PittsburghV1, PascalFrancis, Curation, bibRecord, 000A60

Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers

Identifieur interne : 000A60 ( PascalFrancis/Curation ); précédent : 000A59; suivant : 000A61

Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers

Auteurs : Jian-Min Yuan [États-Unis] ; Yu-Tang Gao [République populaire de Chine] ; RENWEI WANG [États-Unis] ; MENGLAN CHEN [États-Unis] ; Steven G. Carmella [États-Unis] ; Stephen S. Hecht [États-Unis]

Source :

Carcinogenesis : (New York. Print) [ 0143-3334 ] ; 2012.

RBID : Pascal:12-0182505

Descripteurs français

Pascal (Inist)
- Urine, Matière volatile, Carcinogène, Toxicité, Toxique, Marqueur biologique, Bronchopulmonaire, Cancer du poumon, Carcinogenèse, Fumeur, Homme, Tabagisme.
Wicri :
- topic : Homme, Tabagisme.

English descriptors

KwdEn :
- Biological marker, Bronchopulmonary, Carcinogen, Carcinogenesis, Human, Lung cancer, Poison, Smoker, Tobacco smoking, Toxicity, Urine, Volatiles.

Abstract

Besides polycyclic aromatic hydrocarbons (PAH) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which are established lung carcinogens, tobacco smoke also contains relatively large quantities of volatile organic carcinogens and toxicants, including 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde. Although animal experiments showed that some of these compounds can induce tumors in multiple organs including the lung, epidemiological studies of their relationship with lung cancer in smokers have not been reported. Therefore, in this study, we quantified urinary mercapturic acid metabolites of 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde in addition to urinary biomarkers for PAH, NNK and nicotine in 343 lung cancer cases and 392 matched controls among a cohort of 18 244 Chinese men in Shanghai, China, followed from 1986 to 2006. Compared with the lowest quartiles, highest quartiles of all measured mercapturic acids were associated with statistically significantly ˜2-fold increased risk for lung cancer (all P's for trend <0.01) after adjustment for smoking intensity and duration. The positive associations between biomarkers of ethylene oxide, benzene or acrolein and lung cancer risk remained statistically significant after adjustment for biomarkers of PAH and NNK, whereas urinary total cotinine completely explained the mercapturic acid metabolites and lung cancer associations (all P's for trend ≥0.39). We conclude that mercapturic acid metabolites of 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde may not be independent risk predictors of lung cancer among Shanghai smokers, in contrast to biomarkers of PAH, NNK and nicotine exposure.

