Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm: translation from animal models to human control.
Identifieur interne : 001134 ( Ncbi/Merge ); précédent : 001133; suivant : 001135Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm: translation from animal models to human control.
Auteurs : Jennifer L. Collinger ; Michael A. Kryger ; Richard Barbara ; Timothy Betler ; Kristen Bowsher ; Elke H P. Brown ; Samuel T. Clanton ; Alan D. Degenhart ; Stephen T. Foldes ; Robert A. Gaunt ; Ferenc E. Gyulai ; Elizabeth A. Harchick ; Deborah Harrington ; John B. Helder ; Timothy Hemmes ; Matthew S. Johannes ; Kapil D. Katyal ; Geoffrey S F. Ling ; Angus J C. Mcmorland ; Karina Palko ; Matthew P. Para ; Janet Scheuermann ; Andrew B. Schwartz ; Elizabeth R. Skidmore ; Florian Solzbacher ; Anita V. Srikameswaran ; Dennis P. Swanson ; Scott Swetz ; Elizabeth C. Tyler-Kabara ; Meel Velliste ; Wei Wang ; Douglas J. Weber ; Brian Wodlinger ; Michael L. BoningerSource :
- Clinical and translational science [ 1752-8062 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Comportement coopératif, Conception de prothèse, Humains, Interface utilisateur, Interfaces cerveau-ordinateur (), Logiciel, Membres artificiels (), Modèles animaux, Mâle, Primates, Recherche médicale translationnelle, Robotique (), Robotique (instrumentation), Traumatismes de la moelle épinière (rééducation et réadaptation), Tétraplégie (rééducation et réadaptation), Électroencéphalographie.
- MESH :
- rééducation et réadaptation : Traumatismes de la moelle épinière, Tétraplégie.
- instrumentation : Adulte, Animaux, Comportement coopératif, Conception de prothèse, Humains, Interface utilisateur, Interfaces cerveau-ordinateur, Logiciel, Membres artificiels, Modèles animaux, Mâle, Primates, Recherche médicale translationnelle, Robotique, Électroencéphalographie.
English descriptors
- KwdEn :
- Adult, Animals, Artificial Limbs (statistics & numerical data), Brain-Computer Interfaces (statistics & numerical data), Cooperative Behavior, Electroencephalography, Humans, Male, Models, Animal, Primates, Prosthesis Design, Quadriplegia (rehabilitation), Robotics (instrumentation), Robotics (statistics & numerical data), Software, Spinal Cord Injuries (rehabilitation), Translational Medical Research, User-Computer Interface.
- MESH :
- instrumentation : Robotics.
- rehabilitation : Quadriplegia, Spinal Cord Injuries.
- statistics & numerical data : Artificial Limbs, Brain-Computer Interfaces, Robotics.
- Adult, Animals, Cooperative Behavior, Electroencephalography, Humans, Male, Models, Animal, Primates, Prosthesis Design, Software, Translational Medical Research, User-Computer Interface.
Abstract
Our research group recently demonstrated that a person with tetraplegia could use a brain-computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able-bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments into a clinical study. We present a roadmap that may serve as an example for other areas of clinical device research as well as an update on study results. Prior to conducting a multiyear clinical trial, years of animal research preceded BCI testing in an epilepsy monitoring unit, and then in a short-term (28 days) clinical investigation. Scientists and engineers developed the necessary robotic and surgical hardware, software environment, data analysis techniques, and training paradigms. Coordination among researchers, funding institutes, and regulatory bodies ensured that the study would provide valuable scientific information in a safe environment for the study participant. Finally, clinicians from neurosurgery, anesthesiology, physiatry, psychology, and occupational therapy all worked in a multidisciplinary team along with the other researchers to conduct a multiyear BCI clinical study. This teamwork and coordination can be used as a model for others attempting to translate basic science into real-world clinical situations.
DOI: 10.1111/cts.12086
PubMed: 24528900
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003A46
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pubmed:24528900Le document en format XML
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<term>Cooperative Behavior</term>
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<term>Quadriplegia (rehabilitation)</term>
<term>Robotics (instrumentation)</term>
<term>Robotics (statistics & numerical data)</term>
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<term>Conception de prothèse</term>
<term>Humains</term>
<term>Interface utilisateur</term>
<term>Interfaces cerveau-ordinateur ()</term>
<term>Logiciel</term>
<term>Membres artificiels ()</term>
<term>Modèles animaux</term>
<term>Mâle</term>
<term>Primates</term>
<term>Recherche médicale translationnelle</term>
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<term>Électroencéphalographie</term>
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<term>Robotics</term>
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<term>Primates</term>
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<front><div type="abstract" xml:lang="en">Our research group recently demonstrated that a person with tetraplegia could use a brain-computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able-bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments into a clinical study. We present a roadmap that may serve as an example for other areas of clinical device research as well as an update on study results. Prior to conducting a multiyear clinical trial, years of animal research preceded BCI testing in an epilepsy monitoring unit, and then in a short-term (28 days) clinical investigation. Scientists and engineers developed the necessary robotic and surgical hardware, software environment, data analysis techniques, and training paradigms. Coordination among researchers, funding institutes, and regulatory bodies ensured that the study would provide valuable scientific information in a safe environment for the study participant. Finally, clinicians from neurosurgery, anesthesiology, physiatry, psychology, and occupational therapy all worked in a multidisciplinary team along with the other researchers to conduct a multiyear BCI clinical study. This teamwork and coordination can be used as a model for others attempting to translate basic science into real-world clinical situations.</div>
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<ArticleTitle>Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm: translation from animal models to human control.</ArticleTitle>
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<Abstract><AbstractText>Our research group recently demonstrated that a person with tetraplegia could use a brain-computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able-bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments into a clinical study. We present a roadmap that may serve as an example for other areas of clinical device research as well as an update on study results. Prior to conducting a multiyear clinical trial, years of animal research preceded BCI testing in an epilepsy monitoring unit, and then in a short-term (28 days) clinical investigation. Scientists and engineers developed the necessary robotic and surgical hardware, software environment, data analysis techniques, and training paradigms. Coordination among researchers, funding institutes, and regulatory bodies ensured that the study would provide valuable scientific information in a safe environment for the study participant. Finally, clinicians from neurosurgery, anesthesiology, physiatry, psychology, and occupational therapy all worked in a multidisciplinary team along with the other researchers to conduct a multiyear BCI clinical study. This teamwork and coordination can be used as a model for others attempting to translate basic science into real-world clinical situations.</AbstractText>
<CopyrightInformation>Published 2013. This article is a U.S. Government work and is in the public domain in the USA.</CopyrightInformation>
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<ForeName>Jennifer L</ForeName>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2013 Jan 23;33(4):1326-30</RefSource>
<PMID Version="1">23345208</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Inf Technol Biomed. 2011 Sep;15(5):726-36</RefSource>
<PMID Version="1">21708506</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 1983;51(2):247-60</RefSource>
<PMID Version="1">6617794</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 1998 Dec;121 ( Pt 12):2271-99</RefSource>
<PMID Version="1">9874480</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Conf Proc IEEE Eng Med Biol Soc. 2012;2012:4275-8</RefSource>
<PMID Version="1">23366872</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neural Eng. 2008 Dec;5(4):455-76</RefSource>
<PMID Version="1">19015583</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Anesthesiology. 2008 May;108(5):858-63</RefSource>
<PMID Version="1">18431121</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4430-5</RefSource>
<PMID Version="1">20160084</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 May 17;485(7398):372-5</RefSource>
<PMID Version="1">22596161</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Adv Neurol. 2000;84:343-51</RefSource>
<PMID Version="1">11091878</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2002 Mar 14;416(6877):141-2</RefSource>
<PMID Version="1">11894084</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Rehabil Eng. 2000 Jun;8(2):196-8</RefSource>
<PMID Version="1">10896185</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2005 Aug 5;309(5736):951-4</RefSource>
