Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma
Identifieur interne : 001056 ( Pmc/Checkpoint ); précédent : 001055; suivant : 001057Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma
Auteurs : Christopher Fung [États-Unis] ; Pei Zhou [États-Unis] ; Sonali Joyce [États-Unis] ; Kerry Trent [États-Unis] ; Jian-Min Yuan [États-Unis] ; Jennifer R. Grandis [États-Unis] ; Joel L. Weissfeld [États-Unis] ; Marjorie Romkes [États-Unis] ; Daniel E. Weeks [États-Unis] ; Ann Marie Egloff [États-Unis]Source :
- Cancer letters [ 0304-3835 ] ; 2014.
Abstract
Url:
DOI: 10.1016/j.canlet.2014.12.008
PubMed: 25511740
PubMed Central: 4295492
Affiliations:
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PMC:4295492Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1"><italic>EGFR</italic>
polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 <italic>EGFR</italic>
single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk.</p>
<p id="P2"><italic>EGFR</italic>
intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.</p>
</div>
</front>
</TEI>
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7600053</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2780</journal-id>
<journal-id journal-id-type="nlm-ta">Cancer Lett</journal-id>
<journal-id journal-id-type="iso-abbrev">Cancer Lett.</journal-id>
<journal-title-group><journal-title>Cancer letters</journal-title>
</journal-title-group>
<issn pub-type="ppub">0304-3835</issn>
<issn pub-type="epub">1872-7980</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25511740</article-id>
<article-id pub-id-type="pmc">4295492</article-id>
<article-id pub-id-type="doi">10.1016/j.canlet.2014.12.008</article-id>
<article-id pub-id-type="manuscript">NIHMS649245</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Identification of epidermal growth factor receptor (<italic>EGFR</italic>
) genetic variants that modify risk for head and neck squamous cell carcinoma</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Fung</surname>
<given-names>Christopher</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhou</surname>
<given-names>Pei</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Joyce</surname>
<given-names>Sonali</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Trent</surname>
<given-names>Kerry</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yuan</surname>
<given-names>Jian-Min</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grandis</surname>
<given-names>Jennifer R.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weissfeld</surname>
<given-names>Joel L.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Romkes</surname>
<given-names>Marjorie</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weeks</surname>
<given-names>Daniel E.</given-names>
</name>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Egloff</surname>
<given-names>Ann Marie</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A6">f</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A2"><label>b</label>
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A3"><label>c</label>
Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A4"><label>d</label>
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A5"><label>e</label>
Department of Human Genetics and Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A6"><label>f</label>
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author. Tel.: +1 412 648 9545. <email>egloffam@upmc.edu</email>
(A.M. Egloff)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>6</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>12</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><day>28</day>
<month>2</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>28</day>
<month>2</month>
<year>2016</year>
</pub-date>
<volume>357</volume>
<issue>2</issue>
<fpage>549</fpage>
<lpage>556</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.canlet.2014.12.008</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ireland Ltd. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p id="P1"><italic>EGFR</italic>
polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 <italic>EGFR</italic>
single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk.</p>
<p id="P2"><italic>EGFR</italic>
intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.</p>
</abstract>
<kwd-group><kwd>Case–control study</kwd>
<kwd>Genetic polymorphism</kwd>
<kwd>Tobacco-independent</kwd>
<kwd>Nonsmoker</kwd>
<kwd>Head and neck cancer risk</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
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<region><li>Pennsylvanie</li>
</region>
<settlement><li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Fung, Christopher" sort="Fung, Christopher" uniqKey="Fung C" first="Christopher" last="Fung">Christopher Fung</name>
</region>
<name sortKey="Egloff, Ann Marie" sort="Egloff, Ann Marie" uniqKey="Egloff A" first="Ann Marie" last="Egloff">Ann Marie Egloff</name>
<name sortKey="Egloff, Ann Marie" sort="Egloff, Ann Marie" uniqKey="Egloff A" first="Ann Marie" last="Egloff">Ann Marie Egloff</name>
<name sortKey="Grandis, Jennifer R" sort="Grandis, Jennifer R" uniqKey="Grandis J" first="Jennifer R." last="Grandis">Jennifer R. Grandis</name>
<name sortKey="Grandis, Jennifer R" sort="Grandis, Jennifer R" uniqKey="Grandis J" first="Jennifer R." last="Grandis">Jennifer R. Grandis</name>
<name sortKey="Joyce, Sonali" sort="Joyce, Sonali" uniqKey="Joyce S" first="Sonali" last="Joyce">Sonali Joyce</name>
<name sortKey="Romkes, Marjorie" sort="Romkes, Marjorie" uniqKey="Romkes M" first="Marjorie" last="Romkes">Marjorie Romkes</name>
<name sortKey="Trent, Kerry" sort="Trent, Kerry" uniqKey="Trent K" first="Kerry" last="Trent">Kerry Trent</name>
<name sortKey="Weeks, Daniel E" sort="Weeks, Daniel E" uniqKey="Weeks D" first="Daniel E." last="Weeks">Daniel E. Weeks</name>
<name sortKey="Weissfeld, Joel L" sort="Weissfeld, Joel L" uniqKey="Weissfeld J" first="Joel L." last="Weissfeld">Joel L. Weissfeld</name>
<name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name>
<name sortKey="Zhou, Pei" sort="Zhou, Pei" uniqKey="Zhou P" first="Pei" last="Zhou">Pei Zhou</name>
</country>
</tree>
</affiliations>
</record>
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