A01	`01`	`1`		`@0 0143-3334`
A02	`01`			`@0 CRNGDP`
A03		`1`		`@0 Carcinogenesis : (N. Y., Print)`
A05				`@2 33`
A06				`@2 4`
A08	`01`	`1`	`ENG`	`@1 Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers`
A11	`01`	`1`		`@1 YUAN (Jian-Min)`
A11	`02`	`1`		`@1 GAO (Yu-Tang)`
A11	`03`	`1`		`@1 RENWEI WANG`
A11	`04`	`1`		`@1 MENGLAN CHEN`
A11	`05`	`1`		`@1 CARMELLA (Steven G.)`
A11	`06`	`1`		`@1 HECHT (Stephen S.)`
A14	`01`			`@1 University of Pittsburgh Cancer Institute @2 Pittsburgh, PA 15232 @3 USA @Z 1 aut. @Z 3 aut.`
A14	`02`			`@1 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh @2 PA @3 USA @Z 1 aut.`
A14	`03`			`@1 Department of Epidemiology, Shanghai Cancer Institute @2 Shanghai @3 CHN @Z 2 aut.`
A14	`04`			`@1 Masonic Cancer Center, University of Minnesota @2 Minneapolis, MN @3 USA @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A20				`@1 804-809`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18776 @5 354000509771730100`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 50 ref.`
A47	`01`	`1`		`@0 12-0182505`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Carcinogenesis : (New York. Print)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Besides polycyclic aromatic hydrocarbons (PAH) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which are established lung carcinogens, tobacco smoke also contains relatively large quantities of volatile organic carcinogens and toxicants, including 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde. Although animal experiments showed that some of these compounds can induce tumors in multiple organs including the lung, epidemiological studies of their relationship with lung cancer in smokers have not been reported. Therefore, in this study, we quantified urinary mercapturic acid metabolites of 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde in addition to urinary biomarkers for PAH, NNK and nicotine in 343 lung cancer cases and 392 matched controls among a cohort of 18 244 Chinese men in Shanghai, China, followed from 1986 to 2006. Compared with the lowest quartiles, highest quartiles of all measured mercapturic acids were associated with statistically significantly ˜2-fold increased risk for lung cancer (all P's for trend <0.01) after adjustment for smoking intensity and duration. The positive associations between biomarkers of ethylene oxide, benzene or acrolein and lung cancer risk remained statistically significant after adjustment for biomarkers of PAH and NNK, whereas urinary total cotinine completely explained the mercapturic acid metabolites and lung cancer associations (all P's for trend ≥0.39). We conclude that mercapturic acid metabolites of 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde may not be independent risk predictors of lung cancer among Shanghai smokers, in contrast to biomarkers of PAH, NNK and nicotine exposure.
C02	`01`	`X`		`@0 002B04E02`
C02	`02`	`X`		`@0 002B11A`
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C03	`01`	`X`	`FRE`	`@0 Urine @5 02`
C03	`01`	`X`	`ENG`	`@0 Urine @5 02`
C03	`01`	`X`	`SPA`	`@0 Orina @5 02`
C03	`02`	`X`	`FRE`	`@0 Matière volatile @5 03`
C03	`02`	`X`	`ENG`	`@0 Volatiles @5 03`
C03	`02`	`X`	`SPA`	`@0 Materia volátil @5 03`
C03	`03`	`X`	`FRE`	`@0 Carcinogène @5 05`
C03	`03`	`X`	`ENG`	`@0 Carcinogen @5 05`
C03	`03`	`X`	`SPA`	`@0 Carcinógeno @5 05`
C03	`04`	`X`	`FRE`	`@0 Toxicité @5 06`
C03	`04`	`X`	`ENG`	`@0 Toxicity @5 06`
C03	`04`	`X`	`SPA`	`@0 Toxicidad @5 06`
C03	`05`	`X`	`FRE`	`@0 Toxique @5 08`
C03	`05`	`X`	`ENG`	`@0 Poison @5 08`
C03	`05`	`X`	`SPA`	`@0 Tóxico @5 08`
C03	`06`	`X`	`FRE`	`@0 Marqueur biologique @5 09`
C03	`06`	`X`	`ENG`	`@0 Biological marker @5 09`
C03	`06`	`X`	`SPA`	`@0 Marcador biológico @5 09`
C03	`07`	`X`	`FRE`	`@0 Bronchopulmonaire @5 11`
C03	`07`	`X`	`ENG`	`@0 Bronchopulmonary @5 11`
C03	`07`	`X`	`SPA`	`@0 Broncopulmonar @5 11`
C03	`08`	`X`	`FRE`	`@0 Cancer du poumon @2 NM @5 12`
C03	`08`	`X`	`ENG`	`@0 Lung cancer @2 NM @5 12`
C03	`08`	`X`	`SPA`	`@0 Cáncer del pulmón @2 NM @5 12`
C03	`09`	`X`	`FRE`	`@0 Carcinogenèse @5 16`
C03	`09`	`X`	`ENG`	`@0 Carcinogenesis @5 16`
C03	`09`	`X`	`SPA`	`@0 Carcinogénesis @5 16`
C03	`10`	`X`	`FRE`	`@0 Fumeur @5 17`
C03	`10`	`X`	`ENG`	`@0 Smoker @5 17`
C03	`10`	`X`	`SPA`	`@0 Fumador @5 17`
C03	`11`	`X`	`FRE`	`@0 Homme @5 18`
C03	`11`	`X`	`ENG`	`@0 Human @5 18`
C03	`11`	`X`	`SPA`	`@0 Hombre @5 18`
C03	`12`	`X`	`FRE`	`@0 Tabagisme @5 19`
C03	`12`	`X`	`ENG`	`@0 Tobacco smoking @5 19`
C03	`12`	`X`	`SPA`	`@0 Tabaquismo @5 19`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'appareil respiratoire @5 61`
C07	`01`	`X`	`ENG`	`@0 Respiratory disease @5 61`
C07	`01`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 61`
C07	`02`	`X`	`FRE`	`@0 Pathologie des bronches @5 62`
C07	`02`	`X`	`ENG`	`@0 Bronchus disease @5 62`
C07	`02`	`X`	`SPA`	`@0 Bronquio patología @5 62`
C07	`03`	`X`	`FRE`	`@0 Pathologie des poumons @5 63`
C07	`03`	`X`	`ENG`	`@0 Lung disease @5 63`
C07	`03`	`X`	`SPA`	`@0 Pulmón patología @5 63`
C07	`04`	`X`	`FRE`	`@0 Tumeur maligne @2 NM @5 64`
C07	`04`	`X`	`ENG`	`@0 Malignant tumor @2 NM @5 64`
C07	`04`	`X`	`SPA`	`@0 Tumor maligno @2 NM @5 64`
C07	`05`	`X`	`FRE`	`@0 Cancer @2 NM`
C07	`05`	`X`	`ENG`	`@0 Cancer @2 NM`
C07	`05`	`X`	`SPA`	`@0 Cáncer @2 NM`
N21				`@1 135`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Besides polycyclic aromatic hydrocarbons (PAH) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which are established lung carcinogens, tobacco smoke also contains relatively large quantities of volatile organic carcinogens and toxicants, including 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde. Although animal experiments showed that some of these compounds can induce tumors in multiple organs including the lung, epidemiological studies of their relationship with lung cancer in smokers have not been reported. Therefore, in this study, we quantified urinary mercapturic acid metabolites of 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde in addition to urinary biomarkers for PAH, NNK and nicotine in 343 lung cancer cases and 392 matched controls among a cohort of 18 244 Chinese men in Shanghai, China, followed from 1986 to 2006. Compared with the lowest quartiles, highest quartiles of all measured mercapturic acids were associated with statistically significantly ˜2-fold increased risk for lung cancer (all P's for trend <0.01) after adjustment for smoking intensity and duration. The positive associations between biomarkers of ethylene oxide, benzene or acrolein and lung cancer risk remained statistically significant after adjustment for biomarkers of PAH and NNK, whereas urinary total cotinine completely explained the mercapturic acid metabolites and lung cancer associations (all P's for trend ≥0.39). We conclude that mercapturic acid metabolites of 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde may not be independent risk predictors of lung cancer among Shanghai smokers, in contrast to biomarkers of PAH, NNK and nicotine exposure.</div>
