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Measurements of Selected Brominated Flame Retardants in Nursing Women: Implications for Human Exposure

Identifieur interne : 000060 ( PascalFrancis/Corpus ); précédent : 000059; suivant : 000061

Measurements of Selected Brominated Flame Retardants in Nursing Women: Implications for Human Exposure

Auteurs : Simon Ningsun Zhou ; Angelina Buchar ; Shabana Siddique ; Larissa Takser ; Nadia Abdelouahab ; JIPING ZHU

Source :

RBID : Pascal:15-0038201

Descripteurs français

English descriptors

Abstract

We have examined several emerging brominated flame retardants (BFRs) including 2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. Three legacy BFRs were also included in the study for comparison: decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had detection frequencies greater than 55% in both serum and milk samples. Their lipid weight (lw) adjusted median concentrations (ng g-1 lw) in serum and milk were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, respectively. The detection frequencies for the other BFRs measured in serum and milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB over the sum of TBB and TBPH (f.TBB) in serum (0.23) was lower than that in milk (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in humans, and the need to better understand their sources, routes of exposure, and potential human health effects.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0013-936X
A02 01      @0 ESTHAG
A03   1    @0 Environ. sci. technol.
A05       @2 48
A06       @2 15
A08 01  1  ENG  @1 Measurements of Selected Brominated Flame Retardants in Nursing Women: Implications for Human Exposure
A09 01  1  ENG  @1 Understanding the Risks of Unconventional Shale Gas Development
A11 01  1    @1 NINGSUN ZHOU (Simon)
A11 02  1    @1 BUCHAR (Angelina)
A11 03  1    @1 SIDDIQUE (Shabana)
A11 04  1    @1 TAKSER (Larissa)
A11 05  1    @1 ABDELOUAHAB (Nadia)
A11 06  1    @1 JIPING ZHU
A12 01  1    @1 STERN (Paul C.) @9 limin.
A12 02  1    @1 WEBLER (Thomas) @9 limin.
A12 03  1    @1 SMALL (Mitchell J.) @9 limin.
A14 01      @1 Exposure and Biomonitoring Division, Health Canada @2 Ottawa, Ontario K1A 0K9 @3 CAN @Z 1 aut. @Z 3 aut. @Z 6 aut.
A14 02      @1 Existing Substances Risk Assessment Bureau, Health Canada @2 Ottawa, Ontario K1A 0K9 @3 CAN @Z 2 aut.
A14 03      @1 Département de Pédiatrie, Faculté de Médecine, Université de Sherbrooke @2 Sherbrooke, Québec J1K 2R1 @3 CAN @Z 4 aut. @Z 5 aut.
A15 01      @1 National Research Council, Board on Environmental Change and Society @2 Washington, DC20001 @3 USA @Z 1 aut.
A15 02      @1 Social and Environmental Research Institute @2 Amherst, Massachusetts 01002 @3 USA @Z 2 aut.
A15 03      @1 H. John Heinz III Professor of Environmental Engineering, Carnegie Mellon University @2 Pittsburgh, Pennsylvania 15213 @3 USA @Z 3 aut.
A20       @1 8873-8880
A21       @1 2014
A23 01      @0 ENG
A43 01      @1 INIST @2 13615 @5 354000504883950660
A44       @0 0000 @1 © 2015 INIST-CNRS. All rights reserved.
A45       @0 56 ref.
A47 01  1    @0 15-0038201
A60       @1 P
A61       @0 A
A64 01  1    @0 Environmental science & technology
A66 01      @0 USA
C01 01    ENG  @0 We have examined several emerging brominated flame retardants (BFRs) including 2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. Three legacy BFRs were also included in the study for comparison: decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had detection frequencies greater than 55% in both serum and milk samples. Their lipid weight (lw) adjusted median concentrations (ng g-1 lw) in serum and milk were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, respectively. The detection frequencies for the other BFRs measured in serum and milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB over the sum of TBB and TBPH (f.TBB) in serum (0.23) was lower than that in milk (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in humans, and the need to better understand their sources, routes of exposure, and potential human health effects.
C02 01  X    @0 002B03L06
C03 01  X  FRE  @0 Retardateur flamme @5 02
C03 01  X  ENG  @0 Flame retardant @5 02
C03 01  X  SPA  @0 Retardador llama @5 02
C03 02  3  FRE  @0 Brome composé organique @5 03
C03 02  3  ENG  @0 Organic bromine compounds @5 03
C03 03  X  FRE  @0 Brome Composé organique @2 NC @2 FR @2 FX @2 NA @5 05
C03 03  X  ENG  @0 Bromine Organic compounds @2 NC @2 FR @2 FX @2 NA @5 05
C03 03  X  SPA  @0 Bromo Compuesto orgánico @2 NC @2 FR @2 FX @2 NA @5 05
C03 04  X  FRE  @0 Passage lait @5 06
C03 04  X  ENG  @0 Milk transfer @5 06
C03 04  X  SPA  @0 Paso leche @5 06
C03 05  X  FRE  @0 Santé publique @5 08
C03 05  X  ENG  @0 Public health @5 08
C03 05  X  SPA  @0 Salud pública @5 08
C03 06  X  FRE  @0 Santé et environnement @5 09
C03 06  X  ENG  @0 Health and environment @5 09
C03 06  X  SPA  @0 Salud y medio ambiente @5 09
C03 07  X  FRE  @0 Mesure concentration @5 11
C03 07  X  ENG  @0 Concentration measurement @5 11
C03 07  X  SPA  @0 Medición concentración @5 11
C03 08  X  FRE  @0 Liquide biologique @5 12
C03 08  X  ENG  @0 Biological fluid @5 12
C03 08  X  SPA  @0 Líquido biológico @5 12
C03 09  X  FRE  @0 Mère @5 16
C03 09  X  ENG  @0 Mother @5 16
C03 09  X  SPA  @0 Madre @5 16
C03 10  X  FRE  @0 Lait maternel @5 17
C03 10  X  ENG  @0 Breast milk @5 17
C03 10  X  SPA  @0 Leche materna @5 17
C03 11  X  FRE  @0 Canada @2 NG @5 18
C03 11  X  ENG  @0 Canada @2 NG @5 18
C03 11  X  SPA  @0 Canadá @2 NG @5 18
C03 12  X  FRE  @0 Polluant émergent @4 CD @5 96
C03 12  X  ENG  @0 Emerging pollutant @4 CD @5 96
C07 01  X  FRE  @0 Amérique du Nord @2 NG
C07 01  X  ENG  @0 North America @2 NG
C07 01  X  SPA  @0 America del norte @2 NG
C07 02  X  FRE  @0 Amérique @2 NG
C07 02  X  ENG  @0 America @2 NG
C07 02  X  SPA  @0 America @2 NG
C07 03  X  FRE  @0 Composé organique @2 NA @5 61
C07 03  X  ENG  @0 Organic compounds @2 NA @5 61
C07 03  X  SPA  @0 Compuesto orgánico @2 NA @5 61
N21       @1 075

