Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.
Identifieur interne : 000570 ( Ncbi/Merge ); précédent : 000569; suivant : 000571Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.
Auteurs : Young T. Hong [Royaume-Uni] ; Tonny Veenith [Royaume-Uni] ; Deborah Dewar [Royaume-Uni] ; Joanne G. Outtrim [Royaume-Uni] ; Vaithianadan Mani [Royaume-Uni] ; Claire Williams [Royaume-Uni] ; Sally Pimlott [Royaume-Uni] ; Peter J A. Hutchinson [Royaume-Uni] ; Adriana Tavares [Royaume-Uni] ; Roberto Canales [Royaume-Uni] ; Chester A. Mathis [États-Unis] ; William E. Klunk [États-Unis] ; Franklin I. Aigbirhio [Royaume-Uni] ; Jonathan P. Coles [Royaume-Uni] ; Jean-Claude Baron [France] ; John D. Pickard [Royaume-Uni] ; Tim D. Fryer [Royaume-Uni] ; William Stewart [Royaume-Uni] ; David K. Menon [Royaume-Uni]Source :
- JAMA neurology [ 2168-6157 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Dérivés de l'aniline, Encéphale (anatomopathologie), Encéphale (imagerie diagnostique), Encéphale (métabolisme), Facteurs temps, Femelle, Humains, Jeune adulte, Lésions encéphaliques (anatomopathologie), Lésions encéphaliques (imagerie diagnostique), Lésions encéphaliques (métabolisme), Mâle, Peptides bêta-amyloïdes (métabolisme), Radio-isotopes du carbone, Sujet âgé, Thiazoles, Tomographie par émission de positons (), Tritium, Études de cohortes.
- MESH :
- anatomopathologie : Encéphale, Lésions encéphaliques.
- imagerie diagnostique : Encéphale, Lésions encéphaliques.
- métabolisme : Encéphale, Lésions encéphaliques, Peptides bêta-amyloïdes.
- Adulte, Adulte d'âge moyen, Dérivés de l'aniline, Facteurs temps, Femelle, Humains, Jeune adulte, Mâle, Radio-isotopes du carbone, Sujet âgé, Thiazoles, Tomographie par émission de positons, Tritium, Études de cohortes.
English descriptors
- KwdEn :
- Adult, Aged, Amyloid beta-Peptides (metabolism), Aniline Compounds, Brain (diagnostic imaging), Brain (metabolism), Brain (pathology), Brain Injuries (diagnostic imaging), Brain Injuries (metabolism), Brain Injuries (pathology), Carbon Radioisotopes, Cohort Studies, Female, Humans, Male, Middle Aged, Positron-Emission Tomography (methods), Thiazoles, Time Factors, Tritium, Young Adult.
- MESH :
- chemical , metabolism : Amyloid beta-Peptides.
- diagnostic imaging : Brain, Brain Injuries.
- metabolism : Brain, Brain Injuries.
- methods : Positron-Emission Tomography.
- pathology : Brain, Brain Injuries.
- Adult, Aged, Aniline Compounds, Carbon Radioisotopes, Cohort Studies, Female, Humans, Male, Middle Aged, Thiazoles, Time Factors, Tritium, Young Adult.
Abstract
To image amyloid deposition in patients with traumatic brain injury (TBI) using carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) and to validate these findings using tritium-labeled PiB ([3H]PiB) autoradiography and immunocytochemistry in autopsy-acquired tissue.
