Determinants of Heat Generation in Patients Treated With Therapeutic Hypothermia Following Cardiac Arrest
Identifieur interne : 001D59 ( Ncbi/Merge ); précédent : 001D58; suivant : 001D60Determinants of Heat Generation in Patients Treated With Therapeutic Hypothermia Following Cardiac Arrest
Auteurs : Matthew R. Murnin ; Petra Sonder ; Gladys N. Janssens ; Connie L. Henry ; Kees H. Polderman ; Jon C. Rittenberger ; Cameron DezfulianSource :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease [ 2047-9980 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Métabolisme basal, Température du corps, Thermogenèse.
- physiopathologie : Arrêt cardiaque.
- Adulte d'âge moyen, Arrêt cardiaque, Femelle, Humains, Hypothermie provoquée, Indice de gravité médicale, Mâle, Résultat thérapeutique, Études prospectives.
English descriptors
- KwdEn :
- MESH :
- physiology : Basal Metabolism, Body Temperature, Thermogenesis.
- physiopathology : Heart Arrest.
- therapy : Heart Arrest.
- Female, Humans, Hypothermia, Induced, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Treatment Outcome.
Abstract
Therapeutic hypothermia (TH) is recommended to reduce ischemic brain injury after cardiac arrest. The variables that predict heat generation by patients receiving TH are uncertain, as is how this heat generation relates to neurologic outcome. We hypothesized that patient characteristics, medication use, inflammation, and organ injury would be associated with heat generation. We further hypothesized that neurologic outcome would be most strongly associated with heat generation.
Surface and intravascular cooling devices were used to provide TH in 57 consecutive cardiac arrest patients. Device water temperatures during the maintenance (33°C) phase were collected. Patient heat generation was quantified as the “heat index” (HI), which was the inverse average water temperature over a minimum of 2 hours of maintenance hypothermia. Variables measuring reduced ischemic injury and improved baseline health were significantly associated with HI. After controlling for presenting rhythm, a higher HI was independently associated with favorable disposition (OR=2.2; 95% CI 1.2 to 4.1;
In cardiac arrest patients receiving TH, greater heat generation is associated with better baseline health, reduced ischemic injury, and improved neurologic function, which results in higher metabolism. HI can control for confounding effects of patient heat generation in future clinical trials of rapid TH and offers early prognostic information.
Url:
DOI: 10.1161/JAHA.113.000580
PubMed: 24780205
PubMed Central: 4309044
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001B74
- to stream Pmc, to step Curation: 001B49
- to stream Pmc, to step Checkpoint: 001659
- to stream PubMed, to step Corpus: 003121
- to stream PubMed, to step Curation: 003100
- to stream PubMed, to step Checkpoint: 003100
Links to Exploration step
PMC:4309044Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Determinants of Heat Generation in Patients Treated With Therapeutic Hypothermia Following Cardiac Arrest</title><author><name sortKey="Murnin, Matthew R" sort="Murnin, Matthew R" uniqKey="Murnin M" first="Matthew R." last="Murnin">Matthew R. Murnin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sonder, Petra" sort="Sonder, Petra" uniqKey="Sonder P" first="Petra" last="Sonder">Petra Sonder</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Janssens, Gladys N" sort="Janssens, Gladys N" uniqKey="Janssens G" first="Gladys N." last="Janssens">Gladys N. Janssens</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Henry, Connie L" sort="Henry, Connie L" uniqKey="Henry C" first="Connie L." last="Henry">Connie L. Henry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Polderman, Kees H" sort="Polderman, Kees H" uniqKey="Polderman K" first="Kees H." last="Polderman">Kees H. Polderman</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rittenberger, Jon C" sort="Rittenberger, Jon C" uniqKey="Rittenberger J" first="Jon C." last="Rittenberger">Jon C. Rittenberger</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Dezfulian, Cameron" sort="Dezfulian, Cameron" uniqKey="Dezfulian C" first="Cameron" last="Dezfulian">Cameron Dezfulian</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24780205</idno><idno type="pmc">4309044</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309044</idno><idno type="RBID">PMC:4309044</idno><idno type="doi">10.1161/JAHA.113.000580</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001B74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B74</idno><idno type="wicri:Area/Pmc/Curation">001B49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B49</idno><idno type="wicri:Area/Pmc/Checkpoint">001659</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001659</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003121</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003121</idno><idno type="wicri:Area/PubMed/Curation">003100</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003100</idno><idno type="wicri:Area/PubMed/Checkpoint">003100</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003100</idno><idno type="wicri:Area/Ncbi/Merge">001D59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Determinants of Heat Generation in Patients Treated With Therapeutic Hypothermia Following Cardiac Arrest</title><author><name sortKey="Murnin, Matthew R" sort="Murnin, Matthew R" uniqKey="Murnin M" first="Matthew R." last="Murnin">Matthew R. Murnin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sonder, Petra" sort="Sonder, Petra" uniqKey="Sonder P" first="Petra" last="Sonder">Petra Sonder</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Janssens, Gladys N" sort="Janssens, Gladys N" uniqKey="Janssens G" first="Gladys N." last="Janssens">Gladys N. Janssens</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Henry, Connie L" sort="Henry, Connie L" uniqKey="Henry C" first="Connie L." last="Henry">Connie L. Henry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Polderman, Kees H" sort="Polderman, Kees H" uniqKey="Polderman K" first="Kees H." last="Polderman">Kees H. Polderman</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rittenberger, Jon C" sort="Rittenberger, Jon C" uniqKey="Rittenberger J" first="Jon C." last="Rittenberger">Jon C. Rittenberger</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Dezfulian, Cameron" sort="Dezfulian, Cameron" uniqKey="Dezfulian C" first="Cameron" last="Dezfulian">Cameron Dezfulian</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease</title><idno type="eISSN">2047-9980</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal Metabolism (physiology)</term><term>Body Temperature (physiology)</term><term>Female</term><term>Heart Arrest (physiopathology)</term><term>Heart Arrest (therapy)</term><term>Humans</term><term>Hypothermia, Induced</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Thermogenesis (physiology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arrêt cardiaque ()</term><term>Arrêt cardiaque (physiopathologie)</term><term>Femelle</term><term>Humains</term><term>Hypothermie provoquée</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Métabolisme basal (physiologie)</term><term>Résultat thérapeutique</term><term>Température du corps (physiologie)</term><term>Thermogenèse (physiologie)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Métabolisme basal</term><term>Température du corps</term><term>Thermogenèse</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Basal Metabolism</term><term>Body Temperature</term><term>Thermogenesis</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Arrêt cardiaque</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Heart Arrest</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Heart Arrest</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Hypothermia, Induced</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arrêt cardiaque</term><term>Femelle</term><term>Humains</term><term>Hypothermie provoquée</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Therapeutic hypothermia (TH) is recommended to reduce ischemic brain injury after cardiac arrest. The variables that predict heat generation by patients receiving TH are uncertain, as is how this heat generation relates to neurologic outcome. We hypothesized that patient characteristics, medication use, inflammation, and organ injury would be associated with heat generation. We further hypothesized that neurologic outcome would be most strongly associated with heat generation.