Format Inist (serveur)

NO : PASCAL 15-0038201 INIST
ET : Measurements of Selected Brominated Flame Retardants in Nursing Women: Implications for Human Exposure
AU : NINGSUN ZHOU (Simon); BUCHAR (Angelina); SIDDIQUE (Shabana); TAKSER (Larissa); ABDELOUAHAB (Nadia); JIPING ZHU; STERN (Paul C.); WEBLER (Thomas); SMALL (Mitchell J.)
AF : Exposure and Biomonitoring Division, Health Canada/Ottawa, Ontario K1A 0K9/Canada (1 aut., 3 aut., 6 aut.); Existing Substances Risk Assessment Bureau, Health Canada/Ottawa, Ontario K1A 0K9/Canada (2 aut.); Département de Pédiatrie, Faculté de Médecine, Université de Sherbrooke/Sherbrooke, Québec J1K 2R1/Canada (4 aut., 5 aut.); National Research Council, Board on Environmental Change and Society/Washington, DC20001/Etats-Unis (1 aut.); Social and Environmental Research Institute/Amherst, Massachusetts 01002/Etats-Unis (2 aut.); H. John Heinz III Professor of Environmental Engineering, Carnegie Mellon University/Pittsburgh, Pennsylvania 15213/Etats-Unis (3 aut.)
DT : Publication en série; Niveau analytique
SO : Environmental science & technology; ISSN 0013-936X; Coden ESTHAG; Etats-Unis; Da. 2014; Vol. 48; No. 15; Pp. 8873-8880; Bibl. 56 ref.
LA : Anglais
EA : We have examined several emerging brominated flame retardants (BFRs) including 2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. Three legacy BFRs were also included in the study for comparison: decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had detection frequencies greater than 55% in both serum and milk samples. Their lipid weight (lw) adjusted median concentrations (ng g-1 lw) in serum and milk were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, respectively. The detection frequencies for the other BFRs measured in serum and milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB over the sum of TBB and TBPH (f.TBB) in serum (0.23) was lower than that in milk (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in humans, and the need to better understand their sources, routes of exposure, and potential human health effects.
CC : 002B03L06
FD : Retardateur flamme; Brome composé organique; Brome Composé organique; Passage lait; Santé publique; Santé et environnement; Mesure concentration; Liquide biologique; Mère; Lait maternel; Canada; Polluant émergent
FG : Amérique du Nord; Amérique; Composé organique
ED : Flame retardant; Organic bromine compounds; Bromine Organic compounds; Milk transfer; Public health; Health and environment; Concentration measurement; Biological fluid; Mother; Breast milk; Canada; Emerging pollutant
EG : North America; America; Organic compounds
SD : Retardador llama; Bromo Compuesto orgánico; Paso leche; Salud pública; Salud y medio ambiente; Medición concentración; Líquido biológico; Madre; Leche materna; Canadá
LO : INIST-13615.354000504883950660
ID : 15-0038201

