The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury
Identifieur interne : 000266 ( Pmc/Checkpoint ); précédent : 000265; suivant : 000267The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury
Auteurs : Neil C. Lax ; David C. George ; Christopher Ignatz ; Benedict J. KolberSource :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Antagonists of metabotropic glutamate receptors (mGluRs) have the potential to act as analgesic drugs that may help alleviate chronic pain. This study was done to look at the possible rewarding properties of the mGluR5 antagonist, fenobam, in a cognitive assay. Analgesic conditioned place preference (aCPP) was used to examine the effects of fenobam (30 mg/kg) and the prototypical mGluR5 antagonist, MPEP, and these effects were compared to those of a drug with known analgesic properties, morphine (10 mg/kg). In each experiment, one group of mice received spared nerve injury (SNI) surgery to model chronic pain; the other group received a control sham surgery. Both fenobam and MPEP induced preference in the SNI mice, such that SNI mice spent significantly more time in the mGluR5 antagonist-paired chamber compared to a vehicle-paired chamber. No such preference developed for sham mice. Morphine induced preference in male and female mice in both the SNI and sham groups. The results showed that fenobam and MPEP likely reduced on-going distress in the SNI mice, causing them to prefer the chamber paired with the drug compared to the vehicle-paired chamber. Since sham animals did not prefer the drug-paired chamber, these data demonstrate that mGluR5 antagonism is non-rewarding in the absence of pain-like injury.
Url:
DOI: 10.1371/journal.pone.0103524
PubMed: 25061818
PubMed Central: 4111598
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4111598Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury</title><author><name sortKey="Lax, Neil C" sort="Lax, Neil C" uniqKey="Lax N" first="Neil C." last="Lax">Neil C. Lax</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="George, David C" sort="George, David C" uniqKey="George D" first="David C." last="George">David C. George</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ignatz, Christopher" sort="Ignatz, Christopher" uniqKey="Ignatz C" first="Christopher" last="Ignatz">Christopher Ignatz</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kolber, Benedict J" sort="Kolber, Benedict J" uniqKey="Kolber B" first="Benedict J." last="Kolber">Benedict J. Kolber</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25061818</idno><idno type="pmc">4111598</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111598</idno><idno type="RBID">PMC:4111598</idno><idno type="doi">10.1371/journal.pone.0103524</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001D73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D73</idno><idno type="wicri:Area/Pmc/Curation">001D48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D48</idno><idno type="wicri:Area/Pmc/Checkpoint">000266</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000266</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury</title><author><name sortKey="Lax, Neil C" sort="Lax, Neil C" uniqKey="Lax N" first="Neil C." last="Lax">Neil C. Lax</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="George, David C" sort="George, David C" uniqKey="George D" first="David C." last="George">David C. George</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ignatz, Christopher" sort="Ignatz, Christopher" uniqKey="Ignatz C" first="Christopher" last="Ignatz">Christopher Ignatz</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kolber, Benedict J" sort="Kolber, Benedict J" uniqKey="Kolber B" first="Benedict J." last="Kolber">Benedict J. Kolber</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Antagonists of metabotropic glutamate receptors (mGluRs) have the potential to act as analgesic drugs that may help alleviate chronic pain. This study was done to look at the possible rewarding properties of the mGluR5 antagonist, fenobam, in a cognitive assay. Analgesic conditioned place preference (aCPP) was used to examine the effects of fenobam (30 mg/kg) and the prototypical mGluR5 antagonist, MPEP, and these effects were compared to those of a drug with known analgesic properties, morphine (10 mg/kg). In each experiment, one group of mice received spared