Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects
Identifieur interne : 000077 ( Pmc/Corpus ); précédent : 000076; suivant : 000078Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects
Auteurs : Hyun Kook Lim ; Robert Nebes ; Beth Snitz ; Ann Cohen ; Chester Mathis ; Julie Price ; Lisa Weissfeld ; William Klunk ; Howard J. AizensteinSource :
- Brain [ 0006-8950 ] ; 2014.
Abstract
See Toga and Thompson (doi:
Hyun Kook Lim
Url:
DOI: 10.1093/brain/awu271
PubMed: 25266592
PubMed Central: 4240287
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PMC:4240287Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects</title><author><name sortKey="Lim, Hyun Kook" sort="Lim, Hyun Kook" uniqKey="Lim H" first="Hyun Kook" last="Lim">Hyun Kook Lim</name><affiliation><nlm:aff id="awu271-AFF1">1 Department of Psychiatry, The Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Nebes, Robert" sort="Nebes, Robert" uniqKey="Nebes R" first="Robert" last="Nebes">Robert Nebes</name><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name><affiliation><nlm:aff id="awu271-AFF3">3 Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Cohen, Ann" sort="Cohen, Ann" uniqKey="Cohen A" first="Ann" last="Cohen">Ann Cohen</name><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Mathis, Chester" sort="Mathis, Chester" uniqKey="Mathis C" first="Chester" last="Mathis">Chester Mathis</name><affiliation><nlm:aff id="awu271-AFF4">4 Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Price, Julie" sort="Price, Julie" uniqKey="Price J" first="Julie" last="Price">Julie Price</name><affiliation><nlm:aff id="awu271-AFF4">4 Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Weissfeld, Lisa" sort="Weissfeld, Lisa" uniqKey="Weissfeld L" first="Lisa" last="Weissfeld">Lisa Weissfeld</name><affiliation><nlm:aff id="awu271-AFF5">5 Department of Biostatistics University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Klunk, William" sort="Klunk, William" uniqKey="Klunk W" first="William" last="Klunk">William Klunk</name><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="awu271-AFF3">3 Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J." last="Aizenstein">Howard J. Aizenstein</name><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25266592</idno><idno type="pmc">4240287</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240287</idno><idno type="RBID">PMC:4240287</idno><idno type="doi">10.1093/brain/awu271</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000077</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000077</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects</title><author><name sortKey="Lim, Hyun Kook" sort="Lim, Hyun Kook" uniqKey="Lim H" first="Hyun Kook" last="Lim">Hyun Kook Lim</name><affiliation><nlm:aff id="awu271-AFF1">1 Department of Psychiatry, The Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Nebes, Robert" sort="Nebes, Robert" uniqKey="Nebes R" first="Robert" last="Nebes">Robert Nebes</name><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name><affiliation><nlm:aff id="awu271-AFF3">3 Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Cohen, Ann" sort="Cohen, Ann" uniqKey="Cohen A" first="Ann" last="Cohen">Ann Cohen</name><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Mathis, Chester" sort="Mathis, Chester" uniqKey="Mathis C" first="Chester" last="Mathis">Chester Mathis</name><affiliation><nlm:aff id="awu271-AFF4">4 Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Price, Julie" sort="Price, Julie" uniqKey="Price J" first="Julie" last="Price">Julie Price</name><affiliation><nlm:aff id="awu271-AFF4">4 Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Weissfeld, Lisa" sort="Weissfeld, Lisa" uniqKey="Weissfeld L" first="Lisa" last="Weissfeld">Lisa Weissfeld</name><affiliation><nlm:aff id="awu271-AFF5">5 Department of Biostatistics University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Klunk, William" sort="Klunk, William" uniqKey="Klunk W" first="William" last="Klunk">William Klunk</name><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="awu271-AFF3">3 Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J." last="Aizenstein">Howard J. Aizenstein</name><affiliation><nlm:aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>See Toga and Thompson (doi:<related-article id="d35e190" related-article-type="companion" ext-link-type="doi" xlink:href="10.1093/brain/awu276">10.1093/brain/awu276</related-article>) for a scientific commentary on this article.</p><p>Hyun Kook Lim <italic>et al.</italic> investigate the relationship between amyloid burden and intrinsic functional connectivity in cognitively normal older adults. Individuals with amyloid deposition show aberrant functional connectivity in the default mode and central executive networks compared to those without detectable amyloid. Changes may reflect early deleterious effects of amyloid deposition.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Brain</journal-id><journal-id journal-id-type="iso-abbrev">Brain</journal-id><journal-id journal-id-type="publisher-id">brainj</journal-id><journal-id journal-id-type="hwp">brain</journal-id><journal-title-group><journal-title>Brain</journal-title></journal-title-group><issn pub-type="ppub">0006-8950</issn><issn pub-type="epub">1460-2156</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25266592</article-id><article-id pub-id-type="pmc">4240287</article-id><article-id pub-id-type="doi">10.1093/brain/awu271</article-id><article-id pub-id-type="publisher-id">awu271</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Hyun Kook</given-names></name><xref ref-type="aff" rid="awu271-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awu271-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nebes</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="awu271-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Snitz</surname><given-names>Beth</given-names></name><xref ref-type="aff" rid="awu271-AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cohen</surname><given-names>Ann</given-names></name><xref ref-type="aff" rid="awu271-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mathis</surname><given-names>Chester</given-names></name><xref ref-type="aff" rid="awu271-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Price</surname><given-names>Julie</given-names></name><xref ref-type="aff" rid="awu271-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weissfeld</surname><given-names>Lisa</given-names></name><xref ref-type="aff" rid="awu271-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Klunk</surname><given-names>William</given-names></name><xref ref-type="aff" rid="awu271-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awu271-AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Aizenstein</surname><given-names>Howard J.</given-names></name><xref ref-type="aff" rid="awu271-AFF2"><sup>2</sup></xref></contrib><aff id="awu271-AFF1">1 Department of Psychiatry, The Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea</aff><aff id="awu271-AFF2">2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</aff><aff id="awu271-AFF3">3 Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</aff><aff id="awu271-AFF4">4 Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</aff><aff id="awu271-AFF5">5 Department of Biostatistics University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA</aff></contrib-group><author-notes><corresp>Correspondence to: Howard J. Aizenstein MD, PhD, Western Psychiatric Institute and Clinic, 3811 O’Hara St., Pittsburgh, PA 15213, USA E-mail: <email>haizenstein@gmail.com</email></corresp><fn id="awu271-FN4"><p>See Toga and Thompson (doi:<related-article id="d35e136" related-article-type="companion" ext-link-type="doi" xlink:href="10.1093/brain/awu276">10.1093/brain/awu276</related-article>) for a scientific commentary on this article.</p></fn></author-notes><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>27</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>137</volume><issue>12</issue><fpage>3327</fpage><lpage>3338</lpage><history><date date-type="received"><day>23</day><month>4</month><year>2014</year></date><date date-type="rev-recd"><day>12</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>31</day><month>7</month><year>2014</year></date></history><permissions><copyright-statement>© The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract abstract-type="precis"><p>See Toga and Thompson (doi:<related-article id="d35e190" related-article-type="companion" ext-link-type="doi" xlink:href="10.1093/brain/awu276">10.1093/brain/awu276</related-article>) for a scientific commentary on this article.</p><p>Hyun Kook Lim <italic>et al.</italic> investigate the relationship between amyloid burden and intrinsic functional connectivity in cognitively normal older adults. Individuals with amyloid deposition show aberrant functional connectivity in the default mode and central executive networks compared to those without detectable amyloid. Changes may reflect early deleterious effects of amyloid deposition.</p></abstract><abstract><p>Although previous studies demonstrated decreased functional connectivity in the default mode network in the cognitively normal older adults with amyloid burden, effects of amyloid burden in the other large-scale intrinsic connectivity networks are not yet clear. The aim of this study was to investigate the distinctive association pattern of amyloid-β deposition on the three large-scale intrinsic connectivity networks (the default mode network, salience network and central executive network) in older adults with normal cognition. Fifty-six older adults with normal cognition underwent functional magnetic resonance imaging and were dichotomized using <sup>11</sup>C-labelled Pittsburgh compound B positron emission tomography imaging into subjects with (PiB+; <italic>n</italic> = 27) and without (PiB−; <italic>n</italic> = 29) detectable amyloid burden. We found that the functional connectivities of (i) the default mode network were greater; (ii) the salience network were not different; and (iii) the central executive network were lower in the Pittsburgh compound B positive group, compared with the Pittsburgh compound B negative group. Anterior cingulate cortex Pittsburgh compound B retention was negatively correlated with the functional connectivities of the posterior default mode network, and positively correlated with fronto-parietal functional connectivity (within the central executive network) in the Pittsburgh compound B positive group. The anti-correlation strength between the default mode network and the central executive network was negatively correlated with the anterior cingulate cortex Pittsburgh compound B levels. Additionally, significant group × episodic memory interactions with functional connectivities in the posterior default mode network, and the frontal default mode network were observed. Our results of aberrant default mode network functional connectivity and distinctive correlation patterns between the Pittsburgh compound B retention in the anterior cingulate cortex and functional connectivities in the default mode network and central executive network in the Pittsburgh compound B positive group might reflect a detrimental effect of amyloid retention on functional changes in the course of Alzheimer’s disease progression.</p></abstract><kwd-group kwd-group-type="keywords"><kwd>amyloid imaging</kwd><kwd>normal older adults</kwd><kwd>functional MRI</kwd><kwd>large scale intrinsic networks</kwd></kwd-group><counts><page-count count="12"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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