PittsburghV1, Pmc, Checkpoint, bibRecord, 000A78

PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN

Identifieur interne : 000A78 ( Pmc/Checkpoint ); précédent : 000A77; suivant : 000A79

PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN

Auteurs : Sarah Jane Schwarzenberg [États-Unis] ; Melena Bellin [États-Unis] ; Sohail Z. Husain [États-Unis] ; Monika Ahuja [États-Unis] ; Bradley Barth [États-Unis] ; Heather Davis [États-Unis] ; Peter R. Durie [Canada] ; Douglas S. Fishman [États-Unis] ; Steven D. Freedman [États-Unis] ; Cheryl E. Gariepy [États-Unis] ; Matthew J. Giefer [États-Unis] ; Tanja Gonska [Canada] ; Melvin B. Heyman [États-Unis] ; Ryan Himes [États-Unis] ; Soma Kumar [États-Unis] ; Veronique D. Morinville [Canada] ; Mark E. Lowe [États-Unis] ; Neil E. Nuehring [États-Unis] ; Chee Y. Ooi [Australie] ; John F. Pohl [États-Unis] ; David Troendle [États-Unis] ; Steven L. Werlin [États-Unis] ; Michael Wilschanski [Israël] ; Elizabeth Yen [États-Unis] ; Aliye Uc [États-Unis]

Source :

The Journal of pediatrics [ 0022-3476 ] ; 2014.

RBID : PMC:4380827

Abstract

Objective

To determine the clinical presentation, diagnostic variables, risk factors and disease burden in children with chronic pancreatitis.

Study design

We performed a cross-sectional study of data from INSPPIRE (International Study Group of Pediatric Pancreatitis: In search for a cuRE), a registry of children with acute recurrent pancreatitis and chronic pancreatitis. Between-group differences were compared using Wilcoxon rank-sum test.

Results

Among 170 subjects in the registry, 76 (45%) had chronic pancreatitis; 57% were female, 80% were Caucasian, median age at diagnosis was 9.9 years. Pancreatitis-predisposing genetic mutations were identified in 51 (67%) and obstructive risk factors in 25 (33%). Toxic/metabolic and autoimmune factors were uncommon. Imaging demonstrated ductal abnormalities and pancreatic atrophy more commonly than calcifications. Fifty-nine (77%) reported abdominal pain within the past year; pain was reported as constant and receiving narcotics in 28%. Children with chronic pancreatitis reported a median of 3 emergency room visits and 2 hospitalizations in the last year. Forty-seven subjects (70%) missed one day of school in the past month due to chronic pancreatitis; 26 (34%) missed 3 or more days. Children reporting constant pain were more likely to miss school (p=0.002), visit emergency room (p=0.01) and experience hospitalizations (p=0.03) compared with children with episodic pain. Thirty-three children (43%) underwent therapeutic ERCP; one or more pancreatic surgeries were performed in 30 (39%).

Conclusions

Chronic pancreatitis occurs at a young age with distinct clinical features. Genetic and obstructive risk factors are common, and disease burden is substantial.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380827

DOI: 10.1016/j.jpeds.2014.11.019
PubMed: 25556020
PubMed Central: 4380827

Affiliations:

Australie, Canada, Israël, États-Unis
Californie, Iowa, Massachusetts, Minnesota, Ohio, Pennsylvanie, Québec, Texas, Utah, Washington (État), Wisconsin
Montréal
Université McGill

