PittsburghV1, Ncbi, Merge, bibRecord, 002482

Wnt-responsive Lgr5⁺ globose basal cells function as multipotent olfactory epithelium progenitor cells.

Identifieur interne : 002482 ( Ncbi/Merge ); précédent : 002481; suivant : 002483

Wnt-responsive Lgr5⁺ globose basal cells function as multipotent olfactory epithelium progenitor cells.

Auteurs : Mengfei Chen ; Shenghe Tian ; Xiaoling Yang ; Andrew P. Lane ; Randall R. Reed [États-Unis] ; Hongjun Liu [États-Unis]

Source :

The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2014.

RBID : pubmed:24920630

Descripteurs français

English descriptors

KwdEn :
- Animals, Animals, Newborn, Bacterial Capsules (metabolism), Basic Helix-Loop-Helix Transcription Factors (metabolism), Cell Differentiation (physiology), Flow Cytometry, GAP-43 Protein (metabolism), Glial Fibrillary Acidic Protein (metabolism), Green Fluorescent Proteins (genetics), Green Fluorescent Proteins (metabolism), Intercellular Adhesion Molecule-1 (metabolism), Ki-67 Antigen (metabolism), Mice, Mice, Transgenic, Multipotent Stem Cells (physiology), Olfactory Marker Protein (metabolism), Olfactory Mucosa (cytology), Olfactory Receptor Neurons (physiology), Receptors, G-Protein-Coupled (genetics), Receptors, G-Protein-Coupled (metabolism), beta-Galactosidase (metabolism).
MESH :
- chemical , genetics : Green Fluorescent Proteins, Receptors, G-Protein-Coupled.
- chemical , metabolism : Basic Helix-Loop-Helix Transcription Factors, GAP-43 Protein, Glial Fibrillary Acidic Protein, Green Fluorescent Proteins, Intercellular Adhesion Molecule-1, Ki-67 Antigen, Olfactory Marker Protein, Receptors, G-Protein-Coupled, beta-Galactosidase.
- cytology : Olfactory Mucosa.
- metabolism : Bacterial Capsules.
- physiology : Cell Differentiation, Multipotent Stem Cells, Olfactory Receptor Neurons.
- Animals, Animals, Newborn, Flow Cytometry, Mice, Mice, Transgenic.

Abstract

Persistent neurogenesis in the olfactory epithelium provides a unique model to study neural stem cell self-renewal and fate determination. In the olfactory neuroepithelium, globose basal cells (GBCs) are considered to be the direct progenitors of olfactory neurons. However, the study of neurogenesis from GBCs has been impeded by the paucity of GBC-specific markers. Here we report that Lgr5, a recently discovered adult stem cell marker, is exclusively expressed in GBCs in neonatal and adult mice. Lgr5(+) cells display characteristics of cycling stem cells, including Ki67 expression and EdU incorporation. Lineage tracing analysis demonstrates that Lgr5(+) GBCs regenerate multiple cell types under normal turnover condition or after olfactory lesion. Furthermore, upregulation or downregulation of Wnt signaling in vivo indicates a key role of Wnt signaling not only in maintaining Lgr5(+) cell proliferation and promoting neuroregeneration, but also in delaying sensory neuron maturation. Together, our observations provided new insights into the dynamics of neurogenesis in the olfactory epithelium.

DOI: 10.1523/JNEUROSCI.0240-14.2014
PubMed: 24920630

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002B09
to stream PubMed, to step Curation: 002A93
to stream PubMed, to step Checkpoint: 002A93

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pubmed:24920630

Le document en format XML

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<front><div type="abstract" xml:lang="en">Persistent neurogenesis in the olfactory epithelium provides a unique model to study neural stem cell self-renewal and fate determination. In the olfactory neuroepithelium, globose basal cells (GBCs) are considered to be the direct progenitors of olfactory neurons. However, the study of neurogenesis from GBCs has been impeded by the paucity of GBC-specific markers. Here we report that Lgr5, a recently discovered adult stem cell marker, is exclusively expressed in GBCs in neonatal and adult mice. Lgr5(+) cells display characteristics of cycling stem cells, including Ki67 expression and EdU incorporation. Lineage tracing analysis demonstrates that Lgr5(+) GBCs regenerate multiple cell types under normal turnover condition or after olfactory lesion. Furthermore, upregulation or downregulation of Wnt signaling in vivo indicates a key role of Wnt signaling not only in maintaining Lgr5(+) cell proliferation and promoting neuroregeneration, but also in delaying sensory neuron maturation. Together, our observations provided new insights into the dynamics of neurogenesis in the olfactory epithelium.</div>
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<Abstract><AbstractText>Persistent neurogenesis in the olfactory epithelium provides a unique model to study neural stem cell self-renewal and fate determination. In the olfactory neuroepithelium, globose basal cells (GBCs) are considered to be the direct progenitors of olfactory neurons. However, the study of neurogenesis from GBCs has been impeded by the paucity of GBC-specific markers. Here we report that Lgr5, a recently discovered adult stem cell marker, is exclusively expressed in GBCs in neonatal and adult mice. Lgr5(+) cells display characteristics of cycling stem cells, including Ki67 expression and EdU incorporation. Lineage tracing analysis demonstrates that Lgr5(+) GBCs regenerate multiple cell types under normal turnover condition or after olfactory lesion. Furthermore, upregulation or downregulation of Wnt signaling in vivo indicates a key role of Wnt signaling not only in maintaining Lgr5(+) cell proliferation and promoting neuroregeneration, but also in delaying sensory neuron maturation. Together, our observations provided new insights into the dynamics of neurogenesis in the olfactory epithelium.</AbstractText>
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<Keyword MajorTopicYN="N">globose basal cells</Keyword>
<Keyword MajorTopicYN="N">neural stem cells</Keyword>
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<affiliations><list><country><li>États-Unis</li>
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<name sortKey="Tian, Shenghe" sort="Tian, Shenghe" uniqKey="Tian S" first="Shenghe" last="Tian">Shenghe Tian</name>
<name sortKey="Yang, Xiaoling" sort="Yang, Xiaoling" uniqKey="Yang X" first="Xiaoling" last="Yang">Xiaoling Yang</name>
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Wnt-responsive Lgr5⁺ globose basal cells function as multipotent olfactory epithelium progenitor cells.

Wnt-responsive Lgr5⁺ globose basal cells function as multipotent olfactory epithelium progenitor cells.

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