DOI: 10.1001/jamaneurol.2013.4847
PubMed: 24217171
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Hong</name><affiliation wicri:level="2"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Veenith, Tonny" sort="Veenith, Tonny" uniqKey="Veenith T" first="Tonny" last="Veenith">Tonny Veenith</name><affiliation wicri:level="2"><nlm:affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Dewar, Deborah" sort="Dewar, Deborah" uniqKey="Dewar D" first="Deborah" last="Dewar">Deborah Dewar</name><affiliation wicri:level="2"><nlm:affiliation>Institute of Neuroscience and Psychology, University of Glasgow, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Institute of Neuroscience and Psychology, University of Glasgow</wicri:cityArea></affiliation></author><author><name sortKey="Outtrim, Joanne G" sort="Outtrim, Joanne G" uniqKey="Outtrim J" first="Joanne G" last="Outtrim">Joanne G. 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Menon</name><affiliation wicri:level="2"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England2Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England2Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24217171</idno><idno type="pmid">24217171</idno><idno type="doi">10.1001/jamaneurol.2013.4847</idno><idno type="wicri:Area/PubMed/Corpus">004469</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004469</idno><idno type="wicri:Area/PubMed/Curation">004417</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004417</idno><idno type="wicri:Area/PubMed/Checkpoint">004417</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004417</idno><idno type="wicri:Area/Ncbi/Merge">000570</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.</title><author><name sortKey="Hong, Young T" sort="Hong, Young T" uniqKey="Hong Y" first="Young T" last="Hong">Young T. Hong</name><affiliation wicri:level="2"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Veenith, Tonny" sort="Veenith, Tonny" uniqKey="Veenith T" first="Tonny" last="Veenith">Tonny Veenith</name><affiliation wicri:level="2"><nlm:affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Dewar, Deborah" sort="Dewar, Deborah" uniqKey="Dewar D" first="Deborah" last="Dewar">Deborah Dewar</name><affiliation wicri:level="2"><nlm:affiliation>Institute of Neuroscience and Psychology, University of Glasgow, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Institute of Neuroscience and Psychology, University of Glasgow</wicri:cityArea></affiliation></author><author><name sortKey="Outtrim, Joanne G" sort="Outtrim, Joanne G" uniqKey="Outtrim J" first="Joanne G" last="Outtrim">Joanne G. Outtrim</name><affiliation wicri:level="2"><nlm:affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Mani, Vaithianadan" sort="Mani, Vaithianadan" uniqKey="Mani V" first="Vaithianadan" last="Mani">Vaithianadan Mani</name><affiliation wicri:level="2"><nlm:affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Williams, Claire" sort="Williams, Claire" uniqKey="Williams C" first="Claire" last="Williams">Claire Williams</name><affiliation wicri:level="2"><nlm:affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Pimlott, Sally" sort="Pimlott, Sally" uniqKey="Pimlott S" first="Sally" last="Pimlott">Sally Pimlott</name><affiliation wicri:level="2"><nlm:affiliation>University of Glasgow and Southern General Hospital, Glasgow, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>University of Glasgow and Southern General Hospital, Glasgow</wicri:cityArea></affiliation></author><author><name sortKey="Hutchinson, Peter J A" sort="Hutchinson, Peter J A" uniqKey="Hutchinson P" first="Peter J A" last="Hutchinson">Peter J A. Hutchinson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Tavares, Adriana" sort="Tavares, Adriana" uniqKey="Tavares A" first="Adriana" last="Tavares">Adriana Tavares</name><affiliation wicri:level="2"><nlm:affiliation>Institute of Neuroscience and Psychology, University of Glasgow, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Institute of Neuroscience and Psychology, University of Glasgow</wicri:cityArea></affiliation></author><author><name sortKey="Canales, Roberto" sort="Canales, Roberto" uniqKey="Canales R" first="Roberto" last="Canales">Roberto Canales</name><affiliation wicri:level="2"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Mathis, Chester A" sort="Mathis, Chester A" uniqKey="Mathis C" first="Chester A" last="Mathis">Chester A. Mathis</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Radiology and Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Radiology and Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Aigbirhio, Franklin I" sort="Aigbirhio, Franklin I" uniqKey="Aigbirhio F" first="Franklin I" last="Aigbirhio">Franklin I. Aigbirhio</name><affiliation wicri:level="2"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Coles, Jonathan P" sort="Coles, Jonathan P" uniqKey="Coles J" first="Jonathan P" last="Coles">Jonathan P. Coles</name><affiliation wicri:level="2"><nlm:affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Baron, Jean Claude" sort="Baron, Jean Claude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name><affiliation wicri:level="4"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England8INSERM