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Objective Measures of Activity Level and Mortality in Older Men

Identifieur interne : 000B32 ( Pmc/Checkpoint ); précédent : 000B31; suivant : 000B33

Objective Measures of Activity Level and Mortality in Older Men

Auteurs : Kristine E. Ensrud [États-Unis] ; Terri L. Blackwell [États-Unis] ; Jane A. Cauley [États-Unis] ; Thuy-Tien L. Dam [États-Unis] ; Peggy M. Cawthon [États-Unis] ; John T. Schousboe [États-Unis] ; Elizabeth Barrett-Connor [États-Unis] ; Katie L. Stone [États-Unis] ; Douglas C. Bauer [États-Unis] ; James M. Shikany [États-Unis] ; Dawn C. Mackey [États-Unis, Canada]

Source :

RBID : PMC:4241172

Abstract

Objectives

Associations of objectively measured activity across the full range of levels with mortality in the aged population are uncertain. This study examines associations of objective measures of activity level with mortality risk in older men.

Design

Prospective cohort study

Setting

Six U.S. sites

Participants

2918 men age ≥71 years followed an average of 4.5 years

Measurements

Time awake spent in sedentary behavior (MET level ≤1.50), light activity (MET level 1.51–2.99) and at least moderate activity (MET level ≥3.00) measured using an activity monitor (SenseWearPro armband worn ≥5 days) and expressed as quartiles (Q). Deaths confirmed with death certificates; cause of death adjudicated by review of certificates and records.

Results

During follow-up, 409 (14%) men died. After multivariable adjustment, greater time spent in sedentary behavior (hazard ratio [HR] Q4 vs. Q1 1.51 [95% CI, 1.10–2.08]), less time spent in light activity (HR Q1 vs. Q4 1.54 [95% CI, 1.06–2.24]), and less time spent in at least moderate activity (HR Q1 vs. Q4 1.56 [95% CI, 1.09–2.25]), were similarly associated with increased mortality risk primarily due to higher risks of cardiovascular and non-cardiovascular, non-cancer death. The association of time spent in sedentary behavior with mortality varied by time spent at higher activity level. Greater time spent in sedentary behavior was associated with an increased risk of death among men spending ≥1.2 (median) hours/day in at least moderate activity (HR Q4 vs. Q1 2.09 [95% CI, 1.26–3.49]), but not among those spending less time (HR Q4 vs. Q1 1.02 [95% CI, 0.62–1.66]) (p=0.005 for interaction).

Conclusion

In older men exceeding current guidelines on physical activity, greater time spent in sedentary behavior is associated with increased mortality risk.


Url:
DOI: 10.1111/jgs.13101
PubMed: 25367147
PubMed Central: 4241172


Affiliations:

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PMC:4241172

Le document en format XML

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<title>Objectives</title>
<p id="P1">Associations of objectively measured activity across the full range of levels with mortality in the aged population are uncertain. This study examines associations of objective measures of activity level with mortality risk in older men.</p>
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<sec id="S2">
<title>Design</title>
<p id="P2">Prospective cohort study</p>
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<sec id="S3">
<title>Setting</title>
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<p id="P4">2918 men age ≥71 years followed an average of 4.5 years</p>
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<p id="P5">Time awake spent in sedentary behavior (MET level ≤1.50), light activity (MET level 1.51–2.99) and at least moderate activity (MET level ≥3.00) measured using an activity monitor (SenseWearPro armband worn ≥5 days) and expressed as quartiles (Q). Deaths confirmed with death certificates; cause of death adjudicated by review of certificates and records.</p>
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<p id="P6">During follow-up, 409 (14%) men died. After multivariable adjustment, greater time spent in sedentary behavior (hazard ratio [HR] Q4 vs. Q1 1.51 [95% CI, 1.10–2.08]), less time spent in light activity (HR Q1 vs. Q4 1.54 [95% CI, 1.06–2.24]), and less time spent in at least moderate activity (HR Q1 vs. Q4 1.56 [95% CI, 1.09–2.25]), were similarly associated with increased mortality risk primarily due to higher risks of cardiovascular and non-cardiovascular, non-cancer death. The association of time spent in sedentary behavior with mortality varied by time spent at higher activity level. Greater time spent in sedentary behavior was associated with an increased risk of death among men spending ≥1.2 (median) hours/day in at least moderate activity (HR Q4 vs. Q1 2.09 [95% CI, 1.26–3.49]), but not among those spending less time (HR Q4 vs. Q1 1.02 [95% CI, 0.62–1.66]) (p=0.005 for interaction).</p>
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<p id="P7">In older men exceeding current guidelines on physical activity, greater time spent in sedentary behavior is associated with increased mortality risk.</p>
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<name>
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<given-names>Kristine E.</given-names>
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<given-names>Terri L.</given-names>
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<degrees>MD</degrees>
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<name>
<surname>Cawthon</surname>
<given-names>Peggy M.</given-names>
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<degrees>PhD</degrees>
<xref ref-type="aff" rid="A3">c</xref>
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<name>
<surname>Schousboe</surname>
<given-names>John T.</given-names>
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<degrees>MD, PhD</degrees>
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<given-names>Elizabeth</given-names>
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<degrees>MD</degrees>
<xref ref-type="aff" rid="A8">h</xref>
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<contrib contrib-type="author">
<name>
<surname>Stone</surname>
<given-names>Katie L.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bauer</surname>
<given-names>Douglas C.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A9">i</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Shikany</surname>
<given-names>James M.</given-names>
</name>
<degrees>DrPH</degrees>
<xref ref-type="aff" rid="A10">j</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mackey</surname>
<given-names>Dawn C.</given-names>
</name>
<degrees>PhD, MSc</degrees>
<xref ref-type="aff" rid="A3">c</xref>
<xref ref-type="aff" rid="A11">k</xref>
</contrib>
<on-behalf-of>for the Osteoporotic Fractures in Men (MrOS) Study Group</on-behalf-of>
</contrib-group>
<aff id="A1">
<label>a</label>
Department of Medicine and Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN</aff>
<aff id="A2">
<label>b</label>
Center for Chronic Disease Outcomes Research, VA Health Care System, Minneapolis, MN</aff>
<aff id="A3">
<label>c</label>
Research Institute, California Pacific Medical Center, San Francisco, CA</aff>
<aff id="A4">
<label>d</label>
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</aff>
<aff id="A5">
<label>e</label>
Department of Medicine, Columbia University, New York, NY</aff>
<aff id="A6">
<label>f</label>
Park Nicollet Clinic, St. Louis Park, MN</aff>
<aff id="A7">
<label>g</label>
Division of Health Policy & Management, University of Minnesota, Minneapolis, MN</aff>
<aff id="A8">
<label>h</label>
Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, CA</aff>
<aff id="A9">
<label>i</label>
Department of Medicine, University of California at San Francisco, San Francisco, CA</aff>
<aff id="A10">
<label>j</label>
Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL</aff>
<aff id="A11">
<label>k</label>