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PMC:4380827

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN</title>
<author><name sortKey="Schwarzenberg, Sarah Jane" sort="Schwarzenberg, Sarah Jane" uniqKey="Schwarzenberg S" first="Sarah Jane" last="Schwarzenberg">Sarah Jane Schwarzenberg</name>
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<author><name sortKey="Bellin, Melena" sort="Bellin, Melena" uniqKey="Bellin M" first="Melena" last="Bellin">Melena Bellin</name>
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<author><name sortKey="Husain, Sohail Z" sort="Husain, Sohail Z" uniqKey="Husain S" first="Sohail Z." last="Husain">Sohail Z. Husain</name>
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<author><name sortKey="Ahuja, Monika" sort="Ahuja, Monika" uniqKey="Ahuja M" first="Monika" last="Ahuja">Monika Ahuja</name>
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<author><name sortKey="Barth, Bradley" sort="Barth, Bradley" uniqKey="Barth B" first="Bradley" last="Barth">Bradley Barth</name>
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<author><name sortKey="Davis, Heather" sort="Davis, Heather" uniqKey="Davis H" first="Heather" last="Davis">Heather Davis</name>
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<author><name sortKey="Durie, Peter R" sort="Durie, Peter R" uniqKey="Durie P" first="Peter R." last="Durie">Peter R. Durie</name>
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<author><name sortKey="Freedman, Steven D" sort="Freedman, Steven D" uniqKey="Freedman S" first="Steven D." last="Freedman">Steven D. Freedman</name>
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<author><name sortKey="Gariepy, Cheryl E" sort="Gariepy, Cheryl E" uniqKey="Gariepy C" first="Cheryl E." last="Gariepy">Cheryl E. Gariepy</name>
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<wicri:regionArea>Nationwide Children’s Hospital, Columbus, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
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<author><name sortKey="Giefer, Matthew J" sort="Giefer, Matthew J" uniqKey="Giefer M" first="Matthew J." last="Giefer">Matthew J. Giefer</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Seattle Children’s Hospital, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle Children’s Hospital, Seattle, WA</wicri:regionArea>
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<author><name sortKey="Gonska, Tanja" sort="Gonska, Tanja" uniqKey="Gonska T" first="Tanja" last="Gonska">Tanja Gonska</name>
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<wicri:noRegion>ON</wicri:noRegion>
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<author><name sortKey="Heyman, Melvin B" sort="Heyman, Melvin B" uniqKey="Heyman M" first="Melvin B." last="Heyman">Melvin B. Heyman</name>
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<wicri:regionArea>University of California at San Francisco, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
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<author><name sortKey="Himes, Ryan" sort="Himes, Ryan" uniqKey="Himes R" first="Ryan" last="Himes">Ryan Himes</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Baylor College of Medicine, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumar, Soma" sort="Kumar, Soma" uniqKey="Kumar S" first="Soma" last="Kumar">Soma Kumar</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Nationwide Children’s Hospital, Columbus, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Nationwide Children’s Hospital, Columbus, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morinville, Veronique D" sort="Morinville, Veronique D" uniqKey="Morinville V" first="Veronique D." last="Morinville">Veronique D. Morinville</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Montreal Children’s Hospital, McGill University, Montreal, QC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montreal Children’s Hospital, McGill University, Montreal, QC</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lowe, Mark E" sort="Lowe, Mark E" uniqKey="Lowe M" first="Mark E." last="Lowe">Mark E. Lowe</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Children’s Hospital of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nuehring, Neil E" sort="Nuehring, Neil E" uniqKey="Nuehring N" first="Neil E." last="Nuehring">Neil E. Nuehring</name>
<affiliation wicri:level="2"><nlm:aff id="A3">University of Iowa Carver College of Medicine, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ooi, Chee Y" sort="Ooi, Chee Y" uniqKey="Ooi C" first="Chee Y." last="Ooi">Chee Y. Ooi</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Discipline of Paediatrics, School of Women’s and Children’s Health, Medicine, University of New South Wales and Sydney Children’s Hospital Randwick Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Paediatrics, School of Women’s and Children’s Health, Medicine, University of New South Wales and Sydney Children’s Hospital Randwick Sydney</wicri:regionArea>
<wicri:noRegion>University of New South Wales and Sydney Children’s Hospital Randwick Sydney</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pohl, John F" sort="Pohl, John F" uniqKey="Pohl J" first="John F." last="Pohl">John F. Pohl</name>
<affiliation wicri:level="2"><nlm:aff id="A13">University of Utah, Salt Lake City, UT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Utah, Salt Lake City, UT</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Troendle, David" sort="Troendle, David" uniqKey="Troendle D" first="David" last="Troendle">David Troendle</name>
<affiliation wicri:level="2"><nlm:aff id="A4">University of Texas Southwestern Medical School, Dallas, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Texas Southwestern Medical School, Dallas, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Werlin, Steven L" sort="Werlin, Steven L" uniqKey="Werlin S" first="Steven L." last="Werlin">Steven L. Werlin</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Medical College of Wisconsin, Milwaukee, WI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilschanski, Michael" sort="Wilschanski, Michael" uniqKey="Wilschanski M" first="Michael" last="Wilschanski">Michael Wilschanski</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Hadassah Hebrew University Hospital, Jerusalem, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Hadassah Hebrew University Hospital, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yen, Elizabeth" sort="Yen, Elizabeth" uniqKey="Yen E" first="Elizabeth" last="Yen">Elizabeth Yen</name>
<affiliation wicri:level="2"><nlm:aff id="A10">University of California at San Francisco, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California at San Francisco, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uc, Aliye" sort="Uc, Aliye" uniqKey="Uc A" first="Aliye" last="Uc">Aliye Uc</name>
<affiliation wicri:level="2"><nlm:aff id="A3">University of Iowa Carver College of Medicine, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of pediatrics</title>
<idno type="ISSN">0022-3476</idno>
<idno type="eISSN">1097-6833</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To determine the clinical presentation, diagnostic variables, risk factors and disease burden in children with chronic pancreatitis.</p>
</sec>
<sec id="S2"><title>Study design</title>
<p id="P2">We performed a cross-sectional study of data from INSPPIRE (<bold><underline>In</underline>
</bold>
ternational <bold><underline>S</underline>
</bold>
tudy Group of <bold><underline>P</underline>
</bold>
ediatric <bold><underline>P</underline>
</bold>
ancreatitis: <bold><underline>I</underline>
</bold>
n search for a cu<bold><underline>RE</underline>
</bold>
), a registry of children with acute recurrent pancreatitis and chronic pancreatitis. Between-group differences were compared using Wilcoxon rank-sum test.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among 170 subjects in the registry, 76 (45%) had chronic pancreatitis; 57% were female, 80% were Caucasian, median age at diagnosis was 9.9 years. Pancreatitis-predisposing genetic mutations were identified in 51 (67%) and obstructive risk factors in 25 (33%). Toxic/metabolic and autoimmune factors were uncommon. Imaging demonstrated ductal abnormalities and pancreatic atrophy more commonly than calcifications. Fifty-nine (77%) reported abdominal pain within the past year; pain was reported as constant and receiving narcotics in 28%. Children with chronic pancreatitis reported a median of 3 emergency room visits and 2 hospitalizations in the last year. Forty-seven subjects (70%) missed one day of school in the past month due to chronic pancreatitis; 26 (34%) missed 3 or more days. Children reporting constant pain were more likely to miss school (p=0.002), visit emergency room (p=0.01) and experience hospitalizations (p=0.03) compared with children with episodic pain. Thirty-three children (43%) underwent therapeutic ERCP; one or more pancreatic surgeries were performed in 30 (39%).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Chronic pancreatitis occurs at a young age with distinct clinical features. Genetic and obstructive risk factors are common, and disease burden is substantial.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0375410</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5127</journal-id>
<journal-id journal-id-type="nlm-ta">J Pediatr</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Pediatr.</journal-id>
<journal-title-group><journal-title>The Journal of pediatrics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-3476</issn>
<issn pub-type="epub">1097-6833</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25556020</article-id>
<article-id pub-id-type="pmc">4380827</article-id>
<article-id pub-id-type="doi">10.1016/j.jpeds.2014.11.019</article-id>
<article-id pub-id-type="manuscript">NIHMS642580</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Schwarzenberg</surname>
<given-names>Sarah Jane</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Bellin</surname>
<given-names>Melena</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Husain</surname>
<given-names>Sohail Z.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ahuja</surname>
<given-names>Monika</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barth</surname>
<given-names>Bradley</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Davis</surname>
<given-names>Heather</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Durie</surname>