nerve injury (SNI) surgery to model chronic pain; the other group received a control sham surgery. Both fenobam and MPEP induced preference in the SNI mice, such that SNI mice spent significantly more time in the mGluR5 antagonist-paired chamber compared to a vehicle-paired chamber. No such preference developed for sham mice. Morphine induced preference in male and female mice in both the SNI and sham groups. The results showed that fenobam and MPEP likely reduced on-going distress in the SNI mice, causing them to prefer the chamber paired with the drug compared to the vehicle-paired chamber. Since sham animals did not prefer the drug-paired chamber, these data demonstrate that mGluR5 antagonism is non-rewarding in the absence of pain-like injury.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ingham, Jm" uniqKey="Ingham J">JM Ingham</name></author><author><name sortKey="Portenoy, Rk" uniqKey="Portenoy R">RK Portenoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Sc" uniqKey="Ng S">SC Ng</name></author><author><name sortKey="Chan, Fkl" uniqKey="Chan F">FKL Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benyamin, R" uniqKey="Benyamin R">R Benyamin</name></author><author><name sortKey="Trescot, Am" uniqKey="Trescot A">AM Trescot</name></author><author><name sortKey="Datta, S" uniqKey="Datta S">S Datta</name></author><author><name sortKey="Buenaventura, R" uniqKey="Buenaventura R">R Buenaventura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fries, S" uniqKey="Fries S">S Fries</name></author><author><name sortKey="Grosser, T" uniqKey="Grosser T">T Grosser</name></author><author><name sortKey="Price, Ts" uniqKey="Price T">TS Price</name></author><author><name sortKey="Lawson, Ja" uniqKey="Lawson J">JA Lawson</name></author><author><name sortKey="Kapoor, S" uniqKey="Kapoor S">S Kapoor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shigemoto, Rns" uniqKey="Shigemoto R">RNS Shigemoto</name></author><author><name sortKey="Ohishi, H" uniqKey="Ohishi H">H Ohishi</name></author><author><name sortKey="Sugihara, H" uniqKey="Sugihara H">H Sugihara</name></author><author><name sortKey="Nakanishi, S" uniqKey="Nakanishi S">S Nakanishi</name></author><author><name sortKey="Mizuno, N" uniqKey="Mizuno N">N Mizuno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neugebauer, V" uniqKey="Neugebauer V">V Neugebauer</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Bird, Gc" uniqKey="Bird G">GC Bird</name></author><author><name sortKey="Han, Js" uniqKey="Han J">JS Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valerio, A" uniqKey="Valerio A">A Valerio</name></author><author><name sortKey="Paterlini, M" uniqKey="Paterlini M">M Paterlini</name></author><author><name sortKey="Boifava, M" uniqKey="Boifava M">M Boifava</name></author><author><name sortKey="Memo, M" uniqKey="Memo M">M Memo</name></author><author><name sortKey="Spano, P" uniqKey="Spano P">P Spano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kolber, Bj" uniqKey="Kolber B">BJ Kolber</name></author><author><name sortKey="Montana, Mc" uniqKey="Montana M">MC Montana</name></author><author><name sortKey="Carrasquillo, Y" uniqKey="Carrasquillo Y">Y Carrasquillo</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Heinemann, Sf" uniqKey="Heinemann S">SF Heinemann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, K" uniqKey="Fisher K">K Fisher</name></author><author><name sortKey="Coderre, Tj" uniqKey="Coderre T">TJ Coderre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porter, Rhp" uniqKey="Porter R">RHP Porter</name></author><author><name sortKey="Jaeschke, G" uniqKey="Jaeschke G">G Jaeschke</name></author><author><name sortKey="Spooren, W" uniqKey="Spooren W">W Spooren</name></author><author><name sortKey="Ballard, Tm" uniqKey="Ballard T">TM Ballard</name></author><author><name sortKey="Buttelmann, B" uniqKey="Buttelmann B">B Büttelmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montana, Mc" uniqKey="Montana M">MC Montana</name></author><author><name sortKey="Cavallone, Lf" uniqKey="Cavallone L">LF Cavallone</name></author><author><name sortKey="Stubbert, Kk" uniqKey="Stubbert K">KK Stubbert</name></author><author><name sortKey="Stefanescu, Ad" uniqKey="Stefanescu A">AD Stefanescu</name></author><author><name sortKey="Kharasch, Ed" uniqKey="Kharasch E">ED Kharasch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montana, Mc" uniqKey="Montana