U894, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England8INSERM U894, Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Cambridge</settlement></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Pickard, John D" sort="Pickard, John D" uniqKey="Pickard J" first="John D" last="Pickard">John D. Pickard</name><affiliation wicri:level="2"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Fryer, Tim D" sort="Fryer, Tim D" uniqKey="Fryer T" first="Tim D" last="Fryer">Tim D. Fryer</name><affiliation wicri:level="2"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Stewart, William" sort="Stewart, William" uniqKey="Stewart W" first="William" last="Stewart">William Stewart</name><affiliation wicri:level="2"><nlm:affiliation>University of Glasgow and Southern General Hospital, Glasgow, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>University of Glasgow and Southern General Hospital, Glasgow</wicri:cityArea></affiliation></author><author><name sortKey="Menon, David K" sort="Menon, David K" uniqKey="Menon D" first="David K" last="Menon">David K. Menon</name><affiliation wicri:level="2"><nlm:affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England2Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England2Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge</wicri:cityArea></affiliation></author></analytic><series><title level="j">JAMA neurology</title><idno type="eISSN">2168-6157</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Amyloid beta-Peptides (metabolism)</term><term>Aniline Compounds</term><term>Brain (diagnostic imaging)</term><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Brain Injuries (diagnostic imaging)</term><term>Brain Injuries (metabolism)</term><term>Brain Injuries (pathology)</term><term>Carbon Radioisotopes</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography (methods)</term><term>Thiazoles</term><term>Time Factors</term><term>Tritium</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dérivés de l'aniline</term><term>Encéphale (anatomopathologie)</term><term>Encéphale (imagerie diagnostique)</term><term>Encéphale (métabolisme)</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Lésions encéphaliques (anatomopathologie)</term><term>Lésions encéphaliques (imagerie diagnostique)</term><term>Lésions encéphaliques (métabolisme)</term><term>Mâle</term><term>Peptides bêta-amyloïdes (métabolisme)</term><term>Radio-isotopes du carbone</term><term>Sujet âgé</term><term>Thiazoles</term><term>Tomographie par émission de positons ()</term><term>Tritium</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid beta-Peptides</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Lésions encéphaliques</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Brain Injuries</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Encéphale</term><term>Lésions encéphaliques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Brain Injuries</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Encéphale</term><term>Lésions encéphaliques</term><term>Peptides bêta-amyloïdes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Brain Injuries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aniline Compounds</term><term>Carbon Radioisotopes</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Thiazoles</term><term>Time Factors</term><term>Tritium</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dérivés de l'aniline</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Radio-isotopes du carbone</term><term>Sujet âgé</term><term>Thiazoles</term><term>Tomographie par émission de positons</term><term>Tritium</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To image amyloid deposition in patients with traumatic brain injury (TBI) using carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) and to validate these findings using tritium-labeled PiB ([3H]PiB) autoradiography and immunocytochemistry in autopsy-acquired tissue.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24217171</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>15</Day></DateCreated><DateCompleted><Year>2014</Year><Month>03</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2168-6157</ISSN><JournalIssue CitedMedium="Internet"><Volume>71</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Jan</Month></PubDate></JournalIssue><Title>JAMA neurology</Title><ISOAbbreviation>JAMA Neurol</ISOAbbreviation></Journal><ArticleTitle>Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.</ArticleTitle><Pagination><MedlinePgn>23-31</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/jamaneurol.2013.4847</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To image amyloid deposition in patients with traumatic brain injury (TBI) using carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) and to validate these findings using tritium-labeled PiB ([3H]PiB) autoradiography and immunocytochemistry in autopsy-acquired tissue.</AbstractText><AbstractText Label="DESIGN, SETTING, AND PARTICIPANTS" NlmCategory="METHODS">In vivo PET at tertiary neuroscience referral center and ex vivo immunocytochemistry of autopsy-acquired brain tissue from a neuropathology archive. [11C]PiB PET was used to image amyloid deposition in 11 controls (median [range] age, 35 [24-60] years) and in 15 patients (median [range] age, 33 [21-50] years) between 1 and 361 days after a TBI. [3H]PiB autoradiography and immunocytochemistry for β-amyloid (Aβ) and β-amyloid precursor protein in brain tissue were obtained from separate cohorts of 16 patients (median [range] age, 46 [21-70] years) who died between 3 hours and 56 days after a TBI and 7 controls (median [range] age, 61 [29-71] years) who died of other causes.</AbstractText><AbstractText Label="MAIN OUTCOMES AND MEASURES" NlmCategory="METHODS">We quantified the [11C]PiB distribution volume ratio and standardized uptake value ratio in PET images. The distribution volume ratio and the standardized uptake value ratio were measured in cortical gray matter, white matter, and multiple cortical and white matter regions of interest, as well as in striatal and thalamic regions of interest. We examined [3H]PiB binding and Aβ and β-amyloid precursor protein immunocytochemistry in autopsy-acquired brain tissue.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with the controls, the patients with TBI showed significantly increased [11C]PiB distribution volume ratios in cortical gray matter and the striatum (corrected P < .05 for both), but not in the thalamus or white matter. Increases in [11C]PiB distribution volume ratios in patients with TBI were seen across most cortical subregions, were replicated using comparisons of standardized uptake value ratios, and could not be accounted for by methodological confounders. Autoradiography revealed [3H]PiB binding in neocortical gray matter, in regions where amyloid deposition was demonstrated by immunocytochemistry; white matter showed Aβ and β-amyloid precursor protein by immunocytochemistry, but no [3H]PiB binding. No plaque-associated amyloid immunoreactivity or [3H]PiB binding was seen in cerebellar gray matter in autopsy-acquired tissue from either controls or patients with TBI, although 1 sample of cerebellar tissue from a patient with TBI showed amyloid angiopathy in meningeal vessels.</AbstractText><AbstractText Label="CONCLUSIONS AND RELEVANCE" NlmCategory="CONCLUSIONS">[11C]PiB shows increased binding following TBI. The specificity of this binding is supported by neocortical [3H]PiB binding in regions of amyloid deposition in the postmortem tissue of patients with TBI. [11C]PiB PET could be valuable in imaging amyloid deposition following TBI.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Young T</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veenith</LastName><ForeName>Tonny</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dewar</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Neuroscience and Psychology, University of Glasgow, Scotland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Outtrim</LastName><ForeName>Joanne G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mani</LastName><ForeName>Vaithianadan</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pimlott</LastName><ForeName>Sally</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Glasgow and Southern General Hospital, Glasgow, Scotland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutchinson</LastName><ForeName>Peter J A</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavares</LastName><ForeName>Adriana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Neuroscience and Psychology, University of Glasgow, Scotland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canales</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathis</LastName><ForeName>Chester A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Departments of Radiology and Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klunk</LastName><ForeName>William E</ForeName><Initials>WE</Initials><AffiliationInfo><Affiliation>Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aigbirhio</LastName><ForeName>Franklin I</ForeName><Initials>FI</Initials><AffiliationInfo><Affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coles</LastName><ForeName>Jonathan P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baron</LastName><ForeName>Jean-Claude</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England8INSERM U894, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pickard</LastName><ForeName>John D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fryer</LastName><ForeName>Tim D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England5Department of Clinical Neurosciences, University of Cambridge, Cambridge, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stewart</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>University of Glasgow and Southern General Hospital, Glasgow, Scotland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Menon</LastName><ForeName>David K</ForeName><Initials>DK</Initials><AffiliationInfo><Affiliation>Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England2Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, England.