PittsburghV1, Ncbi, Merge, bibRecord, 000B09

Girls' challenging social experiences in early adolescence predict neural response to rewards and depressive symptoms.

Identifieur interne : 000B09 ( Ncbi/Merge ); précédent : 000B08; suivant : 000B10

Girls' challenging social experiences in early adolescence predict neural response to rewards and depressive symptoms.

Auteurs : Melynda D. Casement [États-Unis] ; Amanda E. Guyer [États-Unis] ; Alison E. Hipwell [États-Unis] ; Rose L. Mcaloon [États-Unis] ; Amy M. Hoffmann [États-Unis] ; Kathryn E. Keenan [États-Unis] ; Erika E. Forbes [États-Unis]

Source :

Developmental cognitive neuroscience [ 1878-9307 ] ; 2014.

RBID : pubmed:24397999

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adolescent Development, Amygdala (physiology), Amygdala (physiopathology), Child, Depression (physiopathology), Depression (psychology), Disease Susceptibility, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Models, Psychological, Neostriatum (physiology), Neostriatum (physiopathology), Parenting (psychology), Peer Group, Prefrontal Cortex (physiology), Prefrontal Cortex (physiopathology), Reward, Social Behavior, Stress, Psychological (physiopathology), Stress, Psychological (psychology).
MESH :
- physiology : Amygdala, Neostriatum, Prefrontal Cortex.
- physiopathology : Amygdala, Depression, Neostriatum, Prefrontal Cortex, Stress, Psychological.
- psychology : Depression, Parenting, Stress, Psychological.
- Adolescent, Adolescent Development, Child, Disease Susceptibility, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Models, Psychological, Peer Group, Reward, Social Behavior.

Abstract

Developmental models of psychopathology posit that exposure to social stressors may confer risk for depression in adolescent girls by disrupting neural reward circuitry. The current study tested this hypothesis by examining the relationship between early adolescent social stressors and later neural reward processing and depressive symptoms. Participants were 120 girls from an ongoing longitudinal study of precursors to depression across adolescent development. Low parental warmth, peer victimization, and depressive symptoms were assessed when the girls were 11 and 12 years old, and participants completed a monetary reward guessing fMRI task and assessment of depressive symptoms at age 16. Results indicate that low parental warmth was associated with increased response to potential rewards in the medial prefrontal cortex (mPFC), striatum, and amygdala, whereas peer victimization was associated with decreased response to potential rewards in the mPFC. Furthermore, concurrent depressive symptoms were associated with increased reward anticipation response in mPFC and striatal regions that were also associated with early adolescent psychosocial stressors, with mPFC and striatal response mediating the association between social stressors and depressive symptoms. These findings are consistent with developmental models that emphasize the adverse impact of early psychosocial stressors on neural reward processing and risk for depression in adolescence.

DOI: 10.1016/j.dcn.2013.12.003
PubMed: 24397999

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<term>Child</term>
<term>Depression (physiopathology)</term>
<term>Depression (psychology)</term>
<term>Disease Susceptibility</term>
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<term>Humans</term>
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<term>Prefrontal Cortex (physiopathology)</term>
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<term>Stress, Psychological (physiopathology)</term>
<term>Stress, Psychological (psychology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Amygdale (système limbique) (physiologie)</term>
<term>Amygdale (système limbique) (physiopathologie)</term>
<term>Comportement social</term>
<term>Cortex préfrontal (physiologie)</term>
<term>Cortex préfrontal (physiopathologie)</term>
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<term>Néostriatum (physiopathologie)</term>
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<term>Dépression</term>
<term>Néostriatum</term>
<term>Stress psychologique</term>
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<term>Depression</term>
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<front><div type="abstract" xml:lang="en">Developmental models of psychopathology posit that exposure to social stressors may confer risk for depression in adolescent girls by disrupting neural reward circuitry. The current study tested this hypothesis by examining the relationship between early adolescent social stressors and later neural reward processing and depressive symptoms. Participants were 120 girls from an ongoing longitudinal study of precursors to depression across adolescent development. Low parental warmth, peer victimization, and depressive symptoms were assessed when the girls were 11 and 12 years old, and participants completed a monetary reward guessing fMRI task and assessment of depressive symptoms at age 16. Results indicate that low parental warmth was associated with increased response to potential rewards in the medial prefrontal cortex (mPFC), striatum, and amygdala, whereas peer victimization was associated with decreased response to potential rewards in the mPFC. Furthermore, concurrent depressive symptoms were associated with increased reward anticipation response in mPFC and striatal regions that were also associated with early adolescent psychosocial stressors, with mPFC and striatal response mediating the association between social stressors and depressive symptoms. These findings are consistent with developmental models that emphasize the adverse impact of early psychosocial stressors on neural reward processing and risk for depression in adolescence.</div>
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<Abstract><AbstractText>Developmental models of psychopathology posit that exposure to social stressors may confer risk for depression in adolescent girls by disrupting neural reward circuitry. The current study tested this hypothesis by examining the relationship between early adolescent social stressors and later neural reward processing and depressive symptoms. Participants were 120 girls from an ongoing longitudinal study of precursors to depression across adolescent development. Low parental warmth, peer victimization, and depressive symptoms were assessed when the girls were 11 and 12 years old, and participants completed a monetary reward guessing fMRI task and assessment of depressive symptoms at age 16. Results indicate that low parental warmth was associated with increased response to potential rewards in the medial prefrontal cortex (mPFC), striatum, and amygdala, whereas peer victimization was associated with decreased response to potential rewards in the mPFC. Furthermore, concurrent depressive symptoms were associated with increased reward anticipation response in mPFC and striatal regions that were also associated with early adolescent psychosocial stressors, with mPFC and striatal response mediating the association between social stressors and depressive symptoms. These findings are consistent with developmental models that emphasize the adverse impact of early psychosocial stressors on neural reward processing and risk for depression in adolescence.</AbstractText>
<CopyrightInformation>Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
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<ForeName>Melynda D</ForeName>
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</AffiliationInfo>
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Girls' challenging social experiences in early adolescence predict neural response to rewards and depressive symptoms.

Girls' challenging social experiences in early adolescence predict neural response to rewards and depressive symptoms.

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