M">MC Montana</name></author><author><name sortKey="Conrardy, Ba" uniqKey="Conrardy B">BA Conrardy</name></author><author><name sortKey="Cavallone, Lf" uniqKey="Cavallone L">LF Cavallone</name></author><author><name sortKey="Kolber, Bj" uniqKey="Kolber B">BJ Kolber</name></author><author><name sortKey="Rao, Lk" uniqKey="Rao L">LK Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogil, Js" uniqKey="Mogil J">JS Mogil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Craft, Rm" uniqKey="Craft R">RM Craft</name></author><author><name sortKey="Mogil, Js" uniqKey="Mogil J">JS Mogil</name></author><author><name sortKey="Maria Aloisi, A" uniqKey="Maria Aloisi A">A Maria Aloisi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paller, Cj" uniqKey="Paller C">CJ Paller</name></author><author><name sortKey="Campbell, Cm" uniqKey="Campbell C">CM Campbell</name></author><author><name sortKey="Edwards, Rr" uniqKey="Edwards R">RR Edwards</name></author><author><name sortKey="Dobs, As" uniqKey="Dobs A">AS Dobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richner, M" uniqKey="Richner M">M Richner</name></author><author><name sortKey="Bjerrum, Oj" uniqKey="Bjerrum O">OJ Bjerrum</name></author><author><name sortKey="Nykjaer, A" uniqKey="Nykjaer A">A Nykjaer</name></author><author><name sortKey="Vaegter, Cb" uniqKey="Vaegter C">CB Vaegter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourquin, A F" uniqKey="Bourquin A">A-F Bourquin</name></author><author><name sortKey="Suveges, M" uniqKey="Suveges M">M Süveges</name></author><author><name sortKey="Pertin, M" uniqKey="Pertin M">M Pertin</name></author><author><name sortKey="Gilliard, N" uniqKey="Gilliard N">N Gilliard</name></author><author><name sortKey="Sardy, S" uniqKey="Sardy S">S Sardy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decosterd, I" uniqKey="Decosterd I">I Decosterd</name></author><author><name sortKey="Woolf, Cj" uniqKey="Woolf C">CJ Woolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tzschentke, Tm" uniqKey="Tzschentke T">TM Tzschentke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="King, T" uniqKey="King T">T King</name></author><author><name sortKey="Vera Portocarrero, L" uniqKey="Vera Portocarrero L">L Vera-Portocarrero</name></author><author><name sortKey="Gutierrez, T" uniqKey="Gutierrez T">T Gutierrez</name></author><author><name sortKey="Vanderah, Tw" uniqKey="Vanderah T">TW Vanderah</name></author><author><name sortKey="Dussor, G" uniqKey="Dussor G">G Dussor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Tian, X" uniqKey="Tian X">X Tian</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name></author><author><name sortKey="Porreca, F" uniqKey="Porreca F">F Porreca</name></author><author><name sortKey="Wang, Zj" uniqKey="Wang Z">ZJ Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tryba, M" uniqKey="Tryba M">M Tryba</name></author><author><name sortKey="Gehling, M" uniqKey="Gehling M">M Gehling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xia, Z" uniqKey="Xia Z">Z Xia</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corbett, Ad" uniqKey="Corbett A">AD Corbett</name></author><author><name sortKey="Henderson, G" uniqKey="Henderson G">G Henderson</name></author><author><name sortKey="Mcknight, At" uniqKey="Mcknight A">AT McKnight</name></author><author><name sortKey="Paterson, Sj" uniqKey="Paterson S">SJ Paterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crock, Lw" uniqKey="Crock L">LW Crock</name></author><author><name sortKey="Stemler, Km" uniqKey="Stemler K">KM Stemler</name></author><author><name sortKey="Song, Dg" uniqKey="Song D">DG Song</name></author><author><name sortKey="Abbosh, P" uniqKey="Abbosh P">P Abbosh</name></author><author><name sortKey="Vogt, Sk" uniqKey="Vogt S">SK Vogt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiu, S" uniqKey="Ruiu S">S Ruiu</name></author><author><name sortKey="Longoni, R" uniqKey="Longoni R">R Longoni</name></author><author><name sortKey="Spina, L" uniqKey="Spina L">L Spina</name></author><author><name sortKey="Orru, A" uniqKey="Orru A">A Orru</name></author><author><name sortKey="Cottiglia, F" uniqKey="Cottiglia F">F Cottiglia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattioli, L" uniqKey="Mattioli L">L Mattioli</name></author><author><name sortKey="Titomanlio, F" uniqKey="Titomanlio F">F