Estrongenic steroid hormones in lung cancer.
Identifieur interne : 001257 ( Ncbi/Curation ); précédent : 001256; suivant : 001258Estrongenic steroid hormones in lung cancer.
Auteurs : Jill M. Siegfried [États-Unis] ; Laura P. Stabile [États-Unis]Source :
- Seminars in oncology [ 1532-8708 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Aromatase (métabolisme), Femelle, Hormones sexuelles stéroïdiennes (métabolisme), Humains, Mâle, Oestrogènes (métabolisme), Récepteurs des oestrogènes (métabolisme), Récepteurs à la progestérone (métabolisme), Tumeurs du poumon (diagnostic), Tumeurs du poumon (métabolisme), Tumeurs du poumon (étiologie).
- MESH :
- diagnostic : Tumeurs du poumon.
- métabolisme : Aromatase, Hormones sexuelles stéroïdiennes, Oestrogènes, Récepteurs des oestrogènes, Récepteurs à la progestérone, Tumeurs du poumon.
- étiologie : Tumeurs du poumon.
- Animaux, Femelle, Humains, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Aromatase, Estrogens, Gonadal Steroid Hormones, Receptors, Estrogen, Receptors, Progesterone.
- diagnosis : Lung Neoplasms.
- etiology : Lung Neoplasms.
- metabolism : Lung Neoplasms.
- Animals, Female, Humans, Male.
Abstract
It is becoming increasingly clear that steroid hormones are involved in the biology of many organs outside the reproductive system. Evidence has been accumulating since the mid 1990s that the lung contains receptors for both estrogen and progesterone and that these hormones have some role in lung development, pulmonary inflammation, and lung cancer. The estrogen receptor β (ERβ) is the major ER expressed in lung tissues, while inflammatory cells capable of infiltrating the lung are reported to express both ERα and ERβ. Although there is evidence in animals of preferential effects of ERβ in the lungs of females, human lung tumors from males also contain ERβ-positive cells and express aromatase, the enzyme that converts testosterone to estrogens. This review will discuss current literature findings on the role of the ERs and the progesterone receptor (PR), as well CYP19 (aromatase), the rate-limiting enzyme in the synthesis of estrogen, in lung cancer.
DOI: 10.1053/j.seminoncol.2013.12.009
PubMed: 24565577
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Siegfried</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA; Current address: Department of Pharmacology, University of Minnesota, Minneapolis, MN. Electronic address: jsiegfri@umn.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA; Current address: Department of Pharmacology, University of Minnesota, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Stabile, Laura P" sort="Stabile, Laura P" uniqKey="Stabile L" first="Laura P" last="Stabile">Laura P. Stabile</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Seminars in oncology</title><idno type="eISSN">1532-8708</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Aromatase (metabolism)</term><term>Estrogens (metabolism)</term><term>Female</term><term>Gonadal Steroid Hormones (metabolism)</term><term>Humans</term><term>Lung Neoplasms (diagnosis)</term><term>Lung Neoplasms (etiology)</term><term>Lung Neoplasms (metabolism)</term><term>Male</term><term>Receptors, Estrogen (metabolism)</term><term>Receptors, Progesterone (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Aromatase (métabolisme)</term><term>Femelle</term><term>Hormones sexuelles stéroïdiennes (métabolisme)</term><term>Humains</term><term>Mâle</term><term>Oestrogènes (métabolisme)</term><term>Récepteurs des oestrogènes (métabolisme)</term><term>Récepteurs à la progestérone (métabolisme)</term><term>Tumeurs du poumon (diagnostic)</term><term>Tumeurs du poumon (métabolisme)</term><term>Tumeurs du poumon (étiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aromatase</term><term>Estrogens</term><term>Gonadal Steroid Hormones</term><term>Receptors, Estrogen</term><term>Receptors, Progesterone</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aromatase</term><term>Hormones sexuelles stéroïdiennes</term><term>Oestrogènes</term><term>Récepteurs des oestrogènes</term><term>Récepteurs à la progestérone</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is becoming increasingly clear that steroid hormones are involved in the biology of many organs outside the reproductive system. Evidence has been accumulating since the mid 1990s that the lung contains receptors for both estrogen and progesterone and that these hormones have some role in lung development, pulmonary inflammation, and lung cancer. The estrogen receptor β (ERβ) is the major ER expressed in lung tissues, while inflammatory cells capable of infiltrating the lung are reported to express both ERα and ERβ. Although there is evidence in animals of preferential effects of ERβ in the lungs of females, human lung tumors from males also contain ERβ-positive cells and express aromatase, the enzyme that converts testosterone to estrogens. This review will discuss current literature findings on the role of the ERs and the progesterone receptor (PR), as well CYP19 (aromatase), the rate-limiting enzyme in the synthesis of estrogen, in lung cancer.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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