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Pascal:15-0038201

Le document en format XML

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<div type="abstract" xml:lang="en">We have examined several emerging brominated flame retardants (BFRs) including 2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. Three legacy BFRs were also included in the study for comparison: decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had detection frequencies greater than 55% in both serum and milk samples. Their lipid weight (lw) adjusted median concentrations (ng g
<sup>-1 </sup>
lw) in serum and milk were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, respectively. The detection frequencies for the other BFRs measured in serum and milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB over the sum of TBB and TBPH (f.
<sub>TBB</sub>
) in serum (0.23) was lower than that in milk (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in humans, and the need to better understand their sources, routes of exposure, and potential human health effects.</div>
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</fA11>
<fA11 i1="02" i2="1">
<s1>BUCHAR (Angelina)</s1>
</fA11>
<fA11 i1="03" i2="1">
<s1>SIDDIQUE (Shabana)</s1>
</fA11>
<fA11 i1="04" i2="1">
<s1>TAKSER (Larissa)</s1>
</fA11>
<fA11 i1="05" i2="1">
<s1>ABDELOUAHAB (Nadia)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>JIPING ZHU</s1>
</fA11>
<fA12 i1="01" i2="1">
<s1>STERN (Paul C.)</s1>
<s9>limin.</s9>
</fA12>
<fA12 i1="02" i2="1">
<s1>WEBLER (Thomas)</s1>
<s9>limin.</s9>
</fA12>
<fA12 i1="03" i2="1">
<s1>SMALL (Mitchell J.)</s1>
<s9>limin.</s9>
</fA12>
<fA14 i1="01">
<s1>Exposure and Biomonitoring Division, Health Canada</s1>
<s2>Ottawa, Ontario K1A 0K9</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Existing Substances Risk Assessment Bureau, Health Canada</s1>
<s2>Ottawa, Ontario K1A 0K9</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Département de Pédiatrie, Faculté de Médecine, Université de Sherbrooke</s1>
<s2>Sherbrooke, Québec J1K 2R1</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA15 i1="01">
<s1>National Research Council, Board on Environmental Change and Society</s1>
<s2>Washington, DC20001</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</fA15>
<fA15 i1="02">
<s1>Social and Environmental Research Institute</s1>
<s2>Amherst, Massachusetts 01002</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</fA15>
<fA15 i1="03">
<s1>H. John Heinz III Professor of Environmental Engineering, Carnegie Mellon University</s1>
<s2>Pittsburgh, Pennsylvania 15213</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</fA15>
<fA20>
<s1>8873-8880</s1>
</fA20>
<fA21>
<s1>2014</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>13615</s2>
<s5>354000504883950660</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2015 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>56 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>15-0038201</s0>
</fA47>
<fA60>
<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Environmental science & technology</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>We have examined several emerging brominated flame retardants (BFRs) including 2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. Three legacy BFRs were also included in the study for comparison: decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had detection frequencies greater than 55% in both serum and milk samples. Their lipid weight (lw) adjusted median concentrations (ng g
<sup>-1 </sup>
lw) in serum and milk were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, respectively. The detection frequencies for the other BFRs measured in serum and milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB over the sum of TBB and TBPH (f.
<sub>TBB</sub>
) in serum (0.23) was lower than that in milk (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in humans, and the need to better understand their sources, routes of exposure, and potential human health effects.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B03L06</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Retardateur flamme</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Flame retardant</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Retardador llama</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="3" l="FRE">
<s0>Brome composé organique</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="3" l="ENG">
<s0>Organic bromine compounds</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Brome Composé organique</s0>
<s2>NC</s2>
<s2>FR</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Bromine Organic compounds</s0>
<s2>NC</s2>
<s2>FR</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Bromo Compuesto orgánico</s0>
<s2>NC</s2>