Titomanlio</name></author><author><name sortKey="Perfumi, M" uniqKey="Perfumi M">M Perfumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pecknold, Jc" uniqKey="Pecknold J">JC Pecknold</name></author><author><name sortKey="Mcclure, Dj" uniqKey="Mcclure D">DJ McClure</name></author><author><name sortKey="Appeltauer, L" uniqKey="Appeltauer L">L Appeltauer</name></author><author><name sortKey="Wrezesinski, L" uniqKey="Wrezesinski L">L Wrezesinski</name></author><author><name sortKey="Allan, T" uniqKey="Allan T">T Allan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friedmann, C" uniqKey="Friedmann C">C Friedmann</name></author><author><name sortKey="Davis, L" uniqKey="Davis L">L Davis</name></author><author><name sortKey="Ciccone, P" uniqKey="Ciccone P">P Ciccone</name></author><author><name sortKey="Rubin, R" uniqKey="Rubin R">R Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiechio, S" uniqKey="Chiechio S">S Chiechio</name></author><author><name sortKey="Nicoletti, F" uniqKey="Nicoletti F">F Nicoletti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Cz" uniqKey="Zhu C">CZ Zhu</name></author><author><name sortKey="Hsieh, G" uniqKey="Hsieh G">G Hsieh</name></author><author><name sortKey="Ei Kouhen, O" uniqKey="Ei Kouhen O">O Ei-Kouhen</name></author><author><name sortKey="Wilson, Sg" uniqKey="Wilson S">SG Wilson</name></author><author><name sortKey="Mikusa, Jp" uniqKey="Mikusa J">JP Mikusa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhave, G" uniqKey="Bhave G">G Bhave</name></author><author><name sortKey="Carlton, Sm" uniqKey="Carlton S">SM Carlton</name></author><author><name sortKey="Gereau Iv, Rw" uniqKey="Gereau Iv R">RW Gereau Iv</name></author><author><name sortKey="Karim, F" uniqKey="Karim F">F Karim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, H" uniqKey="Jia H">H Jia</name></author><author><name sortKey="Rustioni, A" uniqKey="Rustioni A">A Rustioni</name></author><author><name sortKey="Valtschanoff, Jg" uniqKey="Valtschanoff J">JG Valtschanoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Neugebauer, V" uniqKey="Neugebauer V">V Neugebauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crock, Lw" uniqKey="Crock L">LW Crock</name></author><author><name sortKey="Kolber, Bj" uniqKey="Kolber B">BJ Kolber</name></author><author><name sortKey="Morgan, Cd" uniqKey="Morgan C">CD Morgan</name></author><author><name sortKey="Sadler, Ke" uniqKey="Sadler K">KE Sadler</name></author><author><name sortKey="Vogt, Sk" uniqKey="Vogt S">SK Vogt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalliomaki, J" uniqKey="Kalliomaki J">J Kalliomaki</name></author><author><name sortKey="Huizar, K" uniqKey="Huizar K">K Huizar</name></author><author><name sortKey="Kagedal, M" uniqKey="Kagedal M">M Kagedal</name></author><author><name sortKey="Hagglof, B" uniqKey="Hagglof B">B Hagglof</name></author><author><name sortKey="Schmelz, M" uniqKey="Schmelz M">M Schmelz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osikowicz, M" uniqKey="Osikowicz M">M Osikowicz</name></author><author><name sortKey="Mika, J" uniqKey="Mika J">J Mika</name></author><author><name sortKey="Makuch, W" uniqKey="Makuch W">W Makuch</name></author><author><name sortKey="Przewlocka, B" uniqKey="Przewlocka B">B Przewlocka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blackburn Munro, G" uniqKey="Blackburn Munro G">G Blackburn-Munro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woller, Sa" uniqKey="Woller S">SA Woller</name></author><author><name sortKey="Moreno, Gl" uniqKey="Moreno G">GL Moreno</name></author><author><name sortKey="Hart, N" uniqKey="Hart N">N Hart</name></author><author><name sortKey="Wellman, Pj" uniqKey="Wellman P">PJ Wellman</name></author><author><name sortKey="Grau, Jw" uniqKey="Grau J">JW Grau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Zhong, P" uniqKey="Zhong P">P Zhong</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Sun, D" uniqKey="Sun D">D Sun</name></author><author><name sortKey="Gao, Hq" uniqKey="Gao H">HQ Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrold, Aa" uniqKey="Herrold A">AA Herrold</name></author><author><name sortKey="Voigt, Rm" uniqKey="Voigt R">RM Voigt</name></author><author><name sortKey="Napier, Tc" uniqKey="Napier T">TC Napier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Popik, P" uniqKey="Popik P">P Popik</name></author><author><name