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<fA14 i1="03"><s1>Department of Epidemiology, Shanghai Cancer Institute</s1>
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<fA14 i1="04"><s1>Masonic Cancer Center, University of Minnesota</s1>
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<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Besides polycyclic aromatic hydrocarbons (PAH) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which are established lung carcinogens, tobacco smoke also contains relatively large quantities of volatile organic carcinogens and toxicants, including 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde. Although animal experiments showed that some of these compounds can induce tumors in multiple organs including the lung, epidemiological studies of their relationship with lung cancer in smokers have not been reported. Therefore, in this study, we quantified urinary mercapturic acid metabolites of 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde in addition to urinary biomarkers for PAH, NNK and nicotine in 343 lung cancer cases and 392 matched controls among a cohort of 18 244 Chinese men in Shanghai, China, followed from 1986 to 2006. Compared with the lowest quartiles, highest quartiles of all measured mercapturic acids were associated with statistically significantly ˜2-fold increased risk for lung cancer (all P's for trend <0.01) after adjustment for smoking intensity and duration. The positive associations between biomarkers of ethylene oxide, benzene or acrolein and lung cancer risk remained statistically significant after adjustment for biomarkers of PAH and NNK, whereas urinary total cotinine completely explained the mercapturic acid metabolites and lung cancer associations (all P's for trend ≥0.39). We conclude that mercapturic acid metabolites of 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonaldehyde may not be independent risk predictors of lung cancer among Shanghai smokers, in contrast to biomarkers of PAH, NNK and nicotine exposure.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B04E02</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B11A</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B03E</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Urine</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Urine</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Orina</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Matière volatile</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Volatiles</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Materia volátil</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Carcinogène</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Carcinogen</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Carcinógeno</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Toxicité</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Toxicity</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Toxicidad</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Toxique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Poison</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Tóxico</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Marqueur biologique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Biological marker</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Marcador biológico</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Bronchopulmonaire</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Bronchopulmonary</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Broncopulmonar</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Cancer du poumon</s0>
<s2>NM</s2>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Lung cancer</s0>
<s2>NM</s2>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Cáncer del pulmón</s0>
<s2>NM</s2>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Carcinogenèse</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Carcinogenesis</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Carcinogénesis</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Fumeur</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Smoker</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Fumador</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Homme</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Human</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Hombre</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Tabagisme</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Tobacco smoking</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Tabaquismo</s0>
<s5>19</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>61</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>61</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>61</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie des bronches</s0>
<s5>62</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Bronchus disease</s0>
<s5>62</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Bronquio patología</s0>
<s5>62</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie des poumons</s0>
<s5>63</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>63</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>63</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s2>NM</s2>
<s5>64</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s2>NM</s2>
<s5>64</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s2>NM</s2>
<s5>64</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Cáncer</s0>
<s2>NM</s2>
</fC07>
<fN21><s1>135</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers

Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers

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