</p></sec><sec><title>Methods and Results</title><p>Surface and intravascular cooling devices were used to provide TH in 57 consecutive cardiac arrest patients. Device water temperatures during the maintenance (33°C) phase were collected. Patient heat generation was quantified as the “heat index” (HI), which was the inverse average water temperature over a minimum of 2 hours of maintenance hypothermia. Variables measuring reduced ischemic injury and improved baseline health were significantly associated with HI. After controlling for presenting rhythm, a higher HI was independently associated with favorable disposition (OR=2.2; 95% CI 1.2 to 4.1; <italic>P</italic>=0.014) and favorable Cerebral Performance Category (OR=1.8; 95% CI 1.0 to 3.1; <italic>P</italic>=0.035). Higher HI predicted favorable disposition (receiver‐operator area under the curve 0.71, <italic>P</italic>=0.029). HI was linearly correlated with arteriovenous CO<sub>2</sub> (<italic>r</italic>=0.69; <italic>P</italic>=0.041) but not O<sub>2</sub> (<italic>r</italic>=0.13; <italic>P</italic>=0.741) gradients.</p></sec><sec><title>Conclusions</title><p>In cardiac arrest patients receiving TH, greater heat generation is associated with better baseline health, reduced ischemic injury, and improved neurologic function, which results in higher metabolism. HI can control for confounding effects of patient heat generation in future clinical trials of rapid TH and offers early prognostic information.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Merchant, Rm" uniqKey="Merchant R">RM Merchant</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Becker, Lb" uniqKey="Becker L">LB Becker</name></author><author><name sortKey="Berg, Ra" uniqKey="Berg R">RA Berg</name></author><author><name sortKey="Nadkarni, V" uniqKey="Nadkarni V">V Nadkarni</name></author><author><name sortKey="Nichol, G" uniqKey="Nichol G">G Nichol</name></author><author><name sortKey="Carr, Bg" uniqKey="Carr B">BG Carr</name></author><author><name sortKey="Mitra, N" uniqKey="Mitra N">N Mitra</name></author><author><name sortKey="Bradley, Sm" uniqKey="Bradley S">SM Bradley</name></author><author><name sortKey="Abella, Bs" uniqKey="Abella B">BS Abella</name></author><author><name sortKey="Groeneveld, Pw" uniqKey="Groeneveld P">PW Groeneveld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nichol, G" uniqKey="Nichol G">G Nichol</name></author><author><name sortKey="Thomas, E" uniqKey="Thomas E">E Thomas</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author><author><name sortKey="Hedges, J" uniqKey="Hedges J">J Hedges</name></author><author><name sortKey="Powell, Jl" uniqKey="Powell J">JL Powell</name></author><author><name sortKey="Aufderheide, Tp" uniqKey="Aufderheide T">TP Aufderheide</name></author><author><name sortKey="Rea, T" uniqKey="Rea T">T Rea</name></author><author><name sortKey="Lowe, R" uniqKey="Lowe R">R Lowe</name></author><author><name sortKey="Brown, T" uniqKey="Brown T">T Brown</name></author><author><name sortKey="Dreyer, J" uniqKey="Dreyer J">J Dreyer</name></author><author><name sortKey="Davis, D" uniqKey="Davis D">D Davis</name></author><author><name sortKey="Idris, A" uniqKey="Idris A">A Idris</name></author><author><name sortKey="Stiell, I" uniqKey="Stiell I">I Stiell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roger, Vl" uniqKey="Roger V">VL Roger</name></author><author><name sortKey="Go, As" uniqKey="Go A">AS Go</name></author><author><name sortKey="Lloyd Ones, Dm" uniqKey="Lloyd Ones D">DM Lloyd‐Jones</name></author><author><name sortKey="Benjamin, Ej" uniqKey="Benjamin E">EJ Benjamin</name></author><author><name sortKey="Berry, Jd" uniqKey="Berry J">JD Berry</name></author><author><name sortKey="Borden, Wb" uniqKey="Borden W">WB Borden</name></author><author><name sortKey="Bravata, Dm" uniqKey="Bravata D">DM Bravata</name></author><author><name sortKey="Dai, S" uniqKey="Dai S">S Dai</name></author><author><name sortKey="Ford, Es" uniqKey="Ford E">ES Ford</name></author><author><name sortKey="Fox, Cs" uniqKey="Fox C">CS Fox</name></author><author><name sortKey="Fullerton, Hj" uniqKey="Fullerton H">HJ Fullerton</name></author><author><name sortKey="Gillespie, C" uniqKey="Gillespie C">C Gillespie</name></author><author><name sortKey="Hailpern, Sm" uniqKey="Hailpern S">SM Hailpern</name></author><author><name sortKey="Heit, Ja" uniqKey="Heit J">JA Heit</name></author><author><name sortKey="Howard, Vj" uniqKey="Howard V">VJ Howard</name></author><author><name sortKey="Kissela, Bm" uniqKey="Kissela B">BM Kissela</name></author><author><name sortKey="Kittner, Sj" uniqKey="Kittner S">SJ Kittner</name></author><author><name sortKey="Lackland, Dt" uniqKey="Lackland D">DT Lackland</name></author><author><name sortKey="Lichtman, Jh" uniqKey="Lichtman J">JH Lichtman</name></author><author><name sortKey="Lisabeth, Ld" uniqKey="Lisabeth L">LD Lisabeth</name></author><author><name sortKey="Makuc, Dm" uniqKey="Makuc D">DM Makuc</name></author><author><name sortKey="Marcus, Gm" uniqKey="Marcus G">GM Marcus</name></author><author><name sortKey="Marelli, A" uniqKey="Marelli A">A Marelli</name></author><author><name sortKey="Matchar, Db" uniqKey="Matchar D">DB Matchar</name></author><author><name sortKey="Moy, Cs" uniqKey="Moy C">CS Moy</name></author><author><name sortKey="Mozaffarian, D" uniqKey="Mozaffarian D">D Mozaffarian</name></author><author><name sortKey="Mussolino, Me" uniqKey="Mussolino M">ME Mussolino</name></author><author><name sortKey="Nichol, G" uniqKey="Nichol G">G Nichol</name></author><author><name sortKey="Paynter, Np" uniqKey="Paynter N">NP Paynter</name></author><author><name sortKey="Soliman, Ez" uniqKey="Soliman E">EZ Soliman</name></author><author><name sortKey="Sorlie, Pd" uniqKey="Sorlie P">PD Sorlie</name></author><author><name sortKey="Sotoodehnia, N" uniqKey="Sotoodehnia N">N Sotoodehnia</name></author><author><name sortKey="Turan, Tn" uniqKey="Turan T">TN Turan</name></author><author><name sortKey="Virani, Ss" uniqKey="Virani S">SS Virani</name></author><author><name sortKey="Wong, Nd" uniqKey="Wong N">ND Wong</name></author><author><name sortKey="Woo, D" uniqKey="Woo D">D Woo</name></author><author><name sortKey="Turner, Mb" uniqKey="Turner M">MB Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laver, S" uniqKey="Laver S">S Laver</name></author><author><name sortKey="Farrow, C" uniqKey="Farrow C">C Farrow</name></author><author><name sortKey="Turner, D" uniqKey="Turner D">D Turner</name></author><author><name sortKey="Nolan, J" uniqKey="Nolan J">J Nolan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernard, Sa" uniqKey="Bernard S">SA Bernard</name></author><author><name sortKey="Gray, Tw" uniqKey="Gray T">TW Gray</name></author><author><name sortKey="Buist, Md" uniqKey="Buist M">MD Buist</name></author><author><name sortKey="Jones, Bm" uniqKey="Jones B">BM Jones</name></author><author><name sortKey="Silvester, W" uniqKey="Silvester W">W Silvester</name></author><author><name sortKey="Gutteridge, G" uniqKey="Gutteridge G">G Gutteridge</name></author><author><name sortKey="Smith, K" uniqKey="Smith K">K Smith</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Peberdy, Ma" uniqKey="Peberdy M">MA Peberdy</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author><author><name sortKey="Neumar, Rw" uniqKey="Neumar R">RW Neumar</name></author><author><name sortKey="Geocadin, Rg" uniqKey="Geocadin R">RG Geocadin</name></author><author><name sortKey="Zimmerman, Jl" uniqKey="Zimmerman J">JL Zimmerman</name></author><author><name sortKey="Donnino, M" uniqKey="Donnino M">M Donnino</name></author><author><name sortKey="Gabrielli, A" uniqKey="Gabrielli A">A Gabrielli</name></author><author><name sortKey="Silvers, Sm" uniqKey="Silvers S">SM Silvers</name></author><author><name sortKey="Zaritsky, Al" uniqKey="Zaritsky A">AL Zaritsky</name></author><author><name sortKey="Merchant, R" uniqKey="Merchant R">R Merchant</name></author><author><name sortKey="Vanden Hoek, Tl" uniqKey="Vanden Hoek T">TL Vanden Hoek</name></author><author><name sortKey="Kronick, Sl" uniqKey="Kronick S">SL Kronick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, Jm" uniqKey="Perlman J">JM Perlman</name></author><author><name sortKey="Wyllie, J" uniqKey="Wyllie J">J Wyllie</name></author><author><name sortKey="Kattwinkel, J" uniqKey="Kattwinkel J">J Kattwinkel</name></author><author><name sortKey="Atkins, Dl" uniqKey="Atkins D">DL Atkins</name></author><author><name sortKey="Chameides, L" uniqKey="Chameides L">L Chameides</name></author><author><name sortKey="Goldsmith, Jp" uniqKey="Goldsmith J">JP Goldsmith</name></author><author><name sortKey="Guinsburg, R" uniqKey="Guinsburg R">R Guinsburg</name></author><author><name sortKey="Hazinski, Mf" uniqKey="Hazinski M">MF Hazinski</name></author><author><name sortKey="Morley, C" uniqKey="Morley C">C Morley</name></author><author><name sortKey="Richmond, S" uniqKey="Richmond S">S Richmond</name></author><author><name sortKey="Simon, Wm" uniqKey="Simon W">WM Simon</name></author><author><name sortKey="Singhal, N" uniqKey="Singhal N">N Singhal</name></author><author><name sortKey="Szyld, E" uniqKey="Szyld E">E Szyld</name></author><author><name sortKey="Tamura, M" uniqKey="Tamura M">M Tamura</name></author><author><name sortKey="Velaphi, S" uniqKey="Velaphi S">S Velaphi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Ha" uniqKey="Choi H">HA Choi</name></author><author><name sortKey="Badjatia, N" uniqKey="Badjatia N">N Badjatia</name></author><author><name sortKey="Mayer, Sa" uniqKey="Mayer S">SA Mayer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tissier, R" uniqKey="Tissier R">R Tissier</name></author><author><name sortKey="Ghaleh, B" uniqKey="Ghaleh B">B Ghaleh</name></author><author><name sortKey="Cohen, Mv" uniqKey="Cohen M">MV Cohen</name></author><author><name sortKey="Downey, Jm" uniqKey="Downey J">JM Downey</name></author><author><name sortKey="Berdeaux, A" uniqKey="Berdeaux A">A Berdeaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nozari, A" uniqKey="Nozari A">A Nozari</name></author><author><name sortKey="Safar, P" uniqKey="Safar P">P Safar</name></author><author><name sortKey="Stezoski, Sw" uniqKey="Stezoski S">SW Stezoski</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author><author><name sortKey="Kostelnik, S" uniqKey="Kostelnik S">S Kostelnik</name></author><author><name sortKey="Radovsky, A" uniqKey="Radovsky A">A Radovsky</name></author><author><name sortKey="Tisherman, S" uniqKey="Tisherman S">S Tisherman</name></author><author><name sortKey="Kochanek, Pm" uniqKey="Kochanek P">PM Kochanek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abella, Bs" uniqKey="Abella B">BS Abella</name></author><author><name sortKey="Zhao, D" uniqKey="Zhao D">D Zhao</name></author><author><name sortKey="Alvarado, J" uniqKey="Alvarado J">J Alvarado</name></author><author><name sortKey="Hamann, K" uniqKey="Hamann K">K Hamann</name></author><author><name sortKey="Vanden Hoek, Tl" uniqKey="Vanden Hoek T">TL Vanden Hoek</name></author><author><name sortKey="Becker, Lb" uniqKey="Becker L">LB Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, D" uniqKey="Che D">D Che</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Kopil, Cm" uniqKey="Kopil C">CM Kopil</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Guo, W" uniqKey="Guo W">W Guo</name></author><author><name sortKey="Neumar, Rw" uniqKey="Neumar R">RW Neumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuboyama, K" uniqKey="Kuboyama K">K Kuboyama</name></author><author><name sortKey="Safar, P" uniqKey="Safar P">P Safar</name></author><author><name sortKey="Radovsky, A" uniqKey="Radovsky A">A Radovsky</name></author><author><name sortKey="Tisherman, Sa" uniqKey="Tisherman S">SA Tisherman</name></author><author><name sortKey="Stezoski, Sw" uniqKey="Stezoski S">SW Stezoski</name></author><author><name sortKey="Alexander, H" uniqKey="Alexander H">H Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolff, B" uniqKey="Wolff B">B Wolff</name></author><author><name sortKey="Machill, K" uniqKey="Machill K">K Machill</name></author><author><name sortKey="Schumacher, D" uniqKey="Schumacher D">D Schumacher</name></author><author><name sortKey="Schulzki, I" uniqKey="Schulzki I">I Schulzki</name></author><author><name sortKey="Werner, D" uniqKey="Werner D">D Werner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yokoyama, H" uniqKey="Yokoyama H">H Yokoyama</name></author><author><name sortKey="Nagao, K" uniqKey="Nagao K">K Nagao</name></author><author><name sortKey="Hase, M" uniqKey="Hase M">M Hase</name></author><author><name sortKey="Tahara, Y" uniqKey="Tahara Y">Y Tahara</name></author><author><name sortKey="Hazui, H" uniqKey="Hazui H">H Hazui</name></author><author><name sortKey="Arimoto, H" uniqKey="Arimoto H">H Arimoto</name></author><author><name sortKey="Kashiwase, K" uniqKey="Kashiwase K">K Kashiwase</name></author><author><name sortKey="Sawano, H" uniqKey="Sawano H">H Sawano</name></author><author><name sortKey="Yasuga, Y" uniqKey="Yasuga Y">Y Yasuga</name></author><author><name sortKey="Kuroda, Y" uniqKey="Kuroda Y">Y Kuroda</name></author><author><name sortKey="Kasaoka, S" uniqKey="Kasaoka S">S Kasaoka</name></author><author><name sortKey="Shirai, S" uniqKey="Shirai S">S Shirai</name></author><author><name sortKey="Yonemoto, N" uniqKey="Yonemoto N">N Yonemoto</name></author><author><name sortKey="Nonogi, H" uniqKey="Nonogi H">H Nonogi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernard, Sa" uniqKey="Bernard S">SA Bernard</name></author><author><name sortKey="Smith, K" uniqKey="Smith K">K Smith</name></author><author><name sortKey="Cameron, P" uniqKey="Cameron P">P Cameron</name></author><author><name sortKey="Masci, K" uniqKey="Masci K">K Masci</name></author><author><name sortKey="Taylor, Dm" uniqKey="Taylor D">DM Taylor</name></author><author><name sortKey="Cooper, Dj" uniqKey="Cooper D">DJ Cooper</name></author><author><name sortKey="Kelly, A" uniqKey="Kelly A">A‐M Kelly</name></author><author><name sortKey="Silvester, W" uniqKey="Silvester W">W Silvester</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Benz Oerner, J" uniqKey="Benz Oerner J">J Benz‐Woerner</name></author><author><name sortKey="Delodder, F" uniqKey="Delodder F">F Delodder</name></author><author><name sortKey="Benz, R" uniqKey="Benz R">R Benz</name></author><author><name sortKey="Cueni Illoz, N" uniqKey="Cueni Illoz N">N Cueni‐Villoz</name></author><author><name sortKey="Feihl, F" uniqKey="Feihl F">F Feihl</name></author><author><name sortKey="Rossetti, Ao" uniqKey="Rossetti A">AO Rossetti</name></author><author><name sortKey="Liaudet, L" uniqKey="Liaudet L">L Liaudet</name></author><author><name sortKey="Oddo, M" uniqKey="Oddo M">M Oddo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyon, Rm" uniqKey="Lyon R">RM Lyon</name></author><author><name sortKey="Richardson, Se" uniqKey="Richardson S">SE Richardson</name></author><author><name sortKey="Hay, Aw" uniqKey="Hay A">AW Hay</name></author><author><name sortKey="Andrews, Pj" uniqKey="Andrews P">PJ Andrews</name></author><author><name sortKey="Robertson, Ce" uniqKey="Robertson C">CE Robertson</name></author><author><name sortKey="Clegg, Gr" uniqKey="Clegg G">GR Clegg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haugk, M" uniqKey="Haugk M">M Haugk</name></author><author><name sortKey="Testori, C" uniqKey="Testori C">C Testori</name></author><author><name sortKey="Sterz, F" uniqKey="Sterz F">F Sterz</name></author><author><name sortKey="Uranitsch, M" uniqKey="Uranitsch M">M Uranitsch</name></author><author><name sortKey="Holzer, M" uniqKey="Holzer M">M Holzer</name></author><author><name sortKey="Behringer, W" uniqKey="Behringer W">W Behringer</name></author><author><name sortKey="Herkner, H" uniqKey="Herkner H">H Herkner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rittenberger, Jc" uniqKey="Rittenberger J">JC Rittenberger</name></author><author><name sortKey="Tisherman, Sa" uniqKey="Tisherman S">SA Tisherman</name></author><author><name sortKey="Holm, Mb" uniqKey="Holm M">MB Holm</name></author><author><name sortKey="Guyette, Fx" uniqKey="Guyette F">FX Guyette</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rittenberger, Jc" uniqKey="Rittenberger J">JC Rittenberger</name></author><author><name sortKey="Guyette, Fx" uniqKey="Guyette F">FX Guyette</name></author><author><name sortKey="Tisherman, Sa" uniqKey="Tisherman S">SA Tisherman</name></author><author><name sortKey="Devita, Ma" uniqKey="Devita M">MA DeVita</name></author><author><name sortKey="Alvarez, Rj" uniqKey="Alvarez R">RJ Alvarez</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rittenberger, Jc" uniqKey="Rittenberger J">JC Rittenberger</name></author><author><name sortKey="Raina, K" uniqKey="Raina K">K Raina</name></author><author><name sortKey="Holm, Mb" uniqKey="Holm M">MB Holm</name></author><author><name sortKey="Kim, Yj" uniqKey="Kim Y">YJ Kim</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanhela, R" uniqKey="Hanhela R">R Hanhela</name></author><author><name sortKey="Mustonen, A" uniqKey="Mustonen A">A Mustonen</name></author><author><name sortKey="Korhonen, I" uniqKey="Korhonen I">I Korhonen</name></author><author><name sortKey="Salom Ki, T" uniqKey="Salom Ki T">T Salomäki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teboul, J" uniqKey="Teboul J">J‐L Teboul</name></author><author><name sortKey="Mercat, A" uniqKey="Mercat A">A Mercat</name></author><author><name sortKey="Lenique, F" uniqKey="Lenique F">F Lenique</name></author><author><name sortKey="Berton, C" uniqKey="Berton C">C Berton</name></author><author><name sortKey="Richard, C" uniqKey="Richard C">C Richard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perman, Sm" uniqKey="Perman S">SM Perman</name></author><author><name sortKey="Kirkpatrick, Jn" uniqKey="Kirkpatrick J">JN Kirkpatrick</name></author><author><name sortKey="Reitsma, Am" uniqKey="Reitsma A">AM Reitsma</name></author><author><name sortKey="Gaieski, Df" uniqKey="Gaieski D">DF Gaieski</name></author><author><name sortKey="Lau, B" uniqKey="Lau B">B Lau</name></author><author><name sortKey="Smith, Tm" uniqKey="Smith T">TM Smith</name></author><author><name sortKey="Leary, M" uniqKey="Leary M">M Leary</name></author><author><name sortKey="Fuchs, Bd" uniqKey="Fuchs B">BD Fuchs</name></author><author><name sortKey="Levine, Jm" uniqKey="Levine J">JM Levine</name></author><author><name sortKey="Abella, Bs" uniqKey="Abella B">BS Abella</name></author><author><name sortKey="Becker, Lb" uniqKey="Becker L">LB Becker</name></author><author><name sortKey="Merchant, Rm" uniqKey="Merchant R">RM Merchant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossetti, Ao" uniqKey="Rossetti A">AO Rossetti</name></author><author><name sortKey="Oddo, M" uniqKey="Oddo M">M Oddo</name></author><author><name sortKey="Logroscino, G" uniqKey="Logroscino G">G Logroscino</name></author><author><name sortKey="Kaplan, Pw" uniqKey="Kaplan P">PW Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mullner, M" uniqKey="Mullner M">M Mullner</name></author><author><name sortKey="Sterz, F" uniqKey="Sterz F">F Sterz</name></author><author><name sortKey="Domanovits, H" uniqKey="Domanovits H">H Domanovits</name></author><author><name sortKey="Behringer, W" uniqKey="Behringer W">W Behringer</name></author><author><name sortKey="Binder, M" uniqKey="Binder M">M Binder</name></author><author><name sortKey="Laggner, An" uniqKey="Laggner A">AN Laggner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kliegel, A" uniqKey="Kliegel A">A Kliegel</name></author><author><name sortKey="Losert, H" uniqKey="Losert H">H Losert</name></author><author><name sortKey="Sterz, F" uniqKey="Sterz F">F Sterz</name></author><author><name sortKey="Holzer, M" uniqKey="Holzer M">M Holzer</name></author><author><name sortKey="Zeiner, A" uniqKey="Zeiner A">A Zeiner</name></author><author><name sortKey="Havel, C" uniqKey="Havel C">C Havel</name></author><author><name sortKey="Laggner, An" uniqKey="Laggner A">AN Laggner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cocchi, Mn" uniqKey="Cocchi M">MN Cocchi</name></author><author><name sortKey="Miller, J" uniqKey="Miller J">J Miller</name></author><author><name sortKey="Hunziker, S" uniqKey="Hunziker S">S Hunziker</name></author><author><name sortKey="Carney, E" uniqKey="Carney E">E Carney</name></author><author><name sortKey="Salciccioli, J" uniqKey="Salciccioli J">J Salciccioli</name></author><author><name sortKey="Farris, S" uniqKey="Farris S">S Farris</name></author><author><name sortKey="Joyce, N" uniqKey="Joyce N">N Joyce</name></author><author><name sortKey="Zimetbaum, P" uniqKey="Zimetbaum P">P Zimetbaum</name></author><author><name sortKey="Howell, Md" uniqKey="Howell M">MD Howell</name></author><author><name sortKey="Donnino, Mw" uniqKey="Donnino M">MW Donnino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheong, Kf" uniqKey="Cheong K">KF Cheong</name></author><author><name sortKey="Chen, Fg" uniqKey="Chen F">FG Chen</name></author><author><name sortKey="Yau, Gh" uniqKey="Yau G">GH Yau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romanovsky, Aa" uniqKey="Romanovsky A">AA Romanovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, Bc" uniqKey="White B">BC White</name></author><author><name sortKey="Grossman, Li" uniqKey="Grossman L">LI Grossman</name></author><author><name sortKey="O Neil, Bj" uniqKey="O Neil B">BJ O'Neil</name></author><author><name sortKey="Degracia, Dj" uniqKey="Degracia D">DJ DeGracia</name></author><author><name sortKey="Neumar, Rw" uniqKey="Neumar R">RW Neumar</name></author><author><name sortKey="Rafols, Ja" uniqKey="Rafols J">JA Rafols</name></author><author><name sortKey="Krause, Gs" uniqKey="Krause G">GS Krause</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, F" uniqKey="Han F">F Han</name></author><author><name sortKey="Da, T" uniqKey="Da T">T Da</name></author><author><name sortKey="Riobo, Na" uniqKey="Riobo N">NA Riobo</name></author><author><name sortKey="Becker, Lb" uniqKey="Becker L">LB Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radhakrishnan, J" uniqKey="Radhakrishnan J">J Radhakrishnan</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Ayoub, Im" uniqKey="Ayoub I">IM Ayoub</name></author><author><name sortKey="Kolarova, Jd" uniqKey="Kolarova J">JD Kolarova</name></author><author><name sortKey="Levine, Rf" uniqKey="Levine R">RF Levine</name></author><author><name sortKey="Gazmuri, Rj" uniqKey="Gazmuri R">RJ Gazmuri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, St" uniqKey="Yeh S">ST Yeh</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H‐L Lee</name></author><author><name sortKey="Aune, Se" uniqKey="Aune S">SE Aune</name></author><author><name sortKey="Chen, C" uniqKey="Chen C">C‐L Chen</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y‐R Chen</name></author><author><name sortKey="Angelos, Mg" uniqKey="Angelos M">MG Angelos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blaisdell, Fw" uniqKey="Blaisdell F">FW Blaisdell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillies, Ma" uniqKey="Gillies M">MA Gillies</name></author><author><name sortKey="Pratt, R" uniqKey="Pratt R">R Pratt</name></author><author><name sortKey="Whiteley, C" uniqKey="Whiteley C">C Whiteley</name></author><author><name sortKey="Borg, J" uniqKey="Borg J">J Borg</name></author><author><name sortKey="Beale, Rj" uniqKey="Beale R">RJ Beale</name></author><author><name sortKey="Tibby, Sm" uniqKey="Tibby S">SM Tibby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ajam, K" uniqKey="Ajam K">K Ajam</name></author><author><name sortKey="Gold, Ls" uniqKey="Gold L">LS Gold</name></author><author><name sortKey="Beck, Ss" uniqKey="Beck S">SS Beck</name></author><author><name sortKey="Damon, S" uniqKey="Damon S">S Damon</name></author><author><name sortKey="Phelps, R" uniqKey="Phelps R">R Phelps</name></author><author><name sortKey="Rea, Td" uniqKey="Rea T">TD Rea</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="24780205"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Determinants of Heat Generation in Patients Treated With Therapeutic Hypothermia Following Cardiac Arrest</title><author><name sortKey="Murnin, Matthew R" sort="Murnin, Matthew R" uniqKey="Murnin M" first="Matthew R." last="Murnin">Matthew R. Murnin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sonder, Petra" sort="Sonder, Petra" uniqKey="Sonder P" first="Petra" last="Sonder">Petra Sonder</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Janssens, Gladys N" sort="Janssens, Gladys N" uniqKey="Janssens G" first="Gladys N." last="Janssens">Gladys N. Janssens</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Henry, Connie L" sort="Henry, Connie L" uniqKey="Henry C" first="Connie L." last="Henry">Connie L. Henry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Polderman, Kees H" sort="Polderman, Kees H" uniqKey="Polderman K" first="Kees H." last="Polderman">Kees H. Polderman</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rittenberger, Jon C" sort="Rittenberger, Jon C" uniqKey="Rittenberger J" first="Jon C." last="Rittenberger">Jon C. Rittenberger</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Dezfulian, Cameron" sort="Dezfulian, Cameron" uniqKey="Dezfulian C" first="Cameron" last="Dezfulian">Cameron Dezfulian</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24780205</idno><idno type="pmc">4309044</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309044</idno><idno type="RBID">PMC:4309044</idno><idno type="doi">10.1161/JAHA.113.000580</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001B74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B74</idno><idno type="wicri:Area/Pmc/Curation">001B49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B49</idno><idno type="wicri:Area/Pmc/Checkpoint">001659</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001659</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Determinants of Heat Generation in Patients Treated With Therapeutic Hypothermia Following Cardiac Arrest</title><author><name sortKey="Murnin, Matthew R" sort="Murnin, Matthew R" uniqKey="Murnin M" first="Matthew R." last="Murnin">Matthew R. Murnin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sonder, Petra" sort="Sonder, Petra" uniqKey="Sonder P" first="Petra" last="Sonder">Petra Sonder</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Janssens, Gladys N" sort="Janssens, Gladys N" uniqKey="Janssens G" first="Gladys N." last="Janssens">Gladys N. Janssens</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Henry, Connie L" sort="Henry, Connie L" uniqKey="Henry C" first="Connie L." last="Henry">Connie L. Henry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Polderman, Kees H" sort="Polderman, Kees H" uniqKey="Polderman K" first="Kees H." last="Polderman">Kees H. Polderman</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rittenberger, Jon C" sort="Rittenberger, Jon C" uniqKey="Rittenberger J" first="Jon C." last="Rittenberger">Jon C. Rittenberger</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Dezfulian, Cameron" sort="Dezfulian, Cameron" uniqKey="Dezfulian C" first="Cameron" last="Dezfulian">Cameron Dezfulian</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease</title><idno type="eISSN">2047-9980</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Therapeutic hypothermia (TH) is recommended to reduce ischemic brain injury after cardiac arrest. The variables that predict heat generation by patients receiving TH are uncertain, as is how this heat generation relates to neurologic outcome. We hypothesized that patient characteristics, medication use, inflammation, and organ injury would be associated with heat generation. We further hypothesized that neurologic outcome would be most strongly associated with heat generation.</p></sec><sec><title>Methods and Results</title><p>Surface and intravascular cooling devices were used to provide TH in 57 consecutive cardiac arrest patients. Device water temperatures during the maintenance (33°C) phase were collected. Patient heat generation was quantified as the “heat index” (HI), which was the inverse average water temperature over a minimum of 2 hours of maintenance hypothermia. Variables measuring reduced ischemic injury and improved baseline health were significantly associated with HI. After controlling for presenting rhythm, a higher HI was independently associated with favorable disposition (OR=2.2; 95% CI 1.2 to 4.1; <italic>P</italic>=0.014) and favorable Cerebral Performance Category (OR=1.8; 95% CI 1.0 to 3.1; <italic>P</italic>=0.035). Higher HI predicted favorable disposition (receiver‐operator area under the curve 0.71, <italic>P</italic>=0.029). HI was linearly correlated with arteriovenous CO<sub>2</sub> (<italic>r</italic>=0.69; <italic>P</italic>=0.041) but not O<sub>2</sub> (<italic>r</italic>=0.13; <italic>P</italic>=0.741) gradients.</p></sec><sec><title>Conclusions</title><p>In cardiac arrest patients receiving TH, greater heat generation is associated with better baseline health, reduced ischemic injury, and improved neurologic function, which results in higher metabolism. HI can control for confounding effects of patient heat generation in future clinical trials of rapid TH and offers early prognostic information.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Merchant, Rm" uniqKey="Merchant R">RM Merchant</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Becker, Lb" uniqKey="Becker L">LB Becker</name></author><author><name sortKey="Berg, Ra" uniqKey="Berg R">RA Berg</name></author><author><name sortKey="Nadkarni, V" uniqKey="Nadkarni V">V Nadkarni</name></author><author><name sortKey="Nichol, G" uniqKey="Nichol G">G Nichol</name></author><author><name sortKey="Carr, Bg" uniqKey="Carr B">BG Carr</name></author><author><name sortKey="Mitra, N" uniqKey="Mitra N">N Mitra</name></author><author><name sortKey="Bradley, Sm" uniqKey="Bradley S">SM Bradley</name></author><author><name sortKey="Abella, Bs" uniqKey="Abella B">BS Abella</name></author><author><name sortKey="Groeneveld, Pw" uniqKey="Groeneveld P">PW Groeneveld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nichol, G" uniqKey="Nichol G">G Nichol</name></author><author><name sortKey="Thomas, E" uniqKey="Thomas E">E Thomas</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author><author><name sortKey="Hedges, J" uniqKey="Hedges J">J Hedges</name></author><author><name sortKey="Powell, Jl" uniqKey="Powell J">JL Powell</name></author><author><name sortKey="Aufderheide, Tp" uniqKey="Aufderheide T">TP Aufderheide</name></author><author><name sortKey="Rea, T" uniqKey="Rea T">T Rea</name></author><author><name sortKey="Lowe, R" uniqKey="Lowe R">R Lowe</name></author><author><name sortKey="Brown, T" uniqKey="Brown T">T Brown</name></author><author><name sortKey="Dreyer, J" uniqKey="Dreyer J">J Dreyer</name></author><author><name sortKey="Davis, D" uniqKey="Davis D">D Davis</name></author><author><name sortKey="Idris, A" uniqKey="Idris A">A Idris</name></author><author><name sortKey="Stiell, I" uniqKey="Stiell I">I Stiell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roger, Vl" uniqKey="Roger V">VL Roger</name></author><author><name sortKey="Go, As" uniqKey="Go A">AS Go</name></author><author><name sortKey="Lloyd Ones, Dm" uniqKey="Lloyd Ones D">DM Lloyd‐Jones</name></author><author><name sortKey="Benjamin, Ej" uniqKey="Benjamin E">EJ Benjamin</name></author><author><name sortKey="Berry, Jd" uniqKey="Berry J">JD Berry</name></author><author><name sortKey="Borden, Wb" uniqKey="Borden W">WB Borden</name></author><author><name sortKey="Bravata, Dm" uniqKey="Bravata D">DM Bravata</name></author><author><name sortKey="Dai, S" uniqKey="Dai S">S Dai</name></author><author><name sortKey="Ford, Es" uniqKey="Ford E">ES Ford</name></author><author><name sortKey="Fox, Cs" uniqKey="Fox C">CS Fox</name></author><author><name sortKey="Fullerton, Hj" uniqKey="Fullerton H">HJ Fullerton</name></author><author><name sortKey="Gillespie, C" uniqKey="Gillespie C">C Gillespie</name></author><author><name sortKey="Hailpern, Sm" uniqKey="Hailpern S">SM Hailpern</name></author><author><name sortKey="Heit, Ja" uniqKey="Heit J">JA Heit</name></author><author><name sortKey="Howard, Vj" uniqKey="Howard V">VJ Howard</name></author><author><name sortKey="Kissela, Bm" uniqKey="Kissela B">BM Kissela</name></author><author><name sortKey="Kittner, Sj" uniqKey="Kittner S">SJ Kittner</name></author><author><name sortKey="Lackland, Dt" uniqKey="Lackland D">DT Lackland</name></author><author><name sortKey="Lichtman, Jh" uniqKey="Lichtman J">JH Lichtman</name></author><author><name sortKey="Lisabeth, Ld" uniqKey="Lisabeth L">LD Lisabeth</name></author><author><name sortKey="Makuc, Dm" uniqKey="Makuc D">DM Makuc</name></author><author><name sortKey="Marcus, Gm" uniqKey="Marcus G">GM Marcus</name></author><author><name sortKey="Marelli, A" uniqKey="Marelli A">A Marelli</name></author><author><name sortKey="Matchar, Db" uniqKey="Matchar D">DB Matchar</name></author><author><name sortKey="Moy, Cs" uniqKey="Moy C">CS Moy</name></author><author><name sortKey="Mozaffarian, D" uniqKey="Mozaffarian D">D Mozaffarian</name></author><author><name sortKey="Mussolino, Me" uniqKey="Mussolino M">ME Mussolino</name></author><author><name sortKey="Nichol, G" uniqKey="Nichol G">G Nichol</name></author><author><name sortKey="Paynter, Np" uniqKey="Paynter N">NP Paynter</name></author><author><name sortKey="Soliman, Ez" uniqKey="Soliman E">EZ Soliman</name></author><author><name sortKey="Sorlie, Pd" uniqKey="Sorlie P">PD Sorlie</name></author><author><name sortKey="Sotoodehnia, N" uniqKey="Sotoodehnia N">N Sotoodehnia</name></author><author><name sortKey="Turan, Tn" uniqKey="Turan T">TN Turan</name></author><author><name sortKey="Virani, Ss" uniqKey="Virani S">SS Virani</name></author><author><name sortKey="Wong, Nd" uniqKey="Wong N">ND Wong</name></author><author><name sortKey="Woo, D" uniqKey="Woo D">D Woo</name></author><author><name sortKey="Turner, Mb" uniqKey="Turner M">MB Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laver, S" uniqKey="Laver S">S Laver</name></author><author><name sortKey="Farrow, C" uniqKey="Farrow C">C Farrow</name></author><author><name sortKey="Turner, D" uniqKey="Turner D">D Turner</name></author><author><name sortKey="Nolan, J" uniqKey="Nolan J">J Nolan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernard, Sa" uniqKey="Bernard S">SA Bernard</name></author><author><name sortKey="Gray, Tw" uniqKey="Gray T">TW Gray</name></author><author><name sortKey="Buist, Md" uniqKey="Buist M">MD Buist</name></author><author><name sortKey="Jones, Bm" uniqKey="Jones B">BM Jones</name></author><author><name sortKey="Silvester, W" uniqKey="Silvester W">W Silvester</name></author><author><name sortKey="Gutteridge, G" uniqKey="Gutteridge G">G Gutteridge</name></author><author><name sortKey="Smith, K" uniqKey="Smith K">K Smith</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Peberdy, Ma" uniqKey="Peberdy M">MA Peberdy</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author><author><name sortKey="Neumar, Rw" uniqKey="Neumar R">RW Neumar</name></author><author><name sortKey="Geocadin, Rg" uniqKey="Geocadin R">RG Geocadin</name></author><author><name sortKey="Zimmerman, Jl" uniqKey="Zimmerman J">JL Zimmerman</name></author><author><name sortKey="Donnino, M" uniqKey="Donnino M">M Donnino</name></author><author><name sortKey="Gabrielli, A" uniqKey="Gabrielli A">A Gabrielli</name></author><author><name sortKey="Silvers, Sm" uniqKey="Silvers S">SM Silvers</name></author><author><name sortKey="Zaritsky, Al" uniqKey="Zaritsky A">AL Zaritsky</name></author><author><name sortKey="Merchant, R" uniqKey="Merchant R">R Merchant</name></author><author><name sortKey="Vanden Hoek, Tl" uniqKey="Vanden Hoek T">TL Vanden Hoek</name></author><author><name sortKey="Kronick, Sl" uniqKey="Kronick S">SL Kronick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, Jm" uniqKey="Perlman J">JM Perlman</name></author><author><name sortKey="Wyllie, J" uniqKey="Wyllie J">J Wyllie</name></author><author><name sortKey="Kattwinkel, J" uniqKey="Kattwinkel J">J Kattwinkel</name></author><author><name sortKey="Atkins, Dl" uniqKey="Atkins D">DL Atkins</name></author><author><name sortKey="Chameides, L" uniqKey="Chameides L">L Chameides</name></author><author><name sortKey="Goldsmith, Jp" uniqKey="Goldsmith J">JP Goldsmith</name></author><author><name sortKey="Guinsburg, R" uniqKey="Guinsburg R">R Guinsburg</name></author><author><name sortKey="Hazinski, Mf" uniqKey="Hazinski M">MF Hazinski</name></author><author><name sortKey="Morley, C" uniqKey="Morley C">C Morley</name></author><author><name sortKey="Richmond, S" uniqKey="Richmond S">S Richmond</name></author><author><name sortKey="Simon, Wm" uniqKey="Simon W">WM Simon</name></author><author><name sortKey="Singhal, N" uniqKey="Singhal N">N Singhal</name></author><author><name sortKey="Szyld, E" uniqKey="Szyld E">E Szyld</name></author><author><name sortKey="Tamura, M" uniqKey="Tamura M">M Tamura</name></author><author><name sortKey="Velaphi, S" uniqKey="Velaphi S">S Velaphi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Ha" uniqKey="Choi H">HA Choi</name></author><author><name sortKey="Badjatia, N" uniqKey="Badjatia N">N Badjatia</name></author><author><name sortKey="Mayer, Sa" uniqKey="Mayer S">SA Mayer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tissier, R" uniqKey="Tissier R">R Tissier</name></author><author><name sortKey="Ghaleh, B" uniqKey="Ghaleh B">B Ghaleh</name></author><author><name sortKey="Cohen, Mv" uniqKey="Cohen M">MV Cohen</name></author><author><name sortKey="Downey, Jm" uniqKey="Downey J">JM Downey</name></author><author><name sortKey="Berdeaux, A" uniqKey="Berdeaux A">A Berdeaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nozari, A" uniqKey="Nozari A">A Nozari</name></author><author><name sortKey="Safar, P" uniqKey="Safar P">P Safar</name></author><author><name sortKey="Stezoski, Sw" uniqKey="Stezoski S">SW Stezoski</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author><author><name sortKey="Kostelnik, S" uniqKey="Kostelnik S">S Kostelnik</name></author><author><name sortKey="Radovsky, A" uniqKey="Radovsky A">A Radovsky</name></author><author><name sortKey="Tisherman, S" uniqKey="Tisherman S">S Tisherman</name></author><author><name sortKey="Kochanek, Pm" uniqKey="Kochanek P">PM Kochanek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abella, Bs" uniqKey="Abella B">BS Abella</name></author><author><name sortKey="Zhao, D" uniqKey="Zhao D">D Zhao</name></author><author><name sortKey="Alvarado, J" uniqKey="Alvarado J">J Alvarado</name></author><author><name sortKey="Hamann, K" uniqKey="Hamann K">K Hamann</name></author><author><name sortKey="Vanden Hoek, Tl" uniqKey="Vanden Hoek T">TL Vanden Hoek</name></author><author><name sortKey="Becker, Lb" uniqKey="Becker L">LB Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, D" uniqKey="Che D">D Che</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Kopil, Cm" uniqKey="Kopil C">CM Kopil</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Guo, W" uniqKey="Guo W">W Guo</name></author><author><name sortKey="Neumar, Rw" uniqKey="Neumar R">RW Neumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuboyama, K" uniqKey="Kuboyama K">K Kuboyama</name></author><author><name sortKey="Safar, P" uniqKey="Safar P">P Safar</name></author><author><name sortKey="Radovsky, A" uniqKey="Radovsky A">A Radovsky</name></author><author><name sortKey="Tisherman, Sa" uniqKey="Tisherman S">SA Tisherman</name></author><author><name sortKey="Stezoski, Sw" uniqKey="Stezoski S">SW Stezoski</name></author><author><name sortKey="Alexander, H" uniqKey="Alexander H">H Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolff, B" uniqKey="Wolff B">B Wolff</name></author><author><name sortKey="Machill, K" uniqKey="Machill K">K Machill</name></author><author><name sortKey="Schumacher, D" uniqKey="Schumacher D">D Schumacher</name></author><author><name sortKey="Schulzki, I" uniqKey="Schulzki I">I Schulzki</name></author><author><name sortKey="Werner, D" uniqKey="Werner D">D Werner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yokoyama, H" uniqKey="Yokoyama H">H Yokoyama</name></author><author><name sortKey="Nagao, K" uniqKey="Nagao K">K Nagao</name></author><author><name sortKey="Hase, M" uniqKey="Hase M">M Hase</name></author><author><name sortKey="Tahara, Y" uniqKey="Tahara Y">Y Tahara</name></author><author><name sortKey="Hazui, H" uniqKey="Hazui H">H Hazui</name></author><author><name sortKey="Arimoto, H" uniqKey="Arimoto H">H Arimoto</name></author><author><name sortKey="Kashiwase, K" uniqKey="Kashiwase K">K Kashiwase</name></author><author><name sortKey="Sawano, H" uniqKey="Sawano H">H Sawano</name></author><author><name sortKey="Yasuga, Y" uniqKey="Yasuga Y">Y Yasuga</name></author><author><name sortKey="Kuroda, Y" uniqKey="Kuroda Y">Y Kuroda</name></author><author><name sortKey="Kasaoka, S" uniqKey="Kasaoka S">S Kasaoka</name></author><author><name sortKey="Shirai, S" uniqKey="Shirai S">S Shirai</name></author><author><name sortKey="Yonemoto, N" uniqKey="Yonemoto N">N Yonemoto</name></author><author><name sortKey="Nonogi, H" uniqKey="Nonogi H">H Nonogi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernard, Sa" uniqKey="Bernard S">SA Bernard</name></author><author><name sortKey="Smith, K" uniqKey="Smith K">K Smith</name></author><author><name sortKey="Cameron, P" uniqKey="Cameron P">P Cameron</name></author><author><name sortKey="Masci, K" uniqKey="Masci K">K Masci</name></author><author><name sortKey="Taylor, Dm" uniqKey="Taylor D">DM Taylor</name></author><author><name sortKey="Cooper, Dj" uniqKey="Cooper D">DJ Cooper</name></author><author><name sortKey="Kelly, A" uniqKey="Kelly A">A‐M Kelly</name></author><author><name sortKey="Silvester, W" uniqKey="Silvester W">W Silvester</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Benz Oerner, J" uniqKey="Benz Oerner J">J Benz‐Woerner</name></author><author><name sortKey="Delodder, F" uniqKey="Delodder F">F Delodder</name></author><author><name sortKey="Benz, R" uniqKey="Benz R">R Benz</name></author><author><name sortKey="Cueni Illoz, N" uniqKey="Cueni Illoz N">N Cueni‐Villoz</name></author><author><name sortKey="Feihl, F" uniqKey="Feihl F">F Feihl</name></author><author><name sortKey="Rossetti, Ao" uniqKey="Rossetti A">AO Rossetti</name></author><author><name sortKey="Liaudet, L" uniqKey="Liaudet L">L Liaudet</name></author><author><name sortKey="Oddo, M" uniqKey="Oddo M">M Oddo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyon, Rm" uniqKey="Lyon R">RM Lyon</name></author><author><name sortKey="Richardson, Se" uniqKey="Richardson S">SE Richardson</name></author><author><name sortKey="Hay, Aw" uniqKey="Hay A">AW Hay</name></author><author><name sortKey="Andrews, Pj" uniqKey="Andrews P">PJ Andrews</name></author><author><name sortKey="Robertson, Ce" uniqKey="Robertson C">CE Robertson</name></author><author><name sortKey="Clegg, Gr" uniqKey="Clegg G">GR Clegg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haugk, M" uniqKey="Haugk M">M Haugk</name></author><author><name sortKey="Testori, C" uniqKey="Testori C">C Testori</name></author><author><name sortKey="Sterz, F" uniqKey="Sterz F">F Sterz</name></author><author><name sortKey="Uranitsch, M" uniqKey="Uranitsch M">M Uranitsch</name></author><author><name sortKey="Holzer, M" uniqKey="Holzer M">M Holzer</name></author><author><name sortKey="Behringer, W" uniqKey="Behringer W">W Behringer</name></author><author><name sortKey="Herkner, H" uniqKey="Herkner H">H Herkner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rittenberger, Jc" uniqKey="Rittenberger J">JC Rittenberger</name></author><author><name sortKey="Tisherman, Sa" uniqKey="Tisherman S">SA Tisherman</name></author><author><name sortKey="Holm, Mb" uniqKey="Holm M">MB Holm</name></author><author><name sortKey="Guyette, Fx" uniqKey="Guyette F">FX Guyette</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rittenberger, Jc" uniqKey="Rittenberger J">JC Rittenberger</name></author><author><name sortKey="Guyette, Fx" uniqKey="Guyette F">FX Guyette</name></author><author><name sortKey="Tisherman, Sa" uniqKey="Tisherman S">SA Tisherman</name></author><author><name sortKey="Devita, Ma" uniqKey="Devita M">MA DeVita</name></author><author><name sortKey="Alvarez, Rj" uniqKey="Alvarez R">RJ Alvarez</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rittenberger, Jc" uniqKey="Rittenberger J">JC Rittenberger</name></author><author><name sortKey="Raina, K" uniqKey="Raina K">K Raina</name></author><author><name sortKey="Holm, Mb" uniqKey="Holm M">MB Holm</name></author><author><name sortKey="Kim, Yj" uniqKey="Kim Y">YJ Kim</name></author><author><name sortKey="Callaway, Cw" uniqKey="Callaway C">CW Callaway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanhela, R" uniqKey="Hanhela R">R Hanhela</name></author><author><name sortKey="Mustonen, A" uniqKey="Mustonen A">A Mustonen</name></author><author><name sortKey="Korhonen, I" uniqKey="Korhonen I">I Korhonen</name></author><author><name sortKey="Salom Ki, T" uniqKey="Salom Ki T">T Salomäki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teboul, J" uniqKey="Teboul J">J‐L Teboul</name></author><author><name sortKey="Mercat, A" uniqKey="Mercat A">A Mercat</name></author><author><name sortKey="Lenique, F" uniqKey="Lenique F">F Lenique</name></author><author><name sortKey="Berton, C" uniqKey="Berton C">C Berton</name></author><author><name sortKey="Richard, C" uniqKey="Richard C">C Richard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perman, Sm" uniqKey="Perman S">SM Perman</name></author><author><name sortKey="Kirkpatrick, Jn" uniqKey="Kirkpatrick J">JN Kirkpatrick</name></author><author><name sortKey="Reitsma, Am" uniqKey="Reitsma A">AM Reitsma</name></author><author><name sortKey="Gaieski, Df" uniqKey="Gaieski D">DF Gaieski</name></author><author><name sortKey="Lau, B" uniqKey="Lau B">B Lau</name></author><author><name sortKey="Smith, Tm" uniqKey="Smith T">TM Smith</name></author><author><name sortKey="Leary, M" uniqKey="Leary M">M Leary</name></author><author><name sortKey="Fuchs, Bd" uniqKey="Fuchs B">BD Fuchs</name></author><author><name sortKey="Levine, Jm" uniqKey="Levine J">JM Levine</name></author><author><name sortKey="Abella, Bs" uniqKey="Abella B">BS Abella</name></author><author><name sortKey="Becker, Lb" uniqKey="Becker L">LB Becker</name></author><author><name sortKey="Merchant, Rm" uniqKey="Merchant R">RM Merchant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossetti, Ao" uniqKey="Rossetti A">AO Rossetti</name></author><author><name sortKey="Oddo, M" uniqKey="Oddo M">M Oddo</name></author><author><name sortKey="Logroscino, G" uniqKey="Logroscino G">G Logroscino</name></author><author><name sortKey="Kaplan, Pw" uniqKey="Kaplan P">PW Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mullner, M" uniqKey="Mullner M">M Mullner</name></author><author><name sortKey="Sterz, F" uniqKey="Sterz F">F Sterz</name></author><author><name sortKey="Domanovits, H" uniqKey="Domanovits H">H Domanovits</name></author><author><name sortKey="Behringer, W" uniqKey="Behringer W">W Behringer</name></author><author><name sortKey="Binder, M" uniqKey="Binder M">M Binder</name></author><author><name sortKey="Laggner, An" uniqKey="Laggner A">AN Laggner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kliegel, A" uniqKey="Kliegel A">A Kliegel</name></author><author><name sortKey="Losert, H" uniqKey="Losert H">H Losert</name></author><author><name sortKey="Sterz, F" uniqKey="Sterz F">F Sterz</name></author><author><name sortKey="Holzer, M" uniqKey="Holzer M">M Holzer</name></author><author><name sortKey="Zeiner, A" uniqKey="Zeiner A">A Zeiner</name></author><author><name sortKey="Havel, C" uniqKey="Havel C">C Havel</name></author><author><name sortKey="Laggner, An" uniqKey="Laggner A">AN Laggner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cocchi, Mn" uniqKey="Cocchi M">MN Cocchi</name></author><author><name sortKey="Miller, J" uniqKey="Miller J">J Miller</name></author><author><name sortKey="Hunziker, S" uniqKey="Hunziker S">S Hunziker</name></author><author><name sortKey="Carney, E" uniqKey="Carney E">E Carney</name></author><author><name sortKey="Salciccioli, J" uniqKey="Salciccioli J">J Salciccioli</name></author><author><name sortKey="Farris, S" uniqKey="Farris S">S Farris</name></author><author><name sortKey="Joyce, N" uniqKey="Joyce N">N Joyce</name></author><author><name sortKey="Zimetbaum, P" uniqKey="Zimetbaum P">P Zimetbaum</name></author><author><name sortKey="Howell, Md" uniqKey="Howell M">MD Howell</name></author><author><name sortKey="Donnino, Mw" uniqKey="Donnino M">MW Donnino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheong, Kf" uniqKey="Cheong K">KF Cheong</name></author><author><name sortKey="Chen, Fg" uniqKey="Chen F">FG Chen</name></author><author><name sortKey="Yau, Gh" uniqKey="Yau G">GH Yau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romanovsky, Aa" uniqKey="Romanovsky A">AA Romanovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, Bc" uniqKey="White B">BC White</name></author><author><name sortKey="Grossman, Li" uniqKey="Grossman L">LI Grossman</name></author><author><name sortKey="O Neil, Bj" uniqKey="O Neil B">BJ O'Neil</name></author><author><name sortKey="Degracia, Dj" uniqKey="Degracia D">DJ DeGracia</name></author><author><name sortKey="Neumar, Rw" uniqKey="Neumar R">RW Neumar</name></author><author><name sortKey="Rafols, Ja" uniqKey="Rafols J">JA Rafols</name></author><author><name sortKey="Krause, Gs" uniqKey="Krause G">GS Krause</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, F" uniqKey="Han F">F Han</name></author><author><name sortKey="Da, T" uniqKey="Da T">T Da</name></author><author><name sortKey="Riobo, Na" uniqKey="Riobo N">NA Riobo</name></author><author><name sortKey="Becker, Lb" uniqKey="Becker L">LB Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radhakrishnan, J" uniqKey="Radhakrishnan J">J Radhakrishnan</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Ayoub, Im" uniqKey="Ayoub I">IM Ayoub</name></author><author><name sortKey="Kolarova, Jd" uniqKey="Kolarova J">JD Kolarova</name></author><author><name sortKey="Levine, Rf" uniqKey="Levine R">RF Levine</name></author><author><name sortKey="Gazmuri, Rj" uniqKey="Gazmuri R">RJ Gazmuri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, St" uniqKey="Yeh S">ST Yeh</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H‐L Lee</name></author><author><name sortKey="Aune, Se" uniqKey="Aune S">SE Aune</name></author><author><name sortKey="Chen, C" uniqKey="Chen C">C‐L Chen</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y‐R Chen</name></author><author><name sortKey="Angelos, Mg" uniqKey="Angelos M">MG Angelos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blaisdell, Fw" uniqKey="Blaisdell F">FW Blaisdell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillies, Ma" uniqKey="Gillies M">MA Gillies</name></author><author><name sortKey="Pratt, R" uniqKey="Pratt R">R Pratt</name></author><author><name sortKey="Whiteley, C" uniqKey="Whiteley C">C Whiteley</name></author><author><name sortKey="Borg, J" uniqKey="Borg J">J Borg</name></author><author><name sortKey="Beale, Rj" uniqKey="Beale R">RJ Beale</name></author><author><name sortKey="Tibby, Sm" uniqKey="Tibby S">SM Tibby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ajam, K" uniqKey="Ajam K">K Ajam</name></author><author><name sortKey="Gold, Ls" uniqKey="Gold L">LS Gold</name></author><author><name sortKey="Beck, Ss" uniqKey="Beck S">SS Beck</name></author><author><name sortKey="Damon, S" uniqKey="Damon S">S Damon</name></author><author><name sortKey="Phelps, R" uniqKey="Phelps R">R Phelps</name></author><author><name sortKey="Rea, Td" uniqKey="Rea T">TD Rea</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Determinants of heat generation in patients treated with therapeutic hypothermia following cardiac arrest.</title><author><name sortKey="Murnin, Matthew R" sort="Murnin, Matthew R" uniqKey="Murnin M" first="Matthew R" last="Murnin">Matthew R. Murnin</name><affiliation wicri:level="2"><nlm:affiliation>Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Sonder, Petra" sort="Sonder, Petra" uniqKey="Sonder P" first="Petra" last="Sonder">Petra Sonder</name></author><author><name sortKey="Janssens, Gladys N" sort="Janssens, Gladys N" uniqKey="Janssens G" first="Gladys N" last="Janssens">Gladys N. Janssens</name></author><author><name sortKey="Henry, Connie L" sort="Henry, Connie L" uniqKey="Henry C" first="Connie L" last="Henry">Connie L. Henry</name></author><author><name sortKey="Polderman, Kees H" sort="Polderman, Kees H" uniqKey="Polderman K" first="Kees H" last="Polderman">Kees H. Polderman</name></author><author><name sortKey="Rittenberger, Jon C" sort="Rittenberger, Jon C" uniqKey="Rittenberger J" first="Jon C" last="Rittenberger">Jon C. Rittenberger</name></author><author><name sortKey="Dezfulian, Cameron" sort="Dezfulian, Cameron" uniqKey="Dezfulian C" first="Cameron" last="Dezfulian">Cameron Dezfulian</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24780205</idno><idno type="pmid">24780205</idno><idno type="doi">10.1161/JAHA.113.000580</idno><idno type="wicri:Area/PubMed/Corpus">003121</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003121</idno><idno type="wicri:Area/PubMed/Curation">003100</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003100</idno><idno type="wicri:Area/PubMed/Checkpoint">003100</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003100</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Determinants of heat generation in patients treated with therapeutic hypothermia following cardiac arrest.</title><author><name sortKey="Murnin, Matthew R" sort="Murnin, Matthew R" uniqKey="Murnin M" first="Matthew R" last="Murnin">Matthew R. Murnin</name><affiliation wicri:level="2"><nlm:affiliation>Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Sonder, Petra" sort="Sonder, Petra" uniqKey="Sonder P" first="Petra" last="Sonder">Petra Sonder</name></author><author><name sortKey="Janssens, Gladys N" sort="Janssens, Gladys N" uniqKey="Janssens G" first="Gladys N" last="Janssens">Gladys N. Janssens</name></author><author><name sortKey="Henry, Connie L" sort="Henry, Connie L" uniqKey="Henry C" first="Connie L" last="Henry">Connie L. Henry</name></author><author><name sortKey="Polderman, Kees H" sort="Polderman, Kees H" uniqKey="Polderman K" first="Kees H" last="Polderman">Kees H. Polderman</name></author><author><name sortKey="Rittenberger, Jon C" sort="Rittenberger, Jon C" uniqKey="Rittenberger J" first="Jon C" last="Rittenberger">Jon C. Rittenberger</name></author><author><name sortKey="Dezfulian, Cameron" sort="Dezfulian, Cameron" uniqKey="Dezfulian C" first="Cameron" last="Dezfulian">Cameron Dezfulian</name></author></analytic><series><title level="j">Journal of the American Heart Association</title><idno type="eISSN">2047-9980</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal Metabolism (physiology)</term><term>Body Temperature (physiology)</term><term>Female</term><term>Heart Arrest (physiopathology)</term><term>Heart Arrest (therapy)</term><term>Humans</term><term>Hypothermia, Induced</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Thermogenesis (physiology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arrêt cardiaque ()</term><term>Arrêt cardiaque (physiopathologie)</term><term>Femelle</term><term>Humains</term><term>Hypothermie provoquée</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Métabolisme basal (physiologie)</term><term>Résultat thérapeutique</term><term>Température du corps (physiologie)</term><term>Thermogenèse (physiologie)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Métabolisme basal</term><term>Température du corps</term><term>Thermogenèse</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Basal Metabolism</term><term>Body Temperature</term><term>Thermogenesis</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Arrêt cardiaque</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Heart Arrest</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Heart Arrest</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Hypothermia, Induced</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arrêt cardiaque</term><term>Femelle</term><term>Humains</term><term>Hypothermie provoquée</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Therapeutic hypothermia (TH) is recommended to reduce ischemic brain injury after cardiac arrest. The variables that predict heat generation by patients receiving TH are uncertain, as is how this heat generation relates to neurologic outcome. We hypothesized that patient characteristics, medication use, inflammation, and organ injury would be associated with heat generation. We further hypothesized that neurologic outcome would be most strongly associated with heat generation.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D59 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001D59 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:4309044
|texte= Determinants of Heat Generation in Patients Treated With Therapeutic Hypothermia Following Cardiac Arrest
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:24780205" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |