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Understanding the biology and use of TNF therapy in jia-clinical outcomes

Identifieur interne : 000587 ( Pmc/Corpus ); précédent : 000586; suivant : 000588

Understanding the biology and use of TNF therapy in jia-clinical outcomes

Auteurs : Daniel Lovell ; Anne Johnson ; Yuki Kimura ; Steve Spalding ; Paula Morris ; Beth Gottlieb ; Karen Onel ; Judyann Olson ; Barbara Edelheit ; Michael Shisov ; Lawrence Jung ; Elaine Cassidy ; Sampath Prahalad ; Murray Passo ; Tim Beukelman ; Jay Mehta ; Kara Schmidt ; Dirk Foell ; Claas Hinze ; Bin Huang ; Edward Giannini

Source :

Pediatric Rheumatology Online Journal [ 1546-0096 ] ; 2014.

RBID : PMC:4190972
Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190972

DOI: 10.1186/1546-0096-12-S1-P137
PubMed: NONE
PubMed Central: 4190972

Links to Exploration step

PMC:4190972

Le document en format XML

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<author><name sortKey="Lovell, Daniel" sort="Lovell, Daniel" uniqKey="Lovell D" first="Daniel" last="Lovell">Daniel Lovell</name>
<affiliation><nlm:aff id="I1">Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johnson, Anne" sort="Johnson, Anne" uniqKey="Johnson A" first="Anne" last="Johnson">Anne Johnson</name>
<affiliation><nlm:aff id="I1">Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kimura, Yuki" sort="Kimura, Yuki" uniqKey="Kimura Y" first="Yuki" last="Kimura">Yuki Kimura</name>
<affiliation><nlm:aff id="I2">Joseph M Sanzari Children’s Hospital, Hackensack, New Jersey, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spalding, Steve" sort="Spalding, Steve" uniqKey="Spalding S" first="Steve" last="Spalding">Steve Spalding</name>
<affiliation><nlm:aff id="I3">Cleveland Clinic Foundation, Cleveland, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morris, Paula" sort="Morris, Paula" uniqKey="Morris P" first="Paula" last="Morris">Paula Morris</name>
<affiliation><nlm:aff id="I4">Arkansas Children's Hospital, Little Rock, Arkansas, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gottlieb, Beth" sort="Gottlieb, Beth" uniqKey="Gottlieb B" first="Beth" last="Gottlieb">Beth Gottlieb</name>
<affiliation><nlm:aff id="I5">Cohen Children's Medical Center, New Hyde Park, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Onel, Karen" sort="Onel, Karen" uniqKey="Onel K" first="Karen" last="Onel">Karen Onel</name>
<affiliation><nlm:aff id="I6">Comer Children's Hospital, Chicago, Illinois, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olson, Judyann" sort="Olson, Judyann" uniqKey="Olson J" first="Judyann" last="Olson">Judyann Olson</name>
<affiliation><nlm:aff id="I7">Children's Hospital of Wisconson, Milwaukee, Wisconsin, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Edelheit, Barbara" sort="Edelheit, Barbara" uniqKey="Edelheit B" first="Barbara" last="Edelheit">Barbara Edelheit</name>
<affiliation><nlm:aff id="I8">Connecticut Children's Medical Center, Hartford, Connecticut, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shisov, Michael" sort="Shisov, Michael" uniqKey="Shisov M" first="Michael" last="Shisov">Michael Shisov</name>
<affiliation><nlm:aff id="I9">Phoenix Children's Hospital, Phoenix, Arizona, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jung, Lawrence" sort="Jung, Lawrence" uniqKey="Jung L" first="Lawrence" last="Jung">Lawrence Jung</name>
<affiliation><nlm:aff id="I10">Children's National Medical Center, Washington, D.C., USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cassidy, Elaine" sort="Cassidy, Elaine" uniqKey="Cassidy E" first="Elaine" last="Cassidy">Elaine Cassidy</name>
<affiliation><nlm:aff id="I11">Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Prahalad, Sampath" sort="Prahalad, Sampath" uniqKey="Prahalad S" first="Sampath" last="Prahalad">Sampath Prahalad</name>
<affiliation><nlm:aff id="I12">Emory University, Atlanta, Georgia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Passo, Murray" sort="Passo, Murray" uniqKey="Passo M" first="Murray" last="Passo">Murray Passo</name>
<affiliation><nlm:aff id="I13">Medical University of South Carolina, Charlestown, South Carolina, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beukelman, Tim" sort="Beukelman, Tim" uniqKey="Beukelman T" first="Tim" last="Beukelman">Tim Beukelman</name>
<affiliation><nlm:aff id="I14">University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehta, Jay" sort="Mehta, Jay" uniqKey="Mehta J" first="Jay" last="Mehta">Jay Mehta</name>
<affiliation><nlm:aff id="I15">Children's Hospital at Montifiore, Bronx, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Kara" sort="Schmidt, Kara" uniqKey="Schmidt K" first="Kara" last="Schmidt">Kara Schmidt</name>
<affiliation><nlm:aff id="I16">Kosair Children's Hospital, Louisville, Kentucky, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foell, Dirk" sort="Foell, Dirk" uniqKey="Foell D" first="Dirk" last="Foell">Dirk Foell</name>
<affiliation><nlm:aff id="I17">University of Muenster, Muenster, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hinze, Claas" sort="Hinze, Claas" uniqKey="Hinze C" first="Claas" last="Hinze">Claas Hinze</name>
<affiliation><nlm:aff id="I17">University of Muenster, Muenster, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huang, Bin" sort="Huang, Bin" uniqKey="Huang B" first="Bin" last="Huang">Bin Huang</name>
<affiliation><nlm:aff id="I1">Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giannini, Edward" sort="Giannini, Edward" uniqKey="Giannini E" first="Edward" last="Giannini">Edward Giannini</name>
<affiliation><nlm:aff id="I1">Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Understanding the biology and use of TNF therapy in jia-clinical outcomes</title>
<author><name sortKey="Lovell, Daniel" sort="Lovell, Daniel" uniqKey="Lovell D" first="Daniel" last="Lovell">Daniel Lovell</name>
<affiliation><nlm:aff id="I1">Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johnson, Anne" sort="Johnson, Anne" uniqKey="Johnson A" first="Anne" last="Johnson">Anne Johnson</name>
<affiliation><nlm:aff id="I1">Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kimura, Yuki" sort="Kimura, Yuki" uniqKey="Kimura Y" first="Yuki" last="Kimura">Yuki Kimura</name>
<affiliation><nlm:aff id="I2">Joseph M Sanzari Children’s Hospital, Hackensack, New Jersey, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spalding, Steve" sort="Spalding, Steve" uniqKey="Spalding S" first="Steve" last="Spalding">Steve Spalding</name>
<affiliation><nlm:aff id="I3">Cleveland Clinic Foundation, Cleveland, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morris, Paula" sort="Morris, Paula" uniqKey="Morris P" first="Paula" last="Morris">Paula Morris</name>
<affiliation><nlm:aff id="I4">Arkansas Children's Hospital, Little Rock, Arkansas, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gottlieb, Beth" sort="Gottlieb, Beth" uniqKey="Gottlieb B" first="Beth" last="Gottlieb">Beth Gottlieb</name>
<affiliation><nlm:aff id="I5">Cohen Children's Medical Center, New Hyde Park, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Onel, Karen" sort="Onel, Karen" uniqKey="Onel K" first="Karen" last="Onel">Karen Onel</name>
<affiliation><nlm:aff id="I6">Comer Children's Hospital, Chicago, Illinois, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olson, Judyann" sort="Olson, Judyann" uniqKey="Olson J" first="Judyann" last="Olson">Judyann Olson</name>
<affiliation><nlm:aff id="I7">Children's Hospital of Wisconson, Milwaukee, Wisconsin, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Edelheit, Barbara" sort="Edelheit, Barbara" uniqKey="Edelheit B" first="Barbara" last="Edelheit">Barbara Edelheit</name>
<affiliation><nlm:aff id="I8">Connecticut Children's Medical Center, Hartford, Connecticut, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shisov, Michael" sort="Shisov, Michael" uniqKey="Shisov M" first="Michael" last="Shisov">Michael Shisov</name>
<affiliation><nlm:aff id="I9">Phoenix Children's Hospital, Phoenix, Arizona, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jung, Lawrence" sort="Jung, Lawrence" uniqKey="Jung L" first="Lawrence" last="Jung">Lawrence Jung</name>
<affiliation><nlm:aff id="I10">Children's National Medical Center, Washington, D.C., USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cassidy, Elaine" sort="Cassidy, Elaine" uniqKey="Cassidy E" first="Elaine" last="Cassidy">Elaine Cassidy</name>
<affiliation><nlm:aff id="I11">Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Prahalad, Sampath" sort="Prahalad, Sampath" uniqKey="Prahalad S" first="Sampath" last="Prahalad">Sampath Prahalad</name>
<affiliation><nlm:aff id="I12">Emory University, Atlanta, Georgia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Passo, Murray" sort="Passo, Murray" uniqKey="Passo M" first="Murray" last="Passo">Murray Passo</name>
<affiliation><nlm:aff id="I13">Medical University of South Carolina, Charlestown, South Carolina, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beukelman, Tim" sort="Beukelman, Tim" uniqKey="Beukelman T" first="Tim" last="Beukelman">Tim Beukelman</name>
<affiliation><nlm:aff id="I14">University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehta, Jay" sort="Mehta, Jay" uniqKey="Mehta J" first="Jay" last="Mehta">Jay Mehta</name>
<affiliation><nlm:aff id="I15">Children's Hospital at Montifiore, Bronx, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Kara" sort="Schmidt, Kara" uniqKey="Schmidt K" first="Kara" last="Schmidt">Kara Schmidt</name>
<affiliation><nlm:aff id="I16">Kosair Children's Hospital, Louisville, Kentucky, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foell, Dirk" sort="Foell, Dirk" uniqKey="Foell D" first="Dirk" last="Foell">Dirk Foell</name>
<affiliation><nlm:aff id="I17">University of Muenster, Muenster, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hinze, Claas" sort="Hinze, Claas" uniqKey="Hinze C" first="Claas" last="Hinze">Claas Hinze</name>
<affiliation><nlm:aff id="I17">University of Muenster, Muenster, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huang, Bin" sort="Huang, Bin" uniqKey="Huang B" first="Bin" last="Huang">Bin Huang</name>
<affiliation><nlm:aff id="I1">Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giannini, Edward" sort="Giannini, Edward" uniqKey="Giannini E" first="Edward" last="Giannini">Edward Giannini</name>
<affiliation><nlm:aff id="I1">Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Pediatric Rheumatology Online Journal</title>
<idno type="eISSN">1546-0096</idno>
<imprint><date when="2014">2014</date>
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<pmc article-type="abstract" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Pediatr Rheumatol Online J</journal-id>
<journal-id journal-id-type="iso-abbrev">Pediatr Rheumatol Online J</journal-id>
<journal-title-group><journal-title>Pediatric Rheumatology Online Journal</journal-title>
</journal-title-group>
<issn pub-type="epub">1546-0096</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmc">4190972</article-id>
<article-id pub-id-type="publisher-id">1546-0096-12-S1-P137</article-id>
<article-id pub-id-type="doi">10.1186/1546-0096-12-S1-P137</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Poster Presentation</subject>
</subj-group>
</article-categories>
<title-group><article-title>Understanding the biology and use of TNF therapy in jia-clinical outcomes</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Lovell</surname>
<given-names>Daniel</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Johnson</surname>
<given-names>Anne</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Kimura</surname>
<given-names>Yuki</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Spalding</surname>
<given-names>Steve</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Morris</surname>
<given-names>Paula</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Gottlieb</surname>
<given-names>Beth</given-names>
</name>
<xref ref-type="aff" rid="I5">5</xref>
</contrib>
<contrib contrib-type="author" id="A7"><name><surname>Onel</surname>
<given-names>Karen</given-names>
</name>
<xref ref-type="aff" rid="I6">6</xref>
</contrib>
<contrib contrib-type="author" id="A8"><name><surname>Olson</surname>
<given-names>Judyann</given-names>
</name>
<xref ref-type="aff" rid="I7">7</xref>
</contrib>
<contrib contrib-type="author" id="A9"><name><surname>Edelheit</surname>
<given-names>Barbara</given-names>
</name>
<xref ref-type="aff" rid="I8">8</xref>
</contrib>
<contrib contrib-type="author" id="A10"><name><surname>Shisov</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="I9">9</xref>
</contrib>
<contrib contrib-type="author" id="A11"><name><surname>Jung</surname>
<given-names>Lawrence</given-names>
</name>
<xref ref-type="aff" rid="I10">10</xref>
</contrib>
<contrib contrib-type="author" id="A12"><name><surname>Cassidy</surname>
<given-names>Elaine</given-names>
</name>
<xref ref-type="aff" rid="I11">11</xref>
</contrib>
<contrib contrib-type="author" id="A13"><name><surname>Prahalad</surname>
<given-names>Sampath</given-names>
</name>
<xref ref-type="aff" rid="I12">12</xref>
</contrib>
<contrib contrib-type="author" id="A14"><name><surname>Passo</surname>
<given-names>Murray</given-names>
</name>
<xref ref-type="aff" rid="I13">13</xref>
</contrib>
<contrib contrib-type="author" id="A15"><name><surname>Beukelman</surname>
<given-names>Tim</given-names>
</name>
<xref ref-type="aff" rid="I14">14</xref>
</contrib>
<contrib contrib-type="author" id="A16"><name><surname>Mehta</surname>
<given-names>Jay</given-names>
</name>
<xref ref-type="aff" rid="I15">15</xref>
</contrib>
<contrib contrib-type="author" id="A17"><name><surname>Schmidt</surname>
<given-names>Kara</given-names>
</name>
<xref ref-type="aff" rid="I16">16</xref>
</contrib>
<contrib contrib-type="author" id="A18"><name><surname>Foell</surname>
<given-names>Dirk</given-names>
</name>
<xref ref-type="aff" rid="I17">17</xref>
</contrib>
<contrib contrib-type="author" id="A19"><name><surname>Hinze</surname>
<given-names>Claas</given-names>
</name>
<xref ref-type="aff" rid="I17">17</xref>
</contrib>
<contrib contrib-type="author" id="A20"><name><surname>Huang</surname>
<given-names>Bin</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
</contrib>
<contrib contrib-type="author" id="A21"><name><surname>Giannini</surname>
<given-names>Edward</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</aff>
<aff id="I2"><label>2</label>
Joseph M Sanzari Children’s Hospital, Hackensack, New Jersey, USA</aff>
<aff id="I3"><label>3</label>
Cleveland Clinic Foundation, Cleveland, Ohio, USA</aff>
<aff id="I4"><label>4</label>
Arkansas Children's Hospital, Little Rock, Arkansas, USA</aff>
<aff id="I5"><label>5</label>
Cohen Children's Medical Center, New Hyde Park, New York, USA</aff>
<aff id="I6"><label>6</label>
Comer Children's Hospital, Chicago, Illinois, USA</aff>
<aff id="I7"><label>7</label>
Children's Hospital of Wisconson, Milwaukee, Wisconsin, USA</aff>
<aff id="I8"><label>8</label>
Connecticut Children's Medical Center, Hartford, Connecticut, USA</aff>
<aff id="I9"><label>9</label>
Phoenix Children's Hospital, Phoenix, Arizona, USA</aff>
<aff id="I10"><label>10</label>
Children's National Medical Center, Washington, D.C., USA</aff>
<aff id="I11"><label>11</label>
Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA</aff>
<aff id="I12"><label>12</label>
Emory University, Atlanta, Georgia, USA</aff>
<aff id="I13"><label>13</label>
Medical University of South Carolina, Charlestown, South Carolina, USA</aff>
<aff id="I14"><label>14</label>
University of Alabama at Birmingham, Birmingham, Alabama, USA</aff>
<aff id="I15"><label>15</label>
Children's Hospital at Montifiore, Bronx, New York, USA</aff>
<aff id="I16"><label>16</label>
Kosair Children's Hospital, Louisville, Kentucky, USA</aff>
<aff id="I17"><label>17</label>
University of Muenster, Muenster, Germany</aff>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>17</day>
<month>9</month>
<year>2014</year>
</pub-date>
<volume>12</volume>
<issue>Suppl 1</issue>
<supplement><named-content content-type="supplement-title">Proceedings of the 21st European Pediatric Rheumatology (PReS) Congress</named-content>
<named-content content-type="supplement-sponsor">The publication charges for this supplement were funded by the PReS 2014 congress.</named-content>
</supplement>
<fpage>P137</fpage>
<lpage>P137</lpage>
<permissions><copyright-statement>Copyright © 2014 Lovell et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>Lovell et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.ped-rheum.com/content/12/S1/P137"></self-uri>
<conference><conf-date>17-21 September 2014</conf-date>
<conf-name>21st European Pediatric Rheumatology (PReS) Congress</conf-name>
<conf-loc>Belgrade, Serbia</conf-loc>
</conference>
</article-meta>
</front>
<body><sec sec-type="intro"><title>Introduction</title>
<p>Treatment with anti-TNF therapies (anti-TNF) for polyarticular forms (extended oligo, Poly RF +/-) of JIA (PF-JIA) results in >50% demonstrating clinical inactive disease (CID).</p>
</sec>
<sec><title>Objectives</title>
<p>The aims of this study were to perform the first prospective, mulicenter trial to determine the frequency, timing and predictors of flare upon withdrawal of anti-TNF in PF-JIA in CID.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>In 16 centers 137 children with PF-JIA in CID on anti-TNF were enrolled and prospectively followed. If CID was maintained for the first 6 study mos, then anti-TNF was stopped and the patients were followed prospectively by protocol. Background meds were stable.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>The study population included 18 (13%) extended oligoarticular, 17 (12%) RF+ Poly and 102 (75%) RF- Poly JIA patients. At enrollment, age (mean/median/range) was 11.3/11.6/3.4-20.1 yrs; disease duration was 5.0/4.1/0.6-18.6 yrs; 103 (75%) were females and 64 (47%) were ANA+. Duration of CID at baseline was 1.2/0.5/1 day-12.1 yrs. Anti-TNF was etanercept in 106 (77%), 25 (18%) adalimumab and 6 (5%) infliximab. 40% were on MTX at baseline (mean/median dose 0.4/0.4 mg/kg/wk).</p>
<p>17% were unable to maintain CID for the first 6 months despite stable background medications. For the extended oligo, Poly RF – and Poly RF+ categories 94%, 82% and 60%, respectively, maintained CID for the first 6 months (chi-square 6.7, p 0.03). ANA status, MTX use, and type of anti-TNF were not associated with the ability to maintain CID (chi-square p values 0.48, 0.14, and 0.75, respectively).</p>
<p>Upon stopping the anti-TNF therapy, the mean time to flare was 18.3 months with a median of 26 months (range 9-32 months). Longer disease duration at baseline was associated with an increasing risk of flare with stopping anti-TNF therapy (chi square 5.62, p = 0.017). Background MTX significantly decreased the risk of flare (p= 0.05) and significantly increased the time to flare (p = 0.05). JIA subtype was significantly associated with both risk of flaring (p=0.02) and time to flare (p= 0.04) with RF+ Poly flaring less frequently than either RF- or Extended oligo which seem similar. RF+ patients were significantly less likely to flare than RF- (p= 0.02). Age, gender, ANA status, duration of CID did not predict risk of or time to flare.</p>
</sec>
<sec sec-type="conclusions"><title>Conclusion</title>
<p>In these patients with Polyarticular forms of JIA in CID for ≥6 mos, upon stopping the anti-TNF therapy, 70% will experience a flare within 3.25 years but ≥ 50% will maintain CID for ≥17 months. Continuing background MTX both decreases the risk of flare and increases the time to flare. Disease duration and JIA subtype are the only predictive clinical parameters. Duration of CID was NOT predictive of risk of flare after stopping anti-TNF therapy.</p>
</sec>
<sec><title>Disclosure of interest</title>
<p>D. Lovell: consultant for: Roche, Genetech, Jannsen, AstraZeneca, Pfizer, Novartis, Abbott, Forest Research, BMS. Speaker Bureau of: Novartis, Roche, Genetech. A. Johnson: none declared. Y. Kimura: Consultant for: Novartis.</p>
<p>S. Spalding: none declared. P. Morris: none declared. B. Gottlieb: none declared. K. Onel: none declared. J. Olson: consultant for: Abbott. B. Edelheit: none declared. M. Shisov: none declared. L. Jung: none declared. E. Cassidy: none declared. S. Prahalad: none declared. M. Passo: none declared. T. Beukelman: grant / research support from Pfizer, consultant for Novartis, Genentech, UCB. J. Mehta: none declared. K. Schmidt: none declared.</p>
<p>D. Foell: none declared. C. Hinze: none declared. B. Huang: none declared. E. Giannini: none declared.</p>
</sec>
</body>
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Understanding the biology and use of TNF therapy in jia-clinical outcomes

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