<PMID Version="1">16081741</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 1986 Sep 26;233(4771):1416-9</RefSource>
<PMID Version="1">3749885</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Neural Syst Rehabil Eng. 2006 Jun;14(2):183-6</RefSource>
<PMID Version="1">16792289</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Anesth Analg. 2011 Jan;112(1):191-7</RefSource>
<PMID Version="1">20966443</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Conf Proc IEEE Eng Med Biol Soc. 2011;2011:5782-5</RefSource>
<PMID Version="1">22255654</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 1969 Feb 28;163(3870):955-8</RefSource>
<PMID Version="1">4974291</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Neurophysiol. 2011 May;122(5):925-33</RefSource>
<PMID Version="1">20888292</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Rehabil Res. 1981;4(4):483-92</RefSource>
<PMID Version="1">7333761</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Conf Proc IEEE Eng Med Biol Soc. 2009;2009:4339-42</RefSource>
<PMID Version="1">19963823</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2005 May 11;25(19):4681-93</RefSource>
<PMID Version="1">15888644</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Conf Proc IEEE Eng Med Biol Soc. 2011;2011:6294-8</RefSource>
<PMID Version="1">22255777</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 1998 Dec;121 ( Pt 12):2301-15</RefSource>
<PMID Version="1">9874481</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neural Eng. 2004 Jun;1(2):63-71</RefSource>
<PMID Version="1">15876624</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1982 Nov;2(11):1527-37</RefSource>
<PMID Version="1">7143039</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2008 Jun 19;453(7198):1098-101</RefSource>
<PMID Version="1">18509337</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(2):e55344</RefSource>
<PMID Version="1">23405137</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Spinal Cord. 2014 Feb;52(2):110-6</RefSource>
<PMID Version="1">23439068</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Phys Med Rehabil Clin N Am. 2010 Feb;21(1):157-78</RefSource>
<PMID Version="1">19951784</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2010 Nov;104(5):2451-61</RefSource>
<PMID Version="1">20739599</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AANA J. 2011 Oct;79(5):433-40</RefSource>
<PMID Version="1">23256274</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Phys Med Rehabil. 2009 Apr;90(4):682-95</RefSource>
<PMID Version="1">19345787</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Front Neuroeng. 2010 Mar 30;3:3</RefSource>
<PMID Version="1">20407639</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2012 Mar;71(3):353-61</RefSource>
<PMID Version="1">22052728</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Vis Exp. 2012;(64). pii: 3993. doi: 10.3791/3993</RefSource>
<PMID Version="1">22782131</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Anesthesiology. 1992 May;76(5):822-43</RefSource>
<PMID Version="1">1575351</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Anaesthesia. 1998 Mar;53(3):273-89</RefSource>
<PMID Version="1">9613273</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2002 Jun 7;296(5574):1829-32</RefSource>
<PMID Version="1">12052948</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Prog Brain Res. 2006;159:275-95</RefSource>
<PMID Version="1">17071238</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2006 Jul 13;442(7099):164-71</RefSource>
<PMID Version="1">16838014</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Conf Proc IEEE Eng Med Biol Soc. 2008;2008:615-9</RefSource>
<PMID Version="1">19162731</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 1994 Jul 22;265(5171):540-2</RefSource>
<PMID Version="1">8036499</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2013 Feb 16;381(9866):557-64</RefSource>
<PMID Version="1">23253623</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Conf Proc IEEE Eng Med Biol Soc. 2009;2009:586-9</RefSource>
<PMID Version="1">19964229</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurotrauma. 2009 Nov;26(11):2113-26</RefSource>
<PMID Version="1">19604097</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Comput Intell Neurosci. 2011;2011:363565</RefSource>
<PMID Version="1">21687575</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Phys Med Rehabil. 2011 Mar;92(3):332-8</RefSource>
<PMID Version="1">21353817</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 May 17;485(7398):368-71</RefSource>
<PMID Version="1">22522928</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Spinal Cord Med. 1997 Jul;20(3):361-4</RefSource>
<PMID Version="1">9261784</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Phys Med Rehabil. 2008 Mar;89(3):422-9</RefSource>
<PMID Version="1">18295618</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Anesthesiology. 1981 Nov;55(5):550-8</RefSource>
<PMID Version="1">7294411</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1988 Aug;8(8):2913-27</RefSource>
<PMID Version="1">3411361</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neural Eng. 2007 Sep;4(3):264-75</RefSource>
<PMID Version="1">17873429</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2003 Nov;1(2):E42</RefSource>
<PMID Version="1">14624244</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Anesth Analg. 1982 Apr;61(4):344-8</RefSource>
<PMID Version="1">7199851</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>IEEE Rev Biomed Eng. 2011;4:140-54</RefSource>
<PMID Version="1">22273796</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
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