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Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: a comparative study from a single tertiary center.

Identifieur interne : 001842 ( Ncbi/Merge ); précédent : 001841; suivant : 001843

Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: a comparative study from a single tertiary center.

Auteurs : Chwee Ming Lim [Singapour] ; Candace Hobson ; Seungwon Kim ; Jonas T. Johnson

Source :

RBID : pubmed:24677516

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English descriptors

Abstract

Carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland is a high-grade cancer and the prognosis of this cancer has not been compared with non-CXPA high-grade primary parotid cancer.

DOI: 10.1002/hed.23638
PubMed: 24677516

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pubmed:24677516

Le document en format XML

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<title xml:lang="en">Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: a comparative study from a single tertiary center.</title>
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<name sortKey="Lim, Chwee Ming" sort="Lim, Chwee Ming" uniqKey="Lim C" first="Chwee Ming" last="Lim">Chwee Ming Lim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Eye and Ear Institute, Pittsburgh, Pennsylvania; Department of Otolaryngology Head and Neck Surgery, National University Health System, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Eye and Ear Institute, Pittsburgh, Pennsylvania; Department of Otolaryngology Head and Neck Surgery, National University Health System</wicri:regionArea>
<wicri:noRegion>National University Health System</wicri:noRegion>
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<name sortKey="Hobson, Candace" sort="Hobson, Candace" uniqKey="Hobson C" first="Candace" last="Hobson">Candace Hobson</name>
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<name sortKey="Kim, Seungwon" sort="Kim, Seungwon" uniqKey="Kim S" first="Seungwon" last="Kim">Seungwon Kim</name>
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<name sortKey="Johnson, Jonas T" sort="Johnson, Jonas T" uniqKey="Johnson J" first="Jonas T" last="Johnson">Jonas T. Johnson</name>
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<title xml:lang="en">Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: a comparative study from a single tertiary center.</title>
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<title level="j">Head & neck</title>
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<term>Adenoma, Pleomorphic (mortality)</term>
<term>Adenoma, Pleomorphic (pathology)</term>
<term>Adenoma, Pleomorphic (surgery)</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parotid Neoplasms (mortality)</term>
<term>Parotid Neoplasms (pathology)</term>
<term>Parotid Neoplasms (surgery)</term>
<term>Prognosis</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte d'âge moyen</term>
<term>Adénome pléomorphe ()</term>
<term>Adénome pléomorphe (anatomopathologie)</term>
<term>Adénome pléomorphe (mortalité)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Tumeurs de la parotide ()</term>
<term>Tumeurs de la parotide (anatomopathologie)</term>
<term>Tumeurs de la parotide (mortalité)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Adénome pléomorphe</term>
<term>Tumeurs de la parotide</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Adenoma, Pleomorphic</term>
<term>Parotid Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Adénome pléomorphe</term>
<term>Tumeurs de la parotide</term>
</keywords>
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<term>Adenoma, Pleomorphic</term>
<term>Parotid Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Adenoma, Pleomorphic</term>
<term>Parotid Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prognosis</term>
<term>Treatment Outcome</term>
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<term>Mâle</term>
<term>Pronostic</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Tumeurs de la parotide</term>
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<front>
<div type="abstract" xml:lang="en">Carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland is a high-grade cancer and the prognosis of this cancer has not been compared with non-CXPA high-grade primary parotid cancer.</div>
</front>
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<DateCreated>
<Year>2015</Year>
<Month>03</Month>
<Day>26</Day>
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<DateCompleted>
<Year>2016</Year>
<Month>02</Month>
<Day>11</Day>
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<Year>2015</Year>
<Month>03</Month>
<Day>26</Day>
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<ISSN IssnType="Electronic">1097-0347</ISSN>
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<Volume>37</Volume>
<Issue>4</Issue>
<PubDate>
<Year>2015</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Head & neck</Title>
<ISOAbbreviation>Head Neck</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: a comparative study from a single tertiary center.</ArticleTitle>
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<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland is a high-grade cancer and the prognosis of this cancer has not been compared with non-CXPA high-grade primary parotid cancer.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Retrospective medical chart review of patients with surgically treated high-grade primary parotid cancer (21 CXPA and 52 non-CXPA) was performed with correlation with disease-specific survival, locoregional recurrence, and distant recurrence.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Despite having similar stage of cancer and extent of surgical resection, patients with CXPA had a lower disease-specific survival compared to non-CXPA high-grade primary parotid cancer (p = .02). Salivary duct cancer (SDC) was the commonest histologic variant in both cohorts and around 40% of patients with SDC died of distant recurrence that occurred within 3 years from diagnosis.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">CXPA of the parotid gland is a more aggressive cancer compared to non-CXPA high-grade primary parotid cancer. SDC was associated with a high chance of delayed distant recurrence, which contributed directly to the mortality of this cancer.</AbstractText>
<CopyrightInformation>© 2014 Wiley Periodicals, Inc.</CopyrightInformation>
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<LastName>Lim</LastName>
<ForeName>Chwee Ming</ForeName>
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<Affiliation>Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Eye and Ear Institute, Pittsburgh, Pennsylvania; Department of Otolaryngology Head and Neck Surgery, National University Health System, Singapore.</Affiliation>
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<Keyword MajorTopicYN="N">salivary duct carcinoma</Keyword>
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