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada</aff>
<author-notes>
<corresp id="FN1">Corresponding Author: Kristine E. Ensrud, MD, MPH, One Veterans Drive (111-0), Minneapolis, MN 55417, Phone: 612-467-5841; Fax: 612-467-2284,
<email>ensru001@umn.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>19</day>
<month>8</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>03</day>
<month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub">
<month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>03</day>
<month>11</month>
<year>2015</year>
</pub-date>
<volume>62</volume>
<issue>11</issue>
<fpage>2079</fpage>
<lpage>2087</lpage>
<pmc-comment>elocation-id from pubmed: 10.1111/jgs.13101</pmc-comment>
<abstract>
<sec id="S1">
<title>Objectives</title>
<p id="P1">Associations of objectively measured activity across the full range of levels with mortality in the aged population are uncertain. This study examines associations of objective measures of activity level with mortality risk in older men.</p>
</sec>
<sec id="S2">
<title>Design</title>
<p id="P2">Prospective cohort study</p>
</sec>
<sec id="S3">
<title>Setting</title>
<p id="P3">Six U.S. sites</p>
</sec>
<sec id="S4">
<title>Participants</title>
<p id="P4">2918 men age ≥71 years followed an average of 4.5 years</p>
</sec>
<sec id="S5">
<title>Measurements</title>
<p id="P5">Time awake spent in sedentary behavior (MET level ≤1.50), light activity (MET level 1.51–2.99) and at least moderate activity (MET level ≥3.00) measured using an activity monitor (SenseWearPro armband worn ≥5 days) and expressed as quartiles (Q). Deaths confirmed with death certificates; cause of death adjudicated by review of certificates and records.</p>
</sec>
<sec id="S6">
<title>Results</title>
<p id="P6">During follow-up, 409 (14%) men died. After multivariable adjustment, greater time spent in sedentary behavior (hazard ratio [HR] Q4 vs. Q1 1.51 [95% CI, 1.10–2.08]), less time spent in light activity (HR Q1 vs. Q4 1.54 [95% CI, 1.06–2.24]), and less time spent in at least moderate activity (HR Q1 vs. Q4 1.56 [95% CI, 1.09–2.25]), were similarly associated with increased mortality risk primarily due to higher risks of cardiovascular and non-cardiovascular, non-cancer death. The association of time spent in sedentary behavior with mortality varied by time spent at higher activity level. Greater time spent in sedentary behavior was associated with an increased risk of death among men spending ≥1.2 (median) hours/day in at least moderate activity (HR Q4 vs. Q1 2.09 [95% CI, 1.26–3.49]), but not among those spending less time (HR Q4 vs. Q1 1.02 [95% CI, 0.62–1.66]) (p=0.005 for interaction).</p>
</sec>
<sec id="S7">
<title>Conclusion</title>
<p id="P7">In older men exceeding current guidelines on physical activity, greater time spent in sedentary behavior is associated with increased mortality risk.</p>
</sec>
</abstract>
<kwd-group>
<kwd>physical activity</kwd>
<kwd>mortality</kwd>
<kwd>aging</kwd>
<kwd>men</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations>
<list>
<country>
<li>Canada</li>
<li>États-Unis</li>
</country>
<region>
<li>Alabama</li>
<li>Californie</li>
<li>Minnesota</li>
<li>Pennsylvanie</li>
<li>État de New York</li>
</region>
</list>
<tree>
<country name="États-Unis">
<region name="Minnesota">
<name sortKey="Ensrud, Kristine E" sort="Ensrud, Kristine E" uniqKey="Ensrud K" first="Kristine E." last="Ensrud">Kristine E. Ensrud</name>
</region>
<name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name>
<name sortKey="Bauer, Douglas C" sort="Bauer, Douglas C" uniqKey="Bauer D" first="Douglas C." last="Bauer">Douglas C. Bauer</name>
<name sortKey="Blackwell, Terri L" sort="Blackwell, Terri L" uniqKey="Blackwell T" first="Terri L." last="Blackwell">Terri L. Blackwell</name>
<name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name>
<name sortKey="Cawthon, Peggy M" sort="Cawthon, Peggy M" uniqKey="Cawthon P" first="Peggy M." last="Cawthon">Peggy M. Cawthon</name>
<name sortKey="Dam, Thuy Tien L" sort="Dam, Thuy Tien L" uniqKey="Dam T" first="Thuy-Tien L." last="Dam">Thuy-Tien L. Dam</name>
<name sortKey="Ensrud, Kristine E" sort="Ensrud, Kristine E" uniqKey="Ensrud K" first="Kristine E." last="Ensrud">Kristine E. Ensrud</name>
<name sortKey="Mackey, Dawn C" sort="Mackey, Dawn C" uniqKey="Mackey D" first="Dawn C." last="Mackey">Dawn C. Mackey</name>
<name sortKey="Schousboe, John T" sort="Schousboe, John T" uniqKey="Schousboe J" first="John T." last="Schousboe">John T. Schousboe</name>
<name sortKey="Schousboe, John T" sort="Schousboe, John T" uniqKey="Schousboe J" first="John T." last="Schousboe">John T. Schousboe</name>
<name sortKey="Shikany, James M" sort="Shikany, James M" uniqKey="Shikany J" first="James M." last="Shikany">James M. Shikany</name>
<name sortKey="Stone, Katie L" sort="Stone, Katie L" uniqKey="Stone K" first="Katie L." last="Stone">Katie L. Stone</name>
</country>
<country name="Canada">
<noRegion>
<name sortKey="Mackey, Dawn C" sort="Mackey, Dawn C" uniqKey="Mackey D" first="Dawn C." last="Mackey">Dawn C. Mackey</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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