sortKey="Wrobel, M" uniqKey="Wrobel M">M Wrobel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munce, Se" uniqKey="Munce S">SE Munce</name></author><author><name sortKey="Stewart, De" uniqKey="Stewart D">DE Stewart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolfe, F" uniqKey="Wolfe F">F Wolfe</name></author><author><name sortKey="Ross, K" uniqKey="Ross K">K Ross</name></author><author><name sortKey="Anderson, J" uniqKey="Anderson J">J Anderson</name></author><author><name sortKey="Russell, Ij" uniqKey="Russell I">IJ Russell</name></author><author><name sortKey="Hebert, L" uniqKey="Hebert L">L Hebert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemens, Jq" uniqKey="Clemens J">JQ Clemens</name></author><author><name sortKey="Meenan, Rt" uniqKey="Meenan R">RT Meenan</name></author><author><name sortKey="Rosetti, Mcok" uniqKey="Rosetti M">MCOK Rosetti</name></author><author><name sortKey="Gao, Sy" uniqKey="Gao S">SY Gao</name></author><author><name sortKey="Calhoun, Ea" uniqKey="Calhoun E">EA Calhoun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beery, Ak" uniqKey="Beery A">AK Beery</name></author><author><name sortKey="Zucker, I" uniqKey="Zucker I">I Zucker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bair, Mj" uniqKey="Bair M">MJ Bair</name></author><author><name sortKey="Robinson, Rl" uniqKey="Robinson R">RL Robinson</name></author><author><name sortKey="Katon, W" uniqKey="Katon W">W Katon</name></author><author><name sortKey="Kroenke, K" uniqKey="Kroenke K">K Kroenke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mutso, Aa" uniqKey="Mutso A">AA Mutso</name></author><author><name sortKey="Radzicki, D" uniqKey="Radzicki D">D Radzicki</name></author><author><name sortKey="Baliki, Mn" uniqKey="Baliki M">MN Baliki</name></author><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name></author><author><name sortKey="Banisadr, G" uniqKey="Banisadr G">G Banisadr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goncalves, L" uniqKey="Goncalves L">L Gonçalves</name></author><author><name sortKey="Silva, R" uniqKey="Silva R">R Silva</name></author><author><name sortKey="Pinto Ribeiro, F" uniqKey="Pinto Ribeiro F">F Pinto-Ribeiro</name></author><author><name sortKey="Pego, Jm" uniqKey="Pego J">JM Pêgo</name></author><author><name sortKey="Bessa, Jm" uniqKey="Bessa J">JM Bessa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reid, Ld" uniqKey="Reid L">LD Reid</name></author><author><name sortKey="Marglin, Sh" uniqKey="Marglin S">SH Marglin</name></author><author><name sortKey="Mattie, Me" uniqKey="Mattie M">ME Mattie</name></author><author><name sortKey="Hubbell, Cl" uniqKey="Hubbell C">CL Hubbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vindenes, V" uniqKey="Vindenes V">V Vindenes</name></author><author><name sortKey="Handal, M" uniqKey="Handal M">M Handal</name></author><author><name sortKey="Ripel, " uniqKey="Ripel ">Å Ripel</name></author><author><name sortKey="Boix, F" uniqKey="Boix F">F Boix</name></author><author><name sortKey="M Rland, J" uniqKey="M Rland J">J Mørland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammed, W" uniqKey="Mohammed W">W Mohammed</name></author><author><name sortKey="Alhaddad, H" uniqKey="Alhaddad H">H Alhaddad</name></author><author><name sortKey="Marie, N" uniqKey="Marie N">N Marie</name></author><author><name sortKey="Tardy, F" uniqKey="Tardy F">F Tardy</name></author><author><name sortKey="Lamballais, F" uniqKey="Lamballais F">F Lamballais</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25061818</article-id><article-id pub-id-type="pmc">4111598</article-id><article-id pub-id-type="publisher-id">PONE-D-14-02957</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0103524</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject><subj-group><subject>Neuroscience</subject><subj-group><subject>Cognitive Science</subject><subj-group><subject>Cognition</subject><subj-group><subject>Animal Cognition</subject></subj-group></subj-group></subj-group><subj-group><subject>Behavioral Neuroscience</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject><subj-group><subject>Pharmacology</subject><subj-group><subject>Behavioral Pharmacology</subject><subject>Drug Information</subject></subj-group></subj-group><subj-group><subject>Clinical Medicine</subject></subj-group><subj-group><subject>Neurology</subject></subj-group><subj-group><subject>Pain Management</subject></subj-group></subj-group></article-categories><title-group><article-title>The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury</article-title><alt-title alt-title-type="running-head">Fenobam Induces Analgesic Conditioned Place Preference</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lax</surname><given-names>Neil C.