<given-names>Peter R.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fishman</surname>
<given-names>Douglas S.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Freedman</surname>
<given-names>Steven D.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gariepy</surname>
<given-names>Cheryl E.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giefer</surname>
<given-names>Matthew J.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gonska</surname>
<given-names>Tanja</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heyman</surname>
<given-names>Melvin B.</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Himes</surname>
<given-names>Ryan</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumar</surname>
<given-names>Soma</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Morinville</surname>
<given-names>Veronique D.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lowe</surname>
<given-names>Mark E.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nuehring</surname>
<given-names>Neil E.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ooi</surname>
<given-names>Chee Y.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pohl</surname>
<given-names>John F.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Troendle</surname>
<given-names>David</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Werlin</surname>
<given-names>Steven L.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilschanski</surname>
<given-names>Michael</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yen</surname>
<given-names>Elizabeth</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Uc</surname>
<given-names>Aliye</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
University of Minnesota Children’s Hospital, Minneapolis, Minnesota, USA</aff>
<aff id="A2"><label>2</label>
Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A3"><label>3</label>
University of Iowa Carver College of Medicine, Iowa City, IA, USA</aff>
<aff id="A4"><label>4</label>
University of Texas Southwestern Medical School, Dallas, TX, USA</aff>
<aff id="A5"><label>5</label>
Hospital for Sick Children, Toronto, ON, Canada</aff>
<aff id="A6"><label>6</label>
Baylor College of Medicine, Houston, TX, USA</aff>
<aff id="A7"><label>7</label>
Harvard Medical School, Boston, MA, USA</aff>
<aff id="A8"><label>8</label>
Nationwide Children’s Hospital, Columbus, OH, USA</aff>
<aff id="A9"><label>9</label>
Seattle Children’s Hospital, Seattle, WA, USA</aff>
<aff id="A10"><label>10</label>
University of California at San Francisco, San Francisco, CA, USA</aff>
<aff id="A11"><label>11</label>
Montreal Children’s Hospital, McGill University, Montreal, QC, Canada</aff>
<aff id="A12"><label>12</label>
Discipline of Paediatrics, School of Women’s and Children’s Health, Medicine, University of New South Wales and Sydney Children’s Hospital Randwick Sydney, Australia</aff>
<aff id="A13"><label>13</label>
University of Utah, Salt Lake City, UT, USA</aff>
<aff id="A14"><label>14</label>
Medical College of Wisconsin, Milwaukee, WI, USA</aff>
<aff id="A15"><label>15</label>
Hadassah Hebrew University Hospital, Jerusalem, Israel</aff>
<author-notes><corresp id="CR1"><bold>Corresponding author:</bold>
 Aliye Uc, M.D., 2865 JPP Stead Family Department of Pediatrics, The University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242; Tel: (319) 384-6032; Fax:(319) 353-8967; <email>aliye-uc@uiowa.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>18</day>
<month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>30</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>4</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>4</month>
<year>2016</year>
</pub-date>
<volume>166</volume>
<issue>4</issue>
<fpage>890</fpage>
<lpage>896.e1</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.jpeds.2014.11.019</pmc-comment>
      <permissions><copyright-statement>© 2014 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Objective</title>
<p id="P1">To determine the clinical presentation, diagnostic variables, risk factors and disease burden in children with chronic pancreatitis.</p>
</sec>
<sec id="S2"><title>Study design</title>
<p id="P2">We performed a cross-sectional study of data from INSPPIRE (<bold><underline>In</underline>
</bold>
ternational <bold><underline>S</underline>
</bold>
tudy Group of <bold><underline>P</underline>
</bold>
ediatric <bold><underline>P</underline>
</bold>
ancreatitis: <bold><underline>I</underline>
</bold>
n search for a cu<bold><underline>RE</underline>
</bold>
