Links between Osteoarthritis and Diabetes:Implications for Management from a Physical Activity Perspective
Identifieur interne : 004142 ( Ncbi/Merge ); précédent : 004141; suivant : 004143Links between Osteoarthritis and Diabetes:Implications for Management from a Physical Activity Perspective
Auteurs : Sara R. Piva [États-Unis] ; Allyn M. Susko [États-Unis] ; Samannaaz S. Khoja [États-Unis] ; Deborah A. Josbeno [États-Unis] ; G. Kelley Fitzgerald [États-Unis] ; Frederico G. S. Toledo [États-Unis]Source :
- Clinics in geriatric medicine [ 0749-0690 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- complications : Diabetes Mellitus, Type 2, Obesity, Osteoarthritis.
- therapy : Diabetes Mellitus, Type 2, Osteoarthritis.
- Age Factors, Aged, Exercise, Humans, Risk Factors.
Abstract
Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often co-exist in older adults. There is increased susceptibility to develop arthritis in those with T2DM, which is supported by observations of higher prevalence of arthritis in those with T2DM (52%) compared to those without it (27%). The association between OA and T2DM has been traditionally attributed to underlying shared risk factors of age and obesity. Emerging evidence suggests that alterations in lipid metabolism and hyperglycemia might have a direct impact on cartilage health and subchondral bone that contribute to the development and/or progression of OA. Adequate management of older persons with both OA and T2DM benefits from a comprehensive understanding of the risk factors associated with these diseases. In this review, we discuss common risk factors and emerging underlying links between OA and T2DM, and emphasize the importance of physical activity to improve metabolism and decrease disability and pain in this population. Implications for safe and effective physical activity approaches in older patients with OA and T2DM are also discussed.
Url:
DOI: 10.1016/j.cger.2014.08.019
PubMed: 25453302
PubMed Central: 4254543
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Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Toledo, Frederico G S" sort="Toledo, Frederico G S" uniqKey="Toledo F" first="Frederico G. S." last="Toledo">Frederico G. S. Toledo</name><affiliation wicri:level="2"><nlm:aff id="A2">Division of Endocrinology and Metabolism, Dept. of Medicine, University of Pittsburgh. 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There is increased susceptibility to develop arthritis in those with T2DM, which is supported by observations of higher prevalence of arthritis in those with T2DM (52%) compared to those without it (27%). The association between OA and T2DM has been traditionally attributed to underlying shared risk factors of age and obesity. Emerging evidence suggests that alterations in lipid metabolism and hyperglycemia might have a direct impact on cartilage health and subchondral bone that contribute to the development and/or progression of OA. Adequate management of older persons with both OA and T2DM benefits from a comprehensive understanding of the risk factors associated with these diseases. In this review, we discuss common risk factors and emerging underlying links between OA and T2DM, and emphasize the importance of physical activity to improve metabolism and decrease disability and pain in this population. Implications for safe and effective physical activity approaches in older patients with OA and T2DM are also discussed.</p></div></front></TEI><double pmid="25453302"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Links between Osteoarthritis and Diabetes:Implications for Management from a Physical Activity Perspective</title><author><name sortKey="Piva, Sara R" sort="Piva, Sara R" uniqKey="Piva S" first="Sara R." last="Piva">Sara R. Piva</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Susko, Allyn M" sort="Susko, Allyn M" uniqKey="Susko A" first="Allyn M." last="Susko">Allyn M. Susko</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Khoja, Samannaaz S" sort="Khoja, Samannaaz S" uniqKey="Khoja S" first="Samannaaz S." last="Khoja">Samannaaz S. Khoja</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Josbeno, Deborah A" sort="Josbeno, Deborah A" uniqKey="Josbeno D" first="Deborah A." last="Josbeno">Deborah A. Josbeno</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Fitzgerald, G Kelley" sort="Fitzgerald, G Kelley" uniqKey="Fitzgerald G" first="G. Kelley" last="Fitzgerald">G. Kelley Fitzgerald</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Toledo, Frederico G S" sort="Toledo, Frederico G S" uniqKey="Toledo F" first="Frederico G. S." last="Toledo">Frederico G. S. Toledo</name><affiliation wicri:level="2"><nlm:aff id="A2">Division of Endocrinology and Metabolism, Dept. of Medicine, University of Pittsburgh. Address: 200 Lothrop St. BST E1140, Pittsburgh, PA 15261</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Endocrinology and Metabolism, Dept. of Medicine, University of Pittsburgh. Address: 200 Lothrop St. BST E1140, Pittsburgh</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25453302</idno><idno type="pmc">4254543</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254543</idno><idno type="RBID">PMC:4254543</idno><idno type="doi">10.1016/j.cger.2014.08.019</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001607</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001607</idno><idno type="wicri:Area/Pmc/Curation">001582</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001582</idno><idno type="wicri:Area/Pmc/Checkpoint">000E26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Links between Osteoarthritis and Diabetes:Implications for Management from a Physical Activity Perspective</title><author><name sortKey="Piva, Sara R" sort="Piva, Sara R" uniqKey="Piva S" first="Sara R." last="Piva">Sara R. Piva</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Susko, Allyn M" sort="Susko, Allyn M" uniqKey="Susko A" first="Allyn M." last="Susko">Allyn M. Susko</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Khoja, Samannaaz S" sort="Khoja, Samannaaz S" uniqKey="Khoja S" first="Samannaaz S." last="Khoja">Samannaaz S. Khoja</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Josbeno, Deborah A" sort="Josbeno, Deborah A" uniqKey="Josbeno D" first="Deborah A." last="Josbeno">Deborah A. Josbeno</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Fitzgerald, G Kelley" sort="Fitzgerald, G Kelley" uniqKey="Fitzgerald G" first="G. Kelley" last="Fitzgerald">G. Kelley Fitzgerald</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh, PA 15219</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh. Address: Bridgeside Point 1, 100 Technology Drive – Suite 210, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Toledo, Frederico G S" sort="Toledo, Frederico G S" uniqKey="Toledo F" first="Frederico G. S." last="Toledo">Frederico G. S. Toledo</name><affiliation wicri:level="2"><nlm:aff id="A2">Division of Endocrinology and Metabolism, Dept. of Medicine, University of Pittsburgh. Address: 200 Lothrop St. BST E1140, Pittsburgh, PA 15261</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Endocrinology and Metabolism, Dept. of Medicine, University of Pittsburgh. Address: 200 Lothrop St. BST E1140, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinics in geriatric medicine</title><idno type="ISSN">0749-0690</idno><idno type="eISSN">1879-8853</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SYNOPSIS</title><p id="P1">Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often co-exist in older adults. There is increased susceptibility to develop arthritis in those with T2DM, which is supported by observations of higher prevalence of arthritis in those with T2DM (52%) compared to those without it (27%). The association between OA and T2DM has been traditionally attributed to underlying shared risk factors of age and obesity. Emerging evidence suggests that alterations in lipid metabolism and hyperglycemia might have a direct impact on cartilage health and subchondral bone that contribute to the development and/or progression of OA. Adequate management of older persons with both OA and T2DM benefits from a comprehensive understanding of the risk factors associated with these diseases. In this review, we discuss common risk factors and emerging underlying links between OA and T2DM, and emphasize the importance of physical activity to improve metabolism and decrease disability and pain in this population. Implications for safe and effective physical activity approaches in older patients with OA and T2DM are also discussed.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Links between osteoarthritis and diabetes: implications for management from a physical activity perspective.</title><author><name sortKey="Piva, Sara R" sort="Piva, Sara R" uniqKey="Piva S" first="Sara R" last="Piva">Sara R. Piva</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA. Electronic address: spiva@pitt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Susko, Allyn M" sort="Susko, Allyn M" uniqKey="Susko A" first="Allyn M" last="Susko">Allyn M. Susko</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Khoja, Samannaaz S" sort="Khoja, Samannaaz S" uniqKey="Khoja S" first="Samannaaz S" last="Khoja">Samannaaz S. Khoja</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Josbeno, Deborah A" sort="Josbeno, Deborah A" uniqKey="Josbeno D" first="Deborah A" last="Josbeno">Deborah A. Josbeno</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Fitzgerald, G Kelley" sort="Fitzgerald, G Kelley" uniqKey="Fitzgerald G" first="G Kelley" last="Fitzgerald">G Kelley Fitzgerald</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Toledo, Frederico G S" sort="Toledo, Frederico G S" uniqKey="Toledo F" first="Frederico G S" last="Toledo">Frederico G S. Toledo</name><affiliation wicri:level="4"><nlm:affiliation>Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, BST E1140, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, BST E1140, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25453302</idno><idno type="pmid">25453302</idno><idno type="doi">10.1016/j.cger.2014.08.019</idno><idno type="wicri:Area/PubMed/Corpus">000609</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000609</idno><idno type="wicri:Area/PubMed/Curation">000609</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000609</idno><idno type="wicri:Area/PubMed/Checkpoint">000609</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000609</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Links between osteoarthritis and diabetes: implications for management from a physical activity perspective.</title><author><name sortKey="Piva, Sara R" sort="Piva, Sara R" uniqKey="Piva S" first="Sara R" last="Piva">Sara R. Piva</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA. Electronic address: spiva@pitt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Susko, Allyn M" sort="Susko, Allyn M" uniqKey="Susko A" first="Allyn M" last="Susko">Allyn M. Susko</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Khoja, Samannaaz S" sort="Khoja, Samannaaz S" uniqKey="Khoja S" first="Samannaaz S" last="Khoja">Samannaaz S. Khoja</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Josbeno, Deborah A" sort="Josbeno, Deborah A" uniqKey="Josbeno D" first="Deborah A" last="Josbeno">Deborah A. Josbeno</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Fitzgerald, G Kelley" sort="Fitzgerald, G Kelley" uniqKey="Fitzgerald G" first="G Kelley" last="Fitzgerald">G Kelley Fitzgerald</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Toledo, Frederico G S" sort="Toledo, Frederico G S" uniqKey="Toledo F" first="Frederico G S" last="Toledo">Frederico G S. Toledo</name><affiliation wicri:level="4"><nlm:affiliation>Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, BST E1140, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, BST E1140, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j">Clinics in geriatric medicine</title><idno type="eISSN">1879-8853</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Diabetes Mellitus, Type 2 (complications)</term><term>Diabetes Mellitus, Type 2 (therapy)</term><term>Exercise</term><term>Humans</term><term>Obesity (complications)</term><term>Osteoarthritis (complications)</term><term>Osteoarthritis (therapy)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Arthrose ()</term><term>Diabète de type 2 ()</term><term>Exercice physique</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Humains</term><term>Obésité ()</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Obesity</term><term>Osteoarthritis</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Osteoarthritis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Exercise</term><term>Humans</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Arthrose</term><term>Diabète de type 2</term><term>Exercice physique</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Humains</term><term>Obésité</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist in older adults. Those with T2DM are more susceptible to developing arthritis, which has been traditionally attributed to common risk factors, namely, age and obesity. Alterations in lipid metabolism and hyperglycemia might directly impact cartilage health and subchondral bone, contributing to the development/progression of OA. Adequate management of older persons with both conditions benefits from a comprehensive understanding of the associated risk factors. We discuss common risk factors and emerging links between OA and T2DM, emphasizing the importance of physical activity and the implications of safe and effective physical activity.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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