high NEFA levels (odds ratio = 3.73, 95% confidence interval: 1.33, 10.44). Six biomarker patterns were identified, and 2 were associated with sPTB: 1) increasing NEFA and HDL cholesterol levels and 2) family history of gestational hypertension. NEFA levels early in pregnancy were independently associated with sPTB, particularly before 34 weeks. We also detected a novel risk pattern suggesting that NEFAs together with HDL cholesterol may be related to sPTB.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Epidemiol</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Epidemiol</journal-id><journal-id journal-id-type="publisher-id">aje</journal-id><journal-id journal-id-type="hwp">amjepid</journal-id><journal-title-group><journal-title>American Journal of Epidemiology</journal-title></journal-title-group><issn pub-type="ppub">0002-9262</issn><issn pub-type="epub">1476-6256</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24714724</article-id><article-id pub-id-type="pmc">4010188</article-id><article-id pub-id-type="doi">10.1093/aje/kwu037</article-id><article-id pub-id-type="publisher-id">kwu037</article-id><article-categories><subj-group subj-group-type="heading"><subject>ORIGINAL CONTRIBUTIONS</subject><subj-group subj-group-type="heading"><subject>Reproductive Health</subject></subj-group></subj-group></article-categories><title-group><article-title>Nonesterified Fatty Acids and Spontaneous Preterm Birth: A Factor Analysis for Identification of Risk Patterns</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Catov</surname><given-names>Janet M.</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Bertolet</surname><given-names>Marnie</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Yi-Fan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Evans</surname><given-names>Rhobert W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hubel</surname><given-names>Carl A.</given-names></name></contrib></contrib-group><author-notes><corresp id="cor1"><label>*</label>Correspondence to Dr. Janet M. Catov, Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, 300 Halket Street, Pittsburgh, PA 15213 (e-mail: <email>catovjm@upmc.edu</email>).</corresp><fn id="fn1"><p>Abbreviations: BMI, body mass index; CI, confidence interval; CRP, C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NEFAs, nonesterified (free) fatty acids; OR, odds ratio; sPTB, spontaneous preterm birth.</p></fn></author-notes><pub-date pub-type="ppub"><day>15</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>08</day><month>4</month><year>2014</year></pub-date><volume>179</volume><issue>10</issue><fpage>1208</fpage><lpage>1215</lpage><history><date date-type="received"><day>14</day><month>8</month><year>2013</year></date><date date-type="accepted"><day>12</day><month>2</month><year>2014</year></date></history><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="kwu037.pdf"></self-uri><abstract><p>We considered that accumulation of nonesterified (free) fatty acids (NEFAs) in the first trimester of pregnancy would mark women at excess risk of spontaneous preterm birth (sPTB) and examined the interplay between NEFAs, lipids, and other markers to explore pathways to sPTB. In a case-control study nested in the Pregnancy Exposures and Preeclampsia Prevention Study (Pittsburgh, Pennsylvania, 1997–2001), we assayed NEFA levels in nonfasting serum collected at a mean gestational week of 9.4 (range, 4–20 weeks) in 115 women with sPTB (<37 weeks) and 222 women with births occurring at ≥37 weeks. C-reactive protein, total cholesterol, low-density lipoprotein and high-density lipoprotein (HDL) cholesterol, triglycerides, and uric acid were also measured. Polytomous logistic regression models were used to evaluate tertiles of NEFA levels and sPTB at <34 weeks and 34–36 weeks; factor analysis was used to characterize patterns of biomarkers. Women with NEFA levels in the highest tertile versus the lowest were 2.02 (95% confidence interval: 1.13, 3.48) times more likely to have sPTB, after adjustment for covariates. Risk of sPTB before 34 weeks was particularly high among women with high NEFA levels (odds ratio = 3.73, 95% confidence interval: 1.33, 10.44). Six biomarker patterns were identified, and 2 were associated with sPTB: 1) increasing NEFA and HDL cholesterol levels and 2) family history of gestational hypertension. NEFA levels early in pregnancy were independently associated with sPTB, particularly before 34 weeks. We also detected a novel risk pattern suggesting that NEFAs together with HDL cholesterol may be related to sPTB.</p></abstract><kwd-group><kwd>factor analysis</kwd><kwd>inflammation</kwd><kwd>nonesterified fatty acids</kwd><kwd>pregnancy</kwd><kwd>prematurity</kwd><kwd>preterm birth</kwd><kwd>risk factors</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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