Bisphosphonates in breast cancer.
Identifieur interne : 002003 ( Ncbi/Merge ); précédent : 002002; suivant : 002004Bisphosphonates in breast cancer.
Auteurs : Aju Mathew [États-Unis] ; Adam Brufsky [États-Unis]Source :
- International journal of cancer [ 1097-0215 ] ; 2015.
Descripteurs français
- KwdFr :
- Diphosphonates (administration et posologie), Femelle, Humains, Inhibiteurs de l'aromatase (administration et posologie), Résorption osseuse (anatomopathologie), Résorption osseuse (traitement médicamenteux), Tumeurs du sein (traitement médicamenteux), Tumeurs osseuses (anatomopathologie), Tumeurs osseuses (secondaire), Tumeurs osseuses (traitement médicamenteux).
- MESH :
- administration et posologie : Diphosphonates, Inhibiteurs de l'aromatase.
- anatomopathologie : Résorption osseuse, Tumeurs osseuses.
- secondaire : Tumeurs osseuses.
- traitement médicamenteux : Résorption osseuse, Tumeurs du sein, Tumeurs osseuses.
- Femelle, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Aromatase Inhibitors, Diphosphonates.
- drug therapy : Bone Neoplasms, Bone Resorption, Breast Neoplasms.
- pathology : Bone Neoplasms, Bone Resorption.
- secondary : Bone Neoplasms.
- Female, Humans.
Abstract
Bisphosphonates are osteoclast inhibitors, currently being used in oncology to prevent or delay bone morbidity in cancer. Oral and intravenous formulations of bisphosphonates have been found to be efficacious in preventing skeletal-related events such as bone pain, pathologic fractures, spinal cord compression and hypercalcemia of malignancy, in patients with bone metastatic breast cancer. Bisphosphonates are also used to prevent bone loss associated with anti-estrogen therapy using aromatase inhibitors. In addition to its role in preventing bone resorption, several pre-clinical studies have noted an anti-tumor role as well. Recent research effort has particularly focused on investigating an adjuvant role for bisphosphonates in early breast cancer. Recently, few randomized trials have found a beneficial effect for adjuvant use of the aminobisphosphonate, zoledronate, in older patients who are post-menopausal. This review article will summarize the various clinical studies investigating the role of bisphosphonates in breast cancer.
DOI: 10.1002/ijc.28965
PubMed: 24824552
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xml:lang="en">Bisphosphonates are osteoclast inhibitors, currently being used in oncology to prevent or delay bone morbidity in cancer. Oral and intravenous formulations of bisphosphonates have been found to be efficacious in preventing skeletal-related events such as bone pain, pathologic fractures, spinal cord compression and hypercalcemia of malignancy, in patients with bone metastatic breast cancer. Bisphosphonates are also used to prevent bone loss associated with anti-estrogen therapy using aromatase inhibitors. In addition to its role in preventing bone resorption, several pre-clinical studies have noted an anti-tumor role as well. Recent research effort has particularly focused on investigating an adjuvant role for bisphosphonates in early breast cancer. Recently, few randomized trials have found a beneficial effect for adjuvant use of the aminobisphosphonate, zoledronate, in older patients who are post-menopausal. 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