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>George</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Ignatz</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Kolber</surname><given-names>Benedict J.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of Biological Sciences and Chronic Pain Research Consortium, Duquesne University, Pittsburgh, Pennsylvania, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Costigan</surname><given-names>Michael</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Boston Children's Hospital and Harvard Medical School, United States of America</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>kolberb@duq.edu</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: NCL DCG BJK. Performed the experiments: NCL DCG CMI BJK. Analyzed the data: NCL DCG CMI BJK. Contributed reagents/materials/analysis tools: NCL DCG BJK. Wrote the paper: NCL DCG BJK.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>25</day><month>7</month><year>2014</year></pub-date><volume>9</volume><issue>7</issue><elocation-id>e103524</elocation-id><history><date date-type="received"><day>21</day><month>1</month><year>2014</year></date><date date-type="accepted"><day>1</day><month>7</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Lax et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><p>Antagonists of metabotropic glutamate receptors (mGluRs) have the potential to act as analgesic drugs that may help alleviate chronic pain. This study was done to look at the possible rewarding properties of the mGluR5 antagonist, fenobam, in a cognitive assay. Analgesic conditioned place preference (aCPP) was used to examine the effects of fenobam (30 mg/kg) and the prototypical mGluR5 antagonist, MPEP, and these effects were compared to those of a drug with known analgesic properties, morphine (10 mg/kg). In each experiment, one group of mice received spared nerve injury (SNI) surgery to model chronic pain; the other group received a control sham surgery. Both fenobam and MPEP induced preference in the SNI mice, such that SNI mice spent significantly more time in the mGluR5 antagonist-paired chamber compared to a vehicle-paired chamber. No such preference developed for sham mice. Morphine induced preference in male and female mice in both the SNI and sham groups. The results showed that fenobam and MPEP likely reduced on-going distress in the SNI mice, causing them to prefer the chamber paired with the drug compared to the vehicle-paired chamber. Since sham animals did not prefer the drug-paired chamber, these data demonstrate that mGluR5 antagonism is non-rewarding in the absence of pain-like injury.</p></abstract><funding-group><funding-statement>Funding for this work came from the following sources: BJK (F32 NS067761; Duquesne University Hunkele Dreaded Disease Fund; American Pain Society Sharon S. Keller Chronic Pain Research Program; International Association for the Study of Pain Early Career Research Award from the Scan|Design Foundation) and Robert W. Gereau, IV (NS486020). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="11"></page-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="George, David C" sort="George, David C" uniqKey="George D" first="David C." last="George">David C. George</name><name sortKey="Ignatz, Christopher" sort="Ignatz, Christopher" uniqKey="Ignatz C" first="Christopher" last="Ignatz">Christopher Ignatz</name><name sortKey="Kolber, Benedict J" sort="Kolber, Benedict J" uniqKey="Kolber B" first="Benedict J." last="Kolber">Benedict J. Kolber</name><name sortKey="Lax, Neil C" sort="Lax, Neil C" uniqKey="Lax N" first="Neil C." last="Lax">Neil C. Lax</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000266 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000266 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:4111598
|texte= The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:25061818" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |