Inflammation, sleep disturbances, and depressed mood among community-dwelling older men
Identifieur interne : 001C00 ( Ncbi/Merge ); précédent : 001B99; suivant : 001C01Inflammation, sleep disturbances, and depressed mood among community-dwelling older men
Auteurs : Stephen F. Smagula [États-Unis] ; Sonia Ancoli-Israel ; Elizabeth Barrett-Connor [États-Unis] ; Nancy E. Lane [États-Unis] ; Susan Redline [États-Unis] ; Katie L. Stone [États-Unis] ; Jane A. Cauley [États-Unis]Source :
- Journal of psychosomatic research [ 0022-3999 ] ; 2014.
Descripteurs français
- KwdFr :
- Dépression (sang), Dépression (étiologie), Facteurs de l'âge, Humains, Inflammation (psychologie), Inflammation (sang), Maladie chronique, Marqueurs biologiques (sang), Mâle, Odds ratio, Protéine C-réactive (métabolisme), Sujet âgé, Sujet âgé de 80 ans ou plus, Troubles de la veille et du sommeil (), Troubles de la veille et du sommeil (sang), Troubles de la veille et du sommeil (étiologie), Vie autonome, Vieillissement, Études transversales.
- MESH :
- métabolisme : Protéine C-réactive.
- psychologie : Inflammation.
- sang : Dépression, Inflammation, Marqueurs biologiques, Troubles de la veille et du sommeil.
- étiologie : Dépression, Troubles de la veille et du sommeil.
- Facteurs de l'âge, Humains, Maladie chronique, Mâle, Odds ratio, Sujet âgé, Sujet âgé de 80 ans ou plus, Troubles de la veille et du sommeil, Vie autonome, Vieillissement, Études transversales.
English descriptors
- KwdEn :
- Age Factors, Aged, Aged, 80 and over, Aging, Biomarkers (blood), C-Reactive Protein (metabolism), Chronic Disease, Cross-Sectional Studies, Depression (blood), Depression (etiology), Humans, Independent Living, Inflammation (blood), Inflammation (psychology), Male, Odds Ratio, Sleep Wake Disorders (blood), Sleep Wake Disorders (complications), Sleep Wake Disorders (etiology).
- MESH :
- chemical , blood : Biomarkers.
- chemical , metabolism : C-Reactive Protein.
- blood : Depression, Inflammation, Sleep Wake Disorders.
- complications : Sleep Wake Disorders.
- etiology : Depression, Sleep Wake Disorders.
- psychology : Inflammation.
- Age Factors, Aged, Aged, 80 and over, Aging, Chronic Disease, Cross-Sectional Studies, Humans, Independent Living, Male, Odds Ratio.
Abstract
High rates of sleep disturbances occur in depression. Sleep disturbances are linked to heightened inflammation. We sought to determine if sleep disturbances explain a portion of the putative inflammation – depression association among older adults. In late life, age-related immunoregulation changes may modify the inflammation-depression relationship.
Cross-sectional associations of a panel of serum inflammatory markers with probable depression (measured with the Geriatric Depression Scale) were assessed among 2,560 community-dwelling older men. We tested whether inflammatory marker - probable depression associations were independent of chronic diseases, as well as objective and subjectively measured sleep disturbances. We also tested whether inflammation-probable depression associations were moderated by age.
Inflammatory markers were not independently associated with higher odds of probable depression. A significant age by C - reactive protein (CRP) interaction (p=0.01) was detected such that the strength of the CRP - probable depression association decreased with age. When stratifying by the median age of 76, elevated odds of probable depression were found for men with CRP levels above the median only among the younger group (OR = 2.08, 95% CI 1.18–3.69). In the final adjusted model, independent effects of chronic diseases and subjective sleep disturbances contributed to a total of 37% attenuation of the original OR (adjusted OR = 1.68, 95% CI 0.911–3.10, p = .09).
In late-life, associations between inflammatory markers and mood may be explained by both chronic diseases and subjectively reported sleep disturbances. Our findings indicate that the association of CRP with probable depression diminishes in strength with age.
Url:
DOI: 10.1016/j.jpsychores.2014.02.005
PubMed: 24745777
PubMed Central: 3997106
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PMC:3997106Le document en format XML
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Smagula</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Ancoli Israel, Sonia" sort="Ancoli Israel, Sonia" uniqKey="Ancoli Israel S" first="Sonia" last="Ancoli-Israel">Sonia Ancoli-Israel</name><affiliation><nlm:aff id="A2">Departments of Psychiatry and Medicine, University of California San Diego, La Jolla, California and Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health (CESAMH)</nlm:aff><wicri:noCountry code="subfield">California and Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health (CESAMH)</wicri:noCountry></affiliation></author><author><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name><affiliation wicri:level="2"><nlm:aff id="A3">Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla</wicri:cityArea></affiliation></author><author><name sortKey="Lane, Nancy E" sort="Lane, Nancy E" uniqKey="Lane N" first="Nancy E." last="Lane">Nancy E. Lane</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento</wicri:cityArea></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Sleep Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Boston, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Sleep Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Stone, Katie L" sort="Stone, Katie L" uniqKey="Stone K" first="Katie L." last="Stone">Katie L. Stone</name><affiliation wicri:level="2"><nlm:aff id="A6">Research Institute, California Pacific Medical Center, San Francisco, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Research Institute, California Pacific Medical Center, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of psychosomatic research</title><idno type="ISSN">0022-3999</idno><idno type="eISSN">1879-1360</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Aging</term><term>Biomarkers (blood)</term><term>C-Reactive Protein (metabolism)</term><term>Chronic Disease</term><term>Cross-Sectional Studies</term><term>Depression (blood)</term><term>Depression (etiology)</term><term>Humans</term><term>Independent Living</term><term>Inflammation (blood)</term><term>Inflammation (psychology)</term><term>Male</term><term>Odds Ratio</term><term>Sleep Wake Disorders (blood)</term><term>Sleep Wake Disorders (complications)</term><term>Sleep Wake Disorders (etiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Dépression (sang)</term><term>Dépression (étiologie)</term><term>Facteurs de l'âge</term><term>Humains</term><term>Inflammation (psychologie)</term><term>Inflammation (sang)</term><term>Maladie chronique</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Odds ratio</term><term>Protéine C-réactive (métabolisme)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Troubles de la veille et du sommeil ()</term><term>Troubles de la veille et du sommeil (sang)</term><term>Troubles de la veille et du sommeil (étiologie)</term><term>Vie autonome</term><term>Vieillissement</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Depression</term><term>Inflammation</term><term>Sleep Wake Disorders</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Sleep Wake Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term><term>Sleep Wake Disorders</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Dépression</term><term>Inflammation</term><term>Marqueurs biologiques</term><term>Troubles de la veille et du sommeil</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dépression</term><term>Troubles de la veille et du sommeil</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Aging</term><term>Chronic Disease</term><term>Cross-Sectional Studies</term><term>Humans</term><term>Independent Living</term><term>Male</term><term>Odds Ratio</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de l'âge</term><term>Humains</term><term>Maladie chronique</term><term>Mâle</term><term>Odds ratio</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Troubles de la veille et du sommeil</term><term>Vie autonome</term><term>Vieillissement</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P2">High rates of sleep disturbances occur in depression. Sleep disturbances are linked to heightened inflammation. We sought to determine if sleep disturbances explain a portion of the putative inflammation – depression association among older adults. In late life, age-related immunoregulation changes may modify the inflammation-depression relationship.</p></sec><sec id="S2"><title>Methods</title><p id="P3">Cross-sectional associations of a panel of serum inflammatory markers with probable depression (measured with the Geriatric Depression Scale) were assessed among 2,560 community-dwelling older men. We tested whether inflammatory marker - probable depression associations were independent of chronic diseases, as well as objective and subjectively measured sleep disturbances. We also tested whether inflammation-probable depression associations were moderated by age.</p></sec><sec id="S3"><title>Results</title><p id="P4">Inflammatory markers were not independently associated with higher odds of probable depression. A significant age by C - reactive protein (CRP) interaction (p=0.01) was detected such that the strength of the CRP - probable depression association decreased with age. When stratifying by the median age of 76, elevated odds of probable depression were found for men with CRP levels above the median only among the younger group (OR = 2.08, 95% CI 1.18–3.69). In the final adjusted model, independent effects of chronic diseases and subjective sleep disturbances contributed to a total of 37% attenuation of the original OR (adjusted OR = 1.68, 95% CI 0.911–3.10, p = .09).</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">In late-life, associations between inflammatory markers and mood may be explained by both chronic diseases and subjectively reported sleep disturbances. Our findings indicate that the association of CRP with probable depression diminishes in strength with age.</p></sec></div></front></TEI><double pmid="24745777"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inflammation, sleep disturbances, and depressed mood among community-dwelling older men</title><author><name sortKey="Smagula, Stephen F" sort="Smagula, Stephen F" uniqKey="Smagula S" first="Stephen F." last="Smagula">Stephen F. Smagula</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Ancoli Israel, Sonia" sort="Ancoli Israel, Sonia" uniqKey="Ancoli Israel S" first="Sonia" last="Ancoli-Israel">Sonia Ancoli-Israel</name><affiliation><nlm:aff id="A2">Departments of Psychiatry and Medicine, University of California San Diego, La Jolla, California and Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health (CESAMH)</nlm:aff><wicri:noCountry code="subfield">California and Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health (CESAMH)</wicri:noCountry></affiliation></author><author><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name><affiliation wicri:level="2"><nlm:aff id="A3">Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla</wicri:cityArea></affiliation></author><author><name sortKey="Lane, Nancy E" sort="Lane, Nancy E" uniqKey="Lane N" first="Nancy E." last="Lane">Nancy E. Lane</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento</wicri:cityArea></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Sleep Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Boston, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Sleep Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Stone, Katie L" sort="Stone, Katie L" uniqKey="Stone K" first="Katie L." last="Stone">Katie L. Stone</name><affiliation wicri:level="2"><nlm:aff id="A6">Research Institute, California Pacific Medical Center, San Francisco, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Research Institute, California Pacific Medical Center, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24745777</idno><idno type="pmc">3997106</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997106</idno><idno type="RBID">PMC:3997106</idno><idno type="doi">10.1016/j.jpsychores.2014.02.005</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000E91</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E91</idno><idno type="wicri:Area/Pmc/Curation">000E66</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E66</idno><idno type="wicri:Area/Pmc/Checkpoint">000F57</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Inflammation, sleep disturbances, and depressed mood among community-dwelling older men</title><author><name sortKey="Smagula, Stephen F" sort="Smagula, Stephen F" uniqKey="Smagula S" first="Stephen F." last="Smagula">Stephen F. Smagula</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Ancoli Israel, Sonia" sort="Ancoli Israel, Sonia" uniqKey="Ancoli Israel S" first="Sonia" last="Ancoli-Israel">Sonia Ancoli-Israel</name><affiliation><nlm:aff id="A2">Departments of Psychiatry and Medicine, University of California San Diego, La Jolla, California and Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health (CESAMH)</nlm:aff><wicri:noCountry code="subfield">California and Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health (CESAMH)</wicri:noCountry></affiliation></author><author><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name><affiliation wicri:level="2"><nlm:aff id="A3">Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla</wicri:cityArea></affiliation></author><author><name sortKey="Lane, Nancy E" sort="Lane, Nancy E" uniqKey="Lane N" first="Nancy E." last="Lane">Nancy E. Lane</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento</wicri:cityArea></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Sleep Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Boston, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Sleep Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Stone, Katie L" sort="Stone, Katie L" uniqKey="Stone K" first="Katie L." last="Stone">Katie L. Stone</name><affiliation wicri:level="2"><nlm:aff id="A6">Research Institute, California Pacific Medical Center, San Francisco, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Research Institute, California Pacific Medical Center, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of psychosomatic research</title><idno type="ISSN">0022-3999</idno><idno type="eISSN">1879-1360</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P2">High rates of sleep disturbances occur in depression. Sleep disturbances are linked to heightened inflammation. We sought to determine if sleep disturbances explain a portion of the putative inflammation – depression association among older adults. In late life, age-related immunoregulation changes may modify the inflammation-depression relationship.</p></sec><sec id="S2"><title>Methods</title><p id="P3">Cross-sectional associations of a panel of serum inflammatory markers with probable depression (measured with the Geriatric Depression Scale) were assessed among 2,560 community-dwelling older men. We tested whether inflammatory marker - probable depression associations were independent of chronic diseases, as well as objective and subjectively measured sleep disturbances. We also tested whether inflammation-probable depression associations were moderated by age.</p></sec><sec id="S3"><title>Results</title><p id="P4">Inflammatory markers were not independently associated with higher odds of probable depression. A significant age by C - reactive protein (CRP) interaction (p=0.01) was detected such that the strength of the CRP - probable depression association decreased with age. When stratifying by the median age of 76, elevated odds of probable depression were found for men with CRP levels above the median only among the younger group (OR = 2.08, 95% CI 1.18–3.69). In the final adjusted model, independent effects of chronic diseases and subjective sleep disturbances contributed to a total of 37% attenuation of the original OR (adjusted OR = 1.68, 95% CI 0.911–3.10, p = .09).</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">In late-life, associations between inflammatory markers and mood may be explained by both chronic diseases and subjectively reported sleep disturbances. Our findings indicate that the association of CRP with probable depression diminishes in strength with age.</p></sec></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inflammation, sleep disturbances, and depressed mood among community-dwelling older men.</title><author><name sortKey="Smagula, Stephen F" sort="Smagula, Stephen F" uniqKey="Smagula S" first="Stephen F" last="Smagula">Stephen F. Smagula</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Ancoli Israel, Sonia" sort="Ancoli Israel, Sonia" uniqKey="Ancoli Israel S" first="Sonia" last="Ancoli-Israel">Sonia Ancoli-Israel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, La Jolla, CA, United States; Department of Medicine, University of California San Diego, La Jolla, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of California San Diego, La Jolla, CA, United States; Department of Medicine, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lane, Nancy E" sort="Lane, Nancy E" uniqKey="Lane N" first="Nancy E" last="Lane">Nancy E. Lane</name><affiliation wicri:level="2"><nlm:affiliation>Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="2"><nlm:affiliation>Division of Sleep Medicine, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Boston, MA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Sleep Medicine, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stone, Katie L" sort="Stone, Katie L" uniqKey="Stone K" first="Katie L" last="Stone">Katie L. Stone</name><affiliation wicri:level="2"><nlm:affiliation>Research Institute, California Pacific Medical Center, San Francisco, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Institute, California Pacific Medical Center, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A" last="Cauley">Jane A. Cauley</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: jcauley@edc.pitt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24745777</idno><idno type="pmid">24745777</idno><idno type="doi">10.1016/j.jpsychores.2014.02.005</idno><idno type="wicri:Area/PubMed/Corpus">002F81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002F81</idno><idno type="wicri:Area/PubMed/Curation">002F60</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002F60</idno><idno type="wicri:Area/PubMed/Checkpoint">002F60</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002F60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inflammation, sleep disturbances, and depressed mood among community-dwelling older men.</title><author><name sortKey="Smagula, Stephen F" sort="Smagula, Stephen F" uniqKey="Smagula S" first="Stephen F" last="Smagula">Stephen F. Smagula</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Ancoli Israel, Sonia" sort="Ancoli Israel, Sonia" uniqKey="Ancoli Israel S" first="Sonia" last="Ancoli-Israel">Sonia Ancoli-Israel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, La Jolla, CA, United States; Department of Medicine, University of California San Diego, La Jolla, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of California San Diego, La Jolla, CA, United States; Department of Medicine, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lane, Nancy E" sort="Lane, Nancy E" uniqKey="Lane N" first="Nancy E" last="Lane">Nancy E. Lane</name><affiliation wicri:level="2"><nlm:affiliation>Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Musculoskeletal Health, Medicine and Rheumatology, University of California at Davis School of Medicine, Sacramento, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="2"><nlm:affiliation>Division of Sleep Medicine, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Boston, MA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Sleep Medicine, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stone, Katie L" sort="Stone, Katie L" uniqKey="Stone K" first="Katie L" last="Stone">Katie L. Stone</name><affiliation wicri:level="2"><nlm:affiliation>Research Institute, California Pacific Medical Center, San Francisco, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Institute, California Pacific Medical Center, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A" last="Cauley">Jane A. Cauley</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: jcauley@edc.pitt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j">Journal of psychosomatic research</title><idno type="eISSN">1879-1360</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Aging</term><term>Biomarkers (blood)</term><term>C-Reactive Protein (metabolism)</term><term>Chronic Disease</term><term>Cross-Sectional Studies</term><term>Depression (blood)</term><term>Depression (etiology)</term><term>Humans</term><term>Independent Living</term><term>Inflammation (blood)</term><term>Inflammation (psychology)</term><term>Male</term><term>Odds Ratio</term><term>Sleep Wake Disorders (blood)</term><term>Sleep Wake Disorders (complications)</term><term>Sleep Wake Disorders (etiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Dépression (sang)</term><term>Dépression (étiologie)</term><term>Facteurs de l'âge</term><term>Humains</term><term>Inflammation (psychologie)</term><term>Inflammation (sang)</term><term>Maladie chronique</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Odds ratio</term><term>Protéine C-réactive (métabolisme)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Troubles de la veille et du sommeil ()</term><term>Troubles de la veille et du sommeil (sang)</term><term>Troubles de la veille et du sommeil (étiologie)</term><term>Vie autonome</term><term>Vieillissement</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Depression</term><term>Inflammation</term><term>Sleep Wake Disorders</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Sleep Wake Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term><term>Sleep Wake Disorders</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Dépression</term><term>Inflammation</term><term>Marqueurs biologiques</term><term>Troubles de la veille et du sommeil</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dépression</term><term>Troubles de la veille et du sommeil</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Aging</term><term>Chronic Disease</term><term>Cross-Sectional Studies</term><term>Humans</term><term>Independent Living</term><term>Male</term><term>Odds Ratio</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de l'âge</term><term>Humains</term><term>Maladie chronique</term><term>Mâle</term><term>Odds ratio</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Troubles de la veille et du sommeil</term><term>Vie autonome</term><term>Vieillissement</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High rates of sleep disturbances occur in depression. Sleep disturbances are linked to heightened inflammation. We sought to determine if sleep disturbances explain a portion of the putative inflammation - depression association among older adults. In late life, age-related immunoregulation changes may modify the inflammation-depression relationship.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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