Time-of-day differences and short-term stability of the neural response to monetary reward: A pilot study
Identifieur interne : 000220 ( Pmc/Checkpoint ); précédent : 000219; suivant : 000221Time-of-day differences and short-term stability of the neural response to monetary reward: A pilot study
Auteurs : Brant P. Hasler ; Erika E. Forbes ; Peter L. FranzenSource :
- Psychiatry research [ 0165-1781 ] ; 2014.
Abstract
Human and animal studies indicate that reward function is modulated by the circadian clock that governs our daily sleep/wake rhythm. For example, a robust circadian rhythm exists in positive affect, which is lower in the morning hours and peaks in the afternoon. A handful of functional neuroimaging studies suggest that systematic diurnal variation exists in brain activity related to other functions, but no published human studies have examined daily variation in the neural processing of reward. In the present study, we attempt to advance this literature by using functional neuroimaging methods to examine time-of-day changes in the responsivity of the reward circuit. Using a within-person design and a functional magnetic resonance imaging (fMRI) monetary reward task, we compared morning and afternoon reward-related brain activation in a sample of healthy young adults within 24 h. Region of interest analyses focused on the striatum, and we hypothesized greater reward activation in the afternoon, concordant with the circadian peak in positive affect. Results were consistent with our hypothesis. Additionally, we counterbalanced the order of morning and afternoon scans in order to explore the short-term stability of the neural response. Whole-brain analyses showed a markedly higher reactivity to reward throughout the brain in the first scan relative to the second scan, consistent with habituation to the monetary reward stimuli. However, these effects did not appear to explain the time-of-day findings. In summary, we report the first preliminary evidence of circadian variation in the neural processing of reward. These findings have both methodological and theoretical implications.
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DOI: 10.1016/j.pscychresns.2014.07.005
PubMed: 25092525
PubMed Central: 4157087
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P2">Human and animal studies indicate that reward function is modulated by the
circadian clock that governs our daily sleep/wake rhythm. For example, a robust circadian
rhythm exists in positive affect, which is lower in the morning hours and peaks in the
afternoon. A handful of functional neuroimaging studies suggest that systematic diurnal
variation exists in brain activity related to other functions, but no published human
studies have examined daily variation in the neural processing of reward. In the present
study, we attempt to advance this literature by using functional neuroimaging methods to
examine time-of-day changes in the responsivity of the reward circuit. Using a
within-person design and a functional magnetic resonance imaging (fMRI) monetary reward
task, we compared morning and afternoon reward-related brain activation in a sample of
healthy young adults within 24 h. Region of interest analyses focused on the striatum, and
we hypothesized greater reward activation in the afternoon, concordant with the circadian
peak in positive affect. Results were consistent with our hypothesis. Additionally, we
counterbalanced the order of morning and afternoon scans in order to explore the
short-term stability of the neural response. Whole-brain analyses showed a markedly higher
reactivity to reward throughout the brain in the first scan relative to the second scan,
consistent with habituation to the monetary reward stimuli. However, these effects did not
appear to explain the time-of-day findings. In summary, we report the first preliminary
evidence of circadian variation in the neural processing of reward. These findings have
both methodological and theoretical implications.</p>
</div>
</front>
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<journal-id journal-id-type="nlm-ta">Psychiatry Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Psychiatry Res</journal-id>
<journal-title-group><journal-title>Psychiatry research</journal-title>
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<title-group><article-title>Time-of-day differences and short-term stability of the neural response to
monetary reward: A pilot study</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Hasler</surname>
<given-names>Brant P.</given-names>
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<xref rid="FN1" ref-type="author-notes">*</xref>
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<contrib contrib-type="author"><name><surname>Forbes</surname>
<given-names>Erika E.</given-names>
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</contrib>
<contrib contrib-type="author"><name><surname>Franzen</surname>
<given-names>Peter L.</given-names>
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<aff id="A1">Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O’Hara Street, Pittsburgh, PA, 15213 USA</aff>
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<author-notes><corresp id="FN1">Correspondence and reprint requests may be sent to: Brant P. Hasler,
Ph.D., University of Pittsburgh School of Medicine, Department of Psychiatry, 3811
O’Hara Street, Pittsburgh, PA 15213; Phone: 412-246-6674; Fax: 412-246-5300;
<email>haslerbp@upmc.edu</email>
</corresp>
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<pub-date pub-type="nihms-submitted"><day>25</day>
<month>7</month>
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<month>7</month>
<year>2014</year>
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<pub-date pub-type="ppub"><day>30</day>
<month>10</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>30</day>
<month>10</month>
<year>2015</year>
</pub-date>
<volume>224</volume>
<issue>1</issue>
<fpage>22</fpage>
<lpage>27</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.pscychresns.2014.07.005</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ireland Ltd. All rights
reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p id="P2">Human and animal studies indicate that reward function is modulated by the
circadian clock that governs our daily sleep/wake rhythm. For example, a robust circadian
rhythm exists in positive affect, which is lower in the morning hours and peaks in the
afternoon. A handful of functional neuroimaging studies suggest that systematic diurnal
variation exists in brain activity related to other functions, but no published human
studies have examined daily variation in the neural processing of reward. In the present
study, we attempt to advance this literature by using functional neuroimaging methods to
examine time-of-day changes in the responsivity of the reward circuit. Using a
within-person design and a functional magnetic resonance imaging (fMRI) monetary reward
task, we compared morning and afternoon reward-related brain activation in a sample of
healthy young adults within 24 h. Region of interest analyses focused on the striatum, and
we hypothesized greater reward activation in the afternoon, concordant with the circadian
peak in positive affect. Results were consistent with our hypothesis. Additionally, we
counterbalanced the order of morning and afternoon scans in order to explore the
short-term stability of the neural response. Whole-brain analyses showed a markedly higher
reactivity to reward throughout the brain in the first scan relative to the second scan,
consistent with habituation to the monetary reward stimuli. However, these effects did not
appear to explain the time-of-day findings. In summary, we report the first preliminary
evidence of circadian variation in the neural processing of reward. These findings have
both methodological and theoretical implications.</p>
</abstract>
<kwd-group><kwd>Circadian</kwd>
<kwd>Reward</kwd>
<kwd>Brain</kwd>
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<kwd>fMRI</kwd>
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