Inhibition of mitochondrial protein import by mutant huntingtin
Identifieur interne : 000F41 ( Pmc/Checkpoint ); précédent : 000F40; suivant : 000F42Inhibition of mitochondrial protein import by mutant huntingtin
Auteurs : Hiroko Yano [États-Unis] ; Sergei V. Baranov [États-Unis] ; Oxana V. Baranova [États-Unis] ; Jinho Kim [États-Unis] ; Yanchun Pan [États-Unis] ; Svitlana Yablonska [États-Unis] ; Diane L. Carlisle [États-Unis] ; Robert J. Ferrante [États-Unis] ; Albert H. Kim [États-Unis] ; Robert M. Friedlander [États-Unis]Source :
- Nature neuroscience [ 1097-6256 ] ; 2014.
Abstract
Mitochondrial dysfunction is associated with neuronal loss in Huntington’s disease (HD), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (Htt). However, the mechanisms linking mutant Htt and mitochondrial dysfunction in HD remain unknown. We identify an interaction between mutant Htt and the TIM23 mitochondrial protein import complex. Remarkably, recombinant mutant Htt directly inhibited mitochondrial protein import
Url:
DOI: 10.1038/nn.3721
PubMed: 24836077
PubMed Central: 4174557
Affiliations:
- États-Unis
- Missouri (État), Pennsylvanie
- Pittsburgh, Saint-Louis (Missouri)
- Université de Pittsburgh, École de médecine (Université Washington de Saint-Louis)
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibition of mitochondrial protein import by mutant huntingtin</title><author><name sortKey="Yano, Hiroko" sort="Yano, Hiroko" uniqKey="Yano H" first="Hiroko" last="Yano">Hiroko Yano</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Baranov, Sergei V" sort="Baranov, Sergei V" uniqKey="Baranov S" first="Sergei V" last="Baranov">Sergei V. 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Carlisle</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Ferrante, Robert J" sort="Ferrante, Robert J" uniqKey="Ferrante R" first="Robert J" last="Ferrante">Robert J. Ferrante</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Kim, Albert H" sort="Kim, Albert H" uniqKey="Kim A" first="Albert H" last="Kim">Albert H. Kim</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Friedlander, Robert M" sort="Friedlander, Robert M" uniqKey="Friedlander R" first="Robert M" last="Friedlander">Robert M. 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Baranov</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Baranova, Oxana V" sort="Baranova, Oxana V" uniqKey="Baranova O" first="Oxana V" last="Baranova">Oxana V. Baranova</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Kim, Jinho" sort="Kim, Jinho" uniqKey="Kim J" first="Jinho" last="Kim">Jinho Kim</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Pan, Yanchun" sort="Pan, Yanchun" uniqKey="Pan Y" first="Yanchun" last="Pan">Yanchun Pan</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Yablonska, Svitlana" sort="Yablonska, Svitlana" uniqKey="Yablonska S" first="Svitlana" last="Yablonska">Svitlana Yablonska</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Carlisle, Diane L" sort="Carlisle, Diane L" uniqKey="Carlisle D" first="Diane L" last="Carlisle">Diane L. Carlisle</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Ferrante, Robert J" sort="Ferrante, Robert J" uniqKey="Ferrante R" first="Robert J" last="Ferrante">Robert J. Ferrante</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Kim, Albert H" sort="Kim, Albert H" uniqKey="Kim A" first="Albert H" last="Kim">Albert H. Kim</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Friedlander, Robert M" sort="Friedlander, Robert M" uniqKey="Friedlander R" first="Robert M" last="Friedlander">Robert M. Friedlander</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Nature neuroscience</title><idno type="ISSN">1097-6256</idno><idno type="eISSN">1546-1726</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Mitochondrial dysfunction is associated with neuronal loss in Huntington’s disease (HD), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (Htt). However, the mechanisms linking mutant Htt and mitochondrial dysfunction in HD remain unknown. We identify an interaction between mutant Htt and the TIM23 mitochondrial protein import complex. Remarkably, recombinant mutant Htt directly inhibited mitochondrial protein import <italic>in vitro</italic>. Furthermore, mitochondria from brain synaptosomes of presymptomatic HD model mice and from mutant Htt-expressing primary neurons exhibited a protein import defect, suggesting that deficient protein import is an early event in HD. The mutant Htt-induced mitochondrial import defect and subsequent neuronal death were attenuated by overexpression of TIM23 complex subunits, demonstrating that deficient mitochondrial protein import causes mutant Htt-induced neuronal death. Collectively, these findings provide evidence for a direct link between mutant Htt, mitochondrial dysfunction and neuronal pathology, with implications for mitochondrial protein import-based therapies in HD.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9809671</journal-id><journal-id journal-id-type="pubmed-jr-id">21092</journal-id><journal-id journal-id-type="nlm-ta">Nat Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Neurosci.</journal-id><journal-title-group><journal-title>Nature neuroscience</journal-title></journal-title-group><issn pub-type="ppub">1097-6256</issn><issn pub-type="epub">1546-1726</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24836077</article-id><article-id pub-id-type="pmc">4174557</article-id><article-id pub-id-type="doi">10.1038/nn.3721</article-id><article-id pub-id-type="manuscript">NIHMS614355</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Inhibition of mitochondrial protein import by mutant huntingtin</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yano</surname><given-names>Hiroko</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Baranov</surname><given-names>Sergei V</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Baranova</surname><given-names>Oxana V</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Jinho</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Yanchun</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yablonska</surname><given-names>Svitlana</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Carlisle</surname><given-names>Diane L</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ferrante</surname><given-names>Robert J</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Albert H</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Friedlander</surname><given-names>Robert M</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A6">6</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Neurological Surgery, Neuroapoptosis Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</aff><aff id="A2"><label>2</label>Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A3"><label>3</label>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A4"><label>4</label>Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A5"><label>5</label>Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A6"><label>6</label>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA</aff><author-notes><corresp id="cor1">Correspondence should be addressed to R.M.F. (<email>friedlanderr@upmc.edu</email>)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>19</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>18</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>9</month><year>2014</year></pub-date><volume>17</volume><issue>6</issue><fpage>822</fpage><lpage>831</lpage><pmc-comment>elocation-id from pubmed: 10.1038/nn.3721</pmc-comment>
<permissions><copyright-statement>© 2014 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P1">Mitochondrial dysfunction is associated with neuronal loss in Huntington’s disease (HD), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (Htt). However, the mechanisms linking mutant Htt and mitochondrial dysfunction in HD remain unknown. We identify an interaction between mutant Htt and the TIM23 mitochondrial protein import complex. Remarkably, recombinant mutant Htt directly inhibited mitochondrial protein import <italic>in vitro</italic>. Furthermore, mitochondria from brain synaptosomes of presymptomatic HD model mice and from mutant Htt-expressing primary neurons exhibited a protein import defect, suggesting that deficient protein import is an early event in HD. The mutant Htt-induced mitochondrial import defect and subsequent neuronal death were attenuated by overexpression of TIM23 complex subunits, demonstrating that deficient mitochondrial protein import causes mutant Htt-induced neuronal death. Collectively, these findings provide evidence for a direct link between mutant Htt, mitochondrial dysfunction and neuronal pathology, with implications for mitochondrial protein import-based therapies in HD.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Missouri (État)</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li><li>Saint-Louis (Missouri)</li></settlement><orgName><li>Université de Pittsburgh</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Yano, Hiroko" sort="Yano, Hiroko" uniqKey="Yano H" first="Hiroko" last="Yano">Hiroko Yano</name></region><name sortKey="Baranov, Sergei V" sort="Baranov, Sergei V" uniqKey="Baranov S" first="Sergei V" last="Baranov">Sergei V. Baranov</name><name sortKey="Baranova, Oxana V" sort="Baranova, Oxana V" uniqKey="Baranova O" first="Oxana V" last="Baranova">Oxana V. Baranova</name><name sortKey="Carlisle, Diane L" sort="Carlisle, Diane L" uniqKey="Carlisle D" first="Diane L" last="Carlisle">Diane L. Carlisle</name><name sortKey="Ferrante, Robert J" sort="Ferrante, Robert J" uniqKey="Ferrante R" first="Robert J" last="Ferrante">Robert J. Ferrante</name><name sortKey="Friedlander, Robert M" sort="Friedlander, Robert M" uniqKey="Friedlander R" first="Robert M" last="Friedlander">Robert M. Friedlander</name><name sortKey="Friedlander, Robert M" sort="Friedlander, Robert M" uniqKey="Friedlander R" first="Robert M" last="Friedlander">Robert M. Friedlander</name><name sortKey="Kim, Albert H" sort="Kim, Albert H" uniqKey="Kim A" first="Albert H" last="Kim">Albert H. Kim</name><name sortKey="Kim, Albert H" sort="Kim, Albert H" uniqKey="Kim A" first="Albert H" last="Kim">Albert H. Kim</name><name sortKey="Kim, Albert H" sort="Kim, Albert H" uniqKey="Kim A" first="Albert H" last="Kim">Albert H. Kim</name><name sortKey="Kim, Jinho" sort="Kim, Jinho" uniqKey="Kim J" first="Jinho" last="Kim">Jinho Kim</name><name sortKey="Pan, Yanchun" sort="Pan, Yanchun" uniqKey="Pan Y" first="Yanchun" last="Pan">Yanchun Pan</name><name sortKey="Yablonska, Svitlana" sort="Yablonska, Svitlana" uniqKey="Yablonska S" first="Svitlana" last="Yablonska">Svitlana Yablonska</name><name sortKey="Yano, Hiroko" sort="Yano, Hiroko" uniqKey="Yano H" first="Hiroko" last="Yano">Hiroko Yano</name><name sortKey="Yano, Hiroko" sort="Yano, Hiroko" uniqKey="Yano H" first="Hiroko" last="Yano">Hiroko Yano</name><name sortKey="Yano, Hiroko" sort="Yano, Hiroko" uniqKey="Yano H" first="Hiroko" last="Yano">Hiroko Yano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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