), a registry of children with acute recurrent pancreatitis and chronic pancreatitis. Between-group differences were compared using Wilcoxon rank-sum test.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among 170 subjects in the registry, 76 (45%) had chronic pancreatitis; 57% were female, 80% were Caucasian, median age at diagnosis was 9.9 years. Pancreatitis-predisposing genetic mutations were identified in 51 (67%) and obstructive risk factors in 25 (33%). Toxic/metabolic and autoimmune factors were uncommon. Imaging demonstrated ductal abnormalities and pancreatic atrophy more commonly than calcifications. Fifty-nine (77%) reported abdominal pain within the past year; pain was reported as constant and receiving narcotics in 28%. Children with chronic pancreatitis reported a median of 3 emergency room visits and 2 hospitalizations in the last year. Forty-seven subjects (70%) missed one day of school in the past month due to chronic pancreatitis; 26 (34%) missed 3 or more days. Children reporting constant pain were more likely to miss school (p=0.002), visit emergency room (p=0.01) and experience hospitalizations (p=0.03) compared with children with episodic pain. Thirty-three children (43%) underwent therapeutic ERCP; one or more pancreatic surgeries were performed in 30 (39%).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Chronic pancreatitis occurs at a young age with distinct clinical features. Genetic and obstructive risk factors are common, and disease burden is substantial.</p>
</sec>
</abstract>
<kwd-group><kwd>abdominal pain</kwd>
<kwd>quality of life</kwd>
<kwd>pediatric gastroenterology</kwd>
<kwd>genetics</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>Israël</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Iowa</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Ohio</li>
<li>Pennsylvanie</li>
<li>Québec</li>
<li>Texas</li>
<li>Utah</li>
<li>Washington (État)</li>
<li>Wisconsin</li>
</region>
<settlement><li>Montréal</li>
</settlement>
<orgName><li>Université McGill</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Schwarzenberg, Sarah Jane" sort="Schwarzenberg, Sarah Jane" uniqKey="Schwarzenberg S" first="Sarah Jane" last="Schwarzenberg">Sarah Jane Schwarzenberg</name>
</region>
<name sortKey="Ahuja, Monika" sort="Ahuja, Monika" uniqKey="Ahuja M" first="Monika" last="Ahuja">Monika Ahuja</name>
<name sortKey="Barth, Bradley" sort="Barth, Bradley" uniqKey="Barth B" first="Bradley" last="Barth">Bradley Barth</name>
<name sortKey="Bellin, Melena" sort="Bellin, Melena" uniqKey="Bellin M" first="Melena" last="Bellin">Melena Bellin</name>
<name sortKey="Davis, Heather" sort="Davis, Heather" uniqKey="Davis H" first="Heather" last="Davis">Heather Davis</name>
<name sortKey="Fishman, Douglas S" sort="Fishman, Douglas S" uniqKey="Fishman D" first="Douglas S." last="Fishman">Douglas S. Fishman</name>
<name sortKey="Freedman, Steven D" sort="Freedman, Steven D" uniqKey="Freedman S" first="Steven D." last="Freedman">Steven D. Freedman</name>
<name sortKey="Gariepy, Cheryl E" sort="Gariepy, Cheryl E" uniqKey="Gariepy C" first="Cheryl E." last="Gariepy">Cheryl E. Gariepy</name>
<name sortKey="Giefer, Matthew J" sort="Giefer, Matthew J" uniqKey="Giefer M" first="Matthew J." last="Giefer">Matthew J. Giefer</name>
<name sortKey="Heyman, Melvin B" sort="Heyman, Melvin B" uniqKey="Heyman M" first="Melvin B." last="Heyman">Melvin B. Heyman</name>
<name sortKey="Himes, Ryan" sort="Himes, Ryan" uniqKey="Himes R" first="Ryan" last="Himes">Ryan Himes</name>
<name sortKey="Husain, Sohail Z" sort="Husain, Sohail Z" uniqKey="Husain S" first="Sohail Z." last="Husain">Sohail Z. Husain</name>
<name sortKey="Kumar, Soma" sort="Kumar, Soma" uniqKey="Kumar S" first="Soma" last="Kumar">Soma Kumar</name>
<name sortKey="Lowe, Mark E" sort="Lowe, Mark E" uniqKey="Lowe M" first="Mark E." last="Lowe">Mark E. Lowe</name>
<name sortKey="Nuehring, Neil E" sort="Nuehring, Neil E" uniqKey="Nuehring N" first="Neil E." last="Nuehring">Neil E. Nuehring</name>
<name sortKey="Pohl, John F" sort="Pohl, John F" uniqKey="Pohl J" first="John F." last="Pohl">John F. Pohl</name>
<name sortKey="Troendle, David" sort="Troendle, David" uniqKey="Troendle D" first="David" last="Troendle">David Troendle</name>
<name sortKey="Uc, Aliye" sort="Uc, Aliye" uniqKey="Uc A" first="Aliye" last="Uc">Aliye Uc</name>
<name sortKey="Werlin, Steven L" sort="Werlin, Steven L" uniqKey="Werlin S" first="Steven L." last="Werlin">Steven L. Werlin</name>
<name sortKey="Yen, Elizabeth" sort="Yen, Elizabeth" uniqKey="Yen E" first="Elizabeth" last="Yen">Elizabeth Yen</name>
</country>
<country name="Canada"><noRegion><name sortKey="Durie, Peter R" sort="Durie, Peter R" uniqKey="Durie P" first="Peter R." last="Durie">Peter R. Durie</name>
</noRegion>
<name sortKey="Gonska, Tanja" sort="Gonska, Tanja" uniqKey="Gonska T" first="Tanja" last="Gonska">Tanja Gonska</name>
<name sortKey="Morinville, Veronique D" sort="Morinville, Veronique D" uniqKey="Morinville V" first="Veronique D." last="Morinville">Veronique D. Morinville</name>
</country>
<country name="Australie"><noRegion><name sortKey="Ooi, Chee Y" sort="Ooi, Chee Y" uniqKey="Ooi C" first="Chee Y." last="Ooi">Chee Y. Ooi</name>
</noRegion>
</country>
<country name="Israël"><noRegion><name sortKey="Wilschanski, Michael" sort="Wilschanski, Michael" uniqKey="Wilschanski M" first="Michael" last="Wilschanski">Michael Wilschanski</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Pmc/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A78 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000A78 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Pmc
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:4380827
   |texte=   PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i   -Sk "pubmed:25556020" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur Pittsburgh

PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN

PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki