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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain Volume as an Integrated Marker for the Risk of Death in a Community-Based Sample: Age Gene/Environment Susceptibility—Reykjavik Study</title><author><name sortKey="Van Elderen, Saskia S G C" sort="Van Elderen, Saskia S G C" uniqKey="Van Elderen S" first="Saskia S. G. C." last="Van Elderen">Saskia S. G. C. Van Elderen</name><affiliation><nlm:aff id="AF0001"><institution>Department of Radiology, Leiden University Medical Centre</institution>,<country>the Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Sigurdsson, Sigudur" sort="Sigurdsson, Sigudur" uniqKey="Sigurdsson S" first="Sigudur" last="Sigurdsson">Sigudur Sigurdsson</name><affiliation><nlm:aff id="AF0003"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur, Iceland</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Haight, Thaddeus J" sort="Haight, Thaddeus J" uniqKey="Haight T" first="Thaddeus J." last="Haight">Thaddeus J. Haight</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Lopez, Oscar" sort="Lopez, Oscar" uniqKey="Lopez O" first="Oscar" last="Lopez">Oscar Lopez</name><affiliation><nlm:aff id="AF0004"><institution>Department of Neurology, University of Pittsburgh, Pennsylvania;</institution></nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="AF0003"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur, Iceland</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Jonsson, Palmi" sort="Jonsson, Palmi" uniqKey="Jonsson P" first="Palmi" last="Jonsson">Palmi Jonsson</name><affiliation><nlm:aff id="AF0005"><institution>Landspitali Hospital</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country>.</nlm:aff></affiliation></author><author><name sortKey="De Jong, Laura" sort="De Jong, Laura" uniqKey="De Jong L" first="Laura" last="De Jong">Laura De Jong</name><affiliation><nlm:aff id="AF0001"><institution>Department of Radiology, Leiden University Medical Centre</institution>,<country>the Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundar" sort="Gudnason, Vilmundar" uniqKey="Gudnason V" first="Vilmundar" last="Gudnason">Vilmundar Gudnason</name><affiliation><nlm:aff id="AF0003"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur, Iceland</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Van Buchem, Mark A" sort="Van Buchem, Mark A" uniqKey="Van Buchem M" first="Mark A." last="Van Buchem">Mark A. Van Buchem</name><affiliation><nlm:aff id="AF0001"><institution>Department of Radiology, Leiden University Medical Centre</institution>,<country>the Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25359930</idno><idno type="pmc">4706101</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706101</idno><idno type="RBID">PMC:4706101</idno><idno type="doi">10.1093/gerona/glu192</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000101</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000101</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain Volume as an Integrated Marker for the Risk of Death in a Community-Based Sample: Age Gene/Environment Susceptibility—Reykjavik Study</title><author><name sortKey="Van Elderen, Saskia S G C" sort="Van Elderen, Saskia S G C" uniqKey="Van Elderen S" first="Saskia S. G. C." last="Van Elderen">Saskia S. G. C. Van Elderen</name><affiliation><nlm:aff id="AF0001"><institution>Department of Radiology, Leiden University Medical Centre</institution>,<country>the Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Sigurdsson, Sigudur" sort="Sigurdsson, Sigudur" uniqKey="Sigurdsson S" first="Sigudur" last="Sigurdsson">Sigudur Sigurdsson</name><affiliation><nlm:aff id="AF0003"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur, Iceland</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Haight, Thaddeus J" sort="Haight, Thaddeus J" uniqKey="Haight T" first="Thaddeus J." last="Haight">Thaddeus J. Haight</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Lopez, Oscar" sort="Lopez, Oscar" uniqKey="Lopez O" first="Oscar" last="Lopez">Oscar Lopez</name><affiliation><nlm:aff id="AF0004"><institution>Department of Neurology, University of Pittsburgh, Pennsylvania;</institution></nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="AF0003"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur, Iceland</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Jonsson, Palmi" sort="Jonsson, Palmi" uniqKey="Jonsson P" first="Palmi" last="Jonsson">Palmi Jonsson</name><affiliation><nlm:aff id="AF0005"><institution>Landspitali Hospital</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country>.</nlm:aff></affiliation></author><author><name sortKey="De Jong, Laura" sort="De Jong, Laura" uniqKey="De Jong L" first="Laura" last="De Jong">Laura De Jong</name><affiliation><nlm:aff id="AF0001"><institution>Department of Radiology, Leiden University Medical Centre</institution>,<country>the Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundar" sort="Gudnason, Vilmundar" uniqKey="Gudnason V" first="Vilmundar" last="Gudnason">Vilmundar Gudnason</name><affiliation><nlm:aff id="AF0003"><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur, Iceland</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Van Buchem, Mark A" sort="Van Buchem, Mark A" uniqKey="Van Buchem M" first="Mark A." last="Van Buchem">Mark A. Van Buchem</name><affiliation><nlm:aff id="AF0001"><institution>Department of Radiology, Leiden University Medical Centre</institution>,<country>the Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="AF0002"><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</nlm:aff></affiliation></author></analytic><series><title level="j">The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</title><idno type="ISSN">1079-5006</idno><idno type="eISSN">1758-535X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background.</title><p>Total brain volume is an integrated measure of health and may be an independent indicator of mortality risk independent of any one clinical or subclinical disease state. We investigate the association of brain volume to total and cause-specific mortality in a large nondemented stroke-free community-based cohort.</p></sec><sec><title>Methods.</title><p>The analysis includes 3,543 men and women (born 1907–1935) participating in the Age, Gene, Environment Susceptibility—Reykjavik Study. Participants with a known brain-related high risk for mortality (cognitive impairment or stroke) were excluded from these analyses. Quantitative estimates of total brain volume, white matter, white matter lesions, total gray matter (GM; cortical GM and subcortical GM separately), and focal cerebral vascular disease were generated from brain magnetic resonance imaging. Brain atrophy was expressed as brain tissue volume divided by total intracranial volume, yielding a percentage. Mean follow-up duration was 7.2 (0–10) years, with 647 deaths. Cox regression was used to analyze the association of mortality to brain atrophy, adjusting for demographics, cardiovascular risk factors, and cerebral vascular disease.</p></sec><sec><title>Results.</title><p>Reduced risk of mortality was significantly associated with higher total brain volume (hazard ratio, 95% confidence interval = 0.71, 0.65–0.78), white matter (0.85, 0.78–0.93), total GM (0.74, 0.68–0.81), and cortical GM (0.78, 0.70-0.87). Overall, the associations were similar for cardiovascular and noncardiovascular-related deaths.</p></sec><sec><title>Conclusions.</title><p>Independent of multiple risk factors and cerebral vascular damage, global brain volume predicts mortality in a large nondemented stroke-free community-dwelling older cohort. Total brain volume may be an integrated measure reflecting a range of health and with further investigation could be a useful clinical tool when assessing risk for mortality.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Gerontol A Biol Sci Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">J. Gerontol. A Biol. Sci. Med. Sci</journal-id><journal-id journal-id-type="hwp">gerona</journal-id><journal-id journal-id-type="publisher-id">gerona</journal-id><journal-title-group><journal-title>The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</journal-title></journal-title-group><issn pub-type="ppub">1079-5006</issn><issn pub-type="epub">1758-535X</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25359930</article-id><article-id pub-id-type="pmc">4706101</article-id><article-id pub-id-type="doi">10.1093/gerona/glu192</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Brain Volume as an Integrated Marker for the Risk of Death in a Community-Based Sample: Age Gene/Environment Susceptibility—Reykjavik Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Van Elderen</surname><given-names>Saskia S. G. C.</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Qian</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sigurdsson</surname><given-names>Sigudur</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haight</surname><given-names>Thaddeus J.</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lopez</surname><given-names>Oscar</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eiriksdottir</surname><given-names>Gudny</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jonsson</surname><given-names>Palmi</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>de Jong</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Tamara B.</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Garcia</surname><given-names>Melissa</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gudnason</surname><given-names>Vilmundar</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>van Buchem</surname><given-names>Mark A.</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Launer</surname><given-names>Lenore J.</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><aff id="AF0001"><sup>1</sup><institution>Department of Radiology, Leiden University Medical Centre</institution>,<country>the Netherlands</country>;</aff><aff id="AF0002"><sup>2</sup><institution>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH</institution>,<addr-line>Bethesda, Maryland;</addr-line>.</aff><aff id="AF0003"><sup>3</sup><institution>Icelandic Heart Association</institution>,<addr-line>Kopavogur, Iceland</addr-line>;</aff><aff id="AF0004"><sup>4</sup><institution>Department of Neurology, University of Pittsburgh, Pennsylvania;</institution></aff><aff id="AF0005"><sup>5</sup><institution>Landspitali Hospital</institution>,<addr-line>Reykjavik</addr-line>,<country>Iceland</country>.</aff></contrib-group><author-notes><corresp id="c1">Address correspondence to Lenore J. Launer, PhD, LEPS/NIA/NIH, 7201 Wisconsin Avenue, Bethesda, MD 20892. Email: <email>launerl@nia.nih.gov</email></corresp><fn fn-type="other" id="fn01"><p>Decision Editor: Stephen Kritchevsky, PhD</p></fn></author-notes><pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>10</month><year>2014</year></pub-date><volume>71</volume><issue>1</issue><fpage>131</fpage><lpage>137</lpage><history><date date-type="received"><day>25</day><month>11</month><year>2013</year></date><date date-type="accepted"><day>14</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>Published by Oxford University Press on behalf of the Gerontological Society of America 2014.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><sec><title>Background.</title><p>Total brain volume is an integrated measure of health and may be an independent indicator of mortality risk independent of any one clinical or subclinical disease state. We investigate the association of brain volume to total and cause-specific mortality in a large nondemented stroke-free community-based cohort.</p></sec><sec><title>Methods.</title><p>The analysis includes 3,543 men and women (born 1907–1935) participating in the Age, Gene, Environment Susceptibility—Reykjavik Study. Participants with a known brain-related high risk for mortality (cognitive impairment or stroke) were excluded from these analyses. Quantitative estimates of total brain volume, white matter, white matter lesions, total gray matter (GM; cortical GM and subcortical GM separately), and focal cerebral vascular disease were generated from brain magnetic resonance imaging. Brain atrophy was expressed as brain tissue volume divided by total intracranial volume, yielding a percentage. Mean follow-up duration was 7.2 (0–10) years, with 647 deaths. Cox regression was used to analyze the association of mortality to brain atrophy, adjusting for demographics, cardiovascular risk factors, and cerebral vascular disease.</p></sec><sec><title>Results.</title><p>Reduced risk of mortality was significantly associated with higher total brain volume (hazard ratio, 95% confidence interval = 0.71, 0.65–0.78), white matter (0.85, 0.78–0.93), total GM (0.74, 0.68–0.81), and cortical GM (0.78, 0.70-0.87). Overall, the associations were similar for cardiovascular and noncardiovascular-related deaths.</p></sec><sec><title>Conclusions.</title><p>Independent of multiple risk factors and cerebral vascular damage, global brain volume predicts mortality in a large nondemented stroke-free community-dwelling older cohort. Total brain volume may be an integrated measure reflecting a range of health and with further investigation could be a useful clinical tool when assessing risk for mortality.</p></sec></abstract><kwd-group><title>Key Words:</title><kwd>Brain aging</kwd><kwd>Epidemiology</kwd><kwd>Neuroimaging </kwd><kwd>Mortality risking.</kwd></kwd-group><counts><page-count count="7"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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