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Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma

Identifieur interne : 001056 ( Pmc/Checkpoint ); précédent : 001055; suivant : 001057

Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma

Auteurs : Christopher Fung [États-Unis] ; Pei Zhou [États-Unis] ; Sonali Joyce [États-Unis] ; Kerry Trent [États-Unis] ; Jian-Min Yuan [États-Unis] ; Jennifer R. Grandis [États-Unis] ; Joel L. Weissfeld [États-Unis] ; Marjorie Romkes [États-Unis] ; Daniel E. Weeks [États-Unis] ; Ann Marie Egloff [États-Unis]

Source :

RBID : PMC:4295492

Abstract

EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk.

EGFR intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.


Url:
DOI: 10.1016/j.canlet.2014.12.008
PubMed: 25511740
PubMed Central: 4295492


Affiliations:


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PMC:4295492

Le document en format XML

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<italic>EGFR</italic>
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<italic>EGFR</italic>
single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk.</p>
<p id="P2">
<italic>EGFR</italic>
intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.</p>
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<article-title>Identification of epidermal growth factor receptor (
<italic>EGFR</italic>
) genetic variants that modify risk for head and neck squamous cell carcinoma</article-title>
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<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Fung</surname>
<given-names>Christopher</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhou</surname>
<given-names>Pei</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Joyce</surname>
<given-names>Sonali</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Trent</surname>
<given-names>Kerry</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yuan</surname>
<given-names>Jian-Min</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Grandis</surname>
<given-names>Jennifer R.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A3">c</xref>
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<contrib contrib-type="author">
<name>
<surname>Weissfeld</surname>
<given-names>Joel L.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Romkes</surname>
<given-names>Marjorie</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Weeks</surname>
<given-names>Daniel E.</given-names>
</name>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Egloff</surname>
<given-names>Ann Marie</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A6">f</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
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<aff id="A1">
<label>a</label>
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A2">
<label>b</label>
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A3">
<label>c</label>
Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A4">
<label>d</label>
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A5">
<label>e</label>
Department of Human Genetics and Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A6">
<label>f</label>
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<author-notes>
<corresp id="cor1">
<label>*</label>
Corresponding author. Tel.: +1 412 648 9545.
<email>egloffam@upmc.edu</email>
(A.M. Egloff)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>6</day>
<month>1</month>
<year>2015</year>
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<pub-date pub-type="epub">
<day>12</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub">
<day>28</day>
<month>2</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>28</day>
<month>2</month>
<year>2016</year>
</pub-date>
<volume>357</volume>
<issue>2</issue>
<fpage>549</fpage>
<lpage>556</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.canlet.2014.12.008</pmc-comment>
<permissions>
<copyright-statement>© 2014 Elsevier Ireland Ltd. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract>
<p id="P1">
<italic>EGFR</italic>
polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60
<italic>EGFR</italic>
single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk.</p>
<p id="P2">
<italic>EGFR</italic>
intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.</p>
</abstract>
<kwd-group>
<kwd>Case–control study</kwd>
<kwd>Genetic polymorphism</kwd>
<kwd>Tobacco-independent</kwd>
<kwd>Nonsmoker</kwd>
<kwd>Head and neck cancer risk</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Pennsylvanie</li>
</region>
<settlement>
<li>Pittsburgh</li>
</settlement>
<orgName>
<li>Université de Pittsburgh</li>
</orgName>
</list>
<tree>
<country name="États-Unis">
<region name="Pennsylvanie">
<name sortKey="Fung, Christopher" sort="Fung, Christopher" uniqKey="Fung C" first="Christopher" last="Fung">Christopher Fung</name>
</region>
<name sortKey="Egloff, Ann Marie" sort="Egloff, Ann Marie" uniqKey="Egloff A" first="Ann Marie" last="Egloff">Ann Marie Egloff</name>
<name sortKey="Egloff, Ann Marie" sort="Egloff, Ann Marie" uniqKey="Egloff A" first="Ann Marie" last="Egloff">Ann Marie Egloff</name>
<name sortKey="Grandis, Jennifer R" sort="Grandis, Jennifer R" uniqKey="Grandis J" first="Jennifer R." last="Grandis">Jennifer R. Grandis</name>
<name sortKey="Grandis, Jennifer R" sort="Grandis, Jennifer R" uniqKey="Grandis J" first="Jennifer R." last="Grandis">Jennifer R. Grandis</name>
<name sortKey="Joyce, Sonali" sort="Joyce, Sonali" uniqKey="Joyce S" first="Sonali" last="Joyce">Sonali Joyce</name>
<name sortKey="Romkes, Marjorie" sort="Romkes, Marjorie" uniqKey="Romkes M" first="Marjorie" last="Romkes">Marjorie Romkes</name>
<name sortKey="Trent, Kerry" sort="Trent, Kerry" uniqKey="Trent K" first="Kerry" last="Trent">Kerry Trent</name>
<name sortKey="Weeks, Daniel E" sort="Weeks, Daniel E" uniqKey="Weeks D" first="Daniel E." last="Weeks">Daniel E. Weeks</name>
<name sortKey="Weissfeld, Joel L" sort="Weissfeld, Joel L" uniqKey="Weissfeld J" first="Joel L." last="Weissfeld">Joel L. Weissfeld</name>
<name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name>
<name sortKey="Zhou, Pei" sort="Zhou, Pei" uniqKey="Zhou P" first="Pei" last="Zhou">Pei Zhou</name>
</country>
</tree>
</affiliations>
</record>

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