<s2>FR</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Passage lait</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Milk transfer</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Paso leche</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Santé publique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Public health</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Salud pública</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Santé et environnement</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Health and environment</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Salud y medio ambiente</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Mesure concentration</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Concentration measurement</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Medición concentración</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Liquide biologique</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Biological fluid</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Líquido biológico</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Mère</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Mother</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Madre</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Lait maternel</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Breast milk</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Leche materna</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Canada</s0>
<s2>NG</s2>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Canada</s0>
<s2>NG</s2>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Canadá</s0>
<s2>NG</s2>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE">
<s0>Polluant émergent</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG">
<s0>Emerging pollutant</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Amérique du Nord</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>North America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>America del norte</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Amérique</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Composé organique</s0>
<s2>NA</s2>
<s5>61</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Organic compounds</s0>
<s2>NA</s2>
<s5>61</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Compuesto orgánico</s0>
<s2>NA</s2>
<s5>61</s5>
</fC07>
<fN21>
<s1>075</s1>
</fN21>
</pA>
</standard>
<server>
<NO>PASCAL 15-0038201 INIST</NO>
<ET>Measurements of Selected Brominated Flame Retardants in Nursing Women: Implications for Human Exposure</ET>
<AU>NINGSUN ZHOU (Simon); BUCHAR (Angelina); SIDDIQUE (Shabana); TAKSER (Larissa); ABDELOUAHAB (Nadia); JIPING ZHU; STERN (Paul C.); WEBLER (Thomas); SMALL (Mitchell J.)</AU>
<AF>Exposure and Biomonitoring Division, Health Canada/Ottawa, Ontario K1A 0K9/Canada (1 aut., 3 aut., 6 aut.); Existing Substances Risk Assessment Bureau, Health Canada/Ottawa, Ontario K1A 0K9/Canada (2 aut.); Département de Pédiatrie, Faculté de Médecine, Université de Sherbrooke/Sherbrooke, Québec J1K 2R1/Canada (4 aut., 5 aut.); National Research Council, Board on Environmental Change and Society/Washington, DC20001/Etats-Unis (1 aut.); Social and Environmental Research Institute/Amherst, Massachusetts 01002/Etats-Unis (2 aut.); H. John Heinz III Professor of Environmental Engineering, Carnegie Mellon University/Pittsburgh, Pennsylvania 15213/Etats-Unis (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Environmental science & technology; ISSN 0013-936X; Coden ESTHAG; Etats-Unis; Da. 2014; Vol. 48; No. 15; Pp. 8873-8880; Bibl. 56 ref.</SO>
<LA>Anglais</LA>
<EA>We have examined several emerging brominated flame retardants (BFRs) including 2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. Three legacy BFRs were also included in the study for comparison: decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had detection frequencies greater than 55% in both serum and milk samples. Their lipid weight (lw) adjusted median concentrations (ng g
<sup>-1 </sup>
lw) in serum and milk were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, respectively. The detection frequencies for the other BFRs measured in serum and milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB over the sum of TBB and TBPH (f.
<sub>TBB</sub>
) in serum (0.23) was lower than that in milk (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in humans, and the need to better understand their sources, routes of exposure, and potential human health effects.</EA>
<CC>002B03L06</CC>
<FD>Retardateur flamme; Brome composé organique; Brome Composé organique; Passage lait; Santé publique; Santé et environnement; Mesure concentration; Liquide biologique; Mère; Lait maternel; Canada; Polluant émergent</FD>
<FG>Amérique du Nord; Amérique; Composé organique</FG>
<ED>Flame retardant; Organic bromine compounds; Bromine Organic compounds; Milk transfer; Public health; Health and environment; Concentration measurement; Biological fluid; Mother; Breast milk; Canada; Emerging pollutant</ED>
<EG>North America; America; Organic compounds</EG>
<SD>Retardador llama; Bromo Compuesto orgánico; Paso leche; Salud pública; Salud y medio ambiente; Medición concentración; Líquido biológico; Madre; Leche materna; Canadá</SD>
<LO>INIST-13615.354000504883950660</LO>
<ID>15-0038201</ID>
</server>
</inist>
</record>

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