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G0001354</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0600986</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G1002277</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>AG025204</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 AG025516</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RG46503</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P50 AG005133</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NIHR-RP-R3-12-013</GrantID><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RF1 AG025516</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G0900903</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G9439390</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P01 AG025204</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JAMA Neurol</MedlineTA><NlmUniqueID>101589536</NlmUniqueID><ISSNLinking>2168-6149</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C475519">2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016229">Amyloid beta-Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000814">Aniline Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002250">Carbon Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013844">Thiazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>10028-17-8</RegistryNumber><NameOfSubstance UI="D014316">Tritium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neuropathol Appl Neurobiol. 2000 Apr;26(2):124-32</RefSource><PMID Version="1">10840275</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 2003 May;98(5):1072-7</RefSource><PMID Version="1">12744368</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol 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Version="1">24296658</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016229" MajorTopicYN="N">Amyloid beta-Peptides</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000814" MajorTopicYN="Y">Aniline Compounds</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001930" MajorTopicYN="N">Brain Injuries</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002250" MajorTopicYN="N">Carbon Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013844" MajorTopicYN="Y">Thiazoles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014316" MajorTopicYN="N">Tritium</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS587966</OtherID><OtherID Source="NLM">PMC4084932</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24217171</ArticleId><ArticleId IdType="pii">1765682</ArticleId><ArticleId IdType="doi">10.1001/jamaneurol.2013.4847</ArticleId><ArticleId IdType="pmc">PMC4084932</ArticleId><ArticleId IdType="mid">NIHMS587966</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Pennsylvanie</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Cambridge</li><li>Paris</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hong, Young T" sort="Hong, Young T" uniqKey="Hong Y" first="Young T" last="Hong">Young T. Hong</name></region><name sortKey="Aigbirhio, Franklin I" sort="Aigbirhio, Franklin I" uniqKey="Aigbirhio F" first="Franklin I" last="Aigbirhio">Franklin I. Aigbirhio</name><name sortKey="Canales, Roberto" sort="Canales, Roberto" uniqKey="Canales R" first="Roberto" last="Canales">Roberto Canales</name><name sortKey="Coles, Jonathan P" sort="Coles, Jonathan P" uniqKey="Coles J" first="Jonathan P" last="Coles">Jonathan P. Coles</name><name sortKey="Dewar, Deborah" sort="Dewar, Deborah" uniqKey="Dewar D" first="Deborah" last="Dewar">Deborah Dewar</name><name sortKey="Fryer, Tim D" sort="Fryer, Tim D" uniqKey="Fryer T" first="Tim D" last="Fryer">Tim D. Fryer</name><name sortKey="Hutchinson, Peter J A" sort="Hutchinson, Peter J A" uniqKey="Hutchinson P" first="Peter J A" last="Hutchinson">Peter J A. Hutchinson</name><name sortKey="Mani, Vaithianadan" sort="Mani, Vaithianadan" uniqKey="Mani V" first="Vaithianadan" last="Mani">Vaithianadan Mani</name><name sortKey="Menon, David K" sort="Menon, David K" uniqKey="Menon D" first="David K" last="Menon">David K. Menon</name><name sortKey="Outtrim, Joanne G" sort="Outtrim, Joanne G" uniqKey="Outtrim J" first="Joanne G" last="Outtrim">Joanne G. Outtrim</name><name sortKey="Pickard, John D" sort="Pickard, John D" uniqKey="Pickard J" first="John D" last="Pickard">John D. Pickard</name><name sortKey="Pimlott, Sally" sort="Pimlott, Sally" uniqKey="Pimlott S" first="Sally" last="Pimlott">Sally Pimlott</name><name sortKey="Stewart, William" sort="Stewart, William" uniqKey="Stewart W" first="William" last="Stewart">William Stewart</name><name sortKey="Tavares, Adriana" sort="Tavares, Adriana" uniqKey="Tavares A" first="Adriana" last="Tavares">Adriana Tavares</name><name sortKey="Veenith, Tonny" sort="Veenith, Tonny" uniqKey="Veenith T" first="Tonny" last="Veenith">Tonny Veenith</name><name sortKey="Williams, Claire" sort="Williams, Claire" uniqKey="Williams C" first="Claire" last="Williams">Claire Williams</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Mathis, Chester A" sort="Mathis, Chester A" uniqKey="Mathis C" first="Chester A" last="Mathis">Chester A. Mathis</name></region><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name></country><country name="France"><region name="Île-de-France"><name sortKey="Baron, Jean Claude" sort="Baron, Jean Claude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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